Andrew Graham

Chief Financial Officer

Trimeris, Inc.

(919) 806-4682

DURHAM, N.C. - November 6, 2008 - Trimeris, Inc. (Nasdaq: TRMS) today announced financial results for the three months ended September 30, 2008, reporting net income of $3.6 million, or $0.16 per share compared with $5.5 million, or $0.25 per share for the three months ended September 30, 2007. This result was primarily driven by decreased FUZEON sales offset, in part, by lower operating expenses.

For the nine months ended September 30, 2008, the Company reported net income of $6.5 million, or $0.29 per share, compared with $18.4 million, or $0.83 per share for the nine months ended September 30, 2007. For the nine months ended September 30, 2008, the Company reported adjusted net income of $8.2 million, or $0.37 per share, compared with $13.3 million, or $0.60 per share for the nine months ended September 30, 2007. A reconciliation and explanation of the differences between GAAP and adjusted earnings is detailed in the table below.

Cash, cash equivalents and investment securities available-for-sale totaled $51.6 million at September 30, 2008, compared to $69.6 million at December 31, 2007. As previously announced, on June 6, 2008, the Company paid a $33.3 million special dividend to stockholders.

Trimeris will host a live conference call to discuss third quarter 2008 financial results at 8:30 a.m. Eastern Time. To access the live call, please dial (800) 399-8403 (U.S.) or (706) 634-6565 (international). The conference ID number is 71138027. Telephone replay is available approximately two hours after the call through 11:59 p.m. Eastern Time, November 20, 2008. To access the replay, please call (800) 642-1687 (U.S.) or (706) 645-9291 (international). The information provided on the teleconference is only accurate at the time of the conference call, and Trimeris will take no responsibility for providing updated information.

Live audio of the conference call will be simultaneously broadcast over the Internet and will be available to members of the news media, investors and the general public. The webcast can be accessed by going to Trimeris' website, www.trimeris.com.

Trimeris, Inc. (Nasdaq: TRMS) is a biopharmaceutical company engaged in the commercialization of therapeutic agents for the treatment of viral disease. The core technology platform of fusion inhibition is based on blocking viral entry into host cells. FUZEON, approved in the U.S., Canada and European Union, is the first in a new class of anti-HIV drugs called fusion inhibitors. For more information about Trimeris, please visit the Company's website at http://www.trimeris.com.

In addition to disclosing financial results calculated in accordance with Generally Accepted Accounting Principles ("GAAP"), the Company has included certain adjusted financial results. Reconciliations between GAAP and adjusted earnings for the nine months ended September 30, 2008 and 2007 are provided in the table below. Adjusted earnings for the for the three months ended September 30, 2008 and 2007 does not show a significant difference from GAAP income and therefore is not presented. The Company believes that the presentation of adjusted results provides meaningful supplemental information regarding our financial results for the nine months ended September 30, 2008 as compared to the nine months ended September 30, 2007 because the adjustments between GAAP and adjusted earnings provide information related to the ongoing operations of the Company. The Company believes that this financial information is useful to management and investors in assessing our historical performance and results. The Company will use these adjusted financial measures when evaluating its financial results, as well as for internal planning and forecasting purposes. The adjusted financial measures disclosed by the Company should not be considered a substitute for or superior to financial measures calculated in accordance with GAAP, and the financial results calculated in accordance with GAAP and reconciliations to those financial statements should be carefully evaluated. The adjusted financial measures used by the Company may be calculated differently from, and therefore may not be comparable to, similarly titled measures used by other companies.

Reconciliations between GAAP and Non-GAAP earnings for the nine months ended September 30, 2008 and 2007 are provided in the following table:

[1] In the second quarter of 2008, the Company shut-down its corporate offices and research facility and relocated to smaller office space. Under Statement of Financial Accounting Standards No. 146 "Accounting for Costs Associated with Exit or Disposal Activities", the Company recorded a liability and non-cash expense based on the remaining rental payments reduced by estimated sublease rental income.

[2] In the second quarter of 2008, in conjunction with the shut-down of the Corporate offices and research facility mentioned above, the Company wrote off all remaining property, furniture and equipment (79% of this write off relates to leasehold improvements.)

[3] On March 13, 2007, the Company entered into an agreement with Hoffmann-La Roche, Inc. ("Roche"), the Company's collaborative partner, that amended the terms of the Research Agreement between the Company and Roche. Under this agreement, all rights and joint patents and other intellectual property rights to the next generation fusion inhibitor peptides falling under the Research Agreement, which includes our lead drug candidate, TRI-1144, reverted to Trimeris. As a result of this agreement, the Company accelerated revenue recognition for past milestone payments received from Roche into the first quarter of 2007 because our period of joint development ended. These milestone payments were previously being amortized over the length of the joint research and development period of the next generation fusion inhibitor peptides or through December 2012.

[4] During the nine months ended September 30, 2007, the Company recorded a charge to the Statement of Operations related to a reduction in workforce.

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[1] On March 13, 2007, the Company entered into an agreement with Roche that amended the terms of the Research Agreement. Under this agreement, all rights and joint patents and other intellectual property rights to the next generation fusion inhibitor peptides falling under the Research Agreement, which includes the lead drug candidate, TRI-1144, reverted to Trimeris. As a result of this agreement, the Company accelerated revenue recognition for past milestone payments received from Roche into the first quarter of 2007 because our period of joint development ended. These milestone payments were previously being amortized over the length of the joint research and development period of the next generation fusion inhibitor peptides or through December 2012.

[2] Collaboration income represents our share of the net operating results from the sale of FUZEON in the United States and Canada under our collaboration agreement with Roche. These net operating results consist of net sales less cost of goods (gross margin), less selling and marketing expenses and other costs related to the sale of FUZEON.

[3] Included in general and administrative expenses for the nine months ended September 30, 2008 is a charge of $939,000 related to future lease commitments recognized as a result of the shut-down of the Company's former corporate offices and research facility.

** may not add due to rounding

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