The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 BBG00QKDZ985 2,505,335 164,500 SH Call SOLE   164,500 0 0
ABCAM PLC ADS 000380204 BBG00XRJJM98 30,184,050 2,242,500 SH   SOLE   2,242,500 0 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109 BBG001SNNWL7 62,197,713 860,868 SH   SOLE   860,868 0 0
ACCOLADE INC COM 00437E102 BBG00S2L1ZR1 36,597,100 2,545,000 SH   SOLE   2,545,000 0 0
ACELRX PHARMACEUTICALS INC COM NEW 00444T209 BBG001TFZCK5 208,231 316,460 SH   SOLE   316,460 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 BBG003LF0QS8 32,051,358 3,961,849 SH   SOLE   3,961,849 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 BBG008G65WD1 3,038,751 2,787,845 SH   SOLE   2,787,845 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 BBG0067L94C1 990,033 3,413,906 SH   SOLE   3,413,906 0 0
AGILON HEALTH INC COM 00857U107 BBG00HCYVQR3 187,209,375 7,882,500 SH   SOLE   7,882,500 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 BBG001T8R687 61,137,067 2,661,605 SH   SOLE   2,661,605 0 0
AKERO THERAPEUTICS INC COM 00973Y108 BBG00L9211Z7 55,639,758 1,454,254 SH   SOLE   1,454,254 0 0
ALIGN TECHNOLOGY INC COM 016255101 BBG001SCF1B9 82,649,529 247,350 SH   SOLE   247,350 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 BBG001S7FTC8 69,110,400 345,000 SH   SOLE   345,000 0 0
ALTIMMUNE INC COM NEW 02155H200 BBG001SNS461 942,136 223,255 SH   SOLE   223,255 0 0
AMICUS THERAPEUTICS INC COM 03152W109 BBG001SN96V9 11,797,609 1,063,806 SH   SOLE   1,063,806 0 0
AMRYT PHARMA PLC SPONSORED ADS 03217L106 BBG00Q9V0S11 19,327,613 1,325,625 SH   SOLE   1,325,625 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101 BBG00DP10YW1 42,625,621 1,452,816 SH   SOLE   1,452,816 0 0
ANAPTYSBIO INC COM 032724106 BBG0026ZDHT8 12,546,816 576,600 SH   SOLE   576,600 0 0
APPLIED THERAPEUTICS INC COM 03828A101 BBG001SMJMY2 633,300 780,791 SH   SOLE   780,791 0 0
ARGENX SE SPONSORED ADR 04016X101 BBG00GHB88Y8 130,403,000 350,000 SH   SOLE   350,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 BBG007R7VP72 45,622,110 425,500 SH   SOLE   425,500 0 0
ATRECA INC CL A COM 04965G109 BBG003FJ19C1 413,284 362,530 SH   SOLE   362,530 0 0
AURA BIOSCIENCES INC COM 05153U107 BBG00226DGP2 9,463,345 1,019,757 SH   SOLE   1,019,757 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 BBG001S68013 5,255,758 479,540 SH   SOLE   479,540 0 0
AZENTA INC COM 114340102 BBG001S8F1B8 19,240,144 431,200 SH   SOLE   431,200 0 0
BEAM THERAPEUTICS INC COM 07373V105 BBG00KXC8655 3,411,987 111,430 SH   SOLE   111,430 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 BBG001S7K151 19,466,269 2,334,085 SH   SOLE   2,334,085 0 0
BIOHAVEN LTD COM G1110E107 BBG017BXV3R8 9,365,610 685,623 SH   SOLE   685,623 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 BBG001S76R05 25,719,980 264,500 SH   SOLE   264,500 0 0
