The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109   18,133,817 324,746 SH   DFND 2 324,746 0 0
4D MOLECULAR THERAPEUTICS IN COM 35104E100   813,150 45,000 SH   DFND 2 45,000 0 0
89BIO INC COM 282559103   1,235,540 65,200 SH   DFND 2 65,200 0 0
ABBOTT LABS COM 002824100   179,501,539 1,646,501 SH   DFND 2 1,646,501 0 0
ABBVIE INC COM 00287Y109   831,823 6,174 SH   DFND 2 6,174 0 0
ABCAM PLC ADS 000380204   62,961 2,573 SH   DFND 2 2,573 0 0
ACCOLADE INC COM 00437E102   11,065,416 821,486 SH   DFND 2 821,486 0 0
ACCOLADE INC COM 00437E102   49,833,248 3,699,573 SH   DFND 3 3,699,573 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104   382,320 13,500 SH   DFND 2 13,500 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104   113,280,000 4,000,000 SH   DFND 1,2 4,000,000 0 0
AKERO THERAPEUTICS INC COM 00973Y108   1,265,299 27,100 SH   DFND 2 27,100 0 0
ALIGN TECHNOLOGY INC COM 016255101   60,521,950 171,140 SH   DFND 2 171,140 0 0
ALKERMES PLC SHS G01767105   2,557,210 81,700 SH   DFND 2 81,700 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   4,682,021 24,650 SH   DFND 2 24,650 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   166,197,500 875,000 SH   DFND 1,2 875,000 0 0
ALPHABET INC CAP STK CL C 02079K107   725,820 6,000 SH   DFND 2 6,000 0 0
AMEDISYS INC COM 023436108   21,426,038 234,318 SH   DFND 3 234,318 0 0
AMERICAN WELL CORP CL A 03044L105   2,002,587 953,613 SH   DFND 2 953,613 0 0
AMERISOURCEBERGEN CORP COM 03073E105   3,061,561 15,910 SH   DFND 2 15,910 0 0
AMGEN INC COM 031162100   6,063,366 27,310 SH   DFND 2 27,310 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   2,988,080 32,800 SH   DFND 2 32,800 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   44,246,815 485,695 SH   DFND 3 485,695 0 0
ARGENX SE SPONSORED ADR 04016X101   22,715,023 58,284 SH   DFND 2 58,284 0 0
ARGENX SE SPONSORED ADR 04016X101   337,116,450 865,000 SH   DFND 1,2 865,000 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100   738,162 20,700 SH   DFND 2 20,700 0 0
ARVINAS INC COM 04335A105   173,740 7,000 SH   DFND 2 7,000 0 0
ARVINAS INC COM 04335A105   52,618,400 2,120,000 SH   DFND 1,2 2,120,000 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108   6,126,392 85,600 SH   DFND 2 85,600 0 0
ATRICURE INC COM 04963C209   36,951,538 748,613 SH   DFND 3 748,613 0 0
AXONICS INC COM 05465P101   39,780,555 788,202 SH   DFND 2 788,202 0 0
AXONICS INC COM 05465P101   72,435,352 1,435,216 SH   DFND 3 1,435,216 0 0
AXSOME THERAPEUTICS INC COM 05464T104   41,273,725 574,363 SH   DFND 3 574,363 0 0
BAXTER INTL INC COM 071813109   9,724,053 213,434 SH   DFND 2 213,434 0 0
BEAM THERAPEUTICS INC COM 07373V105   73,439 2,300 SH   DFND 2 2,300 0 0
BEAM THERAPEUTICS INC COM 07373V105   22,131,354 693,121 SH   DFND 1,2 693,121 0 0
BECTON DICKINSON & CO COM 075887109   89,162,249 337,723 SH   DFND 2 337,723 0 0
BEIGENE LTD SPONSORED ADR 07725L102   1,818,660 10,200 SH   DFND 2 10,200 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108   638,000 25,000 SH   DFND 2 25,000 0 0
BIOGEN INC COM 09062X103   7,291,590 25,598 SH   DFND 2 25,598 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   31,257,155 360,604 SH   DFND 2 360,604 0 0
