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The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89bio, Inc. Common 282559103   1,612,827 105,898 SH   SOLE   1,612,827 0 0
Abbott Laboratories Common 002824100   63,171,557 623,855 SH   SOLE   63,171,557 0 0
AbbVie Inc. Common 00287Y109   81,533,533 511,599 SH   SOLE   81,533,533 0 0
Acadia Healthcare Company, Inc. Common 00404A109   13,473,686 186,487 SH   SOLE   13,473,686 0 0
Adaptive Biotechnologies Corp. Common 00650F109   3,728,741 422,281 SH   SOLE   3,728,741 0 0
Addus HomeCare Corp. Common 006739106   4,524,489 42,380 SH   SOLE   4,524,489 0 0
Adicet Bio, Inc. Common 007002108   232,295 40,329 SH   SOLE   232,295 0 0
Affimed N.V. Common N01045108   436,950 586,038 SH   SOLE   436,950 0 0
Agilent Technologies, Inc. Common 00846U101   5,975,043 43,191 SH   SOLE   5,975,043 0 0
Align Technology, Inc. Common 016255101   2,313,920 6,925 SH   SOLE   2,313,920 0 0
Alkermes plc Shares G01767105   8,727,990 309,613 SH   SOLE   8,727,990 0 0
Alnylam Pharmaceuticals, Inc. Common 02043Q107   28,688,628 143,214 SH   SOLE   28,688,628 0 0
Altimmune, Inc. Common 02155H200   316,500 75,000 SH   SOLE   316,500 0 0
ALX Oncology Holdings Inc. Common 00166B105   299,274 66,211 SH   SOLE   299,274 0 0
Amedisys, Inc. Common 023436108   5,071,199 68,949 SH   SOLE   5,071,199 0 0
Amerisourcebergen Corp. Common 03073E105   3,268,966 20,417 SH   SOLE   3,268,966 0 0
Amgen Inc. Common 031162100   134,398,253 555,939 SH   SOLE   134,398,253 0 0
Apellis Pharmaceuticals, Inc. Common 03753U106   8,912,779 135,124 SH   SOLE   8,912,779 0 0
ARCA biopharma, Inc. Common 00211Y506   64,597 32,461 SH   SOLE   64,597 0 0
Arcus Biosciences, Inc. Common 03969F109   598,983 32,839 SH   SOLE   598,983 0 0
Arcutis Biotherapeutics, Inc. Common 03969K108   1,637,614 148,874 SH   SOLE   1,637,614 0 0
Ardelyx, Inc. Common 039697107   2,583,764 539,408 SH   SOLE   2,583,764 0 0
argenx SE Sponsored ADR 04016X101   32,902,540 88,310 SH   SOLE   32,902,540 0 0
Arrowhead Pharmaceuticals, Inc. Common 04280A100   2,550,719 100,422 SH   SOLE   2,550,719 0 0
Ascendis Pharma A/S Sponsored ADR 04351P101   13,272,871 123,791 SH   SOLE   13,272,871 0 0
Assertio Holdings, Inc. Common 04546C205   2,615,363 410,575 SH   SOLE   2,615,363 0 0
AstraZeneca PLC Sponsored ADR 046353108   68,900,808 992,664 SH   SOLE   68,900,808 0 0
Avantor, Inc. Common 05352A100   9,713,576 459,488 SH   SOLE   9,713,576 0 0
Baxter International, Inc. Common 071813109   2,730,175 67,312 SH   SOLE   2,730,175 0 0
Beam Therapeutics Inc. Common 07373V105   484,317 15,817 SH   SOLE   484,317 0 0
BeiGene, Ltd. Sponsored ADR 07725L102   4,515,785 20,952 SH   SOLE   4,515,785 0 0
Bellicum Pharmaceuticals, Inc. Common 079481404   1,980 6,000 SH   SOLE   1,980 0 0
Bicycle Therapeutics PLC Sponsored ADS 088786108   1,886,139 88,676 SH   SOLE   1,886,139 0 0
BioCryst Pharmaceuticals, Inc. Common 09058V103   4,207,764 504,528 SH   SOLE   4,207,764 0 0
Biogen Inc. Common 09062X103   66,984,656 240,926 SH   SOLE   66,984,656 0 0
