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The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2seventy bio, Inc. COMMON STOCK 901384107   25,274,963 2,497,526 SH   SOLE   2,497,526 0 0
Aadi Bioscience, Inc. COM 00032Q104   6,771,108 989,928 SH   SOLE   989,928 0 0
AbCellera Biologics Inc. COM 00288U106   106,268,163 16,450,180 SH   SOLE   16,450,180 0 0
ACADIA Pharmaceuticals Inc. COM 004225108   1,026,607,457 42,864,612 SH   SOLE   42,864,612 0 0
Achilles Therapeutics plc SPONSORED ADS 00449L102   2,417,017 2,557,149 SH   SOLE   2,557,149 0 0
Adaptimmune Therapeutics plc SPONSORED ADR 00653A107   10,146,586 10,969,282 SH   SOLE   10,969,282 0 0
Aeglea BioTherapeutics, Inc. COM 00773J103   1,536,253 3,410,106 SH   SOLE   3,410,106 0 0
Aerovate Therapeutics, Inc. COM 008064107   33,673,665 1,963,479 SH   SOLE   1,963,479 0 0
Affimed N.V. COM N01045108   3,946,224 6,596,830 SH   SOLE   6,596,830 0 0
Akero Therapeutics, Inc. COM 00973Y108   110,579,569 2,368,378 SH   SOLE   2,368,378 0 0
Alector, Inc. COM 014442107   5,798,755 964,851 SH   SOLE   964,851 0 0
Aligos Therapeutics, Inc. COM 01626L105   2,016,184 2,076,400 SH   SOLE   2,076,400 0 0
Allogene Therapeutics, Inc. COM 019770106   7,837,198 1,576,901 SH   SOLE   1,576,901 0 0
AnaptysBio, Inc. COM 032724106   15,782,294 775,924 SH   SOLE   775,924 0 0
Aravive, Inc. COM 03890D108   4,109,142 3,261,224 SH   SOLE   3,261,224 0 0
argenx SE SPONSORED ADR 04016X101   109,186,367 280,159 SH   SOLE   280,159 0 0
ARS Pharmaceuticals, Inc. COM 82835W108   13,443,222 2,006,451 SH   SOLE   2,006,451 0 0
Athira Pharma, Inc. COM 04746L104   9,303,731 3,153,807 SH   SOLE   3,153,807 0 0
Atreca, Inc. CL A COM 04965G109   3,462,105 3,532,760 SH   SOLE   3,532,760 0 0
Avidity Biosciences, Inc. COM 05370A108   8,865,912 799,451 SH   SOLE   799,451 0 0
BeiGene, Ltd. SPONSORED ADR 07725L102   2,080,564,335 11,668,897 SH   SOLE   11,668,897 0 0
Bicycle Therapeutics plc SPONSORED ADS 088786108   21,534,133 843,814 SH   SOLE   843,814 0 0
BioCryst Pharmaceuticals, Inc. COM 09058V103   89,484,159 12,710,818 SH   SOLE   12,710,818 0 0
BioMarin Pharmaceutical Inc. COM 09061G101   330,272,297 3,810,248 SH   SOLE   3,810,248 0 0
Biomea Fusion, Inc. COM 09077A106   46,291,431 2,108,949 SH   SOLE   2,108,949 0 0
bluebird bio, Inc. COM 09609G100   8,224,062 2,499,715 SH   SOLE   2,499,715 0 0
Cabaletta Bio, Inc. COM 12674W109   20,578,540 1,594,000 SH   SOLE   1,594,000 0 0
Century Therapeutics, Inc. COM 15673T100   3,631,914 1,149,340 SH   SOLE   1,149,340 0 0
Cerus Corporation COM 157085101   39,526,193 16,067,558 SH   SOLE   16,067,558 0 0
Chinook Therapeutics, Inc. COM 16961L106   55,908,861 1,455,202 SH   SOLE   1,455,202 0 0
Cogent Biosciences, Inc. COM 19240Q201   11,598,464 979,600 SH   SOLE   979,600 0 0
Compass Therapeutics, Inc. COM 20454B104   4,953,263 1,557,630 SH   SOLE   1,557,630 0 0
Day One Biopharmaceuticals, Inc. COM 23954D109   11,940,000 1,000,000 SH   SOLE   1,000,000 0 0
DBV Technologies S.A. SPONSORED ADR 23306J101   27,767,102 14,614,264 SH   SOLE   14,614,264 0 0