BIO RAD LABS INC CL A 090572207   51,004,151 134,533 SH   DFND 3 134,533 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105   90,900 18,000 SH   DFND 2 18,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105   40,995,087 8,117,839 SH   DFND 1,2 8,117,839 0 0
BOSTON SCIENTIFIC CORP COM 101137107   143,957,939 2,661,452 SH   DFND 2 2,661,452 0 0
BRIDGEBIO PHARMA INC COM 10806X102   1,666,680 96,900 SH   DFND 2 96,900 0 0
CAREDX INC COM 14167L103   31,590,055 3,716,477 SH   DFND 3 3,716,477 0 0
CASTLE BIOSCIENCES INC COM 14843C105   15,421,870 1,124,043 SH   DFND 3 1,124,043 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   61,074,000 1,800,000 SH   DFND 1,2 1,800,000 0 0
CENTENE CORP DEL COM 15135B101   7,859,544 116,524 SH   DFND 2 116,524 0 0
CENTENE CORP DEL COM 15135B101   11,871,402 176,003 SH   DFND 3 176,003 0 0
CHARLES RIV LABS INTL INC COM 159864107   1,135,350 5,400 SH   DFND 2 5,400 0 0
CHARLES RIV LABS INTL INC COM 159864107   64,991,008 309,113 SH   DFND 3 309,113 0 0
COOPER COS INC COM NEW 216648402   33,192,385 86,567 SH   DFND 2 86,567 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108   1,083,502 19,300 SH   DFND 2 19,300 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108   49,403,200 880,000 SH   DFND 1,2 880,000 0 0
CVS HEALTH CORP COM 126650100   2,441,257 35,314 SH   DFND 2 35,314 0 0
CYTOKINETICS INC COM NEW 23282W605   1,210,202 37,100 SH   DFND 2 37,100 0 0
DANAHER CORPORATION COM 235851102   44,090,160 183,709 SH   DFND 2 183,709 0 0
DENALI THERAPEUTICS INC COM 24823R105   1,299,916 44,050 SH   DFND 2 44,050 0 0
DEXCOM INC COM 252131107   97,888,123 761,716 SH   DFND 2 761,716 0 0
DICE THERAPEUTICS INC COM 23345J104   845,572 18,200 SH   DFND 2 18,200 0 0
DOXIMITY INC CL A 26622P107   15,260,658 448,579 SH   DFND 2 448,579 0 0
DR REDDYS LABS LTD ADR 256135203   5,787,187 91,700 SH   DFND 2 91,700 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108   97,923,218 1,038,092 SH   DFND 2 1,038,092 0 0
ELEVANCE HEALTH INC COM 036752103   12,720,467 28,631 SH   DFND 2 28,631 0 0
ELEVANCE HEALTH INC COM 036752103   32,798,376 73,822 SH   DFND 3 73,822 0 0
LILLY ELI & CO COM 532457108   44,625,792 95,155 SH   DFND 2 95,155 0 0
EQUINIX INC COM 29444U700   31,358 40 SH   DFND 2 40 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105   19,738 14,200 SH   DFND 2 14,200 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105   5,829,749 4,194,064 SH   DFND 1,2 4,194,064 0 0
ESSA PHARMA INC COM NEW 29668H708   51,300 19,000 SH   DFND 2 19,000 0 0
ESSA PHARMA INC COM NEW 29668H708   21,274,874 7,879,583 SH   DFND 1,2 7,879,583 0 0
EVERTEC INC COM 30040P103   27,217 739 SH   DFND 2 739 0 0
EVOLENT HEALTH INC CL A 30050B101   39,921,371 1,317,537 SH   DFND 2 1,317,537 0 0
EVOLENT HEALTH INC CL A 30050B101   64,562,786 2,130,785 SH   DFND 3 2,130,785 0 0
EXACT SCIENCES CORP COM 30063P105   18,875,684 201,019 SH   DFND 2 201,019 0 0
EXACT SCIENCES CORP COM 30063P105   75,660,207 805,753 SH   DFND 3 805,753 0 0
EXELIXIS INC COM 30161Q104   171,990 9,000 SH   DFND 2 9,000 0 0
EXELIXIS INC COM 30161Q104   48,252,750 2,525,000 SH   DFND 1,2 2,525,000 0 0
FATE THERAPEUTICS INC COM 31189P102   76,160 16,000 SH   DFND 2 16,000 0 0
FATE THERAPEUTICS INC COM 31189P102   23,037,348 4,839,779 SH   DFND 1,2 4,839,779 0 0
