Revised consolidated financial statements

EX-99.1 3 dex991.htm REVISED CONSOLIDATED FINANCIAL STATEMENTS Revised consolidated financial statements

EXHIBIT 99.1


SELECTED FINANCIAL DATA		F-2

MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS		F-3

MANAGEMENT’S REPORT ON INTERNAL CONTROL OVER FINANCIAL REPORTING		F-37

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM		F-38

CONSOLIDATED FINANCIAL STATEMENTS		F-40

NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS		F-44

F-1

SELECTED FINANCIAL DATA.

Five Year Financial Summary


Amounts in Millions, except per share data	2008		2007		2006		2005		2004
Income Statement Data:⁽¹⁾
Net Sales	$	20,597	$	18,193	$	16,208	$	17,613	$	17,837
Earnings from Continuing Operations Before Income Taxes		5,471		3,186		2,085		4,016		3,911
Net Earnings from Continuing Operations Attributable to Shareholders		3,155		1,741		1,214		2,652		2,017

Net Earnings from Continuing Operations Attributable to Shareholders per Common Share:
Basic	$	1.60	$	0.88	$	0.62	$	1.36	$	1.04
Diluted	$	1.59	$	0.88	$	0.62	$	1.35	$	1.02

Average common shares outstanding:
Basic		1,977		1,970		1,960		1,952		1,942
Diluted		2,001		1,980		1,963		1,983		1,976

Dividends paid on common and preferred stock	$	2,461	$	2,213	$	2,199	$	2,186	$	2,174

Dividends declared per common share	$	1.24	$	1.15	$	1.12	$	1.12	$	1.12

Financial Position Data at December 31:

Total Assets	$	29,486	$	25,867	$	25,271	$	27,905	$	30,309
Cash and cash equivalents		7,976		1,801		2,018		3,050		3,680
Marketable securities		289		424		1,995		2,749		3,794
Long-term debt		6,585		4,381		7,248		8,364		8,463
Equity		12,208		10,535		10,041		11,074		10,109

⁽¹⁾	The Company recorded items that affected the comparability of results. For a discussion of these items for the years 2008, 2007 and 2006, see “Management’s Discussion and Analysis of Financial Condition and Results of Operations—Specified Items.”

F-2

MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS.

EXECUTIVE SUMMARY

About the Company

Bristol-Myers Squibb Company (which may be referred to as Bristol-Myers Squibb, BMS or the Company) is a global biopharmaceutical and nutritional products company whose mission is to extend and enhance human life by providing the highest quality pharmaceutical and nutritional products. The Company is engaged in the discovery, development, licensing, manufacturing, marketing, distribution and sale of biopharmaceuticals and nutritional products. The Company has two reportable segments—BioPharmaceuticals and Mead Johnson. The BioPharmaceuticals segment consists of the global pharmaceutical/biotechnology and international consumer medicines business, which accounted for approximately 86% of the Company’s 2008 net sales. The Mead Johnson segment consists of Mead Johnson Nutrition Company, primarily an infant formula and children’s nutritionals business, which accounted for approximately 14% of the Company’s 2008 net sales.

2008 Financial Highlights

The following table is a summary of operating activity:


	Year Ended December 31,
Dollars in Millions	2008		2007
Net Sales	$	20,597	$	18,193

Net Earnings from Continuing Operations Attributable to Shareholders		3,155		1,741
Net Earnings from Discontinued Operations		2,092		424
Net Earnings Attributable to Shareholders		5,247		2,165

Net Cash/(Debt)		1,526		(4,047	)

Net Sales

The Company’s net sales from continuing operations increased 13%. PLAVIX* (clopidogrel bisulfate) and ABILIFY* continue to drive worldwide sales growth with sales increases of 18% and 30%, respectively. Significant contributions to sales growth are also provided by other key products including ORENCIA, SPRYCEL and the HIV and hepatitis portfolio.

Net Earnings from Continued Operations Attributable to Shareholders

The increase in net earnings from continuing operations attributable to shareholders is attributed to increased sales growth and favorability in gross margins, a portion of which is attributed to a favorable product mix as well as cost savings and avoidances resulting from the Company’s productivity transformation initiative (PTI). The $582 million after-tax gain related to the tendering of the Company’s shares in ImClone also had a significant impact on net earnings from continuing operations attributable to shareholders amongst other specified items discussed in “—Specified Items” below.

Net Earnings from Discontinued Operations

In 2008, the Company completed the divestitures of its Medical Imaging business for a gross purchase price of $525 million resulting in an after-tax loss of $43 million as well as the ConvaTec business for gross purchase price of approximately $4.1 billion resulting in an after-tax gain of $2.0 billion. The results of the Medical Imaging and ConvaTec businesses and the related gains and losses are included in discontinued operations for all years presented.

Net Cash/(Debt)

Net cash/(debt) position as of December 31, 2008 improved due to proceeds of $4.6 billion from the divestiture of the ConvaTec and Medical Imaging businesses and proceeds of $1.0 billion from the sale of our ImClone shares. Cash generated from operating activities of $3.7 billion was more than adequate to fund dividend payments of $2.5 billion as well as capital expenditure payments of $941 million.

F-3

Business Environment

The Company conducts its business primarily within the pharmaceutical/biotechnology industry, which is highly competitive and subject to numerous government regulations. Many competitive factors may significantly affect the Company’s sales of its products, including product efficacy, safety, price and cost-effectiveness, marketing effectiveness, product labeling, quality control and quality assurance of its manufacturing operations, and research and development of new products. To successfully compete for business in the health care industry, the Company must demonstrate that its products offer medical benefits as well as cost advantages. Currently, most of the Company’s new product introductions compete with other products already on the market in the same therapeutic category, in addition to potential competition of new products that competitors may introduce in the future. The Company manufactures branded products, which are priced higher than generic products. Generic competition is one of the Company’s leading challenges globally.

In the pharmaceutical/biotechnology industry, the majority of an innovative product’s commercial value is usually realized during the period that the product has market exclusivity. When a product loses exclusivity, it is no longer protected by a patent and is subject to new competing products in the form of generic brands. Upon exclusivity loss, the Company can lose a major portion of that product’s sales in a short period of time. Currently, generic versions of biological products cannot be approved under United States (U.S.) law. However, the law could change in the future. Even in the absence of new legislation, the U.S. Food and Drug Administration (FDA) is taking steps toward allowing generic versions of certain biologics. Competitors seeking approval of biological products must file their own safety and efficacy data and address the challenges of biologics manufacturing, which involves more complex processes that are more costly than those of traditional pharmaceutical operations.

Both in the U.S. and internationally, the health care industry is subject to various government-imposed regulations authorizing prices or price controls that have and will continue to have an impact on the Company’s sales. In the U.S., Congress and some state legislatures have considered a number of proposals and have enacted laws that could result in major changes in the current health care system, either nationally or at the state level. Driven in part by budget concerns, Medicaid access and reimbursement restrictions have been implemented in some states and proposed in many others. In addition, the Medicare Prescription Drug Improvement and Modernization Act provides outpatient prescription drug coverage to senior citizens in the U.S. This legislation has had a modest favorable impact on the Company as a result of an increase in the number of seniors with drug coverage. At the same time, there continues to be a potential negative impact on the U.S. BioPharmaceuticals business that could result from pricing pressures or controls. In many markets outside the U.S., the Company operates in environments of government-mandated, cost-containment programs, or under other regulatory bodies or groups that can exert downward pressure on pricing. Pricing freedom is limited in the United Kingdom (UK), for instance, by the operation of a profit control plan and in Germany by the operation of a reference price system. Companies also face significant delays in market access for new products as more than two years can elapse after drug approval before new medicines become available in some countries.

The growth of Managed Care Organizations (MCOs) in the U.S. has played a large role in the competition that surrounds the health care industry. MCOs seek to reduce health care expenditures for participants by making volume purchases and entering into long-term contracts to negotiate discounts with various pharmaceutical providers. Because of the market potential created by the large pool of participants, marketing prescription drugs to MCOs has become an important part of the Company’s strategy. Companies compete for inclusion in MCO formularies and the Company generally has been successful in having its major products included. The Company believes that developments in the managed care industry, including continued consolidation, have had and will continue to have a generally downward pressure on prices.

Pharmaceutical/biotechnology production processes are complex, highly regulated and vary widely from product to product. Shifting or adding manufacturing capacity can be a lengthy process requiring significant capital expenditures and regulatory approvals. Biologics manufacturing involves more complex processes than those of traditional pharmaceutical operations. As biologics become more important to the Company’s product portfolio, the Company will continue to make arrangements with third-party manufacturers and to make substantial investments to increase its internal capacity to produce biologics on a commercial scale. One such investment is a new, state-of-the-art manufacturing facility for the production of biologics in Devens, Massachusetts, the construction of which began in May 2007.

The Company has maintained a competitive position in the market and strives to uphold this position, which is dependent on its success in discovering and developing innovative, cost-effective products that serve unmet medical need. The Company has expanded PTI activities in order to achieve additional savings in order to further reduce costs, streamline operations and rationalize global manufacturing to become a more productive and competitive biopharmaceutical company.

The Company and its subsidiaries are the subject of a number of significant pending lawsuits, claims, proceedings and investigations. It is not possible at this time reasonably to assess the final outcome of these investigations or litigations. For additional discussion of legal matters, see “Financial Statements—Note 25. Legal Proceedings and Contingencies.”

F-4

Strategy

The Company’s multi-year strategy is transformation into a next-generation biopharmaceutical company. The strategy encompasses all aspects and all geographies of the business and will yield substantial cost savings and cost avoidance and increase the Company’s financial flexibility to take advantage of attractive market opportunities that may arise.

Managing costs is one part of the Company’s overall strategy as it transitions to a next-generation biopharmaceutical company, focused on delivering its present commitments, maximizing near-term growth opportunities and improving its earnings base in 2012-2013. The Company announced PTI designed to create a total of $2.5 billion in annual productivity savings and cost avoidance by 2012. The first wave, announced in December 2007, targets $1.5 billion in savings and cost avoidance by 2010. The second wave, announced in July 2008, targets an additional $1.0 billion in savings and cost avoidance by 2012.

The Company will continue to focus on the development of our BioPharmaceuticals business and will maintain its growth by investing in research and development of new product pipeline. The Company will continue to invest in key growth products, including specialty and biologic medicines, and cardiovascular and metabolic drugs. The Company is seeking to reallocate resources to continue its string of pearls strategy and enable strategic transactions, such as the acquisition of Kosan Biosciences, Inc. (Kosan) and strategic alliances, such as the global codevelopment and cocommercialization agreement with Exelixis, Inc. (Exelixis) and a global collaboration agreement with ZymoGenetics, both entered in 2008. The Company will continue pursuing partnerships and expanding other collaborative arrangements with biopharmaceutical companies and will continue entering into strategic alliances with third parties in order to obtain rights to develop, manufacture, market and/or sell pharmaceutical products, the rights to which are owned by such third parties.

The Company will continue to maximize the value of our non-core businesses. In 2008, the Company completed the divestiture of its ConvaTec and Medical Imaging businesses. The Company has also sold its mature brands business located in Egypt.

F-5

New Product and Pipeline Developments

SPRYCEL

•

In January 2009, the Company announced the approval of SPRYCEL in Japan.

IXEMPRA

•

In December 2008, the Company announced new data from studies of IXEMPRA (ixabepilone) plus capecitabine compared to capecitabine alone, including a pre-specified sub set analysis demonstrating a significant increase in progression free survival in patients with triple negative breast cancer.

•

In November 2008, the Committee for Medicinal Products for Human Use (CHMP) in Europe issued a negative opinion on the marketing authorization application for IXEMPRA in the treatment of patients with metastatic breast cancer. The Company requested a re-examination of the case, which is currently under consideration by CHMP.

Exelixis

•

In December 2008, the Company announced a global collaboration with Exelixis covering two novel molecules for cancer with their associated development programs: Exelixis’ XL184, a small molecule inhibitor of MET, VEGFR2 and RET, which is currently in Phase III development for medullary thyroid cancer; and, Exelixis’ XL281, a small molecule inhibitor of RAF kinase, which is currently in Phase I development for the treatment of patients with advanced solid tumor malignancies. Under the agreement, the Company receives development and commercialization rights to both programs.

Dapagliflozin

•

In December 2008, the Company and AstraZeneca announced expansion of their worldwide collaboration to include the development and commercialization of dapagliflozin in Japan. Dapagliflozin, one of two investigational drugs under joint development by the companies, is currently being studied in Phase III clinical trials in several countries, including the U.S., to assess its efficacy and safety as a once-daily treatment for type 2 diabetes.