Denali Therapeutics Inc. COM 24823R105   42,946,552 1,455,322 SH   SOLE   1,455,322 0 0
Design Therapeutics, Inc. COM 25056L103   3,150,000 500,000 SH   SOLE   500,000 0 0
DICE Therapeutics, Inc. COM 23345J104   48,122,618 1,035,786 SH   SOLE   1,035,786 0 0
Edgewise Therapeutics, Inc. COM 28036F105   3,875,000 500,000 SH   SOLE   500,000 0 0
Entrada Therapeutics, Inc. COM 29384C108   73,668,500 4,865,819 SH   SOLE   4,865,819 0 0
Fate Therapeutics, Inc. COM 31189P102   7,957,373 1,671,717 SH   SOLE   1,671,717 0 0
FibroGen, Inc. COM 31572Q808   642,827 238,084 SH   SOLE   238,084 0 0
Foghorn Therapeutics Inc. COM 344174107   316,990 45,027 SH   SOLE   45,027 0 0
Genetron Holdings Limited ADS 37186H100   423,480 455,306 SH   SOLE   455,306 0 0
Geron Corporation COM 374163103   9,826,529 3,061,224 SH   SOLE   3,061,224 0 0
Gracell Biotechnologies Inc. SPONSORED ADS 38406L103   3,810,000 1,000,000 SH   SOLE   1,000,000 0 0
Heron Therapeutics, Inc. COM 427746102   9,432,746 8,131,678 SH   SOLE   8,131,678 0 0
HOOKIPA Pharma Inc. COM 43906K100   3,894,471 4,425,535 SH   SOLE   4,425,535 0 0
IDEAYA Biosciences, Inc. COM 45166A102   24,959,891 1,062,123 SH   SOLE   1,062,123 0 0
IGM Biosciences, Inc. COM 449585108   29,141,048 3,157,210 SH   SOLE   3,157,210 0 0
Immatics N.V. SHS N44445109   65,095,017 5,640,816 SH   SOLE   5,640,816 0 0
Immunocore Holdings plc ADS 45258D105   151,143,031 2,520,731 SH   SOLE   2,520,731 0 0
ImmunoGen, Inc. COM 45253H101   28,684,230 1,520,097 SH   SOLE   1,520,097 0 0
Incyte Corporation COM 45337C102   2,252,083,986 36,178,056 SH   SOLE   36,178,056 0 0
Insmed Incorporated COM PAR $.01 457669307   7,237,300 343,000 SH   SOLE   343,000 0 0
Instil Bio, Inc. COM 45783C101   2,905,858 5,273,789 SH   SOLE   5,273,789 0 0
Invitae Corporation COM 46185L103   10,035,648 8,881,104 SH   SOLE   8,881,104 0 0
iTeos Therapeutics, Inc. COM 46565G104   1,990,581 150,346 SH   SOLE   150,346 0 0
Kala Pharmaceuticals, Inc. COM 483119202   1,695,548 116,213 SH   SOLE   116,213 0 0
Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101   39,558,844 2,809,577 SH   SOLE   2,809,577 0 0
Kodiak Sciences Inc. COM 50015M109   119,442,381 17,310,490 SH   SOLE   17,310,490 0 0
Krystal Biotech, Inc. COM 501147102   19,950,252 169,934 SH   SOLE   169,934 0 0
Kymera Therapeutics, Inc. COM 501575104   100,589,067 4,375,340 SH   SOLE   4,375,340 0 0
Leap Therapeutics, Inc. COM 52187K200   3,668,908 1,172,175 SH   SOLE   1,172,175 0 0
MacroGenics, Inc. COM 556099109   4,775,298 892,579 SH   SOLE   892,579 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105   356,921,103 1,545,113 SH   SOLE   1,545,113 0 0
Mereo BioPharma Group PLC SPONSORED ADS 589492107   4,692,572 3,554,979 SH   SOLE   3,554,979 0 0
Mersana Therapeutics, Inc. COM 59045L106   3,573,318 1,086,115 SH   SOLE   1,086,115 0 0
Mirati Therapeutics, Inc. COM 60468T105   50,935,496 1,409,784 SH   SOLE   1,409,784 0 0
Monte Rosa Therapeutics, Inc. COM 61225M102   20,714,064 3,023,951 SH   SOLE   3,023,951 0 0
Natera, Inc. COM 632307104   4,866,000 100,000 SH   SOLE   100,000 0 0
Neoleukin Therapeutics, Inc. COM 64049K104   3,172,044 3,821,740 SH   SOLE   3,821,740 0 0
