Exhibit 99.1

I-many Reports Record First Quarter 2009 Financial Results

Revenues up 35% Year-over-Year to $9.9 Million, Driving Net Income of $0.02 Per Share and Positive EBITDA of $2.0 Million

EDISON, N.J., April 29, 2009 — I-many, Inc. (NASDAQ: IMNY), a leading provider of contract management software and services for the enterprise, reported financial results for the first quarter ended March 31, 2009.

Q1 2009 Highlights

Financial Results for Q1 2009

Net revenues in the first quarter of 2009 totaled $9.9 million, an increase of 15% from $8.6 million reported in the previous quarter and an increase of 35% from $7.4 million reported in the same period a year ago.

Total operating expenses in the quarter were $8.7 million, a decrease of 23% from $11.3 million in the previous quarter and a decrease of 31% from $12.6 million in the same quarter a year ago.

Research and development expense totaled $2.0 million in the quarter, a decrease of 29% from $2.9 million in the previous quarter and a decrease of 44% from the $3.7 million expensed in the first quarter of 2008.

Net Income totaled $799,000, or $0.02 per basic and diluted share, as compared to a net loss of $3.0 million or ($0.06) in the previous quarter and a net loss of $5.4 million or ($0.10) in the first quarter of 2008.

EBITDA totaled a record $2.0 million, or $0.04 per basic and diluted share, as compared to a negative EBITDA of $1.7 million or ($0.03) in the previous quarter and negative EBITDA of $4.2 million or ($0.08) in the same period a year ago.

Quarter-end cash, restricted cash and short-term investments totaled $9.3 million, as compared to $9.6 million at the end of the previous quarter and $20.6 million at the end of the first quarter of 2008. Approximately $620,000 in net cash was used during the first quarter to pay restructuring and employee severance costs accrued at the end of 2008. Excluding these non-recurring expenditures, the company would have increased its cash balance during the quarter.

Results by Revenue Category

Recurring revenue, which constitutes revenue generated from software subscriptions, maintenance, support and hosting, totaled $5.1 million in the quarter, a decrease of 1% from $5.2 million in the prior quarter and an increase of 4% from $4.9 million reported in the same quarter a year ago.

Services revenue, which is principally revenue from professional services, totaled $2.9 million, a decrease of 6% from $3.1 million in the prior quarter and an increase of 30% from $ 2.2 million reported in the same period a year ago. Excluding revenue of $299,000 from the company’s annual user conference held in October 2008, service revenue increased 5% from the prior quarter.

License revenue, representing one-time perpetual license fees from software license sales, totaled $1.9 million, an increase of 380% from $398,000 in the prior quarter and an increase of 831% from $205,000 reported in the same period a year ago.

Non-GAAP Financial Results

Management believes certain non-GAAP financial measures may present a useful picture of the company’s results since implementing the change in its licensing model to include software subscriptions (see “About the Use of Non-GAAP Financial Information,” below). This includes the gross value of license contracts signed during a period, which the company calls “bookings.” Bookings totaled $3.1 million in the first quarter of 2009. This represented an increase of 108% from $1.5 million signed in the prior quarter and an increase of 506% from $518,000 signed in the first quarter of 2008.

Unamortized software subscriptions (the remaining portion of non-cancelable subscription contracts that have been signed and expected to be recognized over the next five years) totaled $11.9 million at the end of the first quarter of 2009. This was an increase of 1% from $11.8 million at the end of the prior quarter and a decrease of 21% from $15.1 million at the end of the first quarter of 2008. The year-over-year decrease was due to the recognition of subscription revenue exceeding the amount of new subscriptions signed and not yet recognized.

The combined amount of deferred revenue and unamortized software subscriptions, which includes unrecognized multi-year maintenance and support commitments, totaled $30.1 million at the end of the quarter, an increase of 9% from $27.7 million at the end of the prior quarter and an increase of 2% from $29.6 million at the end of the first quarter of 2008. The increase over both periods is principally due to the execution of two significant multi-year maintenance and support agreements in the first quarter, which also helped secure I-many’s long-term recurring revenue stream.

Q1 2009 Operational Highlights

I-many, Inc. - Page 2 of 9

Management Commentary

“We not only exceeded our Q1 expectations with a very strong showing in EBITDA, but also generated positive net income for the first time since we went public in 2000,” said John A. Rade, president and CEO of I-many. “This demonstrates our ability to adapt and perform well in the current economic climate and is perhaps the best indicator of our success in implementing the transformational strategy we announced in December.

