The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS IN COM 004225108   3,616,450 151,000 SH   SOLE   151,000 0 0
AGIOS PHARMS. COM 00847X104   679,680 24,000 SH   SOLE   24,000 0 0
AKERO THERAPEUTICS INC COM 00973Y108   3,662,297 78,489 SH   SOLE   78,489 0 0
ALNYLAM PHARMS. COM 02043Q107   15,499,104 81,600 SH   SOLE   81,600 0 0
AMGEN INC COM COM 031162100   26,025,095 117,246 SH   SOLE   117,246 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   538,500 25,000 SH   SOLE   25,000 0 0
APELLIS PHARMS. COM 03753U106   11,810,482 129,700 SH   SOLE   129,700 0 0
ARVINAS INC COM 04335A105   421,090 17,000 SH   SOLE   17,000 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102   5,551,770 573,530 SH   SOLE   573,530 0 0
AXSOME THERAPEUTICS COM 05464T104   4,185,940 58,300 SH   SOLE   58,300 0 0
BEAM THERAPEUTICS INC COM 07373V105   750,355 23,500 SH   SOLE   23,500 0 0
BEIGENE ADR Sponsored ADR 07725L102   1,548,339 8,700 SH   SOLE   8,700 0 0
BIOGEN INC COM 09062X103   3,132,690 11,000 SH   SOLE   11,000 0 0
BIOMARIN PHARM. COM 09061G101   5,083,129 58,656 SH   SOLE   58,656 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   1,630,075 48,099 SH   SOLE   48,099 0 0
CYTOKINETICS INC COM NEW 23282W605   1,205,830 37,000 SH   SOLE   37,000 0 0
DENALI THERAPEUTICS COM 24823R105   5,538,480 188,000 SH   SOLE   188,000 0 0
DYNE THERAPEUTICS COM 26818M108   3,383,449 300,751 SH   SOLE   300,751 0 0
ERASCA INC COM 29479A108   3,921,500 1,426,000 SH   SOLE   1,426,000 0 0
GILEAD SCIENCES COM 375558103   11,137,306 144,584 SH   SOLE   144,584 0 0
GUARDANT HEALTH COM 40131M109   1,305,605 36,500 SH   SOLE   36,500 0 0
HALOZYME THERAPEUTICS INC COM 40637H109   3,443,730 95,500 SH   SOLE   95,500 0 0
HARMONY BIOSCIENCES HLDGS COM 413197104   20,070,190 570,500 SH   SOLE   570,500 0 0
HORIZON THERAPEUTICS SHS G4617B105   6,890,950 67,000 SH   SOLE   67,000 0 0
HUTCHMED CHINA LTD SPONSORED ADS 44842L103   816,000 68,000 SH   SOLE   68,000 0 0
ILLUMINA INC COM 452327109   9,463,195 50,500 SH   SOLE   50,500 0 0
I-MAB-SPONSORED ADR SPONSORED ADS 44975P103   925,287 310,499 SH   SOLE   310,499 0 0
INCYTE CORP COM 45337C102   22,303,008 358,454 SH   SOLE   358,454 0 0
INSMED INC COM 457669307   845,308 40,100 SH   SOLE   40,100 0 0
INTELLIA THERAPEUTICS COM 45826J105   977,760 24,000 SH   SOLE   24,000 0 0
INTRA-CELLULAR THERAPIES COM 46116X101   11,182,605 176,856 SH   SOLE   176,856 0 0
IONIS PHARMS. COM 462222100   1,763,860 43,000 SH   SOLE   43,000 0 0
IOVANCE BIOTHERAPEUTICS COM 462260100   456,950 65,000 SH   SOLE   65,000 0 0
JAZZ PHARMS. SHS USD G50871105   2,131,768 17,200 SH   SOLE   17,200 0 0
KARUNA THERAPEUTICS INC COM 48576A100   5,566,620 25,700 SH   SOLE   25,700 0 0
KRYSTAL BIOTECH COM 501147102   5,389,349 45,945 SH   SOLE   45,945 0 0
LEGEND BIOTECH SPONSORED ADS 52490G102   2,623,140 38,000 SH   SOLE   38,000 0 0
MADRIGAL PHARMS. COM 558868105   4,227,300 18,300 SH   SOLE   18,300 0 0
MARINUS PHARMACEUTICALS INC COM NEW 56854Q200   977,400 90,000 SH   SOLE   90,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105   9,393,800 260,000 SH   SOLE   260,000 0 0
MIRUM PHARMACEUTICALS INC COM 604749101   1,742,850 67,500 SH   SOLE   67,500 0 0
NEUROCRINE BIOSCIENCES COM 64125C109   6,490,280 68,877 SH   SOLE   68,877 0 0
NOVOCURE LTD ORD SHS G6674U108   1,327,680 32,000 SH   SOLE   32,000 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102   549,240 19,900 SH   SOLE   19,900 0 0
PTC THERAPEUTICS COM 69366J200   691,730 17,000 SH   SOLE   17,000 0 0
REGENERON PHARMS. COM 75886F107   19,400,040 27,000 SH   SOLE   27,000 0 0
RELMADA THERAPEUTICS COM 75955J402   24,700 10,000 SH   SOLE   10,000 0 0
REVANCE THERAPEUTICS INC COM 761330109   7,298,993 288,726 SH   SOLE   288,726 0 0
ROCKET PHARMS. COM 77313F106   3,093,480 156,000 SH   SOLE   156,000 0 0
SAGE THERAPEUTICS INC COM 78667J108   939,400 20,000 SH   SOLE   20,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100   2,152,976 18,800 SH   SOLE   18,800 0 0
SUPERNUS PHARMS. COM 868459108   15,736,410 523,500 SH   SOLE   523,500 0 0
TRAVERE THERAPEUTICS INC COM 89422G107   6,769,642 441,019 SH   SOLE   441,019 0 0
ULTRAGENYX PHARM. COM 90400D108   3,691,198 80,052 SH   SOLE   80,052 0 0
UNIQURE NV SHS N90064101   177,630 15,500 SH   SOLE   15,500 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102   11,647,077 52,759 SH   SOLE   52,759 0 0
VENTYX BIOSCIENCES INC COM 92332V107   491,400 15,000 SH   SOLE   15,000 0 0
VERA THERAPEUTICS CL A 92337R101   15,642,641 975,227 SH   SOLE   975,227 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100   7,386,750 21,000 SH   SOLE   21,000 0 0
XENON PHARMACEUTICALS INC COM 98420N105   981,750 25,500 SH   SOLE   25,500 0 0
Zai Lab Ltd ADR (V1 Ord) ADR 98887Q104   2,189,505 78,958 SH   SOLE   78,958 0 0