GENERATION BIO CO COM 37148K100   66,000 12,000 SH   DFND 2 12,000 0 0
GENERATION BIO CO COM 37148K100   19,845,540 3,608,280 SH   DFND 1,2 3,608,280 0 0
GILEAD SCIENCES INC COM 375558103   8,681,936 112,650 SH   DFND 2 112,650 0 0
GLOBUS MED INC CL A 379577208   38,560,783 647,645 SH   DFND 2 647,645 0 0
GRACELL BIOTECHNOLOGIES INC SPONSORED ADS 38406L103   554,911 145,646 SH   DFND 2 145,646 0 0
GRUPO AEROPORTUARIO DEL SURE SPON ADR SER B 40051E202   37,488 135 SH   DFND 2 135 0 0
GUARDANT HEALTH INC COM 40131M109   2,942,653 82,197 SH   DFND 2 82,197 0 0
HCA HEALTHCARE INC COM 40412C101   48,713,092 160,515 SH   DFND 2 160,515 0 0
HOLOGIC INC COM 436440101   23,492,312 290,136 SH   DFND 2 290,136 0 0
HUMANA INC COM 444859102   56,952,289 127,373 SH   DFND 2 127,373 0 0
HUTCHMED CHINA LTD SPONSORED ADS 44842L103   21,666,996 1,805,583 SH   DFND 3 1,805,583 0 0
IDEXX LABS INC COM 45168D104   57,475,703 114,441 SH   DFND 2 114,441 0 0
ILLUMINA INC COM 452327109   15,754,035 84,026 SH   DFND 2 84,026 0 0
INCYTE CORP COM 45337C102   1,479,371 23,765 SH   DFND 2 23,765 0 0
INCYTE CORP COM 45337C102   162,908,250 2,617,000 SH   DFND 1,2 2,617,000 0 0
INFOSYS LTD SPONSORED ADR 456788108   18,159 1,130 SH   DFND 2 1,130 0 0
INHIBRX INC COM 45720L107   1,266,848 48,800 SH   DFND 2 48,800 0 0
INSMED INC COM PAR $.01 457669307   69,649,222 3,300,911 SH   DFND 3 3,300,911 0 0
INSPIRE MED SYS INC COM 457730109   115,902,973 357,020 SH   DFND 2 357,020 0 0
INSULET CORP COM 45784P101   93,305,094 323,594 SH   DFND 2 323,594 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101   3,279,976 51,800 SH   DFND 2 51,800 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101   199,458,000 3,150,000 SH   DFND 1,2 3,150,000 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602   253,877,114 742,461 SH   DFND 2 742,461 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602   34,112,960 99,763 SH   DFND 3 99,763 0 0
IONIS PHARMACEUTICALS INC COM 462222100   3,307,018 80,600 SH   DFND 2 80,600 0 0
IONIS PHARMACEUTICALS INC COM 462222100   381,566,691 9,299,700 SH   DFND 1,2 9,299,700 0 0
IQVIA HLDGS INC COM 46266C105   36,439,712 162,120 SH   DFND 2 162,120 0 0
ISHARES TR MSCI CHINA ETF 46429B671   183,434 4,100 SH   DFND 2 4,100 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105   27,826,306 224,460 SH   DFND 2 224,460 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105   7,973,626 64,319 SH   DFND 3 64,319 0 0
JOHNSON & JOHNSON COM 478160104   3,513,162 21,225 SH   DFND 2 21,225 0 0
JUMIA TECHNOLOGIES AG SPONSORED ADS 48138M105   61,560 18,000 SH   DFND 2 18,000 0 0
KARUNA THERAPEUTICS INC COM 48576A100   2,190,185 10,100 SH   DFND 2 10,100 0 0
KEZAR LIFE SCIENCES INC COM 49372L100   24,500 10,000 SH   DFND 2 10,000 0 0
KOSMOS ENERGY LTD COM 500688106   1,906,617 318,300 SH   DFND 2 318,300 0 0
KRYSTAL BIOTECH INC COM 501147102   2,113,200 18,000 SH   DFND 2 18,000 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409   1,686,414 6,988 SH   DFND 2 6,988 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102   19,035,299 275,754 SH   DFND 2 275,754 0 0
MACROGENICS INC COM 556099109   160,233 29,950 SH   DFND 2 29,950 0 0
