The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
9 METERS BIOPHARMA INC COM 654405208   697,832 1,038,440 SH   DFND 1 0 1,038,440 0
ADITXT INC COM 007025505   265,302 589,560 SH   DFND 1 0 589,560 0
AKARI THERAPEUTICS PLC ADR 00972G108   1,256,662 7,392,131 SH   DFND 1 0 7,392,131 0
AMPLITECH GROUP INC *W 03211Q119   175,610 424,178 SH   DFND 1 0 424,178 0
ARCADIA BIOSCIENCES INC COM 039014303   458,666 118,213 SH   DFND 1 0 118,213 0
ARCIMOTO INC COM 039587209   36,354 24,900 SH   DFND 1 0 24,900 0
ASCENT SOLAR TECHNOLOGIES INC COM 043635606   71,797 579,007 SH   DFND 1 0 579,007 0
ASSURE HOLDINGS CORP COM 04625J303   125,980 132,610 SH   DFND 1 0 132,610 0
AVENUE THERAPEUTICS INC COM 05360L304   647,405 553,338 SH   DFND 1 0 553,338 0
BIOLINERX LTD ADS 09071M955   173,696 1,089 SH Put DFND 1 0 1,089 0
BIONDVAX PHARMACEUTICALS LTD ADS 09073Q204   269,207 190,927 SH   DFND 1 0 190,927 0
BIORA THERAPEUTICS INC COM 74319F305   1,858,045 482,609 SH   DFND 1 0 482,609 0
BIT BROTHER LTD CL A G1144D125   478,610 911,464 SH   DFND 1 0 911,464 0
BIT DIGITAL INC SHS G1144A955   64,960 160 SH Put DFND 1 0 160 0
BONE BIOLOGICS CORP COM 098070303   15,468 10,817 SH   DFND 1 0 10,817 0
BRAINSTORM CELL THERAPEUTICS COM 10501E951   21,836 106 SH Put DFND 1 0 106 0
BRAINSTORM CELL THERAPEUTICS COM 10501E901   2,611,814 1,267,871 SH   DFND 1 0 1,267,871 0
BRIACELL THERAPEUTICS CORP COM 10778Y952   544,416 848 SH Put DFND 1 0 848 0
BRIDGEBIO PHARMA INC COM 10806X902   333,680 194 SH Call DFND 1 0 194 0
BRIGHT GREEN CORP COM 10920G950   83,224 824 SH Put DFND 1 0 824 0
BRUUSH ORAL CARE INC *W 11750K120   42,889 536,107 SH   DFND 1 0 536,107 0
BULLFROG AI HOLDINGS WTS *W 12021E117   102,358 159,935 SH   DFND 1 0 159,935 0
CANAAN INC COM 134748902   30,033 141 SH Call DFND 1 0 141 0
CASTOR MARITIME INC COM Y1146L955   36,998 824 SH Put DFND 1 0 824 0
CASTOR MARITIME INC COM Y1146L125   36,768 81,889 SH   DFND 1 0 81,889 0
CINGULATE INC *W 17248W113   119,202 567,628 SH   DFND 1 0 567,628 0
CN ENERGY GROUP INC CL A G2181K105   44,041 218,457 SH   DFND 1 0 218,457 0
COSMOS HEALTH INC COM 221413305   104,668 35,006 SH   DFND 1 0 35,006 0
DOGNESS INTL CORP CL A G2788T193   67,598 926 SH Call DFND 1 0 926 0
DOGNESS INTL CORP CL A G2788T103   853,455 1,169,116 SH   DFND 1 0 1,169,116 0
EDIBLE GARDEN AG INC SHS 28059P204   157,607 124,100 SH   DFND 1 0 124,100 0
EFFECTOR THERAPEUTICS INC COM 28202V958   8,883 107 SH Put DFND 1 0 107 0
ENSYSCE BIOSCIENCES INC COM 293602405   580,136 322,298 SH   DFND 1 0 322,298 0
ESPORTS ENTMT GROUP INC *W 29667K132   30,555 4,629,529 SH   DFND 1 0 4,629,529 0
FORZA X1 INC COM 34988N104   578,314 393,411 SH   DFND 1 0 393,411 0
G MED INNOVATIONS HLDGS LTD SHS G39462141   262,603 690,334 SH   DFND 1 0 690,334 0
GAMIDA CELL LTD SHS M47364950   433,092 2,244 SH Put DFND 1 0 2,244 0
GAMIDA CELL LTD SHS M47364100   113,758 58,942 SH   DFND 1 0 58,942 0
GEVO INC COM 374396906   64,600 425 SH Call DFND 1 0 425 0
GLOBUS MARITIME LTD COM Y27265956   47,478 529 SH Put DFND 1 0 529 0
GLOBUS MARITIME LTD COM Y27265126   369,687 411,907 SH   DFND 1 0 411,907 0
GLUCOTRACK INC COM 45824Q507   701,531 2,032,833 SH   DFND 1 0 2,032,833 0
HARBOR CUSTOM DEVELOPMENT INC COM 41150T306   465,512 154,143 SH   DFND 1 0 154,143 0
HARBOR CUSTOM DEVELOPMENT INC *W 41150T124   6,405 753,522 SH   DFND 1 0 753,522 0
HEARTBEAM INC *W 42238H116   7,163 17,908 SH   DFND 1 0 17,908 0