ERBITUX*

•

In January 2009, the Company and its marketing partner ImClone Systems, Inc. (ImClone), a wholly-owned subsidiary of Eli Lilly and Company (Lilly), announced, that the companies will withdraw, and eventually resubmit, an application with the FDA to broaden the use of ERBITUX* to include first-line treatment of patients with advanced non-small cell lung cancer in combination with platinum-based chemotherapy (cisplatin/vinorelbine).

•

In October 2008, the FDA has accepted for filing and priority review, the supplemental Biologics License Application (sBLA) to broaden the indication for ERBITUX* to include use in combination with platinum-based chemotherapy for the first-line treatment of patients with recurrent or metastatic squamous cell carcinoma of the head and neck.

•

In October 2008, publication of study results showing that metastatic colorectal cancer (mCRC) patients with wild-type or “normal” K-ras tumors who were treated with ERBITUX* plus best supportive care (BSC) had a statistically significant increase in overall survival and progression-free survival compared to those treated with BSC alone. Specifically, patients whose tumors had the normal (mutant negative) K-ras gene achieved a near two-fold improvement in overall survival and progression-free survival over patients treated with BSC alone. In patients with mutated K-ras tumors, there was no significant difference in overall or progression-free survival between those treated with ERBITUX* plus BSC and those treated with BSC alone. The Company and the FDA are in discussions regarding possible label changes related to this study.

•

In September 2008, the announcement of five year data showing significant improvements in overall survival for patients with locally or regionally advanced head and neck cancer and the EXTREME study was published in the New England Journal of Medicine showing that ERBITUX* improved survival in first-line recurrent and/or metastatic head and neck cancer.

•

In July 2008, ERBITUX* received marketing approval in Japan for treatment of patients with advanced or recurrent colorectal cancer.

•

In May 2008, at the annual meeting of the American Society of Clinical Oncology (ASCO), a landmark Phase III study (FLEX) showed that the addition of ERBITUX* to platinum-based chemotherapy significantly increased overall survival in the first-line treatment of patients with advanced non-small cell lung cancer, when compared to platinum-based chemotherapy alone.

F-6

ABILIFY*

•

A supplemental New Drug Application for ABILIFY* was approved by the FDA in February 2008 for the acute treatment of manic and mixed episodes associated with certain pediatric patients (age 10-17) with Bipolar I Disorder.

•

FDA approval was received in May 2008 for new ABILIFY* indications for pediatric bipolar (ages 10-17) maintenance therapy, pediatric schizophrenia (ages 10-17) maintenance therapy, and as add-on treatment to lithium or valproate for acute treatment of bipolar disorder in both pediatric (age 10-17) and adult patients.

•

The European Commission authorized marketing of ABILIFY* in March 2008 in the treatment of moderate to severe manic episodes in Bipolar I Disorder and for the prevention of a new manic episode in patients who experienced predominantly manic episodes and whose manic episodes responded to ABILIFY* treatment.

ORENCIA

•

In October 2008, the Company announced results from a 10-month study, which showed that ORENCIA, compared to placebo (PBO), significantly improved multiple aspects of health-related quality of life: physical and psychosocial well being, pain and sleep quality in juvenile idiopathic arthritis (JIA) patients between the ages 6 and 17 years. These results were part of a study looking at the safety and efficacy of ORENCIA in children with JIA who had failed on previous treatments such as methotrexate (MTX) or biologics.

•

In October 2008, the Company announced results from a Phase IIIb study in adult patients with early moderate-to-severe erosive rheumatoid arthritis (RA) who had never received previous MTX treatment. This study showed that ORENCIA in combination with MTX had significantly more patients achieve a Disease Activity Score 28 using C-reactive protein-defined remission, compared with MTX plus PBO. The safety profile of ORENCIA in combination with MTX was similar to that of MTX plus PBO. Also, in the same quarter, the Company filed an sBLA with the FDA for the use of ORENCIA for patients with early RA.

•

In June 2008, new Phase II data presented at the European League Against Rheumatism demonstrated that ORENCIA may delay the development of RA in people with undifferentiated inflammatory arthritis.

•

In April 2008, ORENCIA was approved by the FDA for treatment of juvenile RA. Additionally, the U.S. label for ORENCIA was revised with an indication that means ORENCIA is now an appropriate option for patients with moderate-to-severe RA, regardless of prior treatment received.

REYATAZ

•

In October 2008, the Company announced 96-week data from the CASTLE study, in which 74% of the 440 patients in the REYATAZ/r arm achieved an undetectable viral load, defined as human immunodeficiency virus (HIV)-1 RNA less than 50 copies/mL, compared with 68% of the 443 patients in the lopinavir/r arm. The difference between treatment arms may have been related to the 16% discontinuation rate in the REYATAZ/r arm and the 21% discontinuation rate in the lopinavir/r arm.

•

In October 2008, the FDA approved the use of REYATAZ (atazanavir sulfate) 300 milligram once-daily boosted with ritonavir 100 milligram as part of combination therapy in previously untreated (treatment-naïve) HIV-1 infected patients. This use of once-daily REYATAZ/ritonavir in HIV-1 infected treatment-naïve adult patients is based upon 48-week results from the CASTLE study, which demonstrated similar antiviral efficacy of REYATAZ/ritonavir to twice-daily lopinavir/ritonavir, each as part of HIV combination therapy in treatment-naïve HIV-1 infected adult patients. Data from the CASTLE study was published in the August 23 issue of The Lancet.

•

In June 2008, European approval was received for an expanded indication for REYATAZ 300 mg once-daily boosted with ritonavir 100 mg as part of combination therapy in treatment-naïve HIV-1 infected patients.

•

In February 2008, the first data comparing boosted REYATAZ (REYATAZ plus ritonavir) and lopinavir/ritonavir was presented at the Congress on Retroviruses and Opportunistic Infections.

BARACLUDE

•

The Company announced in November 2008 data from two separate cohort evaluations, in which long-term treatment with BARACLUDE was associated with improved liver histology, including improvement in fibrosis, in chronic hepatitis B patients. The histology data were presented at the 59th Annual Meeting of the American Association for the Study of Liver Diseases.

•

New data at the March 2008 Asian Pacific Association for the Study of the Liver meeting, demonstrated a continued low incidence of resistance to BARACLUDE in nucleoside-naive patients through five years of treatment, which is important for many chronic hepatitis B patients requiring long-term treatment.

F-7

Apixaban

•

In September 2008, the Company and its development partner Pfizer announced a Phase II study (APPRAISE-1) of apixaban – a novel anticoagulant – provided encouraging trends suggesting that anticoagulation with apixaban on top of current standards of care and continued beyond the initial hospitalization may reduce the risk of a second heart attack, stroke or death.

•

The primary endpoint was not met in a Phase III study of apixaban for prevention of venous thromboembolism (VTE) in patients undergoing total knee replacement. The results of the trial do not necessitate any changes in protocols of any other ongoing apixaban studies. The companies are considering further studies in preventing VTE in knee surgery and will not submit the U.S. regulatory filing for VTE prevention in the second half of 2009, as previously communicated. Programs directed toward prevention of VTE, including European Medicines Evaluation Agency registration studies, treatment of VTE, Acute Coronary Systems and in the prevention of stroke in atrial fibrillation continue as planned.

Ipilimumab

•

Favorable updated survival data was announced in September 2008 from three Phase II studies of ipilimumab.

Saxagliptin

•

Favorable results were announced in September 2008 of Phase III studies of ONGLYZA (saxagliptin).

•

Regulatory submissions for ONGLYZA were made in both the U.S. and in Europe on June 30 and July 1, respectively.

•

At the annual scientific sessions of the American Diabetes Association, a Phase III study demonstrated that saxagliptin produced significant reductions in key measures of glucose control in treatment-naïve people with type 2 diabetes compared to placebo.

Elotuzumab

•

The Company entered into an agreement with PDL BioPharma, Inc. in August 2008, for the global development and commercialization of elotuzumab, an anti-CS1 antibody currently in Phase I development for multiple myeloma.

KAI-9803

•

In May 2008, the Company entered into an agreement with KAI to develop and commercialize KAI’s novel acute heart attack medicine, KAI-9803.

Kosan

•

In June 2008, Bristol-Myers Squibb completed the acquisition of Kosan, a cancer therapeutics company with a library of novel compounds, including Hsp90 inhibitors for cancer and microtubule stabilizers, which may have additional potential in neurodegenerative diseases.

ZymoGenetics

•

In January 2009, the Company and ZymoGenetics announced a global collaboration for PEG-Interferon lambda, a novel type 3 interferon currently in Phase Ib development for the treatment of Hepatitis C, and its related development program.

PLAVIX*

•

The European Committee for Medicinal Products for Human Use in March 2008 issued a positive opinion recommending approval of the 300 milligram loading dose tablet of PLAVIX*. This positive opinion was ratified by the European Commission.

F-8

RESULTS OF OPERATIONS

The following discussions of the Company’s results of continuing operations exclude the results related to the Medical Imaging business prior to its divestiture in January 2008, and the ConvaTec business prior to its divestiture in August 2008. Both Medical Imaging and ConvaTec were previously presented as a component of the former Other Health Care operating segment, which was renamed the ConvaTec operating segment subsequent to the Medical Imaging divestiture. These businesses have been segregated from continuing operations and included in discontinued operations for all periods presented.

The Company’s results of operations were as follows:


										% Change
Dollars in Millions	2008			2007			2006			2008 vs. 2007		2007 vs. 2006
Net Sales	$	20,597		$	18,193		$	16,208		13	%	12	%
Earnings from Continuing Operations Before Income Taxes	$	5,471		$	3,186		$	2,085		72	%	53	%
% of net sales		26.6	%		17.5	%		12.9	%

Provision for Income Taxes	$	1,320		$	682		$	431		94	%	58	%
Effective tax rate		24.1	%		21.4	%		20.7	%

Net Earnings from Continuing Operations Attributable to Shareholders	$	3,155		$	1,741		$	1,214		81	%	43	%
% of net sales		15.3	%		9.6	%		7.5	%

Net Sales

The composition of the changes in net sales was as follows:


							2008 vs. 2007								2007 vs. 2006
	Net Sales						Analysis of % Change								Analysis of % Change
Dollars in Millions	2008		2007		2006		Total Change		Volume		Price		Foreign Exchange		Total Change		Volume		Price		Foreign Exchange
U.S.	$	12,042	$	10,422	$	8,785	16	%	9	%	7	%	—		19	%	15	%	4	%	—
Non-U.S.		8,555		7,771		7,423	10	%	4	%	1	%	5	%	5	%	(1	)%	—		6	%

Total	$	20,597	$	18,193	$	16,208	13	%	7	%	4	%	2	%	12	%	7	%	2	%	3	%

The 2008 and 2007 increase in U.S. net sales is primarily driven by growth in key U.S. BioPharmaceuticals products which are described below in further detail. Increases in international net sales in 2008 and 2007 were aided by a weakened U.S. dollar relative to certain foreign currencies, especially the euro and U.K. pound.

In general, the Company’s business is not seasonal. For information on U.S. pharmaceutical prescriber demand, reference is made to the table within “—BioPharmaceuticals” below, which sets forth a comparison of changes in net sales to the estimated total prescription growth (for both retail and mail order customers) for certain of the Company’s key biopharmaceutical products and new products sold by the U.S. BioPharmaceuticals business. The U.S. and non-U.S. net sales are based upon the location of the customer.

The Company’s net sales by segment were as follows:


	Net Sales						% Change				% of Total Net Sales
Dollars in Millions	2008		2007		2006		2008 vs. 2007		2007 vs. 2006		2008		2007		2006
BioPharmaceuticals	$	17,715	$	15,622	$	13,861	13	%	13	%	86	%	86	%	86	%
Mead Johnson		2,882		2,571		2,347	12	%	10	%	14	%	14	%	14	%

Total	$	20,597	$	18,193	$	16,208	13	%	12	%	100	%	100	%	100	%

The Company recognizes revenue net of various sales adjustments to arrive at net sales as reported on the consolidated statements of earnings. These adjustments are referred to as gross-to-net sales adjustments and are further described in “—Critical Accounting Policies” below.