“Within a fairly short period of time we streamlined operations, cut costs, and refocused our sales force and customer service personnel. We have emerged as a stronger organization, better able to leverage our multi-million dollar investment in upgrading and expanding our ContractSphere® suite. The completion of this major development cycle is evident in a nearly 50% year-over-year reduction in our R&D expense. These results put us well on our way towards realizing our goals for the year, including generating cash in 2009 through achieving positive EBITDA in every quarter.

“Through this process I-many has remained the leader in delivering enterprise contract management solutions to the Life Science industry, with 80% of the top 25 and all of the top 10 pharmaceutical companies using one or more of our products. Our well-established customer relationships continued to maintain our recurring revenue stream and they form the backbone of our business plan for 2009. In this first quarter, key members of this esteemed group of customers made the financial commitment to renew their relationship with I-many despite these challenging economic times. They recognize the strong ROI our products provide, which has become more critical to their bottom line than ever before.

“Despite this successful quarter, we continue to face a difficult set of challenges regarding our outstanding debt obligations and possible NASDAQ de-listing. We issued a separate press release today announcing a merger agreement with LLR Partners, Inc. Please refer to that press release for additional details on the transaction.”

Conference Call

Today at 4:30 p.m. Eastern time, I-many will hold a conference call to discuss the merger agreement with LLR Partners and the financial performance for the first quarter of 2009. I-many President and CEO John A. Rade and CFO Kevin M. Harris will host the presentation, followed by a question and answer period.

Date: Wednesday, April 29, 2009

Time: 4:30 pm Eastern time (1:30 pm Pacific time)

Dial-In Number: 1-800-894-5910

International: 1-785-424-1052

Conference ID#: 7IMANY

Please call the conference telephone number 5-10 minutes prior to the start time. An operator will register your name and organization and ask you to wait until the call begins. If you have any difficulty connecting with the conference call, please contact the Liolios Group at 949-574-3860.

A simultaneous webcast and replay of the call will be accessible via the investor section of I-many’s website at www.imany.com.

A telephone replay of the call will be available within approximately 48 hours of the call until May 29, 2009: Dial 1-800-374-1375 or 1-402-220-0682 (No passcode required).

I-many, Inc. - Page 3 of 9

Use of Non-GAAP Financial Information

EBITDA is not a financial measure calculated and presented in accordance with U.S. generally accepted accounting principles (“GAAP”) and should not be considered as an alternative to net income, operating income or any other financial measures so calculated and presented, nor as an alternative to cash flow from operating activities as a measure of the company’s liquidity. I-many defines EBITDA as net income/(loss) before interest expense and other non-cash financing costs; taxes; depreciation; and amortization of non-cash stock-based compensation and acquired intangibles. Other companies (including the company’s competitors) may define EBITDA differently. The company presents EBITDA because it believes it to be an important supplemental measure of performance that is commonly used by securities analysts, investors and other interested parties in the evaluation of companies in a similar industry. Management also uses this information internally for forecasting and budgeting. It may not be indicative of the historical operating results of I-many nor is it intended to be predictive of potential future results. Investors should not consider EBITDA in isolation or as a substitute for analysis of results as reported under GAAP. See “Reconciliation of GAAP Income (Loss) to EBITDA (Loss)” below for further information on this non-GAAP measure and reconciliation of EBITDA to GAAP net income (loss) for the periods indicated.

I-MANY, INC. AND SUBSIDIARIES

Reconciliation of GAAP Income (Loss) to EBITDA (Loss)

(in thousands, except per share amounts)

(unaudited)

I-many, Inc. - Page 4 of 9

The company also supplements its GAAP financial statements in this release and in its annual report on Form 10-K and quarterly reports on Form 10-Q with a reconciliation of the non-GAAP gross value of license transactions to its reported GAAP license revenues (see “Reconciliation of Gross Value of License Bookings to Reportable License Revenue,” below). This non-GAAP financial information is provided as additional information for investors and is not in accordance with or an alternative to GAAP. Management has included a table that shows the results for the period being reported as compared to previous comparable periods for new license transactions including subscription contracts, the recognition into reportable revenue of deferred non-subscription license transactions, and the reconciliation of those numbers to total license revenue according to GAAP. Management believes its inclusion can enhance an overall understanding of the company’s past operational performance and also its prospects for the future. This reconciliation of license revenues is made with the intent of providing both management and investors a more complete understanding of the revenue performance of the company, as opposed to GAAP revenue results, which do not include the full impact of newly-executed subscription agreements and other deferred revenue arrangements that are material to the ongoing performance of the company’s business. This information quantifies the various components comprising current license revenue, which in each quarter consists of revenues from licenses sold in current periods plus revenues deferred from prior periods, less revenue deferred from licenses sold in current periods. Management uses this information as a basis for planning and forecasting core business activity in future periods and believes it is useful in understanding our results of operations. The presentation of this additional revenue information is not meant to be considered in isolation or as a substitute for revenues reported in accordance with generally accepted accounting principles in the United States.