BIOMEA FUSION INC COM 09077A106 BBG00YS4WDD8 40,226,575 1,297,213 SH   SOLE   1,297,213 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 BBG001V11BV0 91,466,830 2,033,048 SH   SOLE   2,033,048 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 BBG001S7QN20 15,165,714 421,504 SH   SOLE   421,504 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 BBG00VCYVLJ2 61,314,411 2,513,916 SH   SOLE   2,513,916 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 BBG001T20HH5 11,748,903 507,512 SH   SOLE   507,512 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 BBG001T535S9 15,593,500 650,000 SH   SOLE   650,000 0 0
COMPASS THERAPEUTICS INC COM 20454B104 BBG00LPXKF34 18,030,087 5,513,788 SH   SOLE   5,513,788 0 0
COMPUGEN LTD ORD M25722105 BBG001S5PQC7 905,573 1,289,990 SH   SOLE   1,289,990 0 0
CONMED CORP COM 207410101 BBG001S5PZH2 21,291,300 205,000 SH   SOLE   205,000 0 0
CYTOKINETICS INC COM NEW 23282W605 BBG001SGMVF2 15,751,044 447,600 SH   SOLE   447,600 0 0
DESIGN THERAPEUTICS INC COM 25056L103 BBG00SNC49W7 2,656,456 460,391 SH   SOLE   460,391 0 0
DEXCOM INC COM 252131107 BBG001SKZG99 56,986,290 490,500 SH   SOLE   490,500 0 0
DISC MEDICINE INC COM 254604101 BBG00W9MJL04 6,642,387 313,468 SH   SOLE   313,468 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 BBG001S7HTB7 17,792,966 1,813,758 SH   SOLE   1,813,758 0 0
EDAP TMS S A SPONSORED ADR 268311107 BBG001SB3ML7 11,402,100 1,030,000 SH   SOLE   1,030,000 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 BBG001SF2288 53,435,307 645,900 SH   SOLE   645,900 0 0
ESSA PHARMA INC COM NEW 29668H708 BBG0080GLFK7 1,559,084 524,944 SH   SOLE   524,944 0 0
EVOLENT HEALTH INC CL A 30050B101 BBG005CHLMB3 123,423,575 3,803,500 SH   SOLE   3,803,500 0 0
EXACT SCIENCES CORP COM 30063P105 BBG001SGCLB9 63,843,115 941,500 SH   SOLE   941,500 0 0
FATE THERAPEUTICS INC COM 31189P102 BBG001T888S2 3,489,626 612,215 SH   SOLE   612,215 0 0
FRESHPET INC COM 358039105 BBG001V04FM0 43,850,875 662,500 SH   SOLE   662,500 0 0
FULCRUM THERAPEUTICS INC COM 359616109 BBG00DDY1RM7 2,073,868 727,673 SH   SOLE   727,673 0 0
GAMIDA CELL LTD SHS M47364100 BBG00M4RGJ53 1,899,166 2,344,649 SH   SOLE   2,344,649 0 0
GOSSAMER BIO INC COM 38341P102 BBG00MVWLMC1 1,386,345 1,100,274 SH   SOLE   1,100,274 0 0
GOSSAMER BIO INC NOTE 5.000% 6/0 38341PAA0   2,641,308 9,573,000 PRN   SOLE   9,573,000 0 0
GUARDANT HEALTH INC COM 40131M109 BBG006D97VZ8 4,688,000 200,000 SH   SOLE   200,000 0 0
HEALTH CATALYST INC COM 42225T107 BBG00LDPZMT5 10,851,933 929,900 SH   SOLE   929,900 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 BBG001T9M4T2 80,774,514 740,100 SH   SOLE   740,100 0 0
HUMANA INC COM 444859102 BBG001S5S1X6 207,048,690 426,500 SH   SOLE   426,500 0 0
ICOSAVAX INC COM 45114M109 BBG00QHK2J96 5,014,158 864,510 SH   SOLE   864,510 0 0
IDEXX LABS INC COM 45168D104 BBG001S5S4Y9 103,766,600 207,500 SH   SOLE   207,500 0 0