F-9

The reconciliations of the Company’s gross sales to net sales by each significant category of gross-to-net sales adjustments were as follows:


	Year Ended December 31,
Dollars in Millions	2008			2007			2006
Gross Sales	$	23,344		$	20,814		$	18,909
Gross-to-Net Sales Adjustments
Prime Vendor Charge-Backs		(529	)		(551	)		(624	)
Women, Infants and Children (WIC) Rebates		(796	)		(848	)		(872	)
Managed Health Care Rebates and Other Contract Discounts		(376	)		(333	)		(274	)
Medicaid Rebates		(205	)		(169	)		(174	)
Cash Discounts		(282	)		(239	)		(214	)
Sales Returns		(228	)		(155	)		(224	)
Other Adjustments		(331	)		(326	)		(319	)

Total Gross-to-Net Sales Adjustments		(2,747	)		(2,621	)		(2,701	)

Net Sales	$	20,597		$	18,193		$	16,208

The gross-to-net adjustments are primarily a function of gross sales and activity is typically correlated with current sales trends as is the case with managed health care rebates and other contract discounts, Medicaid rebates, cash discounts, and other adjustments in 2008, 2007 and 2006. Managed health care rebates and other contract discounts and Medicaid rebates are also affected by changes to sales mix and contractual and legislative discount rates. The 2007 increases in managed health care rebates and other contract discounts were also impacted by the reduction of reserves in 2006 related to the TRICARE Retail Pharmacy Refund Program.

Prime vendor charge-backs decreased throughout 2008 and 2007 as a result lower sales of TAXOL attributed to the loss of exclusivity. The Women, Infant and Children (WIC) rebates decrease is related to the net impact of several WIC contract transactions.

The 2008 increase in sales returns is primarily attributed to increased provisions for PRAVACHOL, driven by higher retail sales returns than previously assumed, and the loss of exclusivity of ZERIT. The 2007 variance in sales returns when compared to the prior year is attributed to higher provisions in 2006 for cardiovascular non-exclusive brands and from the discontinued commercialization of TEQUIN (gatifloxacin).

The activities and ending balances of each significant category of gross-to-net sales adjustments were as follows:


Dollars in Millions	Prime Vendor Charge- Backs			Women, Infants and Children (WIC) Rebates			Managed Health Care Rebates and Other Contract Discounts			Medicaid Rebates			Cash Discounts			Sales Returns			Other Adjustments			Total
Balance at January 1, 2007	$	63			230		$	111		$	137		$	18		$	221		$	124		$	904
Provision related to sales made in current period		551			845			340			176			238			137			328			2,615
Provision related to sales made in prior periods		—			3			(7	)		(7	)		1			18			(2	)		6
Returns and payments		(551	)		(880	)		(306	)		(181	)		(234	)		(201	)		(334	)		(2,687	)
Impact of foreign currency translation		—			—			6			—			—			4			10			20
Discontinued operations		7			—			(10	)		—			1			(1	)		2			(1	)

Balance at December 31, 2007	$	70		$	198		$	134		$	125		$	24		$	178		$	128		$	857
Provision related to sales made in current period		529			799			383			213			281			136			338			2,679
Provision related to sales made in prior periods		—			(3	)		(7	)		(8	)		1			92			(7	)		68
Returns and payments		(531	)		(799	)		(357	)		(197	)		(274	)		(189	)		(333	)		(2,680	)
Impact of foreign currency translation		—			—			2			—			(1	)		(5	)		(3	)		(7	)
Discontinued operations		(23	)		—			(1	)		—			—			(3	)		(8	)		(35	)

Balance at December 31, 2008	$	45		$	195		$	154		$	133		$	31		$	209		$	115		$	882

In 2008 and 2007, the Company recorded gross-to-net sales adjustments related to sales made in prior periods. The significant items included charges for sales returns of $92 million in 2008 and $18 million in 2007, primarily resulting from higher than expected returns of certain non-exclusive products.

No other significant revisions were made to the estimates for gross-to-net sales adjustments in 2008 and 2007.

F-10

BioPharmaceuticals

The composition of the changes in BioPharmaceuticals net sales was as follows:


							2008 vs. 2007								2007 vs. 2006
	Net Sales						Analysis of % Change								Analysis of % Change
Dollars in Millions	2008		2007		2006		Total Change		Volume		Price		Foreign Exchange		Total Change		Volume		Price		Foreign Exchange
U.S.	$	10,611	$	8,992	$	7,417	18	%	11	%	7	%	—		21	%	16	%	5	%	—
Non-U.S.		7,104		6,630		6,444	7	%	3	%	(1	)%	5	%	3	%	(2	)%	(1	)%	6	%

Total	$	17,715	$	15,622	$	13,861	13	%	8	%	3	%	2	%	13	%	8	%	2	%	3	%

In 2008, most of the key U.S. BioPharmaceuticals products contributed to the growth in sales. PLAVIX* and ABILIFY*, represented approximately 46% and 16%, of total U.S. BioPharmaceuticals net sales and represented approximately 53% and 23% of the total growth in BioPharmaceuticals sales when compared to prior year. In 2007, PLAVIX* and ABILIFY* represented approximately 45% and 15%, of total U.S. BioPharmaceuticals net sales and contributed approximately 89% and 16%, of total growth in U.S. BioPharmaceuticals net sales. This growth more than offsets decreases in U.S. net sales attributed to generic competition for PRAVACHOL.

Both 2008 and 2007 international BioPharmaceuticals sales were aided by a weakened U.S. dollar against many foreign currencies when compared to the previous period. The Company’s reported international net sales do not include copromotion sales reported by its alliance partner, Sanofi-Aventis (Sanofi) for PLAVIX* and AVAPRO*/AVALIDE*, which continued to show growth in 2008.

F-11

Net sales of key BioPharmaceuticals products represent 80%, 76% and 72% of total BioPharmaceuticals net sales in 2008, 2007 and 2006, respectively. The following table details U.S. and international BioPharmaceuticals net sales by key products, the percentage change from prior year as well as the foreign exchange impact when compared to the prior year. Commentary detailing the reasons for significant variances by key product is provided below.


	Net Sales							% Change				% Change Attributable to Foreign Exchange
Dollars in Millions	2008			2007		2006		2008 vs. 2007		2007 vs. 2006		2008 vs. 2007		2007 vs. 2006
Cardiovascular
PLAVIX*
U.S.	$	4,920		$	4,060	$	2,655	21	%	53	%	—		—
Non-U.S.		683			695		602	(2	)%	15	%	3	%	8	%
Total		5,603			4,755		3,257	18	%	46	%	1	%	1	%
AVAPRO/AVALIDE
U.S.		735			692		647	6	%	7	%	—		—
Non-U.S.		555			512		450	8	%	14	%	4	%	8	%
Total		1,290			1,204		1,097	7	%	10	%	2	%	3	%
PRAVACHOL
U.S.		(10	)^(a)		139		553	(107	)%	(75	)%	—		—
Non-U.S.		213			304		644	(30	)%	(53	)%	4	%	3	%
Total		203			443		1,197	(54	)%	(63	)%	2	%	2	%
Virology
REYATAZ
U.S.		667			587		514	14	%	14	%	—		—
Non-U.S.		625			537		417	16	%	29	%	5	%	8	%
Total		1,292			1,124		931	15	%	21	%	2	%	4	%
SUSTIVA Franchise (total revenue)
U.S.		724			604		495	20	%	22	%	—		—
Non-U.S.		425			352		296	21	%	19	%	4	%	10	%
Total		1,149			956		791	20	%	21	%	2	%	4	%
BARACLUDE
U.S.		140			88		50	59	%	76	%	—		—
Non-U.S.		401			187		33	114	%	*	*	9	%	N/A
Total		541			275		83	97	%	*	*	6	%	N/A
Oncology
ERBITUX*
U.S.		739			683		646	8	%	6	%	—		—
Non-U.S.		10			9		6	11	%	50	%	—		2	%
Total		749			692		652	8	%	6	%	—		—
TAXOL
U.S.		6			14		12	(57	)%	17	%	—		—
Non-U.S.		379			408		551	(7	)%	(26	)%	8	%	1	%
Total		385			422		563	(9	)%	(25	)%	8	%	1	%
SPRYCEL
U.S.		92			58		22	59	%	164	%	—		—
Non-U.S.		218			100		3	118	%	*	*	8	%	N/A
Total		310			158		25	96	%	*	*	5	%	N/A
IXEMPRA
U.S.		98			15		—	*	*	—		N/A		—
Non-U.S.		3			—		—	—		—		—		—
Total		101			15		—	*	*	—		N/A		—
Affective (Psychiatric) Disorders
ABILIFY*
U.S.		1,676			1,305		1,052	28	%	24	%	—		—
Non-U.S.		477			355		230	34	%	54	%	7	%	12	%
Total		2,153			1,660		1,282	30	%	29	%	1	%	2	%
Immunoscience
ORENCIA
U.S.		363			216		88	68	%	145	%	—		—
Non-U.S.		78			15		1	*	*	*	*	N/A		N/A
Total		441			231		89	91	%	160	%	1	%	1	%

^(a)	Negative PRAVACHOL U.S. sales in 2008 reflect higher retail sales returns than previously assumed.

**	Change is in excess of 200%.

F-12

PLAVIX* - a platelet aggregation inhibitor that is part of the Company’s alliance with Sanofi

•

U.S. sales increases in 2008 and 2007 were primarily attributed to increased prescription demand and higher average selling prices. Demand was negatively affected beginning in the third quarter of 2006 through the second quarter of 2007 by the launch of a generic clopidogrel bisulfate. The generic in the distribution channel was substantially depleted by June 30, 2007. In 2008 and 2007, estimated total U.S. prescription demand for clopidogrel bisulfate (branded and generic) increased approximately 4% and 8%, respectively, whereas estimated U.S. prescription demand for branded PLAVIX* increased 19% and 34% respectively.

•

International net sales in 2008 were negatively impacted by the August 2008 launch of a clopidogrel alternative salt (clopidogrel beyslate) launched in Germany.

•

See “Financial Statements—Note 25. Legal Proceedings and Contingencies—PLAVIX* Litigation,” for further discussion on PLAVIX* exclusivity litigation in both the U.S. and EU.

AVAPRO* /AVALIDE* (known in the EU as APROVEL*/KARVEA*) - an angiotensin II receptor blocker for the treatment of hypertension and diabetic nephropathy that is also part of the Sanofi alliance

•

Worldwide sales increases in 2008 and 2007 were primarily attributed to higher average selling prices which more than offset declines in overall demand. Total U.S. prescription demand for AVAPRO*/AVALIDE* decreased approximately 7% in 2008 and approximately 4% in 2007.

PRAVACHOL - an HMG Co-A reductase inhibitor for the treatment of hypercholesterolemia and reducing the risk of heart attack

•

Worldwide sales decreases in 2008 and 2007 were attributed to continued generic competition in the U.S. and key European markets. Market exclusivity ended in the U.S in April 2006 and in 2004 for most EU countries.

•

U.S. sales in 2008 were negatively impacted by higher retail sales returns than previously assumed.

REYATAZ - a protease inhibitor for the treatment of HIV

•

U.S. sales increases in 2008 and 2007 were primarily due to a higher prescription demand of 14% and 13%, respectively.

•

The international sales increase in 2008 was primarily due to higher demand across most markets with Europe being the key driver due to the June 2008 approval for front-line treatment. Growth in 2007 international revenue was attributed to increased demand in Europe and Latin America.

SUSTIVA Franchise - a non-nucleoside reverse transcriptase inhibitor for the treatment of HIV, which includes SUSTIVA, an

antiretroviral drug, and bulk efavirenz, which is also included in the combination therapy, ATRIPLA* (efavirenez 600mg/ emtricitabine 200 mg/tenofovir disoproxil fumarate 300 mg), a product sold through a joint venture with Gilead Sciences, Inc.

•

Worldwide sales increases in 2008 and 2007 were primarily due to higher demand attributed to the successful launch of ATRIPLA* in the U.S. in July 2006; in the EU in December 2007; and in Canada in October 2007. U.S. prescription demand for the Sustiva franchise increased approximately 14% in 2008 and 20% in 2007. To a lesser extent, higher average selling prices contributed to the increase in net revenues.

BARACLUDE - an oral antiviral agent for the treatment of chronic hepatitis B

•

Worldwide sales increases in 2008 and 2007 were primarily due to the continued growth across all markets, particularly international markets, due to the successful launch in various countries including China in February 2006, the UK and Germany in July 2006, France and Japan in September 2006 and the U.S. in April 2005.

•

There continues to be increased awareness and acceptance of its long-term efficacy, safety and resistance data as evidenced by the American Association for the Study of Liver Disease treatment guidelines that recommended BARACLUDE as a first line treatment option.