MACROGENICS INC COM 556099109   51,252,802 9,579,963 SH   DFND 1,2 9,579,963 0 0
MCKESSON CORP COM 58155Q103   1,408,414 3,296 SH   DFND 2 3,296 0 0
MEDTRONIC PLC SHS G5960L103   124,264,345 1,410,492 SH   DFND 2 1,410,492 0 0
MERCK & CO INC COM 58933Y105   35,389,421 306,694 SH   DFND 2 306,694 0 0
MERSANA THERAPEUTICS INC COM 59045L106   44,415 13,500 SH   DFND 2 13,500 0 0
MERSANA THERAPEUTICS INC COM 59045L106   17,127,493 5,205,925 SH   DFND 1,2 5,205,925 0 0
MERUS N V COM N5749R100   1,171,685 44,500 SH   DFND 2 44,500 0 0
MODERNA INC COM 60770K107   6,082,169 50,059 SH   DFND 2 50,059 0 0
MODERNA INC COM 60770K107   179,212,500 1,475,000 SH   DFND 1,2 1,475,000 0 0
MOLECULAR TEMPLATES INC COM 608550109   18,240 38,000 SH   DFND 2 38,000 0 0
MOLECULAR TEMPLATES INC COM 608550109   5,372,161 11,192,003 SH   DFND 1,2 11,192,003 0 0
MOLINA HEALTHCARE INC COM 60855R100   49,505,179 164,338 SH   DFND 2 164,338 0 0
NATERA INC COM 632307104   11,326,832 232,775 SH   DFND 2 232,775 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109   2,150,040 22,800 SH   DFND 2 22,800 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109   244,237,000 2,590,000 SH   DFND 1,2 2,590,000 0 0
NEVRO CORP COM 64157F103   5,556,126 218,573 SH   DFND 2 218,573 0 0
OLINK HLDG AB SPONSORED ADS 680710100   4,492,950 239,624 SH   DFND 2 239,624 0 0
OMNICELL COM COM 68213N109   21,610,726 293,345 SH   DFND 2 293,345 0 0
OPTION CARE HEALTH INC COM NEW 68404L201   74,324,871 2,287,623 SH   DFND 3 2,287,623 0 0
OUTSET MED INC COM 690145107   22,022,106 1,006,955 SH   DFND 2 1,006,955 0 0
OUTSET MED INC COM 690145107   46,341,021 2,118,931 SH   DFND 3 2,118,931 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108   33,052,535 2,485,153 SH   DFND 2 2,485,153 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108   67,267,091 5,057,676 SH   DFND 3 5,057,676 0 0
PENUMBRA INC COM 70975L107   80,585,733 234,220 SH   DFND 2 234,220 0 0
PHREESIA INC COM 71944F106   19,804,630 638,653 SH   DFND 2 638,653 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109   11,381,145 1,256,197 SH   DFND 3 1,256,197 0 0
PRIVIA HEALTH GROUP INC COM 74276R102   29,312,235 1,122,644 SH   DFND 2 1,122,644 0 0
PROCEPT BIOROBOTICS CORP COM 74276L105   26,212,626 741,517 SH   DFND 2 741,517 0 0
QUEST DIAGNOSTICS INC COM 74834L100   272,968 1,942 SH   DFND 2 1,942 0 0
REGENERON PHARMACEUTICALS COM 75886F107   11,731,603 16,327 SH   DFND 2 16,327 0 0
RELAY THERAPEUTICS INC COM 75943R102   889,248 70,800 SH   DFND 2 70,800 0 0
RELAY THERAPEUTICS INC COM 75943R102   51,496,000 4,100,000 SH   DFND 1,2 4,100,000 0 0
RESMED INC COM 761152107   21,473,088 98,275 SH   DFND 2 98,275 0 0
REVOLUTION MEDICINES INC COM 76155X100   1,899,250 71,000 SH   DFND 2 71,000 0 0
REVOLUTION MEDICINES INC COM 76155X100   125,056,250 4,675,000 SH   DFND 1,2 4,675,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   1,104,772 55,600 SH   DFND 2 55,600 0 0
SAGE THERAPEUTICS INC COM 78667J108   1,616,313 34,375 SH   DFND 2 34,375 0 0
SAGE THERAPEUTICS INC COM 78667J108   144,821,600 3,080,000 SH   DFND 1,2 3,080,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100   1,297,512 11,330 SH   DFND 2 11,330 0 0