Biohaven Ltd. Common G1110E107   479,288 35,087 SH   SOLE   479,288 0 0
BioMarin Pharmaceutical Inc. Common 09061G101   29,180,654 300,089 SH   SOLE   29,180,654 0 0
BioNTech SE Sponsored ADS 09075V102   12,937,591 103,858 SH   SOLE   12,937,591 0 0
Black Diamond Therapeutics, Inc. Common 09203E105   249,461 131,990 SH   SOLE   249,461 0 0
Blueprint Medicines Corp. Common 09627Y109   3,046,273 67,710 SH   SOLE   3,046,273 0 0
Boston Scientific Corp. Common 101137107   28,316,480 565,990 SH   SOLE   28,316,480 0 0
Bridgebio Pharma, Inc. Common 10806X102   2,502,270 150,921 SH   SOLE   2,502,270 0 0
Bristol-Myers Squibb Company Common 110122108   46,007,701 663,796 SH   SOLE   46,007,701 0 0
Cardiovascular Systems, Inc. Common 141619106   3,472,700 174,859 SH   SOLE   3,472,700 0 0
Caribou Biosciences, Inc. Common 142038108   3,011,551 567,147 SH   SOLE   3,011,551 0 0
Catalent, Inc. Common 148806102   3,246,468 49,406 SH   SOLE   3,246,468 0 0
Cerevel Therapeutics Holdings, Inc. Common 15678U128   4,304,420 176,483 SH   SOLE   4,304,420 0 0
Charles River Laboratories International, Inc. Common 159864107   23,831,511 118,083 SH   SOLE   23,831,511 0 0
Chinook Therapeutics, Inc. Common 16961L106   1,933,025 83,500 SH   SOLE   1,933,025 0 0
The Cigna Group Common 125523100   46,667,699 182,631 SH   SOLE   46,667,699 0 0
Codexis Inc Common 192005106   286,178 69,125 SH   SOLE   286,178 0 0
Community Health Systems, Inc. Common 203668108   432,842 88,335 SH   SOLE   432,842 0 0
Community Healthcare Trust Inc. Common 20369C106   545,340 14,900 SH   SOLE   545,340 0 0
Corbus Pharmaceuticals Holdings, Inc. Common 21833P301   37,390 5,143 SH   SOLE   37,390 0 0
Crinetics Pharmaceuticals, Inc. Common 22663K107   1,261,176 78,529 SH   SOLE   1,261,176 0 0
CRISPR Therapeutics AG Namen AKT H17182108   2,491,268 55,080 SH   SOLE   2,491,268 0 0
CVS Health Corp. Common 126650100   6,956,977 93,621 SH   SOLE   6,956,977 0 0
Cytokinetics, Inc. Common 23282W605   7,707,490 219,025 SH   SOLE   7,707,490 0 0
Danaher Corp. Common 235851102   26,638,108 105,690 SH   SOLE   26,638,108 0 0
Denali Therapeutics, Inc. Common 24823R105   7,484,060 324,829 SH   SOLE   7,484,060 0 0
Dexcom, Inc. Common 252131107   26,575,826 228,747 SH   SOLE   26,575,826 0 0
Diversified Healthcare Trust Common 25525P107   482,922 357,720 SH   SOLE   482,922 0 0
Edgewise Therapeutics, Inc. Common 28036F105   1,300,817 195,025 SH   SOLE   1,300,817 0 0
Edwards Lifesciences Corp. Common 28176E108   14,158,909 171,146 SH   SOLE   14,158,909 0 0
Elevance Health, Inc. Common 036752103   52,450,527 114,070 SH   SOLE   52,450,527 0 0
Eli Lilly and Company Common 532457108   99,219,876 288,917 SH   SOLE   99,219,876 0 0
Exelixis, Inc. Common 30161Q104   14,104,063 726,639 SH   SOLE   14,104,063 0 0
Fulcrum Therapeutics, Inc. Common 359616109   166,830 58,537 SH   SOLE   166,830 0 0
Fusion Pharmaceuticals Inc. Common 36118A100   163,595 43,394 SH   SOLE   163,595 0 0
G1 Therapeutics, Inc. Common 3621LQ109   1,135,969 423,869 SH   SOLE   1,135,969 0 0