Nkarta, Inc. COM 65487U108   594,211 271,329 SH   SOLE   271,329 0 0
Nurix Therapeutics, Inc. COM 67080M103   38,782,429 3,882,125 SH   SOLE   3,882,125 0 0
Opthea Limited SPONSORED ADS 68386J208   7,535,895 2,691,391 SH   SOLE   2,691,391 0 0
Pacific Biosciences of California, Inc. COM 69404D108   14,999,501 1,127,782 SH   SOLE   1,127,782 0 0
Perspective Therapeutics, Inc. COM 46489V104   1,549,283 2,319,286 SH   SOLE   2,319,286 0 0
PMV Pharmaceuticals, Inc. COM 69353Y103   2,015,870 322,024 SH   SOLE   322,024 0 0
POINT Biopharma Global Inc. COM 730541109   10,592,073 1,169,103 SH   SOLE   1,169,103 0 0
Praxis Precision Medicines, Inc. COM 74006W108   2,161,902 1,879,915 SH   SOLE   1,879,915 0 0
Prelude Therapeutics Inc. COM 74065P101   45,557,208 10,123,824 SH   SOLE   10,123,824 0 0
Prime Medicine, Inc. COM 74168J101   15,067,027 1,028,466 SH   SOLE   1,028,466 0 0
Protara Therapeutics, Inc. COM STK 74365U107   477,214 199,671 SH   SOLE   199,671 0 0
Relay Therapeutics, Inc. COM 75943R102   14,571,070 1,160,117 SH   SOLE   1,160,117 0 0
Replimune Group, Inc. COM 76029N106   106,307,662 4,578,280 SH   SOLE   4,578,280 0 0
Revolution Medicines, Inc. COM 76155X100   71,997,438 2,691,493 SH   SOLE   2,691,493 0 0
Rhythm Pharmaceuticals, Inc. COM 76243J105   107,156,423 6,498,267 SH   SOLE   6,498,267 0 0
Roivant Sciences Ltd. SHS G76279101   95,040,207 9,428,592 SH   SOLE   9,428,592 0 0
Sana Biotechnology, Inc. COM 799566104   11,920,000 2,000,000 SH   SOLE   2,000,000 0 0
Seagen Inc. COM 81181C104   8,574,894,019 44,554,162 SH   SOLE   44,554,162 0 0
Sera Prognostics, Inc. CLASS A COM 81749D107   5,856,648 1,777,435 SH   SOLE   1,777,435 0 0
SpringWorks Therapeutics, Inc. COM 85205L107   78,655,962 2,999,846 SH   SOLE   2,999,846 0 0
Stoke Therapeutics, Inc. COM 86150R107   22,644,430 2,130,238 SH   SOLE   2,130,238 0 0
Summit Therapeutics Inc. COM 86627T108   15,824,810 6,304,705 SH   SOLE   6,304,705 0 0
Surrozen, Inc. W EXP 8/11/2026 86889P117   46,000 833,333 SH   SOLE   833,333 0 0
Talis Biomedical Corporation COM 87424L207   3,659,921 7,624,835 SH   SOLE   7,624,835 0 0
Tango Therapeutics, Inc. COM 87583X109   2,490,000 750,000 SH   SOLE   750,000 0 0
TScan Therapeutics, Inc. COM 89854M101   6,961,980 2,784,792 SH   SOLE   2,784,792 0 0
Ultragenyx Pharmaceutical Inc. COM 90400D108   36,122,512 783,059 SH   SOLE   783,059 0 0
Vaxcyte, Inc. COM 92243G108   2,441,317 48,885 SH   SOLE   48,885 0 0
Vera Therapeutics, Inc. CL A 92337R101   2,350,747 146,464 SH   SOLE   146,464 0 0
Verastem, Inc. COM 92337C203   9,943,448 1,336,485 SH   SOLE   1,336,485 0 0
Verve Therapeutics, Inc. COM 92539P101   26,559,938 1,416,530 SH   SOLE   1,416,530 0 0
Vincerx Pharma, Inc. COM 92731L106   293,253 225,579 SH   SOLE   225,579 0 0
Vor Biopharma Inc. COM 929033108   1,958,590 633,848 SH   SOLE   633,848 0 0
Xencor, Inc. COM 98401F105   3,074,481 123,127 SH   SOLE   123,127 0 0
Xenon Pharmaceuticals Inc. COM 98420N105   28,938,102 751,639 SH   SOLE   751,639 0 0
Invitae Corporation Note 1.5% 4/1/2028 46185LAD5   135,000,000 300,000,000 PRN   SOLE   300,000,000 0 0