ERBITUX* - a monoclonal antibody designed to exclusively target and block the Epidermal Growth Factor Receptor, which is expressed on the surface of certain cancer cells in multiple tumor types as well as normal cells and is currently indicated for use against colorectal cancer and head and neck cancer. ERBITUX* is part of the Company’s strategic alliance with ImClone

•

Sold by the Company almost exclusively in the U.S., the sales increases in 2008 and 2007 were primarily due to increased demand for a recent indication for usage in the treatment of head and neck cancer.

•

Sales in 2007 were also positively impacted by a transition to a broader distribution model resulting in higher sales associated with initial shipments of inventory to distributors.

F-13

TAXOL - an anti-cancer agent, currently sold almost exclusively in non-U.S. markets

•

Sales decreases in 2008 and 2007 were due primarily to generic competition in Japan.

SPRYCEL - an oral inhibitor of multiple tyrosine kinases, for the treatment of adults with chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia with resistance or intolerance to prior therapy, including GLEEVEC* (imatinib meslylate)

•

Worldwide sales increases in 2008 and 2007 were primarily due to higher demand associated with the successful launch in the U.S. in July 2006 and in most European markets beginning in the fourth quarter of 2006, higher U.S. selling prices and continued launches in Russia and Turkey in 2008.

IXEMPRA- a microtubule inhibitor for the treatment of patients with metastatic or locally advanced breast cancer

•

The sales increase in 2008 reflects the launch of the product in the U.S. in October 2007.

ABILIFY* - an antipsychotic agent for the treatment of schizophrenia, bipolar mania disorder and major depressive disorder and is part of the Company’s strategic alliance with Otsuka Pharmaceutical Co., Ltd. (Otsuka)

•

U.S. sales increases in 2008 and 2007 were primarily attributed to increased demand and higher average selling prices. Prescription demand increased approximately 23% in 2008 and approximately 12% in 2007. Contributing to the prescription growth are new indications in 2008 and 2007 for certain patients with bipolar disorder and major depressive disorder.

•

International sales increases in 2008 and 2007 were also primarily attributed to increased prescription demand. 2008 sales growth was aided by a new bipolar indication in the second quarter of 2008 in the EU.

ORENCIA - a fusion protein indicated for adult patients with moderate to severe RA who have had an inadequate response to one or more currently available treatments, such as MTX or anti-tumor necrosis factor therapy

•

U.S. sales increases in 2008 and 2007 were primarily due to the continued growth since the launch of this biologic product in the U.S. in February 2006.

•

International sales increase in 2008 reflects the European launch in May 2007.

The estimated U.S. prescription change data provided throughout this Form 10-K includes information only from the retail and mail order channels and does not reflect information from other channels, such as hospitals, institutions and long-term care, among others. The estimated prescription data is based on the Next-Generation Prescription Service (NGPS) version 2.0 of the National Prescription Audit provided by IMS Health (IMS), a supplier of market research for the pharmaceutical industry, as described below. The data provided by IMS is a product of IMS’ own recordkeeping process and is an estimate based on IMS’ sampling procedures. The data is subject to the inherent limitations of estimates based on sampling and may include a margin of error.

The Company has calculated the estimated total U.S. prescription change based on NGPS data on a weighted-average basis to reflect the fact that mail order prescriptions include a greater volume of product supplied compared to retail prescriptions. Mail order prescriptions typically reflect a 90-day prescription whereas retail prescriptions typically reflect a 30-day prescription. The calculation is derived by multiplying NGPS mail order prescription data by a factor that approximates three and adding to this the NGPS retail prescriptions. The Company believes that this calculation of the estimated total U.S. prescription change based on the weighted-average approach with respect to the retail and mail order channels provides a superior estimate of total prescription demand. The Company uses this methodology for its internal demand forecasts.

The Company continuously seeks to improve the quality of its estimates of prescription change amounts and ultimate patient/consumer demand through review of its methodologies and processes for calculation of these estimates and review and analysis of its own and third parties data used in such calculations. The Company expects that it will continue to review and refine its methodologies and processes for calculation of these estimates and will continue to review and analyze its own and third parties’ data used in such calculations.

F-14

Estimated End-User Demand

The following tables set forth for each of the Company’s key pharmaceutical products sold by the U.S. BioPharmaceuticals business, for the years ended December 31, 2008, 2007 and 2006: (i) total U.S. net sales for the period; (ii) change in reported U.S. net sales for the period; (iii) estimated total U.S. prescription change for the retail and mail order channels calculated by the Company based on NGPS data on a weighted-average basis and (iv) months of inventory on hand in the wholesale distribution channel.


								Year Ended December 31,												At December 31,
	Total U.S. Net Sales							% Change in U.S. Net Sales^(a)						% Change in U.S. Total Prescriptions ^(b)						Months on Hand
Dollars in Millions	2008			2007		2006		2008		2007		2006		2008		2007		2006		2008	2007	2006
PLAVIX*	$	4,920		$	4,060	$	2,655	21	%	53	%	(18	)%	19	%	34	%	(21	)%	0.4	0.5	0.6
AVAPRO/AVALIDE		735			692		647	6	%	7	%	13	%	(7	)%	(4	)%	2	%	0.5	0.5	0.5
PRAVACHOL^(h)		(10	)		139		553	(107	)%	(75	)%	(57	)%	(75	)%	(82	)%	(59	)%	0.8	0.7	0.6
REYATAZ		667			587		514	14	%	14	%	27	%	14	%	13	%	14	%	0.5	0.6	0.7
SUSTIVA Franchise ^(c)		724			604		495	20	%	22	%	23	%	14	%	20	%	9	%	0.6	0.6	0.7
BARACLUDE		140			88		50	59	%	76	%	*	*	55	%	77	%	*	*	0.7	0.6	0.7
ERBITUX* ^(d)		739			683		646	8	%	6	%	57	%	N/A		N/A		N/A		0.5	0.5	0.4
SPRYCEL ^(e)		92			58		22	59	%	164	%	—		36	%	*	*	—		0.8	0.9	1.4
IXEMPRA^{(d, f)}		98			15		—	*	*	—		—		N/A		N/A		N/A		0.7	0.9	—
ABILIFY*		1,676			1,305		1,052	28	%	24	%	40	%	23	%	12	%	21	%	0.5	0.5	0.5
ORENCIA ^{(d, g)}		363			216		88	68	%	145	%	—		N/A		N/A		N/A		0.5	0.5	0.4

^(a)	Reflects percentage change in net sales in dollar terms.

^(b)	Derived by multiplying NGPS mail order prescription data by a factor that approximates three and adding to this the NGPS retail prescriptions.

^(c)

Beginning in the third quarter of 2006, the SUSTIVA Franchise (total revenue) includes sales of SUSTIVA, as well as revenue of bulk efavirenz included in the combination therapy, ATRIPLA*. The change in U.S. total prescriptions growth for the SUSTIVA Franchise includes both branded SUSTIVA and ATRIPLA* prescription units.

^(d)	ERBITUX*, ORENCIA and IXEMPRA are parenterally administered products and do not have prescription-level data as physicians do not write prescriptions for these products.

^(e)	SPRYCEL was launched in the U.S. in July 2006.

^(f)	IXEMPRA was launched in the U.S. in October 2007.

^(g)	ORENCIA was launched in the U.S. in February 2006.

^(h)	Negative net sales attributed to higher retail returns than previously assumed.

**	Change is in excess of 200%.

Pursuant to the U.S. Securities and Exchange Commission (SEC) Consent Order described below under “—SEC Consent Order”, the Company monitors the level of inventory on hand in the U.S. wholesaler distribution channel and outside of the U.S. in the direct customer distribution channel. The Company is obligated to disclose products with levels of inventory in excess of one month on hand or expected demand, subject to a de minimis exception. The following products had estimated levels of inventory in the distribution channel in excess of one month on hand (1) in the case of the Company’s U.S. BioPharmaceuticals products, December 31, 2008 and (2) in the case of the Company’s international BioPharmaceuticals and Mead Johnson products, September 30, 2008.

At September 30, 2008, BUFFERIN, a salicylatate drug, had approximately 1.1 months of inventory on hand at direct customers compared to approximately 0.9 months of inventory on hand at December 31, 2007. The increased level of inventory on hand was due primarily to increased inventory levels in China caused by distributors’ preparations for national holidays.

At September 30, 2008, DAFALGAN, an analgesic product sold principally in Europe, had approximately 1.1 months of inventory on hand as compared to 1.2 months of inventory on hand at December 31, 2007. The previously stated level of inventory on hand as of September 30, 2008 was due primarily to private pharmacists purchasing DAFALGAN approximately once every eight weeks and the seasonality of the product.

At September 30, 2008, VIDEX/VIDEX EC, an antiviral product, had approximately 1.3 months of inventory on hand at direct customers compared to 1.3 months of inventory on hand at December 31, 2007. The previously stated level of inventory on hand was due primarily to government purchasing patterns in Brazil. The Company is contractually obligated to provide VIDEX/VIDEX EC to the Brazilian government upon placement of an order for product by the government. Under the terms of the contract, the Company has no control over the inventory levels relating to such orders.

In the U.S., for all products sold exclusively through wholesalers or through distributors, the Company determines its months on hand estimates using information with respect to inventory levels of product on hand and the amount of out-movement of products provided by the Company’s three largest wholesalers, which accounted for approximately 90% of total gross sales of U.S. BioPharmaceuticals products in 2008, and provided by the Company’s distributors. Factors that may influence the Company’s estimates include generic competition, seasonality of products, wholesaler purchases in light of increases in wholesaler list prices, new product launches, new warehouse openings by wholesalers and new customer stockings by wholesalers. In addition, such estimates are calculated using third-party data, which represent their own record-keeping processes and may also reflect estimates.

F-15

For pharmaceutical products in the U.S. that are not sold exclusively through wholesalers or distributors and for the Company’s BioPharmaceuticals business outside of the U.S. and Mead Johnson business units around the world, the Company has significantly more direct customers. Limited information on direct customer product level inventory and corresponding out-movement information and the reliability of third-party demand information, where available, varies widely. In cases where direct customer product level inventory, ultimate patient/consumer demand or out-movement data does not exist or is otherwise not available, the Company has developed a variety of other methodologies to calculate estimates of such data, including using such factors as historical sales made to direct customers and third-party market research data related to prescription trends and end-user demand. Accordingly, the Company relies on a variety of methods to estimate direct customer product level inventory and to calculate months on hand for these business units. Factors that may affect the Company’s estimates include generic competition, seasonality of products, direct customer purchases in light of price increases, new product or product presentation launches, new warehouse openings by direct customers, new customer stockings by direct customers and expected direct customer purchases for governmental bidding situations.

Mead Johnson

The composition of the change in Mead Johnson net sales was as follows:


	Net Sales						2008 vs. 2007 Analysis of % Change								2007 vs. 2006 Analysis of % Change
Dollars in Millions	2008		2007		2006		Total Change		Volume		Price		Foreign Exchange		Total Change		Volume		Price		Foreign Exchange
U.S.	$	1,108	$	1,128	$	1,091	(2	)%	(6	)%	4	%	—		3	%	1	%	2	%	—
Non-U.S.		1,774		1,443		1,256	23	%	8	%	12	%	3	%	15	%	4	%	5	%	6	%

Total	$	2,882	$	2,571	$	2,347	12	%	2	%	8	%	2	%	10	%	3	%	4	%	3	%

Infant formulas and toddler/children’s nutritionals, representing 97%, 96% and 96% of total Mead Johnson net sales in 2008, 2007 and 2006, respectively, were as follows:


	Net Sales						% Change
Dollars in Millions	2008		2007		2006		2008 vs. 2007		2007 vs. 2006
Infant Formulas	$	1,932	$	1,786	$	1,637	8	%	9	%
ENFAMIL		1,157		1,082		1,007	7	%	7	%
Toddler/Children’s Nutritionals		856		693		606	24	%	14	%

In 2008, the decrease in U.S. Mead Johnson net sales was primarily due to decreased sales of infant formulas. The increase in international Mead Johnson net sales was primarily due to growth in both infant formulas and children’s nutritionals.

In 2007, the increase in U.S. Mead Johnson net sales was primarily due to increased sales of infant formulas. International Mead Johnson net sales increased primarily due to growth in both infant formulas and children’s nutritionals.

