The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
DAIICHI SANKYO CO LTD Common Stock J11257102   22,049,300 4,846 SH   SOLE   22,049,300 0 0
AGILENT TECHNOLOGIES INC Common Stock 00846U101   322,150 2,679 SH   SOLE   322,150 0 0
APPLE INC Common Stock 037833100   290,955 1,500 SH   SOLE   290,955 0 0
ABBVIE INC Common Stock 00287Y109   282,125 2,094 SH   SOLE   282,125 0 0
ACADIA PHARMACEUTICALS INC Common Stock 004225108   392,014 16,368 SH   SOLE   392,014 0 0
ALBEMARLE CORP Common Stock 012653101   1,606,248 7,200 SH   SOLE   1,606,248 0 0
ALNYLAM PHARMACEUTICALS INC Common Stock 02043Q107   356,327 1,876 SH   SOLE   356,327 0 0
AMAZON.COM INC Common Stock 023135106   351,972 2,700 SH   SOLE   351,972 0 0
ARISTA NETWORKS INC Common Stock 040413106   486,180 3,000 SH   SOLE   486,180 0 0
ARGENX SE - ADR ADR 04016X101   500,803 1,285 SH   SOLE   500,803 0 0
ASCENDIS PHARMA - ADR ADR 04351P101   206,792 2,317 SH   SOLE   206,792 0 0
ACTIVISION BLIZZARD INC Common Stock 00507V109   9,905,250 117,500 SH   SOLE   9,905,250 0 0
ASTRAZENECA PLC-SPONS ADR ADR 046353108   708,758 9,903 SH   SOLE   708,758 0 0
BECTON DICKINSON AND CO Common Stock 075887109   369,086 1,398 SH   SOLE   369,086 0 0
BEIGENE LTD-ADR ADR 07725L102   745,651 4,182 SH   SOLE   745,651 0 0
BLACKROCK INC Common Stock 09247X101   380,127 550 SH   SOLE   380,127 0 0
BIOMARIN PHARMACEUTICAL INC Common Stock 09061G101   235,163 2,713 SH   SOLE   235,163 0 0
CADENCE DESIGN SYS INC Common Stock 127387108   328,328 1,400 SH   SOLE   328,328 0 0
CIGNA CORP Common Stock 125523100   241,877 862 SH   SOLE   241,877 0 0
CENTENE CORP Common Stock 15135B101   272,228 4,036 SH   SOLE   272,228 0 0
CRH PLC-SPONSORED ADR ADR 12626K203   1,393,250 25,000 SH   SOLE   1,393,250 0 0
DANAHER CORP Common Stock 235851102   686,160 2,859 SH   SOLE   686,160 0 0
WALT DISNEY CO/THE Common Stock 254687106   624,960 7,000 SH   SOLE   624,960 0 0
ELEVANCE HEALTH INC Common Stock 036752103   535,814 1,206 SH   SOLE   535,814 0 0
ISHARES MSCI SOUTH KOREA CAP ETP 464286772   221,830 3,500 SH   SOLE   221,830 0 0
MARKET VECTORS GOLD MINERS ETP 92189F106   770,304 25,583 SH   SOLE   770,304 0 0
GENMAB A/S Common Stock K3967W102   1,006,200 390 SH   SOLE   1,006,200 0 0
ALPHABET INC-CL C Common Stock 02079K107   1,826,647 15,100 SH   SOLE   1,826,647 0 0
HCA HOLDINGS INC Common Stock 40412C101   232,769 767 SH   SOLE   232,769 0 0
HUMANA INC Common Stock 444859102   376,036 841 SH   SOLE   376,036 0 0
ISHARES EXPANDED TECH-SOFTWA ETP 464287515   1,037,730 3,000 SH   SOLE   1,037,730 0 0
INCYTE CORP Common Stock 45337C102   776,195 12,469 SH   SOLE   776,195 0 0
INTUITIVE SURGICAL INC Common Stock 46120E602   744,061 2,176 SH   SOLE   744,061 0 0
ITAU UNIBANCO HLDNG-PREF ADR ADR 465562106   295,330 50,056 SH   SOLE   295,330 0 0
ELI LILLY & CO Common Stock 532457108   1,580,932 3,371 SH   SOLE   1,580,932 0 0
LITHIUM IONIC CORP Common Stock 53680V107   5,443,386 2,203,800 SH   SOLE   5,443,386 0 0
