-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, GnKbUzcsXrNdysEaWl7crfLRgSymXfQnpfYw2w3MgG8n1ZV1AHP/3gMdwfYgkj1m I+UU9tQZNo8p2IABz/+7DA== 0000950116-99-000246.txt : 19990217 0000950116-99-000246.hdr.sgml : 19990217 ACCESSION NUMBER: 0000950116-99-000246 CONFORMED SUBMISSION TYPE: SC 13G PUBLIC DOCUMENT COUNT: 1 FILED AS OF DATE: 19990216 GROUP MEMBERS: HAROLD R. WERNER GROUP MEMBERS: HEALTHCARE PARTNERS II, L.P. GROUP MEMBERS: HEALTHCARE PARTNERS III, L.P. GROUP MEMBERS: HEALTHCARE PARTNERS IV, L.P. GROUP MEMBERS: HEALTHCARE PARTNERS V, L.P. GROUP MEMBERS: HEALTHCARE VENTURES II LP GROUP MEMBERS: HEALTHCARE VENTURES II, L.P. GROUP MEMBERS: HEALTHCARE VENTURES III, L.P. GROUP MEMBERS: HEALTHCARE VENTURES IV, L.P. GROUP MEMBERS: HEALTHCARE VENTURES V, L.P. GROUP MEMBERS: JAMES H. CAVANAUGH, PH.D. GROUP MEMBERS: JOHN W. LITTLECHILD GROUP MEMBERS: MARK LESCHLY GROUP MEMBERS: WILLIAM CROUSE SUBJECT COMPANY: COMPANY DATA: COMPANY CONFORMED NAME: SHIRE PHARMACEUTICALS GROUP PLC CENTRAL INDEX KEY: 0000936402 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 000000000 FILING VALUES: FORM TYPE: SC 13G SEC ACT: SEC FILE NUMBER: 005-55755 FILM NUMBER: 99541460 BUSINESS ADDRESS: STREET 1: FOSSE HOUSE E ANTON COURT STREET 2: ICKNIELD WAY CITY: ANDOVER HANTS SP10 5 STATE: X0 BUSINESS PHONE: 1264333455 FILED BY: COMPANY DATA: COMPANY CONFORMED NAME: HEALTHCARE VENTURES II LP CENTRAL INDEX KEY: 0000859649 STANDARD INDUSTRIAL CLASSIFICATION: UNKNOWN SIC - 0000 [0000] IRS NUMBER: 223015728 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G BUSINESS ADDRESS: STREET 1: TWIN TOWERS AT METRO PARK STREET 2: 379 THORNALL AVENUE CITY: EDISON STATE: NJ ZIP: 08837 BUSINESS PHONE: 9089064613 MAIL ADDRESS: STREET 1: TWIN TOWERS AT METRO PARK STREET 2: 379 THORNALL AVENUE CITY: EDISON STATE: NJ ZIP: 08837 SC 13G 1 SCHEDULE 13G SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. )(1) SHIRE PHARMACEUTICALS GROUP plc - -------------------------------------------------------------------------------- (Name of Issuer) Ordinary Shares, nominal value 5p - -------------------------------------------------------------------------------- (Title of Class of Securities) 82481R106* - -------------------------------------------------------------------------------- (CUSIP Number) December 31, 1998 - -------------------------------------------------------------------------------- (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [ ] Rule 13d-1 (b) [X] Rule 13d-1 (c) [ ] Rule 13d-1 (d) - ---------- (1) The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page. The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). (Continued on following page(s)) Page 1 of 22 Pages - ----------- * The CUSIP number provided is assigned to the American Depository Shares representing the Ordinary Shares of the Issuer. The positions reported herein by the Reporting Persons are held in the form of Ordinary Shares and American Depository Receipts. - ------------------------------- ----------------------------- CUSIP NO. 82481R106 13G Page 2 of 22 Pages --------------- - ------------------------------- ----------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON HealthCare Ventures II, L.P. - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER ---------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 3,554,720 OWNED BY EACH ---------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH ---------------------------------------------------- 8 SHARED DISPOSITIVE POWER 3,554,720 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 3,554,720 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 2.5% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* PN - -------------------------------------------------------------------------------- * SEE INSTRUCTION BEFORE FILLING OUT! - ------------------------------- ----------------------------- CUSIP NO. 82481R106 13G Page 3 of 22 Pages --------------- - ------------------------------- ----------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON HealthCare Partners II, L.P. - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER ---------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 3,554,720 OWNED BY EACH ---------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH ---------------------------------------------------- 8 SHARED DISPOSITIVE POWER 3,554,720 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 3,554,720 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 2.5% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* PN - -------------------------------------------------------------------------------- * SEE INSTRUCTION BEFORE FILLING OUT! - ------------------------------- ----------------------------- CUSIP NO. 82481R106 13G Page 4 of 22 Pages --------------- - ------------------------------- ----------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON HealthCare Ventures III, L.P. - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER ---------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 5,508,032 OWNED BY EACH ---------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH ---------------------------------------------------- 8 SHARED DISPOSITIVE POWER 5,508,032 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 5,508,032 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 3.9% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* PN - -------------------------------------------------------------------------------- * SEE INSTRUCTION BEFORE FILLING OUT! - ------------------------------- ----------------------------- CUSIP NO. 82481R106 13G Page 5 of 22 Pages --------------- - ------------------------------- ----------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON HealthCare Partners III, L.P. - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER ---------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 5,508,032 OWNED BY EACH ---------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH ---------------------------------------------------- 8 SHARED DISPOSITIVE POWER 5,508,032 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 5,508,032 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 3.9% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* PN - -------------------------------------------------------------------------------- * SEE INSTRUCTION BEFORE FILLING OUT! - ------------------------------- ----------------------------- CUSIP NO. 82481R106 13G Page 6 of 22 Pages --------------- - ------------------------------- ----------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON HealthCare Ventures IV, L.P. - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER ---------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 1,617,528 OWNED BY EACH ---------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH ---------------------------------------------------- 8 SHARED DISPOSITIVE POWER 1,617,528 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,617,528 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 1.15% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* PN - -------------------------------------------------------------------------------- * SEE INSTRUCTION BEFORE FILLING OUT! - ------------------------------- ----------------------------- CUSIP NO. 82481R106 13G Page 7 of 22 Pages --------------- - ------------------------------- ----------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON HealthCare Partners IV, L.P. - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER ---------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 1,617,528 OWNED BY EACH ---------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH ---------------------------------------------------- 8 SHARED DISPOSITIVE POWER 1,617,528 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,617,528 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 1.15% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* PN - -------------------------------------------------------------------------------- * SEE INSTRUCTION BEFORE FILLING OUT! - ------------------------------- ----------------------------- CUSIP NO. 82481R106 13G Page 8 of 22 Pages --------------- - ------------------------------- ----------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON HealthCare Ventures V, L.P. - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER ---------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 1,564,530 OWNED BY EACH ---------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH ---------------------------------------------------- 8 SHARED DISPOSITIVE POWER 1,564,530 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,564,530 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 1.1% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* PN - -------------------------------------------------------------------------------- * SEE INSTRUCTION BEFORE FILLING OUT! - ------------------------------- ----------------------------- CUSIP NO. 82481R106 13G Page 9 of 22 Pages --------------- - ------------------------------- ----------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON HealthCare Partners V, L.P. - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER ---------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 1,564,530 OWNED BY EACH ---------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH ---------------------------------------------------- 8 SHARED DISPOSITIVE POWER 1,564,530 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 1,564,530 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 1.1% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* PN - -------------------------------------------------------------------------------- * SEE INSTRUCTION BEFORE FILLING OUT! - ------------------------------- ----------------------------- CUSIP NO. 82481R106 13G Page 10 of 22 Pages --------------- - ------------------------------- ----------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON James H. Cavanaugh, Ph.D. - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION United States - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER ---------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 12,244,810 OWNED BY EACH ---------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH ---------------------------------------------------- 8 SHARED DISPOSITIVE POWER 12,244,810 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 12,244,810 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 8.7% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* IN - -------------------------------------------------------------------------------- * SEE INSTRUCTION BEFORE FILLING OUT! - ------------------------------- ----------------------------- CUSIP NO. 82481R106 13G Page 11of 22 Pages --------------- - ------------------------------- ----------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON Harold R. Werner - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION United States - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER ---------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 12,244,810 OWNED BY EACH ---------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH ---------------------------------------------------- 8 SHARED DISPOSITIVE POWER 12,244,810 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 12,244,810 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 8.7% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* IN - -------------------------------------------------------------------------------- * SEE INSTRUCTION BEFORE FILLING OUT! - ------------------------------- ----------------------------- CUSIP NO. 82481R106 13G Page 12 of 22 Pages --------------- - ------------------------------- ----------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON William Crouse - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION United States - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER ---------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 12,244,810 OWNED BY EACH ---------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH ---------------------------------------------------- 8 SHARED DISPOSITIVE POWER 12,244,810 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 12,244,810 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 8.7% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* IN - -------------------------------------------------------------------------------- * SEE INSTRUCTION BEFORE FILLING OUT! - ------------------------------- ----------------------------- CUSIP NO. 82481R106 13G Page 13 of 22 Pages --------------- - ------------------------------- ----------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON John W. Littlechild - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION United States - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER ---------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 12,244,810 OWNED BY EACH ---------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH ---------------------------------------------------- 8 SHARED DISPOSITIVE POWER 12,244,810 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 12,244,810 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 8.7% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* IN - -------------------------------------------------------------------------------- * SEE INSTRUCTION BEFORE FILLING OUT! - ------------------------------- ----------------------------- CUSIP NO. 82481R106 13G Page 14of 22 Pages --------------- - ------------------------------- ----------------------------- - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON Mark Leschly - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [ ] (b) [ ] - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION United States - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER ---------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 8,690,090 OWNED BY EACH ---------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH ---------------------------------------------------- 8 SHARED DISPOSITIVE POWER 8,690,090 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 8,690,090 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [ ] - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 6.2% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* IN - -------------------------------------------------------------------------------- * SEE INSTRUCTION BEFORE FILLING OUT! Page 15 of 22 Item 1. (a) Name of Issuer: Shire Pharmaceuticals Group plc (b) Address of Issuer's Principal Executive Offices: East Anton Andover, Hampshire SP10 5RG England Item 2. (a) Name of Person Filing: HealthCare Ventures II, L.P. ("HCV II"), HealthCare Partners II, L.P. ("HCP II"), HealthCare Ventures III, L.P. ("HCV III"), HealthCare Partners III, L.P. ("HCP III"), HealthCare Ventures IV, L.P. ("HCV IV"), HealthCare Partners IV, L.P. ("HCP IV"), HealthCare Ventures V, L.P. ("HCV V"), HealthCare Partners V, L.P. ("HCP V"), Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly. See attached Exhibit A which is a copy of their agreement in writing to file this statement on behalf of each of them.