IMMATICS N.V SHS N44445109 BBG00VTL2J09 17,346,069 2,513,923 SH   SOLE   2,513,923 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105 BBG00YYCXG54 148,402,169 3,001,662 SH   SOLE   3,001,662 0 0
INOZYME PHARMA INC COM 45790W108 BBG00J7QJMD0 18,421,377 3,214,900 SH   SOLE   3,214,900 0 0
INSULET CORP COM 45784P101 BBG001SRF439 171,201,780 536,750 SH   SOLE   536,750 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 BBG001S7XR78 76,257,795 298,500 SH   SOLE   298,500 0 0
INVITAE CORP COM 46185L103 BBG005DJFD52 4,375,924 3,241,425 SH   SOLE   3,241,425 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 BBG001TSQV70 38,381,084 309,450 SH   SOLE   309,450 0 0
KARUNA THERAPEUTICS INC COM 48576A100 BBG00NN875H9 89,644,244 493,527 SH   SOLE   493,527 0 0
KINNATE BIOPHARMA INC COM 49705R105 BBG00R4SGVH0 4,668,581 746,973 SH   SOLE   746,973 0 0
KYMERA THERAPEUTICS INC COM 501575104 BBG00SDHC8F9 36,396,870 1,228,379 SH   SOLE   1,228,379 0 0
LEAP THERAPEUTICS INC COM 52187K101 BBG00DQ929Z3 1,582,763 4,655,186 SH   SOLE   4,655,186 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 BBG00TTGH6N2 22,097,538 458,265 SH   SOLE   458,265 0 0
LIFESTANCE HEALTH GROUP INC COM 53228F101 BBG01138DHT2 21,547,000 2,900,000 SH   SOLE   2,900,000 0 0
MACROGENICS INC COM 556099109 BBG001S9C8R7 8,052,598 1,123,096 SH   SOLE   1,123,096 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 BBG001SNKQ42 84,335,793 348,121 SH   SOLE   348,121 0 0
MEREO BIOPHARMA GROUP PLC SPON ADS 589492107 BBG00KFWZCX7 4,414,518 6,244,897 SH   SOLE   6,244,897 0 0
MERSANA THERAPEUTICS INC COM 59045L106 BBG001TZ57P0 16,866,630 4,103,803 SH   SOLE   4,103,803 0 0
MINERALYS THERAPEUTICS INC COM 603170101 BBG00ZXN1GR9 18,282,925 1,167,492 SH   SOLE   1,167,492 0 0
MIRATI THERAPEUTICS INC COM 60468T105 BBG001SF6HK7 39,606,404 1,065,261 SH   SOLE   1,065,261 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 BBG00MH7T2N6 43,133,507 1,795,733 SH   SOLE   1,795,733 0 0
NEUROCRINE BIOSCIENCES INC NOTE 2.250% 5/1 64125CAD1   1,351,500 1,000,000 PRN   SOLE   1,000,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 BBG001S8W4X9 122,486,322 1,210,100 SH   SOLE   1,210,100 0 0
NEVRO CORP NOTE 2.750% 4/0 64157FAC7   470,000 500,000 PRN   SOLE   500,000 0 0
NEVRO CORP COM 64157F103 BBG001V0KW81 38,966,085 1,077,900 SH   SOLE   1,077,900 0 0
NKARTA INC COM 65487U108 BBG00JXHS9H6 1,396,531 393,389 SH   SOLE   393,389 0 0
NOVAVAX INC COM NEW 670002401 BBG001SGL8G3 3,710,322 535,400 SH   SOLE   535,400 0 0
NOVOCURE LTD ORD SHS G6674U108 BBG009XW8QY0 7,517,500 125,000 SH   SOLE   125,000 0 0
NUVATION BIO INC *W EXP 07/07/202 67080N119   16,083 134,028 SH   SOLE   134,028 0 0
OLINK HLDG AB SPONSORED ADS 680710100 BBG00ZHZXZ84 37,174,500 1,650,000 SH   SOLE   1,650,000 0 0
PACIRA BIOSCIENCES INC COM 695127100 BBG001S77N12 42,140,406 1,032,600 SH   SOLE   1,032,600 0 0
PARATEK PHARMACEUTICALS INC COM 699374302 BBG001SQHLP7 4,404,454 1,734,037 SH   SOLE   1,734,037 0 0
