The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109   81,691,463 1,462,956 SH   SOLE 1,2,3 1,462,956 0 0
ACADIA PHARMACEUTICALS INC COM 004225108   234,308,814 9,783,249 SH   SOLE 1,2,3 9,783,249 0 0
ACELYRIN INC COM 00445A100   20,446,679 978,310 SH   SOLE 1,2,3 978,310 0 0
ADICET BIO INC COM 007002108   10,306,777 4,241,472 SH   SOLE 1,2,3 4,241,472 0 0
AKOYA BIOSCIENCES INC COM 00974H104   2,500,939 338,422 SH   SOLE 1,2,3 338,422 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   319,737,778 1,683,362 SH   SOLE 1,2,3 1,683,362 0 0
APYX MEDICAL CORPORATION COM 03837C106   8,939,286 1,777,194 SH   SOLE 1,2 1,777,194 0 0
ARGENX SE SPONSORED ADR 04016X101   187,925,857 482,195 SH   SOLE 1,2,3 482,195 0 0
ARYA SCIENCES ACQU CORP IV CL A G31659108   1,347,524 127,970 SH   SOLE 1,2,3 127,970 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104   112,239,364 6,810,641 SH   SOLE 1,2,3 6,810,641 0 0
AVIDITY BIOSCIENCES INC COM 05370A108   74,189,760 6,689,789 SH   SOLE 1,2,3 6,689,789 0 0
AXONICS INC COM 05465P101   44,664,638 884,974 SH   SOLE 1,2,3 884,974 0 0
AXSOME THERAPEUTICS INC COM 05464T104   307,868,145 4,284,277 SH   SOLE 1,2,3 4,284,277 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105   8,585,000 1,700,000 SH   SOLE 1,2,3 1,700,000 0 0
BRUKER CORP COM 116794108   218,773,854 2,959,603 SH   SOLE 1,2,3 2,959,603 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   117,506,410 3,463,201 SH   SOLE 1,2,3 3,463,201 0 0
CUTERA INC COM 232109108   27,938,997 1,846,596 SH   SOLE 1,2,3 1,846,596 0 0
CYTOKINETICS INC COM NEW 23282W605   83,970,339 2,574,198 SH   SOLE 1,2,3 2,574,198 0 0
DERMTECH INC COM 24984K105   7,067,726 2,718,356 SH   SOLE 1,2,3 2,718,356 0 0
DESIGN THERAPEUTICS INC COM 25056L103   9,847,095 1,563,031 SH   SOLE 1,2,3 1,563,031 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108   171,122,808 2,494,138 SH   SOLE 1,2,3 2,494,138 0 0
EXAGEN INC COM 30068X103   4,328,053 1,492,432 SH   SOLE 1,2,3 1,492,432 0 0
FULCRUM THERAPEUTICS INC COM 359616109   20,011,606 6,064,123 SH   SOLE 1,2,3 6,064,123 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106   25,734,675 2,168,957 SH   SOLE 1,2,3 2,168,957 0 0
GUARDANT HEALTH INC COM 40131M109   17,931,755 500,887 SH   SOLE 1,2,3 500,887 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101   102,850,000 1,000,000 SH   SOLE 1,2,3 1,000,000 0 0
ILLUMINA INC COM 452327109   70,543,113 376,250 SH   SOLE 1,2,3 376,250 0 0
IMMATICS N.V SHS N44445109   9,751,300 845,000 SH   SOLE 1,2,3 845,000 0 0
IMMUNIC INC COM 4525EP101   10,779,092 4,294,459 SH   SOLE 1,2,3 4,294,459 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105   361,536,795 6,029,633 SH   SOLE 1,2,3 6,029,633 0 0
INSMED INC COM PAR $.01 457669307   21,100,000 1,000,000 SH   SOLE 1,2,3 1,000,000 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602   58,129,800 170,000 SH   SOLE 1,2,3 170,000 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   51,180,822 221,562 SH   SOLE 1,2,3 221,562 0 0
MARAVAI LIFESCIENCES HLDGS I COM CL A 56600D107   19,051,275 1,532,685 SH   SOLE 1,2,3 1,532,685 0 0
MASIMO CORP COM 574795100   247,070,673 1,501,493 SH   SOLE 1,2,3 1,501,493 0 0
MERSANA THERAPEUTICS INC COM 59045L106   2,022,817 614,838 SH   SOLE 1,2,3 614,838 0 0
MERUS N V COM N5749R100   27,670,013 1,050,893 SH   SOLE 1,2,3 1,050,893 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107   9,279,891 3,256,102 SH   SOLE 1,2,3 3,256,102 0 0
MINERALYS THERAPEUTICS INC COM 603170101   15,721,805 922,100 SH   SOLE 1,2,3 922,100 0 0
MIRATI THERAPEUTICS INC COM 60468T105   161,608,948 4,472,985 SH   SOLE 1,2,3 4,472,985 0 0
MIROMATRIX MED INC COM 60471P108   779,139 445,222 SH   SOLE 1,2,3 445,222 0 0
MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104   25,500,000 500,000 SH   SOLE 1,2,3 500,000 0 0
NATERA INC COM 632307104   127,089,361 2,611,783 SH   SOLE 1,2,3 2,611,783 0 0
OLINK HLDG AB SPONSORED ADS 680710100   12,273,975 654,612 SH   SOLE 1,2,3 654,612 0 0
ORCHESTRA BIOMED HLDGS INC COM 68572M106   39,344,480 5,620,640 SH   SOLE 1,2,3 5,620,640 0 0
OUTSET MED INC COM 690145107   17,685,350 808,658 SH   SOLE 1,2,3 808,658 0 0
PENUMBRA INC COM 70975L107   231,680,026 673,371 SH   SOLE 1,2,3 673,371 0 0
PMV PHARMACEUTICALS INC COM 69353Y103   18,964,989 3,029,551 SH   SOLE 1,2,3 3,029,551 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102   149,576,497 5,415,514 SH   SOLE 1,2,3 5,415,514 0 0
PTC THERAPEUTICS INC COM 69366J200   294,255,421 7,235,196 SH   SOLE 1,2,3 7,235,196 0 0
RELMADA THERAPEUTICS INC COM 75955J402   5,244,314 2,131,835 SH   SOLE 1,2,3 2,131,835 0 0
ROCKET PHARMACEUTICALS INC *W EXP 09/02/202 77313F114   66,500 350,000 SH   SOLE 1,2,3 350,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   351,456,030 17,687,772 SH   SOLE 1,2,3 17,687,772 0 0
ROIVANT SCIENCES LTD SHS G76279101   15,651,387 1,552,717 SH   SOLE 1,2,3 1,552,717 0 0
SCPHARMACEUTICALS INC COM 810648105   33,605,020 3,297,843 SH   SOLE 1,2,3 3,297,843 0 0
STOKE THERAPEUTICS INC COM 86150R107   46,671,632 4,390,558 SH   SOLE 1,2,3 4,390,558 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103   46,044,619 2,548,125 SH   SOLE 1,2,3 2,548,125 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102   151,481,765 290,334 SH   SOLE 1,2,3 290,334 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108   249,336,756 5,405,089 SH   SOLE 1,2,3 5,405,089 0 0
UROGEN PHARMA LTD COM M96088105   8,874,752 857,464 SH   SOLE 1,2,3 857,464 0 0
VERICEL CORP COM 92346J108   123,675,669 3,291,873 SH   SOLE 1,2,3 3,291,873 0 0
VIKING THERAPEUTICS INC COM 92686J106   16,210,000 1,000,000 SH   SOLE 1,2,3 1,000,000 0 0