Galera Therapeutics, Inc. Common 36338D108   2,299,837 898,374 SH   SOLE   2,299,837 0 0
Gilead Sciences, Inc. Common 375558103   129,423,575 1,559,884 SH   SOLE   129,423,575 0 0
Global Medical REIT Inc. Common 37954A204   1,593,312 174,897 SH   SOLE   1,593,312 0 0
GSK plc Sponsored ADR 37733W204   1,489,094 41,852 SH   SOLE   1,489,094 0 0
Guardant Health, Inc. Common 40131M109   11,067,993 472,184 SH   SOLE   11,067,993 0 0
Harpoon Therapeutics, Inc. Common 41358P106   193,425 259,910 SH   SOLE   193,425 0 0
HCA Healthcare, Inc. Common 40412C101   23,389,207 88,703 SH   SOLE   23,389,207 0 0
Healthcare Realty Trust Inc. Common 42226K105   3,376,680 174,686 SH   SOLE   3,376,680 0 0
Healthpeak Properties, Inc. Common 42250P103   3,304,112 150,392 SH   SOLE   3,304,112 0 0
Humana Inc. Common 444859102   17,862,015 36,794 SH   SOLE   17,862,015 0 0
I-Mab Sponsored ADS 44975P103   562,527 162,580 SH   SOLE   562,527 0 0
Icon plc Shares G4705A100   1,993,649 9,334 SH   SOLE   1,993,649 0 0
IDEXX Laboratories, Inc. Common 45168D104   29,302,188 58,595 SH   SOLE   29,302,188 0 0
Illumina, Inc. Common 452327109   80,945,771 348,079 SH   SOLE   80,945,771 0 0
Immunovant, Inc. Common 45258J102   1,789,854 115,400 SH   SOLE   1,789,854 0 0
Intellia Therapeutics, Inc. Common 45826J105   5,749,606 154,269 SH   SOLE   5,749,606 0 0
Intercept Pharmaceuticals, Inc. Common 45845P108   699,260 52,067 SH   SOLE   699,260 0 0
Intra-Cellular Therapies, Inc. Common 46116X101   9,333,890 172,371 SH   SOLE   9,333,890 0 0
Intuitive Surgical, Inc. Common 46120E602   28,786,360 112,680 SH   SOLE   28,786,360 0 0
Ionis Pharmaceuticals, Inc. Common 462222100   3,139,402 87,840 SH   SOLE   3,139,402 0 0
IQVIA Holdings Inc. Common 46266C105   12,553,340 63,117 SH   SOLE   12,553,340 0 0
Ishares Biothechnology ETF Common 464287556   3,173,332 24,569 SH   SOLE   3,173,332 0 0
iTeos Therapeutics, Inc. Common 46565G104   622,453 45,735 SH   SOLE   622,453 0 0
Jazz Pharmaceuticals plc Shares G50871105   21,624,501 147,779 SH   SOLE   21,624,501 0 0
Johnson & Johnson Common 478160104   111,875,745 721,779 SH   SOLE   111,875,745 0 0
Karuna Therapeutics, Inc. Common 48576A100   9,709,021 53,452 SH   SOLE   9,709,021 0 0
Koninklijke Philips N.V. NY Reg Shares 500472303   2,015,931 109,860 SH   SOLE   2,015,931 0 0
Kura Oncology, Inc. Common 50127T109   3,464,527 283,281 SH   SOLE   3,464,527 0 0
Laboratory Corporation of America Holdings Common 50540R409   9,186,436 40,042 SH   SOLE   9,186,436 0 0
Lantheus Holdings, Inc. Common 516544103   6,563,107 79,495 SH   SOLE   6,563,107 0 0
LivaNova plc Common G5509L101   2,783,890 63,880 SH   SOLE   2,783,890 0 0
LTC Properties, Inc. Common 502175102   6,403,953 182,293 SH   SOLE   6,403,953 0 0
Madrigal Pharmaceuticals, Inc. Common 558868105   3,023,647 12,481 SH   SOLE   3,023,647 0 0
Mallinckrodt plc Shares G5890A102   255,503 35,048 SH   SOLE   255,503 0 0
Marinus Pharmaceuticals, Inc. Common 56854Q200   3,151,782 456,780 SH   SOLE   3,151,782 0 0