Reconciliation of Gross Value of License Bookings to Reportable License Revenue

(Unaudited)

I-many, Inc. - Page 5 of 9

About I-many

I-many (NasdaqCM:IMNY) is a leading provider of contract management software and services for the enterprise. With hundreds of companies across 21 industries worldwide, I-many is enabling businesses to manage the entire contract life cycle, from pre-contract processes and contract management to active compliance, contract optimization, demand channel visibility and control. The result is an end-to-end solution that provides greater levels of insight into contract performance, allowing companies to improve profitability and achieve a measurable return on investment. For more information, please visit www.imany.com.

Additional Information and Where to Find It

I-many plans to file with the SEC and mail to its stockholders a proxy statement (the “Proxy Statement”) in connection with the Merger Agreement with LLR Partners (the “Merger Agreement”) and related transactions. The Proxy Statement will contain important information about I-many, LLR Partners, the Merger Agreement and related matters. Investors and security holders are urged to read the Proxy Statement carefully when it is available.

Investors and security holders will be able to obtain free copies of the Proxy Statement (when it is available) and other documents filed with the SEC by the Company through the website maintained by the SEC at www.sec.gov.

In addition, investors and security holders will be able to obtain free copies of the Proxy Statement (when it is available) from the Company by contacting I-many, Inc., Attn: Secretary, 399 Thornall Street, 12th Floor, Edison, NJ.

I-many and LLR Partners, and their respective directors and executive officers may be deemed to be participants in the solicitation of proxies from the stockholders of I-many in respect of the transactions contemplated by the Merger Agreement. Information regarding I-many’s directors and executive officers will be included in the Proxy Statement. Additional information regarding these directors and executive officers is contained in I-many’s Annual Report on Form 10-K for the fiscal year ended December 31, 2008, as amended by Amendment No. 1 dated April 29, 2009, which is filed with the SEC and available free of charge at the SEC’s web site at www.sec.gov. As of March 31, 2009, I-many’s directors and executive officers beneficially owned approximately 5,885,994 shares, or 10.9%, of I-many’s common stock. This excludes 7,383,264 shares owned by Ramius LLC, of which Mark R. Mitchell, a director of I-many, is an executive officer and for which Mr. Mitchell disclaims beneficial ownership. Information regarding LLR Partners’ directors and officers and a more complete description of the interests of I-many’s directors and officers will be available in the Proxy Statement.

Forward-looking Statements

This news release contains forward-looking statements, and actual results may vary from those expressed or implied herein. Factors that could affect these results include the risk that our appeal of the delisting of our common stock from the NASDAQ Capital Market will not be successful; the risk that current economic conditions and consolidation in the pharmaceutical industry could weaken demand for our products; the risk of unforeseen technical or practical impediments to planned software development, which could affect the company’s product release timetable; the risk that the ratio of subscription license sales to perpetual license sales could be higher than anticipated, possibly leading to lower revenue in current periods and less cash than predicted in the near term; the risk of lower demand for the company’s new products than management anticipates; the inherent risks of large software implementation projects, which can cause customer disagreements that could affect I-many’s ability to collect both services and license revenue, whether recognized or deferred; the possibility that customers could cancel maintenance and support services at the time of annual renewal, which could decrease I-many’s base of recurring revenue; the possibility that extraordinary events outside the company’s control could extend the length of the sales cycle for the company’s products or make the market for the company’s products more unpredictable; and other risk factors set forth from time to time in the company’s filings with the Securities and Exchange Commission.

I-many, Inc. - Page 6 of 9

I-MANY, INC. AND SUBSIDIARIES

Condensed Consolidated Statements of Operations

(in thousands, except per share amounts)

(Unaudited)

I-many, Inc. - Page 7 of 9

I-MANY, INC. AND SUBSIDIARIES

Condensed Consolidated Balance Sheets

(in thousands)

Company Contacts

I-many, Inc.

Kevin Harris, CFO

732-452-1515

kharris@Imany.com

or

I-many, Inc. - Page 8 of 9

Investor Relations:

Liolios Group, Inc.

Ron Both or Geoffrey Plank

949-574-3860

info@liolios.com

I-many, Inc. - Page 9 of 9