HILLSTREAM BIOPHARMA INC COM 432705101   483,440 1,325,219 SH   DFND 1 0 1,325,219 0
IBIO INC COM 451033959   181,414 2,974 SH Put DFND 1 0 2,974 0
IMPERIAL PETE INC COM Y3894J957   244,860 795 SH Put DFND 1 0 795 0
INFOBIRD CO LTD ORD G47724110   29,433 23,929 SH   DFND 1 0 23,929 0
INNOVATIVE EYEWEAR INC *W 45791D117   19,862 104,535 SH   DFND 1 0 104,535 0
ISHARES TR ETF 464287955   63,840,343 3,409 SH Put DFND 1 0 3,409 0
ITERUM THERAPEUTICS PLC SHS G6333L200   1,125,000 75,000 SH   DFND 1 0 75,000 0
JEFFS BRANDS LTD *W M61472110   5,479 77,282 SH   DFND 1 0 77,282 0
JUPITER WELLNESS INC COM 48208F105   597,155 1,421,797 SH   DFND 1 0 1,421,797 0
KIORA PHARMACEUTICALS INC COM 49721T309   200,822 312,369 SH   DFND 1 0 312,369 0
LEXARIA BIOSCIENCE CORP *W 52886N117   52,845 240,206 SH   DFND 1 0 240,206 0
MARPAI INC COM 571354208   642,905 375,968 SH   DFND 1 0 375,968 0
MOBIQUITY TECHNOLOGIES INC COM 60743F508   247,503 2,167,280 SH   DFND 1 0 2,167,280 0
NEPTUNE WELLNESS SOLUTIONS INC COM 64079L204   237,494 1,615,607 SH   DFND 1 0 1,615,607 0
NETCAPITAL INC COM 64113L103   422,482 381,301 SH   DFND 1 0 381,301 0
NISUN INTL ENT DVPMT GP CO LTD SHS G6593L122   892,154 241,999 SH   DFND 1 0 241,999 0
NRX PHARMACEUTICALS INC COM 629444100   338,320 699,731 SH   DFND 1 0 699,731 0
OCEAN POWER TECHNOLOGIES INC COM 674870506   15,958 26,597 SH   DFND 1 0 26,597 0
OCEANPAL INC COM Y6430L202   194,921 118,854 SH   DFND 1 0 118,854 0
ONION GLOBAL LTD ADS 68277G107   29,772 1,200,489 SH   DFND 1 0 1,200,489 0
PANBELA THERAPEUTICS INC COM 69833W305   542,384 235,819 SH   DFND 1 0 235,819 0
PHIO PHARMACEUTICALS CORP COM 71880W402   449,878 156,752 SH   DFND 1 0 156,752 0
PULMATRIX INC COM 74584P301   493,318 184,074 SH   DFND 1 0 184,074 0
RECON TECHNOLOGY LTD CL A G7415M124   1,085,702 3,154,278 SH   DFND 1 0 3,154,278 0
REVELATION BIOSCIENCES INC COM 76135L309   332,039 353,233 SH   DFND 1 0 353,233 0
REVIVA PHARMACEUTCLS HLDGS INC COM 76152G950   554,356 946 SH Put DFND 1 0 946 0
REVIVA PHARMACEUTCLS HLDGS INC COM 76152G900   1,367,138 2,333 SH Call DFND 1 0 2,333 0
REWALK ROBOTICS LTD SHS M8216Q200   340,436 567,394 SH   DFND 1 0 567,394 0
SHF HOLDINGS INC CL A 824430102   669,273 1,262,779 SH   DFND 1 0 1,262,779 0
SIDUS SPACE INC CL A 826165102   1,160,870 6,413,644 SH   DFND 1 0 6,413,644 0
SMART FOR LIFE INC COM 83204U301   192,026 249,385 SH   DFND 1 0 249,385 0
SOLIGENIX INC COM 834223505   573,066 814,245 SH   DFND 1 0 814,245 0
SONNET BIOTHERAPEUTICS HLDNG INC COM 83548R204   1,612,619 3,291,060 SH   DFND 1 0 3,291,060 0
SPDR S&P 500 ETF 78462F953   24,868,008 561 SH Put DFND 1 0 561 0
SPHERE 3D CORP COM 84841L907   109,610 565 SH Call DFND 1 0 565 0
SPHERE 3D CORP COM 84841L957   105,115 843 SH Put DFND 1 0 843 0
T2 BIOSYSTEMS INC COM 89853L203   31,692 448,900 SH   DFND 1 0 448,900 0
TRANSCODE THERAPEUTICS INC COM 89357L204   433,405 188,437 SH   DFND 1 0 188,437 0
TROIKA MEDIA GROUP INC COM 89689F404   121,727 54,586 SH   DFND 1 0 54,586 0
TUANCHE LTD ADS 89856T203   995,738 1,991,476 SH   DFND 1 0 1,991,476 0
VERB TECHNOLOGY CO INC COM 92337U203   140,292 129,900 SH   DFND 1 0 129,900 0
VINCERX PHARMA INC COM 92731L106   134,030 103,100 SH   DFND 1 0 103,100 0
VIRPAX PHARMACEUTICALS INC COM 928251107   432,000 400,000 SH   DFND 1 0 400,000 0
WEARABLE DEVICES LTD *W M97838110   230,258 1,151,292 SH   DFND 1 0 1,151,292 0