McKesson Corp. Common 58155Q103   23,661,303 66,455 SH   SOLE   23,661,303 0 0
Medical Properties Trust, Inc. Common 58463J304   3,384,527 411,743 SH   SOLE   3,384,527 0 0
Medpace Holdings, Inc. Common 58506Q109   1,774,252 9,435 SH   SOLE   1,774,252 0 0
Medtronic plc Shares G5960L103   27,774,961 344,517 SH   SOLE   27,774,961 0 0
Merck & Co., Inc. Common 58933Y105   58,740,260 552,122 SH   SOLE   58,740,260 0 0
Mereo BioPharma Group plc ADS 589492107   1,096,460 1,551,082 SH   SOLE   1,096,460 0 0
Mersana Therapeutics, Inc. Common 59045L106   667,394 162,383 SH   SOLE   667,394 0 0
Merus N.V. Common N5749R100   1,270,060 69,025 SH   SOLE   1,270,060 0 0
Mirati Therapeutics, Inc. Common 60468T105   2,434,918 65,490 SH   SOLE   2,434,918 0 0
Moderna, Inc. Common 60770K107   49,486,087 322,217 SH   SOLE   49,486,087 0 0
Molina Healthcare, Inc. Common 60855R100   16,545,861 61,856 SH   SOLE   16,545,861 0 0
MorphoSys AG Sponsored ADS 617760202   323,375 81,867 SH   SOLE   323,375 0 0
Natera, Inc. Common 632307104   2,735,581 49,272 SH   SOLE   2,735,581 0 0
National Health Investors, Inc. Common 63633D104   517,760 10,038 SH   SOLE   517,760 0 0
Neurocrine Biosciences, Inc. Common 64125C109   11,428,548 112,908 SH   SOLE   11,428,548 0 0
NexGel, Inc. Common 65344E107   5,516 4,243 SH   SOLE   5,516 0 0
Nkarta, Inc. Common 65487U108   102,907 28,988 SH   SOLE   102,907 0 0
Novartis AG Sponsored ADR 66987V109   12,532,700 136,225 SH   SOLE   12,532,700 0 0
Novavax, Inc. Common 670002401   442,134 63,800 SH   SOLE   442,134 0 0
Novo Nordisk A/S Sponsored ADR 670100205   17,715,942 111,323 SH   SOLE   17,715,942 0 0
Oculis Holding AG Common 952KVL905   11,047,302 1,690,741 SH   SOLE   11,047,302 0 0
Omega Healthcare Investors, Inc. Common 681936100   8,399,329 306,433 SH   SOLE   8,399,329 0 0
Option Care Health, Inc. Common 68404L201   2,064,256 64,975 SH   SOLE   2,064,256 0 0
Perrigo Company plc Shares G97822103   1,837,405 51,224 SH   SOLE   1,837,405 0 0
Pfizer Inc. Common 717081103   72,423,101 1,775,076 SH   SOLE   72,423,101 0 0
Physicians Realty Trust Common 71943U104   13,043,669 873,655 SH   SOLE   13,043,669 0 0
Praxis Precision Medicines, Inc. Common 74006W108   60,675 75,000 SH   SOLE   60,675 0 0
Precision BioSciences, Inc. Common 74019P108   169,209 224,534 SH   SOLE   169,209 0 0
Prometheus Biosciences, Inc. Common 74349U108   5,423,738 50,538 SH   SOLE   5,423,738 0 0
Pyxis Oncology, Inc. Common 747324101   2,840,295 708,303 SH   SOLE   2,840,295 0 0
R1 RCM Inc. Common 77634L105   5,352,765 356,851 SH   SOLE   5,352,765 0 0
Rallybio Corporation Common 75120L100   9,861,553 1,727,067 SH   SOLE   9,861,553 0 0
Reata Pharmaceuticals, Inc. Class A Class A 75615P103   1,622,922 17,850 SH   SOLE   1,622,922 0 0
Regeneron Pharmaceuticals, Inc. Common 75886F107   117,542,359 143,053 SH   SOLE   117,542,359 0 0
Repare Therapeutics Inc. Common 760273102   286,836 29,150 SH   SOLE   286,836 0 0
ResMed Inc. Common 761152107   16,027,659 73,189 SH   SOLE   16,027,659 0 0
Sabra Health Care REIT, Inc. Common 78573L106   5,872,590 510,660 SH   SOLE   5,872,590 0 0