F-16

Geographic Areas

In general, the Company’s products are available in most countries in the world. The largest markets are in the U.S., France, Spain, Canada, China, Japan, Italy, Mexico and Germany. The Company’s sales by geographic areas based on the location of the entity selling the product were as follows:


	Net Sales						% Change				% of Total Net Sales
Dollars in Millions	2008		2007		2006		2008 vs. 2007		2007 vs. 2006		2008		2007		2006
United States	$	12,042	$	10,422	$	8,785	16	%	19	%	58	%	57	%	54	%
Europe, Middle East and Africa		4,514		4,036		3,979	12	%	1	%	22	%	22	%	25	%
Other Western Hemisphere		1,622		1,628		1,517	—		7	%	8	%	9	%	9	%
Pacific		2,419		2,107		1,927	15	%	9	%	12	%	12	%	12	%

Total	$	20,597	$	18,193	$	16,208	13	%	12	%	100	%	100	%	100	%

See items previously discussed in “—BioPharmaceuticals” for items impacting the increase in U.S. net sales for 2008 and 2007.

Europe, Middle East and Africa sales increases in 2008 are primarily due to sales growth in major European markets for ABILIFY*, SPRYCEL, and the HIV and hepatitis portfolio in addition to a favorable foreign exchange impact of 6%. Sales in 2007 were essentially flat as sales growth in major European markets for SPRYCEL, ABILIFY* and the HIV and hepatitis portfolio, and a favorable foreign exchange impact of 8%, was offset by generic competition for PRAVACHOL and TAXOL.

Other Western Hemisphere countries sales in 2008 were essentially flat with a minimum foreign exchange impact. Sales increases in 2007 are primarily due to increased sales of PLAVIX* in Canada and Mexico, key nutritional products and AVAPRO*/AVALIDE* in Canada, and a favorable foreign exchange impact of 4%. These increases were partially offset by the discontinued commercialization of TEQUIN.

Pacific region sales increases in 2008 and 2007 are primarily due to sales growth of BARACLUDE in China, Japan, and Korea and key nutritional products throughout the region in addition to favorable foreign exchange impacts of 6% and 5%, respectively. In addition, sales in 2007 were negatively impacted by increased generic competition for TAXOL and PRAVACHOL.

No single country outside the U.S. contributed more than 10% of the Company’s total revenues in 2008, 2007 or 2006. Net sales in France, Canada, Spain and Japan exceeded $500 million in both 2008 and 2007. Net sales in China and Italy exceeded $500 million in 2008, while Mexico had more than $500 million in sales in 2007.

Expenses/Gains


										% Change				% of Net Sales
Dollars in Millions	2008			2007			2006			2008 vs. 2007		2007 vs. 2006		2008		2007		2006
Costs of products sold	$	6,396		$	5,868		$	5,420		9	%	8	%	31	%	32	%	33	%
Marketing, selling and administrative		4,792			4,516			4,469		6	%	1	%	23	%	25	%	28	%
Advertising and product promotion		1,550			1,415			1,304		10	%	9	%	8	%	8	%	8	%
Research and development		3,585			3,227			2,951		11	%	9	%	17	%	18	%	18	%
Acquired in-process research and development		32			230			—		(86	)%	—		—		1	%	—
Provision for restructuring, net		218			183			59		19	%	*	*	1	%	1	%	—
Litigation expense, net		33			14			302		136	%	(95	)%	—		—		2	%
Gain on sale of product lines and businesses		(159	)		(273	)		(200	)	42	%	(37	)%	(1	)%	(2	)%	(1	)%
Equity in net income of affiliates		(617	)		(524	)		(474	)	(18	)%	(11	)%	(3	)%	(3	)%	(3	)%
Gain on sale of ImClone shares		(895	)		—			—		—		—		(4	)%	—		—
Other expense, net		191			351			292		(46	)%	20	%	1	%	2	%	2	%

Total Expenses, net	$	15,126		$	15,007		$	14,123		1	%	6	%	73	%	82	%	87	%

**	Change is in excess of 200%.

Costs of products sold

•

The improvement in costs of products sold as a percentage of net sales in 2008 was primarily attributed to a more favorable worldwide BioPharmaceuticals product sales mix, higher U.S. BioPharmaceuticals average selling prices, and realized manufacturing savings from PTI. These factors were partially offset by product and material price increases. The 2008 costs include manufacturing rationalization charges of $249 million related to the implementation of PTI in 2008, or 1.2% of net sales, compared to $179 million of rationalization charges recorded in 2007, or 1.0% of net sales.

F-17

•

The improvement in costs of products sold as a percentage of sales in 2007 was primarily due to sales growth in higher margin products including PLAVIX*.

Marketing, selling and administrative

•

The increase in 2008 was primarily related to $104 million of increased process standardization costs incurred as part of PTI when compared to the prior period, $41 million of costs incurred as part of the initial public offering for Mead Johnson, higher selling expenses in support of key products, and an unfavorable 2% foreign exchange impact.

•

The increase in 2007 was primarily due to an unfavorable impact of foreign exchange and higher marketing expenses, partially offset by lower sales force expenses.

•

The decrease in marketing, selling and administrative expenses as a percentage of net sales was the result of increased sales growth outpacing expenses which are being managed through PTI.

Advertising and product promotion

•

The increase in 2008 was primarily related to increased promotions for new indications of ABILIFY* in the U.S., increased promotion for ORENCIA, increased expenses in the international Mead Johnson business, and an unfavorable foreign exchange impact.

•

The increase in 2007 was primarily related to increased spending for direct-to-customer advertising for PLAVIX*, ABILIFY* and ORENCIA, expenses to support the launch of IXEMPRA, higher spending on newer products in Europe, and an unfavorable foreign exchange impact.

Research and development

•

The increase in 2008 was primarily related to increased licensing and upfront and milestone payments, increased spending for pipeline compounds, and an unfavorable foreign exchange impact. The 2008 increase was partially offset by sharing of codevelopment costs with alliance partners AstraZeneca and Pfizer.

•

The increase in 2007 was primarily attributed to continued investment in late-stage compounds and developing a pipeline in disease areas that address significant unmet medical needs, as well as increased upfront and milestone payments in 2007 when compared to 2006 as detailed below. The 2007 increase was partially offset by sharing of codevelopment costs with alliance partners AstraZeneca and Pfizer.

•

Upfront and milestone payments made in 2008 and expensed to research and development totaled $348 million and were paid primarily to Exelixis, PDL BioPharma, Inc., and KAI. The 2007 charges totaled $162 million and were paid to Exelixis, Pfizer, Adnexus and Isis. The 2006 charges totaled $70 million and were paid to Exelixis and Solvay Global.

•

Research and development expenses dedicated to BioPharmaceuticals products were 19.6%, 20.0% and 20.3% of BioPharmaceuticals net sales in 2008, 2007 and 2006, respectively.

Acquired in-process research and development

•

Acquired in-process research and development costs (IPRD) consisted of the estimated fair value of research and development acquired as part of an acquisition which, through December 31, 2008, were immediately expensed at the acquisition date.

•

The 2008 charge related to IPRD from the acquisition of Kosan whereas the 2007 charge related to IPRD obtained from the acquisition of Adnexus Therapeutics, Inc. (Adnexus).

Provision for restructuring, net

•

The increase in provision for restructuring, net was attributed to the timing of the implementation of PTI, which was announced in December 2007 and expanded in July 2008.

•

The increase in 2007 was attributed to the charges, primarily severance related, associated with the announcement of the PTI in December 2007. See “Financial Statements—Note 3. Restructuring.”

Litigation expense, net

•

Litigation expenses in 2006 related to reserves for the settlement in principle of certain pricing and sales investigations, partially offset by insurance recoveries from an unrelated matter and positive settlement of a litigation matter. For additional information on litigation matters, see “Financial Statements—Note 25. Legal Proceedings and Contingencies.”

F-18

Gain on sale of product lines and businesses

•

The gain in 2008 was primarily attributable to the sale of the mature brands businesses in Egypt.

•

The gain in 2007 was attributed to the sale of the BUFFERIN* and EXCEDRIN* brands in Japan, Asia (excluding China and Taiwan) and certain Oceanic countries, as well as certain assets related to U.S. dermatology products.

•

The gain in 2006 was attributed to the sale of inventory, patent and intellectual property rights related to DOVONEX*.

•

For additional information on these transactions, see “Financial Statements—Note 4. Acquisitions and Divestitures.”

Equity in net income of affiliates

•

Equity in net income of affiliates was principally related to the Company’s international joint venture with Sanofi. The increases in 2008 and 2007 are correlated with increases in international PLAVIX* sales. For additional information on equity in net income of affiliates, see “Financial Statements—Note 2. Alliances and Collaborations.”

Gain on sale of ImClone shares

•

The gain on sale of ImClone shares was attributed to the Company’s receipt of approximately $1.0 billion in cash for the tendering of its investment in ImClone. See “Financial Statements—Note 2. Alliances and Collaborations” for further detail.

Other expense, net

•

The components of other expense, net are as follows:


	Year Ended December 31,
Dollars in Millions	2008			2007			2006
Interest expense	$	310		$	422		$	498
Interest income		(130	)		(241	)		(274	)
ARS impairment charge		305			275			—
(Gain)/loss on debt buyback and termination of interest rate swap agreements		(57	)		—			220
Foreign exchange transaction (gains)/losses		(76	)		15			—
Other, net		(161	)		(120	)		(152	)

Other expense, net	$	191		$	351		$	292

•

Interest expense decreases in 2008 and 2007 were primarily due to decreases in interest rates.

•

Interest income relates primarily to interest earned on cash, cash equivalents and investments in marketable securities. The decrease in interest income in 2008 was primarily due to the change in mix in the Company’s short-term investment portfolio as well as a decrease in the rate of return on short-term investments, including U.S. Treasury Bills, when compared to the prior year.

•

ARS impairment charge was attributed to the Company’s auction rate securities (ARS). In addition, a $19 million loss on the sale of ARS in 2008 was recognized and is included in other, net. See “Financial Statements—Note 11. Cash, Cash Equivalents and Marketable Securities” for further detail.

•

The gain on debt buyback in 2008 is attributed to the repurchase of certain debt and the monetization of certain interest rate swaps due to the recent appreciation of value. See “Financial Statements —Note 18. Short-Term Borrowing and Long-Term Debt” for further information.

•

Foreign exchange transaction gains in 2008 were attributed to a strengthening U.S. dollar impact on non-qualifying foreign exchange hedges and on the re-measurement of non-functional currency denominated transactions when compared to the prior year.

•

Other, net includes income from third-party contract manufacturing, certain royalty income and expense, debt retirement costs, gains and losses on sale of property, plant and equipment, gains and losses on the sale of marketable securities, insurance recoveries, deferred income recognized, certain other litigation matters, ConvaTec and Medical Imaging net transitional service fees, amortization of certain upfront payments related to the Company’s alliances, proceeds from swap terminations, and pension curtailments. See “Financial Statements—Note 8. Other Expense, Net” for further information.

F-19

Specified Items

During the years ended December 31, 2008, 2007 and 2006, the following specified items affected the comparability of results for the periods presented herein. For a discussion of these items, see “Financial Statements—Note 2. Alliances and Collaborations;” “—Note 3. Restructuring;” “—Note 4. Acquisitions and Divestitures;” “—Note 9. Income Taxes;” “—Note 11. Cash, Cash Equivalents and Marketable Securities;” “—Note 18. Short-Term Borrowings and Long-Term Debt;” and “—Note 25. Legal Proceedings and Contingencies.” These specified items are excluded from the segment results. However, $223 million, $836 million, and $641 million of these amounts in 2008, 2007 and 2006, respectively, were related to the BioPharmaceuticals segment and the remaining amounts were related to the Mead Johnson segment.