PENUMBRA INC COM 70975L107 BBG001TRHPB0 120,812,115 433,500 SH   SOLE   433,500 0 0
PHREESIA INC COM 71944F106 BBG001TG2W25 42,057,725 1,302,500 SH   SOLE   1,302,500 0 0
PLIANT THERAPEUTICS INC COM 729139105 BBG00C8083P2 13,066,479 491,221 SH   SOLE   491,221 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 BBG00PPP6G63 110,705,946 1,031,550 SH   SOLE   1,031,550 0 0
PROTHENA CORP PLC SHS G72800108 BBG00393H6N0 36,520,303 753,462 SH   SOLE   753,462 0 0
PULMONX CORP COM 745848101 BBG001T4HJ52 7,293,832 652,400 SH   SOLE   652,400 0 0
RELAY THERAPEUTICS INC COM 75943R102 BBG00DSS08L8 11,100,220 673,966 SH   SOLE   673,966 0 0
RENEO PHARMACEUTICALS INC COM 75974E103 BBG00JVRSRD0 6,836,246 1,143,185 SH   SOLE   1,143,185 0 0
REVOLUTION MEDICINES INC COM 76155X100 BBG00829F4Q7 15,220,742 702,712 SH   SOLE   702,712 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 BBG007DLZ629 28,492,674 1,597,123 SH   SOLE   1,597,123 0 0
SAREPTA THERAPEUTICS INC COM 803607100 BBG001S6KJC6 60,989,775 442,500 SH   SOLE   442,500 0 0
SEAGEN INC COM 81181C104 BBG001S9M4Q6 81,028,494 400,200 SH   SOLE   400,200 0 0
SELECT SECTOR SPDR TR SBI HEALTHCARE 81369Y209 BBG001S7SCQ6 25,892,000 200,000 SH   SOLE   200,000 0 0
SHOCKWAVE MED INC COM 82489T104 BBG005XVXMM4 24,957,133 115,100 SH   SOLE   115,100 0 0
SPERO THERAPEUTICS INC COM 84833T103 BBG00HXSJ1S1 970,823 669,533 SH   SOLE   669,533 0 0
SPRUCE BIOSCIENCES INC COM 85209E109 BBG00HYZ1559 6,029,156 2,728,125 SH   SOLE   2,728,125 0 0
TEMPEST THERAPEUTICS INC COM 87978U108 BBG002NDK348 1,910,877 823,654 SH   SOLE   823,654 0 0
THESEUS PHARMACEUTICALS INC COM 88369M101 BBG00Z0GRC64 3,883,482 437,329 SH   SOLE   437,329 0 0
TRAVERE THERAPEUTICS INC NOTE 2.500% 9/1 761299AB2   3,126,481 3,250,000 PRN   SOLE   3,250,000 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 BBG001SL72C5 28,711,859 1,276,650 SH   SOLE   1,276,650 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 BBG001V2MJJ2 53,589,680 1,336,401 SH   SOLE   1,336,401 0 0
UNITEDHEALTH GROUP INC COM 91324P102 BBG001S6WCJ1 127,599,300 270,000 SH   SOLE   270,000 0 0
VERVE THERAPEUTICS INC COM 92539P101 BBG00P33TD13 8,058,430 558,837 SH   SOLE   558,837 0 0
VIGIL NEUROSCIENCE INC COM 92673K108 BBG00YGBK4R3 4,620,469 471,958 SH   SOLE   471,958 0 0
VINCERX PHARMA INC COM NEW 92731L106 BBG00RRQXMY1 927,388 891,719 SH   SOLE   891,719 0 0
WARBY PARKER INC CL A COM 93403J106 BBG005DWN8L7 13,767,000 1,300,000 SH   SOLE   1,300,000 0 0
WEST PHARMACEUTICAL SVSC INC COM 955306105 BBG001S5XK22 69,986,940 202,000 SH   SOLE   202,000 0 0
XENON PHARMACEUTICALS INC COM 98420N105 BBG002VBMLS5 42,160,692 1,178,002 SH   SOLE   1,178,002 0 0
XILIO THERAPEUTICS INC COM 98422T100 BBG00M4D4XC8 4,567,206 1,440,759 SH   SOLE   1,440,759 0 0
ZAI LAB LTD ADR 98887Q104 BBG00HFX3P04 35,245,622 1,059,700 SH   SOLE   1,059,700 0 0