The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109   51,844,866 929,286 SH   SOLE 1,2,3 929,286 0 0
ACADIA PHARMACEUTICALS INC C COM 004225108   155,130,700 8,242,864 SH   SOLE 1,2,3 8,242,864 0 0
ADICET BIO INC COM 007002108   24,430,879 4,241,472 SH   SOLE 1,2,3 4,241,472 0 0
AKOYA BIOSCIENCES INC COM 00974H104   2,686,492 328,422 SH   SOLE 1,2,3 328,422 0 0
ALLAKOS INC COM 01671P100   5,903,406 1,326,608 SH   SOLE 1,2,3 1,326,608 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   337,211,076 1,683,362 SH   SOLE 1,2,3 1,683,362 0 0
APYX MEDICAL CORPORATION COM 03837C106   9,787,044 3,398,279 SH   SOLE 1,2,3 3,398,279 0 0
ARGENX SE SPONSORED ADR 04016X101   179,656,213 482,195 SH   SOLE 1,2,3 482,195 0 0
ARYA SCIENCES ACQU CORP IV CL A G31659108   1,324,490 127,970 SH   SOLE 1,2,3 127,970 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104   52,596,161 5,741,939 SH   SOLE 1,2,3 5,741,939 0 0
AVIDITY BIOSCIENCES INC COM 05370A108   98,043,182 6,387,178 SH   SOLE 1,2,3 6,387,178 0 0
AXONICS INC COM 05465P101   48,284,181 884,974 SH   SOLE 1,2,3 884,974 0 0
AXSOME THERAPEUTICS INC COM 05464T104   233,203,136 3,780,855 SH   SOLE 1,2,3 3,780,855 0 0
BRUKER CORP COM 116794108   93,610,043 1,187,342 SH   SOLE 1,2,3 1,187,342 0 0
CASTLE BIOSCIENCES INC COM 14843C105   5,873,075 258,498 SH   SOLE 1,2,3 258,498 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   110,970,056 3,084,215 SH   SOLE 1,2,3 3,084,215 0 0
CUTERA INC COM 232109108   43,616,598 1,846,596 SH   SOLE 1,2,3 1,846,596 0 0
CYTOKINETICS INC COM NEW 23282W605   90,586,028 2,574,198 SH   SOLE 1,2,3 2,574,198 0 0
DERMTECH INC COM 24984K105   10,003,550 2,718,356 SH   SOLE 1,2,3 2,718,356 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108   161,840,208 2,389,138 SH   SOLE 1,2,3 2,389,138 0 0
EXAGEN INC COM 30068X103   3,380,577 1,391,184 SH   SOLE 1,2,3 1,391,184 0 0
FULCRUM THERAPEUTICS INC COM 359616109   15,708,741 5,511,839 SH   SOLE 1,2,3 5,511,839 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106   17,329,966 2,168,957 SH   SOLE 1,2,3 2,168,957 0 0
GUARDANT HEALTH INC COM 40131M109   10,099,991 430,887 SH   SOLE 1,2,3 430,887 0 0
ILLUMINA INC COM 452327109   87,496,938 376,250 SH   SOLE 1,2,3 376,250 0 0
IMMATICS N.V SHS N44445109   5,830,500 845,000 SH   SOLE 1,2,3 845,000 0 0
IMMUNIC INC COM 4525EP101   6,398,744 4,294,459 SH   SOLE 1,2,3 4,294,459 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105   279,333,182 5,649,943 SH   SOLE 1,2,3 5,649,943 0 0
JASPER THERAPEUTICS INC COM 471871103   4,216,954 2,329,809 SH   SOLE 1,2,3 2,329,809 0 0
MASIMO CORP COM 574795100   277,085,518 1,501,493 SH   SOLE 1,2,3 1,501,493 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107   12,829,042 3,256,102 SH   SOLE 1,2,3 3,256,102 0 0
MINERALYS THERAPEUTICS INC COM 603170101   14,440,086 922,100 SH   SOLE 1,2,3 922,100 0 0
MIRATI THERAPEUTICS INC COM 60468T105   135,450,979 3,643,114 SH   SOLE 1,2,3 3,643,114 0 0
MIROMATRIX MED INC COM 60471P108   747,973 445,222 SH   SOLE 1,2,3 445,222 0 0
MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104   10,695,000 500,000 SH   SOLE 1,2,3 500,000 0 0
NATERA INC COM 632307104   145,006,192 2,611,783 SH   SOLE 1,2,3 2,611,783 0 0
OLINK HLDG AB SPONSORED ADS 680710100   14,748,408 654,612 SH   SOLE 1,2,3 654,612 0 0
ORCHESTRA BIOMED HLDGS INC COM 68572M106   100,169,182 5,118,507 SH   SOLE 1,2,3 5,118,507 0 0
OUTSET MED INC COM 690145107   14,879,307 808,658 SH   SOLE 1,2,3 808,658 0 0
PENUMBRA INC COM 70975L107   187,661,764 673,371 SH   SOLE 1,2,3 673,371 0 0
PMV PHARMACEUTICALS INC COM 69353Y103   14,305,697 2,999,098 SH   SOLE 1,2,3 2,999,098 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108   351,162,201 3,272,104 SH   SOLE 1,2,3 3,272,104 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102   105,818,377 4,600,799 SH   SOLE 1,2,3 4,600,799 0 0
PTC THERAPEUTICS INC COM 69366J200   343,599,355 7,093,298 SH   SOLE 1,2,3 7,093,298 0 0
RELMADA THERAPEUTICS INC COM 75955J402   4,817,947 2,131,835 SH   SOLE 1,2,3 2,131,835 0 0
ROCKET PHARMACEUTICALS INC *W EXP 09/02/202 77313F114   38,500 350,000 SH   SOLE 1,2,3 350,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   302,991,534 17,687,772 SH   SOLE 1,2,3 17,687,772 0 0
ROIVANT SCIENCES LTD SHS G76279101   11,459,051 1,552,717 SH   SOLE 1,2,3 1,552,717 0 0
SCPHARMACEUTICALS INC COM 810648105   29,911,436 3,297,843 SH   SOLE 1,2,3 3,297,843 0 0
SIGHT SCIENCES INC COM 82657M105   361,224 41,330 SH   SOLE 1,2,3 41,330 0 0
STOKE THERAPEUTICS INC COM 86150R107   36,573,348 4,390,558 SH   SOLE 1,2,3 4,390,558 0 0
THIRD HARMONIC BIO INC COM 88427A107   2,202,910 534,687 SH   SOLE 1,2,3 534,687 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103   32,029,931 2,548,125 SH   SOLE 1,2,3 2,548,125 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102   167,339,808 290,334 SH   SOLE 1,2,3 290,334 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108   171,266,940 4,270,996 SH   SOLE 1,2,3 4,270,996 0 0
UROGEN PHARMA LTD COM M96088105   7,922,967 857,464 SH   SOLE 1,2,3 857,464 0 0
VENTYX BIOSCIENCES INC COM 92332V107   46,527,514 1,388,881 SH   SOLE 1,2,3 1,388,881 0 0
VERICEL CORP COM 92346J108   96,517,716 3,291,873 SH   SOLE 1,2,3 3,291,873 0 0
VIKING THERAPEUTICS INC COM 92686J106   16,650,000 1,000,000 SH   SOLE 1,2,3 1,000,000 0 0
YS BIOPHARMA CO LTD ORDINARY SHARES G9845F109   545,744 341,090 SH   SOLE 1,2,3 341,090 0 0