Dollars in Millions *Year Ended December 31, 2008*	Cost of products sold		Marketing, selling and administrative		Research and development		Acquired in-process research and development		Provision for restructuring, net		Litigation expense, net		Gain on sale of product lines and businesses			Gain on sale of ImClone shares			Other expense, net			Total
Productivity Transformation Initiative:
Downsizing and streamlining of worldwide operations	$	—	$	—	$	—	$	—	$	189	$	—	$	—		$	—		$	—		$	189
Accelerated depreciation, asset impairment and other shutdown costs		213		—		—		—		20		—		—			—			8			241
Pension settlements/curtailments		9		—		—		—		—		—		—			—			8			17
Process standardization implementation costs		—		109		—		—		—		—		—			—			—			109
Gain on sale and leaseback of properties		—		—		—		—		—		—		—			—			(9	)		(9	)
Termination of lease contracts		—		—		—		—		9		—		—			—			6			15
Gain on sale of product lines and businesses		—		—		—		—		—		—		(159	)		—			—			(159	)

		222		109		—		—		218		—		(159	)		—			13			403
Other:
Litigation settlement		—		—		—		—		—		33		—			—			—			33
Insurance recovery		—		—		—		—		—		—		—			—			(20	)		(20	)
Mead Johnson charges		—		41		—		—		—		—		—			—			3			44
Product liability		—		—		—		—		—		—		—			—			18			18
Upfront and milestone payments and acquired in-process research and development		—		—		348		32		—		—		—			—			—			380
Asset impairment		27		—		13		—		—		—		—			—			—			40
ARS impairment charges and loss on sale		—		—		—		—		—		—		—			—			324			324
Debt buyback and swap terminations		—		—		—		—		—		—		—			—			(57	)		(57	)
Gain on sale of ImClone shares		—		—		—		—		—		—		—			(895	)		—			(895	)

	$	249	$	150	$	361	$	32	$	218	$	33	$	(159	)	$	(895	)	$	281			270


Income taxes on items above																							39

Decrease to Net Earnings from Continuing Operations																						$	309

F-20


Dollars in Millions *Year Ended December 31, 2007*	Cost of products sold		Marketing, selling and administrative		Research and development		Acquired in-process research and development		Provision for restructuring, net		Litigation expense, net		Gain on sale of product lines and businesses			Other expense, net			Total
Productivity Transformation Initiative:
Downsizing and streamlining of worldwide operations	$	—	$	—	$	—	$	—	$	139	$	—	$	—		$	6		$	145
Accelerated depreciation and asset impairment		102		8		—		—		—		—		—			—			110
Process standardization implementation costs		—		5		—		—		—		—		—			32			37

		102		13		—		—		139		—		—			38			292
Other:
Litigation settlement		—		—		—		—		—		14		—			—			14
Insurance recovery		—		—		—		—		—		—		—			(11	)		(11	)
Product liability		—		—		—		—		—		—		—			15			15
Upfront and milestone payments and acquired in-process research and development		—		—		162		230		—		—		—			—			392
ARS impairment charges		—		—		—		—		—		—		—			275			275
Downsizing and streamlining of worldwide operations		—		—		—		—		44		—		—			—			44
Accelerated depreciation, asset impairment and contract termination		77		—		—		—		—		—		—			23			100
Gain on sale of properties and product lines and businesses		—		—		—		—		—		—		(273	)		(9	)		(282	)

	$	179	$	13	$	162	$	230	$	183	$	14	$	(273	)	$	331			839

Income taxes on items above																				(33	)
Change in estimate for taxes on a prior year specified item																				(39	)

Decrease to Net Earnings from Continuing Operations																			$	767


Dollars in Millions *Year Ended December 31, 2006*	Cost of products sold		Marketing, selling and administrative		Research and development		Provision for restructuring, net		Litigation expense, net			Gain on sale of product lines and businesses			Other expense, net		Total
Litigation Matters:
Pharmaceutical pricing and sales litigation	$	—	$	—	$	—	$	—	$	353		$	—		$	—	$	353
Product liability		—		—		—		—		—			—			11		11
Claim for damages		—		—		—		—		—			—			13		13
Commercial litigations		—		—		—		—		(14	)		—			—		(14	)
Insurance recovery		—		—		—		—		(37	)		—			—		(37	)

		—		—		—		—		302			—			24		326
Other:
Debt retirement costs		—		—		—		—		—			—			220		220
Accelerated depreciation, asset impairment and contract termination		167		4		15		—		—			—			—		186
Upfront and milestone payments		—		—		70		—		—			—			—		70
Downsizing and streamlining of worldwide operations		—		—		—		59		—			—			—		59
Gain on sale of product lines and businesses		—		—		—		—		—			(200	)		—		(200	)

	$	167	$	4	$	85	$	59	$	302		$	(200	)	$	244		661

Income taxes on items above																		(149	)
Change in estimate for taxes on prior year specified items																		39

Decrease to Net Earnings from Continuing Operations																	$	551

F-21

Segment Results

Effective January 1, 2009, the Company changed its measurement of segment income for all periods presented. The following summarizes the most significant changes from the previously reported amounts:

•

Certain items that were previously excluded from segment results are now included, including among other items, costs attributed to certain corporate administrative functions and programs, stock-based compensation expense and net interest expense;

•

Certain specified items that were previously included in segment results are now excluded, including among other items, costs attributed to PTI, upfront milestone payments and acquired in-process research and development (see “—Specified Items” above); and

•

The pre-tax income attributable to noncontrolling interest is excluded from the segment results.

Reconciliation of segment results to earnings from continuing operations before income taxes for years ending December 31, 2008, 2007 and 2006 is as follows:


	Segment Results									% Change				% Segment Net Sales
Dollars in Millions	2008			2007			2006			2008 vs. 2007		2007 vs. 2006		2008		2007		2006
BioPharmaceuticals	$	3,581		$	2,234		$	1,469		60	%	52	%	20	%	14	%	11	%
Mead Johnson		692			659			649		5	%	2	%	24	%	26	%	28	%

Total segment results		4,273			2,893			2,118		48	%	37	%
Reconciliation of segment results to earnings from continuing operations before income taxes:
Specified items		(270	)		(839	)		(661	)
Noncontrolling interest—pre-tax		1,468			1,132			628		30	%	80	%

Earnings from continuing operations before income taxes	$	5,471		$	3,186		$	2,085		72	%	53	%	27	%	18	%	13	%

F-22

BioPharmaceuticals

Earnings increased in 2008 primarily due to increased sales of PLAVIX*, ABILIFY*, the HIV and hepatitis portfolio and ORENCIA. The increase in segment income as a percentage of segment net sales in 2008 was primarily due to similar factors discussed in the analysis of consolidated expenses. A more favorable product sales mix, higher average selling prices and realized manufacturing savings from PTI contributed to a reduction of costs of products sold as a percentage of net sales. The results of PTI also contributed to a reduction of marketing, selling and administrative expense as a percentage of net sales.

Earnings increased in 2007 primarily due to increased PLAVIX* sales and strong sales growth of other key products. The increase in segment income as a percentage of segment net sales in 2007 was similar to the reasons discussed above although to a lesser extent as PTI was beginning in 2007.

Mead Johnson

Earnings increased in 2008 primarily due to increased international net sales. These earnings were partially offset by higher dairy prices, advertising and promotion expenses and additional legal, accounting and consulting expenses incurred in preparation of the initial public offering. The decrease in segment income as a percentage of segment net sales in 2008 was primarily due to the growth rate for marketing, selling and administrative expenses, interest expense and research and development as well as a 2007 bad debt charge for a distributor insolvency exceeding the growth rate in net sales

Earnings increased in 2007 primarily due to growth of key products. The decrease in segment income as a percentage of segment net sales in 2007 was primarily due to higher dairy prices, unfavorable product mix and a bad debt charge for a distributor insolvency.

Income Taxes

The effective income tax rate on earnings from continuing operations before income taxes was 24.1% in 2008, compared with 21.4% in 2007 and 20.7% in 2006.

The increase in the 2008 effective tax rate from 2007 was primarily due to higher pre-tax income in the U.S., including the gain on sale of ImClone, and earnings mix in high tax jurisdictions in 2008. Partially off-setting these impacts were lower non-deductible charges in 2008 for acquired in-process research and development expenses and lower ARS impairment charges with little or no tax benefit. The tax rate in 2008 was favorably impacted by a benefit of $91 million of tax related to the final settlement of the 2002-2003 audit with the Internal Revenue Service.

The 2007 tax rate was unfavorably impacted by the impairment on the Company’s investment in certain ARS with little tax benefit and the non-deductible write-off of acquired in-process research and development expenses related to the acquisition of Adnexus, partially offset by a tax benefit of $105 million in the first quarter of 2007 due to the favorable resolution of certain tax matters with the Internal Revenue Service related to the deductibility of litigation settlement expenses and U.S foreign tax credits claimed. The effective tax rate for 2006 was unfavorably impacted by the elimination of tax benefits under Section 936 of the Internal Revenue Code, the treatment of provisions for a portion of certain litigation reserves as non-deductible, partially offset by favorable U.S. tax legislation enacted in 2006 related to the tax treatment of certain intercompany transactions amongst the Company’s foreign subsidiaries, and the implementation of tax planning strategies related to the utilization of certain charitable contributions.

The Company has recognized significant deferred tax assets at December 31, 2008 related to U.S. Federal foreign tax credit carryforwards of approximately $451 million and U.S. Federal research and development tax credit carryforwards of approximately $271 million. The U.S. Federal charitable contribution carryforwards were fully utilized during 2008 due to gains related to the ConvaTec and Medical Imaging divestitures, while the foreign tax credit and research and development tax credit carryforwards expire in varying amounts beginning in 2014. The foreign tax credit and research and development tax credit carryforwards have been reduced due to derecognition under FIN No. 48. The ConvaTec and Medical Imaging divestitures have resulted in a significant reduction to the foreign tax credit and research and development tax credit carryforwards in 2008. The realization of the foreign tax credit and research and development tax credit carryforwards is dependent on generating sufficient domestic-sourced taxable income prior to their expiration. Although realization is not assured, management believes it is more likely than not that these deferred tax assets will be realized.

F-23

Noncontrolling Interest

Noncontrolling interest is primarily related to the Company’s partnerships with Sanofi for the territory covering the Americas related to PLAVIX* sales. Increases of noncontrolling interest correspond to the increased sales of PLAVIX*.


Dollars in Millions	2008		2007		2006
Sanofi partnerships	$	1,444	$	1,106	$	609
Others - BioPharmaceuticals		17		19		12
Others – Mead Johnson		7		7		7

Noncontrolling interest—pre-tax		1,468		1,132		628
Income taxes		472		369		188

Noncontrolling interest—net of taxes	$	996	$	763	$	440

Financial Position, Liquidity and Capital Resources

The Company continues to maintain a sufficient level of working capital, which was approximately $8.1 billion at December 31, 2008 and $1.7 billion at December 31, 2007. In 2008 and future periods, the Company expects cash generated by its U.S. operations, together with existing cash, cash equivalents, marketable securities and borrowings from the capital markets, to be sufficient to cover cash needs for working capital, capital expenditures (which the Company expects to include investments in facilities to increase and maintain the Company’s capacity to provide biologics on a commercial scale), strategic alliances and acquisitions, milestone payments and dividends paid in the U.S. Cash and cash equivalents, marketable securities, the conversion of other working capital items and borrowings are expected to fund near-term operations outside the U.S.

In December 2006, the Company obtained a $2.0 billion five year revolving credit facility from a syndicate of lenders, which is extendable on the anniversary date with the consent of the lenders. This facility contains customary terms and conditions, including a financial covenant whereby the ratio of consolidated debt to consolidated capital cannot exceed 50% at the end of each quarter. The Company has been in compliance with this covenant since the inception of this new facility. There were no borrowings outstanding under the revolving credit facility at December 31, 2008.

On February 17, 2009, Mead Johnson entered into a three year syndicated revolving credit facility agreement. The credit facility is unsecured and provides for borrowings and letters of credit up to $410 million.

Net Financial Assets

Net financial asset position at December 31 was as follows:


Dollars in Millions	2008		2007
Financial assets:
Cash and cash equivalents	$	7,976	$	1,801
Marketable securities-current		289		424

Total financial assets		8,265		2,225

Debt:
Short-term borrowings, including current portion of long-term debt		154		1,891
Long-term debt		6,585		4,381

Total debt		6,739		6,272

Net cash/(debt)	$	1,526	$	(4,047	)

Net Cash/(Debt)

Net cash/(debt) position at December 31, 2008 improved due to proceeds of $4.6 billion from the divestiture of the ConvaTec and Medical Imaging businesses and proceeds of $1.0 billion from the sale of our ImClone shares. Cash generated from operating activities of $3.7 billion was more than adequate to fund dividend payments of $2.5 billion as well as capital expenditure payments of $941 million.

F-24

Investments

The following table summarizes the Company’s carrying value and related unrealized (loss)/gain position of its current and non-current marketable securities, which include U.S. dollar-denominated floating rate securities (FRS) and ARS, both of which are accounted for as “available for sale” debt securities. See “Financial Statements—Note 11. Cash, Cash Equivalents and Marketable Securities,” for further discussion on the Company FRS and ARS portfolio including the related cost basis and fair value for each investment.