SAREPTA THERAPEUTICS INC COM 803607100   21,631,683 188,890 SH   DFND 3 188,890 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103   55,042 7,300 SH   DFND 2 7,300 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103   16,080,747 2,132,725 SH   DFND 1,2 2,132,725 0 0
SEAGEN INC COM 81181C104   4,234,120 22,000 SH   DFND 2 22,000 0 0
SEER INC COM CL A 81578P106   581,288 136,133 SH   DFND 2 136,133 0 0
SHOCKWAVE MED INC COM 82489T104   77,210,826 270,526 SH   DFND 2 270,526 0 0
SIGHT SCIENCES INC COM 82657M105   2,370,432 286,284 SH   DFND 2 286,284 0 0
SILK RD MED INC COM 82710M100   44,081,230 1,356,763 SH   DFND 3 1,356,763 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103   797,904 1,800 SH   DFND 2 1,800 0 0
SPDR SER TR S&P OILGAS EXP 78468R556   502,437 3,900 SH   DFND 2 3,900 0 0
STRYKER CORPORATION COM 863667101   145,511,455 476,946 SH   DFND 2 476,946 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108   19,546,695 650,256 SH   DFND 2 650,256 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100   109,902 1,089 SH   DFND 2 1,089 0 0
TANDEM DIABETES CARE INC COM NEW 875372203   14,430,428 588,037 SH   DFND 2 588,037 0 0
TANDEM DIABETES CARE INC COM NEW 875372203   36,930,172 1,504,897 SH   DFND 3 1,504,897 0 0
TELADOC HEALTH INC COM 87918A105   9,932,124 392,264 SH   DFND 2 392,264 0 0
TENET HEALTHCARE CORP COM NEW 88033G407   54,443 669 SH   DFND 2 669 0 0
THE CIGNA GROUP COM 125523100   14,141,959 50,399 SH   DFND 2 50,399 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102   50,140,697 96,101 SH   DFND 2 96,101 0 0
TRANSMEDICS GROUP INC COM 89377M109   51,447,240 612,613 SH   DFND 2 612,613 0 0
UNITED MICROELECTRONICS CORP SPON ADR NEW 910873405   21,287 2,698 SH   DFND 2 2,698 0 0
UNITEDHEALTH GROUP INC COM 91324P102   53,830,238 111,997 SH   DFND 2 111,997 0 0
UNITEDHEALTH GROUP INC COM 91324P102   47,165,203 98,130 SH   DFND 3 98,130 0 0
VANECK ETF TRUST GOLD MINERS ETF 92189F106   993,630 33,000 SH   DFND 2 33,000 0 0
VANECK ETF TRUST JUNIOR GOLD MINE 92189F791   178,300 5,000 SH   DFND 2 5,000 0 0
VAXCYTE INC COM 92243G108   1,298,440 26,000 SH   DFND 2 26,000 0 0
VEEVA SYS INC CL A COM 922475108   53,593,926 271,046 SH   DFND 2 271,046 0 0
VENTYX BIOSCIENCES INC COM 92332V107   803,600 24,500 SH   DFND 2 24,500 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106   1,226,120 58,000 SH   DFND 2 58,000 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106   10,872,619 514,315 SH   DFND 3 514,315 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100   49,479,602 140,603 SH   DFND 2 140,603 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100   37,500,585 106,563 SH   DFND 3 106,563 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100   299,123,500 850,000 SH   DFND 1,2 850,000 0 0
VIKING THERAPEUTICS INC COM 92686J106   534,930 33,000 SH   DFND 2 33,000 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   1,056,276 44,400 SH   DFND 2 44,400 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105   16,359,827 4,494,458 SH   DFND 1,2 4,494,458 0 0
XENON PHARMACEUTICALS INC COM 98420N105   920,150 23,900 SH   DFND 2 23,900 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102   41,471,976 284,835 SH   DFND 2 284,835 0 0
ZOETIS INC CL A 98978V103   1,118,676 6,496 SH   DFND 2 6,496 0 0