Sanofi Sponsored ADR 80105N105   6,718,367 123,454 SH   SOLE   6,718,367 0 0
Sarepta Therapeutics, Inc. Common 803607100   39,371,553 285,653 SH   SOLE   39,371,553 0 0
Scholar Rock Holding Corp. Common 80706P103   870,664 108,833 SH   SOLE   870,664 0 0
Seagen Inc. Common 81181C104   45,487,518 224,663 SH   SOLE   45,487,518 0 0
Smith & Nephew plc Sponsored ADR 83175M205   5,071,526 181,710 SH   SOLE   5,071,526 0 0
SPDR S&P Biotech ETF S&P Biotech ETF 78464A870   11,254,464 147,677 SH   SOLE   11,254,464 0 0
Spectrum Pharmaceuticals, Inc. Common 84763A108   86,003 114,670 SH   SOLE   86,003 0 0
STERIS plc Shares G8473T100   5,943,452 31,072 SH   SOLE   5,943,452 0 0
Stryker Corp. Common 863667101   20,433,372 71,578 SH   SOLE   20,433,372 0 0
Sutro Biopharma, Inc. Common 869367102   454,395 98,354 SH   SOLE   454,395 0 0
Syndax Pharmaceuticals, Inc. Common 87164F105   2,486,183 117,717 SH   SOLE   2,486,183 0 0
Tactile Systems Technology, Inc. Common 87357P100   565,373 34,432 SH   SOLE   565,373 0 0
Takeda Pharmaceutical Company Ltd. Sponsored ADS 874060205   1,731,603 105,073 SH   SOLE   1,731,603 0 0
Teva Pharmaceutical Industries Ltd. Sponsored ADR 881624209   4,067,911 459,651 SH   SOLE   4,067,911 0 0
Thermo Fisher Scientific Inc. Common 883556102   54,008,751 93,705 SH   SOLE   54,008,751 0 0
Theseus Pharmaceuticals, Inc. Common 88369M101   666,000 75,000 SH   SOLE   666,000 0 0
Travere Therapeutics, Inc. Common 89422G107   9,412,515 418,520 SH   SOLE   9,412,515 0 0
TScan Therapeutics, Inc. Common 89854M101   420,000 200,000 SH   SOLE   420,000 0 0
Ultragenyx Pharmaceutical Inc. Common 90400D108   2,689,307 67,065 SH   SOLE   2,689,307 0 0
uniQure N.V. Shares N90064101   13,140,262 652,446 SH   SOLE   13,140,262 0 0
United Therapeutics Corp. Common 91307C102   13,706,352 61,200 SH   SOLE   13,706,352 0 0
Unitedhealth Group Inc. Common 91324P102   110,667,818 234,173 SH   SOLE   110,667,818 0 0
Universal Health Realty Income Trust Common 91359E105   541,622 11,258 SH   SOLE   541,622 0 0
Vaxcyte, Inc. Common 92243G108   187,400 5,000 SH   SOLE   187,400 0 0
VectivBio Holding AG Common H9060V101   5,872,372 682,834 SH   SOLE   5,872,372 0 0
Ventas, Inc. Common 92276F100   2,890,621 66,681 SH   SOLE   2,890,621 0 0
Veradigm, Inc. Common 01988P108   5,592,969 428,580 SH   SOLE   5,592,969 0 0
Vertex Pharmaceuticals Inc. Common 92532F100   104,081,169 330,343 SH   SOLE   104,081,169 0 0
VYNE Therapeutics, Inc. Common 92941V308   23,162 7,520 SH   SOLE   23,162 0 0
Welltower Inc. Common 95040Q104   2,973,988 41,484 SH   SOLE   2,973,988 0 0
West Pharmaceutical Services, Inc. Common 955306105   5,209,523 15,036 SH   SOLE   5,209,523 0 0
Xenon Pharmaceuticals Inc. Common 98420N105   2,996,124 83,714 SH   SOLE   2,996,124 0 0
Zai Lab Ltd. ADR 98887Q104   1,152,126 34,640 SH   SOLE   1,152,126 0 0
Zimmer Biomet Holdings, Inc. Common 98956P102   8,702,395 67,356 SH   SOLE   8,702,395 0 0
Zoetis Inc. Class A 98978V103   22,787,966 136,914 SH   SOLE   22,787,966 0 0