	December 31, 2008					December 31, 2007
Dollars in Millions	Carrying Value		Unrealized (Loss)/Gain in Accumulated OCI			Carrying Value		Unrealized (Loss)/Gain in Accumulated OCI
Current:
Available for sale
Floating rate securities	$	109	$	(6	)	$	337	$	(25	)
U.S. Treasury Bills		180		1			—		—
Other		—		—			87		—

Total current	$	289	$	(5	)	$	424	$	(25	)


Non-current:
Available for sale
Auction rate securities	$	94	$	—		$	419	$	(117	)
Floating rate securities		94		(45	)		—		—

Total non-current	$	188	$	(45	)	$	419	$	(117	)

During 2008, the Company received $108 million of principal at par primarily on a FRS that matured in March 2008 and temporarily reduced the carrying value of the remaining FRS by $26 million to $203 million as an unrealized loss in accumulated other comprehensive income (OCI). In addition, during 2008 the Company reclassified $94 million of the remaining FRS with maturity dates beyond 2009 from current assets to non-current other assets due to liquidity concerns and the continued uncertainty in the capital markets.

During 2008, the Company received $118 million primarily in connection with the sale of ARS with a carrying value of $137 million, resulting in a loss of $19 million. In addition, a $305 million other-than-temporary impairment charge was recognized, including $117 million that was previously determined to be temporary at December 31, 2007. The 2008 impairment charge was required after an analysis of other-than-temporary impairment factors, including the severity and duration of the decline in value, future prospects of the issuer and the Company’s ability and intent to hold the securities to recovery. The ARS sold were securities generally backed by sub-prime mortgages, collateralized debt obligations and structured credit. The ARS remaining at December 31, 2008 represents interests in insurance securitizations and to a lesser extent, structured credit.

If uncertainties in the credit and capital markets continue, these markets deteriorate further or the Company experiences any additional ratings downgrades on any investments in its portfolio (including FRS and ARS), the Company may incur additional impairments to its investment portfolio, which could negatively affect the Company’s financial condition and reported earnings. The Company believes that, based on the Company’s current level of cash, cash equivalents and marketable securities and expected operating cash flows, the current lack of liquidity in the credit and capital markets will not have a material impact on the Company’s liquidity, cash flow, financial flexibility or its ability to fund its operations, including the dividend.

Credit Ratings

The Moody’s Investors Service (Moody’s) long-term and short-term credit ratings for the Company are currently A2 and Prime-1, respectively. Moody’s revised the long-term credit rating outlook to negative from stable. Standard & Poor’s (S&P) long-term and short-term credit ratings for the Company are currently A+ and A-1, respectively. S&P’s long-term credit rating remains on stable outlook. Fitch Ratings (Fitch) long-term and short-term credit ratings for the Company are currently A+ and F1, respectively. Fitch’s long-term credit rating remains on stable outlook.

F-25

Working Capital

The following is a discussion of working capital:


	December 31,
Dollars in Millions	2008		2007
Working capital	$	7,987	$	1,645

The increase in working capital of $6.3 billion from December 31, 2007 to December 31, 2008 was impacted by:

•

Proceeds from the sale of the ConvaTec business ($4.1 billion);

•

Proceeds from the sale of our ImClone shares ($1.0 billion); and

•

Proceeds from issuance of 6.125% Notes due 2038 ($1.0 billion) and 5.45% Notes due 2018 ($600 million).

Cash Flows

The following is a discussion of cash flow activities:


	Year Ended December 31,
Dollars in Millions	2008			2007			2006
Cash flow provided by/(used in):
Operating activities	$	3,707		$	3,153		$	2,083
Investing activities		5,079			(202	)		206
Financing activities		(2,582	)		(3,213	)		(3,351	)

Operating Activities

Cash flow from operating activities represents the cash receipts and cash disbursements related to all activities of the Company other than to investing activities and financing activities. Operating cash flow is derived by adjusting net earnings for:

•

Noncontrolling interest;

•

Non-cash operating items such as depreciation and amortization; impairment charges; stock-based compensation charges;

•

Gains and losses attributed to investing and financing activities such as gains and losses on the sale of product lines and businesses; and

•

Changes in operating assets and liabilities which reflect timing differences between the receipt and payment of cash associated with transactions and when they are recognized in results of operations.

The Company’s operating cash flow has grown consistently throughout the three years ended December 31, 2008 as the increases in net income, attributed to reasons noted throughout this MD&A, continue to directly impact operating cash flows. This is evident as the net income adjusted for non-cash operating items as well as gains and losses attributed to investing and financing activities amounted to $3.6 billion in 2008, $3.2 billion in 2007 and $2.5 billion in 2006. These amounts exclude the changes in operating assets and liabilities, discussed below.

The net impact of the changes in operating assets and liabilities, which are discussed in more detail below, include the impact of changes in receivables, inventories, deferred income, accounts payable, income taxes receivable/payable and other operating assets and liabilities. The Company continues to maximize its operating cash flows with its recently announced working capital initiative designed to continue to improve those working capital items that are most directly affected by changes in sales volume, such as accounts receivable, inventories and accounts payable.

In 2008, changes in operating assets resulted in a net cash inflow of $117 million which was impacted by:

•

Cash inflows from income tax payable/receivable ($371 million) which includes the impact of the receipt of a $432 million tax refund, including interest, related to a prior year foreign tax credit carryback claim;

•

Cash inflows from accounts payables ($253 million) which are primarily attributed to the timing of vendor and alliance payments;

•

Cash inflows from inventory ($130 million) which is primarily attributed to the utilization of inventories which were built up in the prior year for new product launches and strategic builds for existing products launches including for new indications of ABILIFY*;

•

Cash inflows from deferred income ($61 million) which are primarily due to receipt of upfront and milestone payments from alliance partners;

F-26

•

Cash outflows from other operating assets and liabilities ($338 million) which are primarily due to net litigation related payments made in the current period ($190 million) attributed to the settlement of certain pricing and sales litigation accrued in prior periods; pension funding in excess of current year expense ($120 million); and increase in non-current inventory ($112 million); and

•

Cash outflows from accounts receivables ($360 million) which are attributed to increased sales.

In 2007, changes in operating assets resulted in a net cash outflow of $7 million which was impacted by:

•

Cash outflows from accounts receivable ($458 million) which are primarily attributed to increased sales;

•

Cash outflows from U.S and foreign income taxes payable ($199 million) which are primarily attributed to tax payments which included settlement payments associated with various tax issues for the 2002-2003 IRS audit;

•

Cash inflows from deferred income ($454 million) which are primarily due to receipt of upfront and milestone payments from alliance partners including Pfizer and AstraZeneca;

•

Cash inflows from other operating assets and liabilities ($109 million) which are primarily due to increases in accrued royalties attributed to increased PLAVIX* sales; and increases in accrued salaries and bonuses due to the timing of payments; partially offset by cash outflows primarily related to litigation related payments ($318 million) for the settlement of pricing and sales litigation accrued in prior periods; and

•

Cash inflows from accounts payables ($141 million) which include the impact of increased purchases of raw materials for planned inventory buildup.

In 2006, changes in operating assets resulted in a net cash outflow of $464 million which was impacted by:

•

Cash outflows from other operating assets and liabilities ($410 million) which are primarily due to the pay down of accrued rebates and returns primarily resulting from exclusivity loss of PRAVACHOL, volume erosion on highly rebated PARAPLATIN and TAXOL and lower PLAVIX* volumes; and reduced royalties from lower PLAVIX* sales; Additions in the litigation settlement accrual related to the pricing and sales litigation settlements are primarily offset by net litigation related payments related to other matters accrued in prior years ($272 million);

•

Cash outflows from accounts payable ($349 million) which are primarily due to lower purchases of PRAVACHOL raw materials, due to the loss of PRAVACHOL exclusivity and a significant reduction of payables in early 2006 resulting from lower payment of invoices in December 2005; and

•

Cash inflows from accounts receivables ($281 million) are primarily due to lower PLAVIX* sales and the loss of exclusivity of PRAVACHOL.

Investing Activities

Net cash provided by investing activities was $5.1 billion in 2008 and included:

•

Proceeds from the divestiture of ConvaTec ($4.1 billion); Medical Imaging ($483 million); and mature brands business in Egypt ($209 million);

•

Proceeds from the tendering of the Company’s shares in ImClone ($1.0 billion);

•

Proceeds from the sale and leaseback of the Paris, France facility ($227 million);

•

Capital expenditures ($941 million) which included expenditures associated with the construction of the Company’s biologic facility in Devens, Massachusetts; and

•

Acquisition of Kosan ($191 million).

Net cash used in investing activities was $202 million in 2007 and included:

•

Capital expenditures ($843 million);

•

Acquisition of Adnexus ($432 million);

•

Net proceeds from the sale of marketable securities ($756 million); and

•

Proceeds from the sales of the BUFFERIN* and EXCEDRIN* brands in Japan, Asia (excluding China and Taiwan) and certain Oceanic countries and U.S. dermatology products ($273 million).

Net cash provided by investing activities was $206 million in 2006 and included:

•

Net proceeds from the sale of marketable securities ($762 million);

•

Proceeds from the disposal of properties in connection with sale and lease back of administrative facilities in New Jersey ($281 million);

•

Proceeds from the sale of various product assets primarily from the sale of several assets related to DOVONEX ($226 million);

F-27

•

Capital expenditures ($785 million); and

•

Milestone payments primarily related to ImClone ($280 million).

Financing Activities

Net cash used in financing activities was $2.6 billion in 2008 and included:

•

Dividend payments ($2.5 billion);

•

Redemption of Floating Rate Convertible Senior Debentures due 2023 ($1.2 billion);

•

Repayment of 4.00% Notes due August 2008 ($400 million) and 1.10% Yen Notes due 2008 ($117 million);

•

Repurchase of some of the Company’s Notes ($228 million);

•

Net proceeds from the issuance of 5.45% Notes due 2018 ($600 million) and 6.125% Notes due 2038 ($1.0 billion);

•

Net proceeds from the termination of interest rate swap agreements ($211 million); and

•

Net proceeds from stock option exercises in 2008 ($5 million) reflects the exercise of fewer stock options in 2008 due to the decrease in the average stock price when compared to the prior periods.

Net cash used in financing activities was $3.2 billion in 2007 and included:

•

Dividend payments ($2.2 billion);

•

Repayment of the floating rate bank facility ($1.3 billion); and

•

Proceeds from the exercise of stock options ($333 million).

Net cash used in financing activities was $3.4 billion in 2006 and included:

•

Debt payments associated with the early retirement of 5.75% Notes due 2011 ($2.5 billion) and floating rate bank facility ($1.2 billion);

•

Dividend payments ($2.2 billion); and

•

Proceeds from the issuance of 5.87% Notes due 2036 ($1.3 billion), and Euro Notes ($1.3 billion).

Dividends declared per common share were $1.24 for 2008, $1.15 for 2007 and $1.12 for 2006. In December 2008, the Company declared a quarterly dividend of $0.31 per common share and indicated a dividend for the full year 2009 of $1.24 per share. Dividend decisions are made on a quarterly basis by the Company’s Board of Directors.

Contractual Obligations

Payments due by period for the Company’s contractual obligations at December 31, 2008 were as follows:


	Obligations Expiring by Period
Dollars in Millions	Total		2009		2010		2011		2012		2013		Later Years
Short-term borrowings	$	154	$	154	$	—	$	—	$	—	$	—	$	—
Long-term debt ⁽¹⁾		5,737		—		45		—		—		647		5,045
Interest on long-term debt⁽²⁾		6,360		246		251		271		278		272		5,042
Operating leases		674		136		110		93		79		73		183
Purchase obligations		2,907		621		409		401		406		411		659
Stand-by letters of credit/performance guarantees		168		96		33		11		15		3		10
Uncertain tax positions⁽³⁾		120		120		—		—		—		—		—
Other long-term liabilities		381		—		120		57		34		25		145

Total⁽⁴⁾	$	16,501	$	1,373	$	968	$	833	$	812	$	1,431	$	11,084

⁽¹⁾	The current portion of long-term debt obligations is included in short-term borrowings on the Company’s consolidated balance sheet at December 31, 2008 and all balances approximate the outstanding nominal long-term debt values.

⁽²⁾

Includes estimated future interest payments on our short-term and long-term debt. Also includes accrued interest payable recorded on our consolidated balance sheets, which consists primarily of the accrual of interest on short-term and long-term debt as well as the accrual of periodic cash settlements of derivatives, netted by counterparty.