(1) (b) Address of Principal Business Office or, if none, Residence: The business address for HCV II, HCP II, HCV III, HCP III, HCV IV, HCP IV, HCV V, HCP V, Dr. Cavanaugh and Messrs. Werner and Crouse is 44 Nassau Street, Princeton, New Jersey 08542. The business address for Messrs. Littlechild and Leschly is One Kendall Square, Building 300, Cambridge, Massachusetts 02139. (c) Citizenship: HCV II, HCP II, HCV III, HCP III, HCV IV, HCP IV, HCV V and HCP V, are limited partnerships organized under the laws of the State of Delaware. Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly are each United States citizens. - -------- (1) Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse are general partners of HCP II, which is the general partner of HCV II, the record holder of 3,554,720 shares of Issuer's securities reported hereto. Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly are general partners of each of HCP III, HCP IV and HCP V, which are the general partner of HCV III, HCV IV and HCV V respectively, the record holder of 5,508,032, 1,617,528 and 1,564,530 shares of Issuer's securities, respectively, reported hereto. Page 16 of 22 (d) Title of Class of Securities: Ordinary Shares, nominal value 5p ("Shares"). (e) CUSIP Number: 82481R106 (American Depository Shares) Item 3. If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b) or (c), check whether the person filing is a: Inapplicable. If this statement is filed pursuant to Rule 13d-1(c), check this Box. [ ] Item 4. Ownership. (a) Amount Beneficially Owned: As of December 31, 1998: HCV II and HCP II beneficially owned 3,554,720 Ordinary Shares of Issuer; HCV III and HCP III beneficially owned 5,508,032 Ordinary Shares of Issuer; HCV IV and HCP IV beneficially owned 1,617,528 Ordinary Shares of Issuer; HCV V and HCP V beneficially owned 1,564,530 Shares of Issuer, consisting of 1,534,530 Ordinary Shares and 10,000 American Depository Shares(2); Dr. Cavanaugh, Messrs. Littlechild, Werner and Crouse each beneficially owned 12,244,810 Ordinary Shares of Issuer consisting of 12,214,810 Ordinary Shares and 10,000 American Depository Shares; and Mr. Leschly beneficially owned 8,690,090 Ordinary Shares of Issuer consisting of 8,660,090 Ordinary Shares and 10,000 American Depository Shares. (b) Percent of Class: As of December 31, 1998: the 3,554,720 Ordinary Shares of Issuer beneficially owned by HCV II and HCP II constitute 2.5% of Issuer's Shares outstanding; the 5,508,032 Ordinary Shares of Issuer beneficially owned by HCV III and HCP III constitute 3.9% of Issuer's Shares outstanding; the 1,617,528 Ordinary Shares of Issuer beneficially owned by HCV IV and HCP IV constitute 1.15% of Issuer's Shares outstanding; the 1,564,530 Ordinary Shares of Issuer beneficially owned by HCV V and HCP V constitute 1.1% of Issuer's Shares outstanding; the 12,244,810 Ordinary Shares of Issuer beneficially owned by each of Dr. Cavanaugh and Messrs. Littlechild, Crouse, and Werner constitute 8.7% of Issuer's Shares outstanding; and the 8,690,090 Ordinary Shares of Issuer beneficially owned by Mr. Leschly constitute 6.2% of Issuer's Shares outstanding. - -------- (2) Each American Depository Share represents three Ordinary Shares. Page 17 of 22 (c) Number of shares as to which such person has: (i) sole power to vote or to direct the vote: Inapplicable (ii) shared power to vote or to direct the vote: HCV II, HCP II, Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse share the power to vote or direct the vote of those shares owned by HCV II. HCV III, HCP III, Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly share the power to vote or direct the vote of those shares owned by HCV III. HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly share the power to vote or direct the vote of those shares owned by HCV IV. HCV V, HCP V, Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly share the power to vote or direct the vote of those shares owned by HCV V. (iii) sole power to dispose or to direct the disposition of: Inapplicable (iv) shared power to dispose of or to direct the disposition of: HCV II, HCP II, Dr. Cavanaugh and Messrs. Werner, Littlechild and Crouse share the power to dispose of or direct the disposition of those Shares owned by HCV II. HCV III, HCP III, Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly share the power to dispose of or direct the disposition of those Shares owned by HCV III. HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly share the power to dispose of or direct the disposition of those Shares owned by HCV IV. HCV V, HCP V, Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly share the power to dispose of or direct the disposition of those Shares owned by HCV V. Page 18 of 22 Item 5. Ownership of Five Percent or less of a Class: Inapplicable. Item 6. Ownership of More than Five Percent on Behalf of Another Person: Inapplicable. Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company: Inapplicable. Item 8. Identification and Classification of Members of the Group: Inapplicable. Item 9. Notice of Dissolution of Group: Inapplicable. Item 10. Certification: By signing below I certify that, to the best of my knowledge and belief, the securities referred to below were not acquired and were not held for purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. Page 19 of 22 SIGNATURES After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. Dated: February 12, 1999 HealthCare Ventures II, L.P., Princeton, New Jersey by its General Partner, HealthCare Partners II, L.P., By: /s/ Jeffrey Steinberg -------------------------------- Jeffrey Steinberg Administrative Partner Dated: February 12, 1999 HealthCare Partners II, L.P. Princeton, New Jersey By: /s/ Jeffrey Steinberg -------------------------------- Jeffrey Steinberg Administrative Partner Dated: February 12, 1999 HealthCare Ventures III, L.P., Princeton, New Jersey by its General Partner, HealthCare Partners III, L.P., By: /s/ Jeffrey Steinberg -------------------------------- Jeffrey Steinberg Administrative Partner Dated: February 12, 1999 HealthCare Partners III, L.P. Princeton, New Jersey By: /s/ Jeffrey Steinberg -------------------------------- Jeffrey Steinberg Administrative Partner Dated: February 12, 1999 HealthCare Ventures IV, L.P., Princeton, New Jersey by its General Partner, HealthCare Partners IV, L.P., By: /s/ Jeffrey Steinberg -------------------------------- Jeffrey Steinberg Administrative Partner Dated: February 12, 1999 HealthCare Partners IV, L.P. Princeton, New Jersey By: /s/ Jeffrey Steinberg -------------------------------- Jeffrey Steinberg Administrative Partner Page 20 of 2 Dated: February 12, 1999 HealthCare Ventures V, L.P., Princeton, New Jersey by its General Partner, HealthCare Partners V, L.P., By: /s/ Jeffrey Steinberg ------------------------------- Jeffrey Steinberg Administrative Partner Dated: February 12, 1999 HealthCare Partners V, L.P. Princeton, New Jersey By: /s/ Jeffrey Steinberg ------------------------------- Jeffrey Steinberg Administrative Partner Dated: February 12, 1999 By: * Princeton, New Jersey ------------------------------- James H. Cavanaugh, Ph.D. Dated: February 12, 1999 By: * Princeton, New Jersey ------------------------------- Harold R. Werner Dated: February 12, 1999 By: * Cambridge, Massachusetts ------------------------------- John W. Littlechild Dated: February 12, 1999 By: * Princeton, New Jersey ------------------------------- William Crouse Dated: February 12, 1999 By: * Cambridge, Massachusetts ------------------------------- Mark Leschly -------------------------- *Signed by Jeffrey Steinberg as Attorney-in-Fact pursuant to the Power of Attorney filed previously and incorporated herein by reference. Page 21 of 22 EXHIBIT A AGREEMENT JOINT FILING OF SCHEDULE 13G The undersigned hereby agree to jointly prepare and file with regulatory authorities a Schedule 13G and any future amendments thereto reporting each of the undersigned's ownership of securities of Shire Pharmaceuticals Group plc and hereby affirm that such Schedule 13G is being filed on behalf of each of the undersigned. Dated: February 12, 1999 HealthCare Ventures II, L.P., Princeton, New Jersey by its General Partner, HealthCare Partners II, L.P., By: /s/ Jeffrey Steinberg -------------------------------- Jeffrey Steinberg Administrative Partner Dated: February 12, 1999 HealthCare Partners II, L.P. Princeton, New Jersey By: /s/ Jeffrey Steinberg -------------------------------- Jeffrey Steinberg Administrative Partner Dated: February 12, 1999 HealthCare Ventures III, L.P., Princeton, New Jersey by its General Partner, HealthCare Partners III, L.P., By: /s/ Jeffrey Steinberg -------------------------------- Jeffrey Steinberg Administrative Partner Dated: February 12, 1999 HealthCare Partners III, L.P. Princeton, New Jersey By: /s/ Jeffrey Steinberg -------------------------------- Jeffrey Steinberg Administrative Partner Dated: February 12, 1999 HealthCare Ventures IV, L.P., Princeton, New Jersey by its General Partner, HealthCare Partners IV, L.P., By: /s/ Jeffrey Steinberg -------------------------------- Jeffrey Steinberg Administrative Partner Dated: February 12, 1999 HealthCare Partners IV, L.P. Princeton, New Jersey By: /s/ Jeffrey Steinberg -------------------------------- Jeffrey Steinberg Administrative Partner Page 22 of 22 Dated: February 12, 1999 HealthCare Ventures V, L.P., Princeton, New Jersey by its General Partner, HealthCare Partners V, L.P., By: /s/ Jeffrey Steinberg -------------------------------- Jeffrey Steinberg Administrative Partner Dated: February 12, 1999 HealthCare Partners V, L.P. Princeton, New Jersey By: /s/ Jeffrey Steinberg -------------------------------- Jeffrey Steinberg Administrative Partner Dated: February 12, 1999 By: * Princeton, New Jersey -------------------------------- James H. Cavanaugh, Ph.D. Dated: February 12, 1999 By: * Princeton, New Jersey -------------------------------- Harold R. Werner Dated: February 12, 1999 By: * Cambridge, Massachusetts -------------------------------- John W. Littlechild Dated: February 12, 1999 By: * Princeton, New Jersey -------------------------------- William Crouse Dated: February 12, 1999 By: * Cambridge, Massachusetts -------------------------------- Mark Leschly - ------------------- *Signed by Jeffrey Steinberg as Attorney-in-Fact -----END PRIVACY-ENHANCED MESSAGE-----