MERCADOLIBRE INC Common Stock 58733R102   781,836 660 SH   SOLE   781,836 0 0
MOLINA HEALTHCARE INC Common Stock 60855R100   278,045 923 SH   SOLE   278,045 0 0
MERCK & CO. INC. Common Stock 58933Y105   722,572 6,262 SH   SOLE   722,572 0 0
MICROSOFT CORP Common Stock 594918104   5,618,910 16,500 SH   SOLE   5,618,910 0 0
NU HOLDINGS LTD/CAYMAN ISL-A Common Stock G6683N103   1,993,803 252,700 SH   SOLE   1,993,803 0 0
NVIDIA CORP Common Stock 67066G104   4,589,767 10,850 SH   SOLE   4,589,767 0 0
NOVO-NORDISK A/S-SPONS ADR ADR 670100205   970,980 6,000 SH   SOLE   970,980 0 0
OI SA-ADR ADR 670851500   2,070 575,000 SH   SOLE   2,070 0 0
PENUMBRA INC Common Stock 70975L107   286,946 834 SH   SOLE   286,946 0 0
PFIZER INC Common Stock 717081103   318,529 8,684 SH   SOLE   318,529 0 0
REGENERON PHARMACEUTICALS Common Stock 75886F107   594,233 827 SH   SOLE   594,233 0 0
SBERBANK PJSC - SPONSORED ADR ADR 80585Y308   7,248 160,000 SH   SOLE   7,248 0 0
SEAGEN INC Common Stock 81181C104   3,388,066 17,604 SH   SOLE   3,388,066 0 0
SIGMA LITHIUM CORP Common Stock 826599102   6,019,611 149,370 SH   SOLE   6,019,611 0 0
SPINNOVA OYJ Common Stock X84439102   182,108 37,127 SH   SOLE   182,108 0 0
QUIMICA Y MINERA CHIL-SP ADR ADR 833635105   1,234,540 17,000 SH   SOLE   1,234,540 0 0
STRYKER CORP Common Stock 863667101   558,010 1,829 SH   SOLE   558,010 0 0
THERMO FISHER SCIENTIFIC INC Common Stock 883556102   990,803 1,899 SH   SOLE   990,803 0 0
TAIWAN SEMICONDUCTOR-SP ADR ADR 874039100   353,220 3,500 SH   SOLE   353,220 0 0
UNITEDHEALTH GROUP INC Common Stock 91324P102   1,523,629 3,170 SH   SOLE   1,523,629 0 0
UNION PACIFIC CORP Common Stock 907818108   511,550 2,500 SH   SOLE   511,550 0 0
VERTEX PHARMACEUTICALS INC Common Stock 92532F100   532,440 1,513 SH   SOLE   532,440 0 0
XP INC - CLASS A Common Stock G98239109   51,309,483 2,187,105 SH   SOLE   51,309,483 0 0
ACTIVISION BLIZZARD INC Common Stock 00507V109   47,180 280 SH Put SOLE   47,180 0 0
ACTIVISION BLIZZARD INC Common Stock 00507V109   3,315 15 SH Call SOLE   3,315 0 0
ACTIVISION BLIZZARD INC Common Stock 00507V109   1,863 25 SH Put SOLE   1,863 0 0
ACTIVISION BLIZZARD INC Common Stock 00507V109   980 10 SH Put SOLE   980 0 0
ACTIVISION BLIZZARD INC Common Stock 00507V109   1,495,000 2,000 SH Call SOLE   1,495,000 0 0
ACTIVISION BLIZZARD INC Common Stock 00507V109   146,000 2,000 SH Put SOLE   146,000 0 0
ALPHABET INC-CL C Common Stock 02079K107   1,863 25 SH Call SOLE   1,863 0 0
ALPHABET INC-CL C Common Stock 02079K107   2,800 25 SH Put SOLE   2,800 0 0
NVIDIA CORP Common Stock 67066G104   42,000 2,000 SH Put SOLE   42,000 0 0
NVIDIA CORP Common Stock 67066G104   680,750 3,500 SH Put SOLE   680,750 0 0
SIGMA LITHIUM CORP Common Stock 826599102   2,380 3,000 SH Put SOLE   2,380 0 0
SIGMA LITHIUM CORP Common Stock 826599102   297,443 8,000 SH Put SOLE   297,443 0 0
XP INC - CLASS A Common Stock G98239109   82,000 8,200 SH Put SOLE   82,000 0 0
XP INC - CLASS A Common Stock G98239109   15,750 1,050 SH Put SOLE   15,750 0 0