⁽³⁾	Due to the uncertainty related to the timing of the reversal of uncertain tax positions, only the short-term uncertain tax benefits have been provided in the table above.

⁽⁴⁾

The table above excludes future contributions by the Company to its pension, postretirement and postemployment benefit plans. Required contributions are contingent upon numerous factors including minimum regulatory funding requirements and the funded status of each plan. Due to the uncertainty of such future obligations, they are excluded from the table. Contributions for both U.S. and international plans are expected to be up to $690 million in 2009. See “Financial Statements—Note 24 Pension, Postretirement and Postemployment Benefits” for further detail.

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In addition to the above, the Company has committed to make approximately $3.0 billion potential future research and development milestone payments to third parties as part of in-licensing and development programs. Payments under these agreements generally become due and payable only upon achievement of certain developmental and regulatory milestones, for which the specific timing cannot be predicted. Because the achievement of these milestones is neither probable nor reasonably estimable, such contingencies have not been recorded on the Company’s consolidated balance sheets.

For a discussion of contractual obligations, see “Financial Statements—Note 18. Short-Term Borrowings and Long-Term Debt,” “—Note 21. Financial Instruments,” “—Note 23. Leases,” and “—Note 24. Pension, Postretirement and Postemployment Liabilities.”

SEC Consent Order

As previously disclosed, on August 4, 2004, the Company entered into a final settlement with the SEC, concluding an investigation concerning certain wholesaler inventory and accounting matters. The settlement was reached through a Consent, a copy of which was attached as Exhibit 10 to the Company’s quarterly report on Form 10-Q for the period ended September 30, 2004.

Under the terms of the Consent, the Company agreed, subject to certain defined exceptions, to limit sales of all products sold to its direct customers (including wholesalers, distributors, hospitals, retail outlets, pharmacies and government purchasers) based on expected demand or on amounts that do not exceed approximately one month of inventory on hand, without making a timely public disclosure of any change in practice. The Company also agreed in the Consent to certain measures that it has implemented including: (a) establishing a formal review and certification process of its annual and quarterly reports filed with the SEC; (b) establishing a business risk and disclosure group; (c) retaining an outside consultant to comprehensively study and help re-engineer the Company’s accounting and financial reporting processes; (d) publicly disclosing any sales incentives offered to direct customers for the purpose of inducing them to purchase products in excess of expected demand; and (e) ensuring that the Company’s budget process gives appropriate weight to inputs that come from the bottom to the top, and not just from the top to the bottom, and adequately documenting that process.

The Company has established a company-wide policy to limit its sales to direct customers for the purpose of complying with the Consent. This policy includes the adoption of various procedures to monitor and limit sales to direct customers in accordance with the terms of the Consent. These procedures include a governance process to escalate to appropriate management levels potential questions or concerns regarding compliance with the policy and timely resolution of such questions or concerns. In addition, compliance with the policy is monitored on a regular basis.

The Company maintains Inventory Management Agreements (IMAs) with most of its U.S. pharmaceutical wholesalers, which account for nearly 100% of total gross sales of U.S. BioPharmaceuticals products. Under the current terms of the IMAs, the Company’s three largest wholesaler customers provide the Company with weekly information with respect to months on hand product-level inventories and the amount of out-movement of products. These three wholesalers currently account for approximately 90% of total gross sales of U.S. BioPharmaceuticals products in 2008, 2007 and 2006. The inventory information received from these wholesalers, together with the Company’s internal information, is used to estimate months on hand product level inventories at these wholesalers. The Company estimates months on hand product inventory levels for its U.S. BioPharmaceuticals business’s wholesaler customers other than the three largest wholesalers by extrapolating from the months on hand calculated for the three largest wholesalers. In contrast, for the Company’s BioPharmaceuticals business outside of the U.S. and Mead Johnson business units around the world, the Company has significantly more direct customers, limited information on direct customer product level inventory and corresponding out-movement information and the reliability of third-party demand information, where available, varies widely. Accordingly, the Company relies on a variety of methods to estimate months on hand product level inventories for these business units.

The Company believes the above-described procedures provide a reasonable basis to ensure compliance with the Consent.

Recently Issued Accounting Standards

In 2008, the following new accounting pronouncements, critical to the Company’s financial statements, discussed in “Financial Statements—Note 1. Accounting Policies—Recently Issued Accounting Standards”, have been considered and evaluated for required application and their impact (except for SFAS No. 160, Noncontrolling interests in Consolidated Financial Statements – an amendment of ARB No.51, which has now been adopted):

•

EITF Issue No. 07-3, Accounting for Nonrefundable Advance Payments for Goods or Services Received for Use in Future Research and Development Activities

•

SFAS No. 159, The Fair Value Option for Financial Assets and Financial Liabilities

•

SFAS No. 157, Fair Value Measurements

•

SFAS No. 161, Disclosures about Derivative Instruments and Hedging Activities

•

EITF Issue No. 07-1, Accounting for Collaborative Arrangements Related to the Development and Commercialization of Intellectual Property

•

SFAS No. 160, Noncontrolling Interests in Consolidated Financial Statements—an amendment of ARB No. 51

•

SFAS No. 141(R), Business Combinations

F-29

Critical Accounting Policies

The Company prepares its financial statements in conformity with accounting principles generally accepted in the U.S. The preparation of financial statements in conformity with U.S. generally accepted accounting principles (GAAP) requires the use of estimates and assumptions that affect the reported amounts of assets and liabilities, including disclosure of contingent assets and contingent liabilities, at the date of the financial statements and the reported amounts of revenue and expenses during the reporting period. The Company’s critical accounting policies are those that are both most important to the Company’s financial condition and results of operations and require the most difficult, subjective or complex judgments on the part of management in their application, often as a result of the need to make estimates about the effect of matters that are inherently uncertain. Because of the uncertainty of factors surrounding the estimates or judgments used in the preparation of the consolidated financial statements, actual results may vary from these estimates.

The Company believes that the following discussion represents its critical accounting policies. Management has discussed the Company’s critical accounting policies with the Audit Committee of the Board of Directors.

Revenue Recognition

The Company recognizes revenue in accordance with Staff Accounting Bulletin (SAB) No. 101, Revenue Recognition in Financial Statements, as amended by SAB No. 104, Revenue Recognition. The Company’s accounting policy for revenue recognition has a substantial impact on its reported results and relies on certain estimates that require difficult, subjective and complex judgments on the part of management. The Company recognizes revenue (net of the gross-to-net sales adjustments discussed below, all of which involve significant estimates and judgments) when title and substantially all the risks and rewards of ownership have transferred to the customer, which generally occurs on the date of shipment.

In the case of new products for which the product introduction is not an extension of an existing line of product, where the Company determines that there are not products in a similar therapeutic category, or where the Company determines the new product has dissimilar characteristics with existing products, such that the Company cannot reliably estimate expected returns of the new product, the Company defers recognition of revenue until the right of return no longer exists or until the Company has developed sufficient historical experience to estimate sales returns.

For discussions on revenue recognition, see “Financial Statements—Note 1. Accounting Policies—Revenue Recognition and Sales Rebate and Return Accruals.”

Gross-to-Net Sales Adjustments

The Company has the following significant categories of gross-to-net sales adjustments: prime vendor charge-backs, WIC rebates, managed health care rebates and other contract discounts, Medicaid rebates, cash discounts, sales returns, and other adjustments, all of which involve significant estimates and judgments and require the Company to use information from external sources. The Company accounts for these gross-to-net sales adjustments in accordance with EITF Issue No. 01-9, Accounting for Consideration Given by a Vendor to a Customer (Including a Reseller of the Vendor’s Products), and SFAS No. 48, Revenue Recognition When Right of Return Exists, as applicable. See “—Net Sales” section above for a reconciliation of the Company’s gross sales to net sales by each significant category of gross-to-net sales adjustment.

Prime vendor charge-backs

The Company’s U.S. businesses participate in prime vendor programs with government entities, the most significant of which are the U.S. Department of Defense and the U.S. Department of Veterans Affairs, and other parties whereby pricing on products is extended below wholesaler list price to participating entities. These entities purchase products through wholesalers at the lower prime vendor price and the wholesalers charge the difference between their acquisition cost and the lower prime vendor price back to the Company. The Company accounts for prime vendor charge-backs by reducing accounts receivable in an amount equal to the Company’s estimate of charge-back claims attributable to a sale. The Company determines its estimate of the prime vendor charge-backs primarily based on historical experience regarding prime vendor charge-backs and current contract prices under the prime vendor programs. The Company considers prime vendor payments, levels of inventory in the distribution channel, and the Company’s claim processing time lag and adjusts the reduction to accounts receivable periodically throughout each quarter to reflect actual experience.

WIC rebates

The Company’s U.S. Mead Johnson business participates on a competitive bidding basis in nutrition programs sponsored by states, tribal governments, the Commonwealth of Puerto Rico and the U.S. territories for WIC. Under these programs, the Company reimburses these entities for the difference between wholesaler list price and the contract price on eligible products. The Company accounts for WIC rebates by establishing an accrual in an amount equal to the Company’s estimate of WIC rebate claims attributable to a sale. The Company determines its estimate of the WIC rebate accrual primarily based on historical experience regarding WIC rebates and current contract prices under the WIC programs. The Company considers levels of inventory in the distribution channel, new WIC contracts, terminated WIC contracts, changes in existing WIC contracts, and WIC participation and adjusts the accrual periodically throughout each quarter to reflect actual experience.

F-30

Managed health care rebates and other contract discounts

The Company offers rebates and discounts to managed health care organizations in the U.S. which manage prescription drug programs and Medicare Advantage prescription drug plans covering the Medicare Part D drug benefit in addition to their commercial plans, as well as globally to other contract counterparties such as hospitals and group purchasing organizations. In addition, the Company pays rebates under U.S. Department of Defense TRICARE Retail Pharmacy Refund Program. The Company accounts for managed health care rebates and other contract discounts by establishing an accrual in an amount equal to the Company’s estimate of managed health care rebates and other contract discounts attributable to a sale. The Company determines its estimate of the managed health care rebates and other contract discounts accrual primarily based on historical experience regarding these rebates and discounts and current contract prices. The Company considers the sales performance of products subject to managed health care rebates and other contract discounts and levels of inventory in the distribution channel and adjusts the accrual periodically throughout each quarter to reflect actual experience.

Medicaid rebates

The Company’s U.S. businesses participate in state government-managed Medicaid programs as well as certain other qualifying Federal and state government programs whereby discounts and rebates are provided to participating state and local government entities. Discounts and rebates provided through these latter programs are included in the Company’s Medicaid rebate accrual and are considered Medicaid rebates for the purposes of this discussion. The Company accounts for Medicaid rebates by establishing an accrual in an amount equal to the Company’s estimate of Medicaid rebate claims attributable to a sale. The Company determines its estimate of the Medicaid rebates accrual primarily based on historical experience regarding Medicaid rebates, as well as any expansion on a prospective basis of its participation in the non-mandatory aspects of the qualifying Federal and state government programs, legal interpretations of applicable laws related to Medicaid and qualifying Federal and state government programs, and any new information regarding changes in the Medicaid programs’ regulations and guidelines that would impact the amount of the rebates. The Company considers outstanding Medicaid claims, Medicaid payments, and levels of inventory in the distribution channel and adjusts the accrual periodically throughout each quarter to reflect actual experience.

Cash discounts

In the U.S. and certain other countries, the Company offers cash discounts, approximating 2% of the sales price, as an incentive for prompt payment. The Company accounts for cash discounts by reducing accounts receivable by the full amount of the discounts. The Company considers payment performance and adjusts the accrual to reflect actual experience.

Sales returns

The Company accounts for sales returns in accordance with SFAS No. 48, Revenue Recognition When Right of Return Exists, by establishing an accrual in an amount equal to the Company’s estimate of sales recorded for which the related products are expected to be returned. The provision for sales returns was $228 million in 2008, $155 million in 2007 and $224 million in 2006, which approximates 1% of gross sales for each of the three years.

For returns of established products, the Company determines its estimate of the sales return accrual primarily based on historical experience regarding sales returns, but also considers other factors that could impact sales returns. These factors include levels of inventory in the distribution channel, estimated shelf life, product recalls, product discontinuances, price changes of competitive products, introductions of generic products and introductions of competitive new products. The Company considers all of these factors and adjusts the accrual periodically throughout each quarter to reflect actual experience.

In the event of a product recall or product discontinuance, the Company considers the reasons for and impact of such actions and adjusts the sales return accrual as appropriate, taking into account historical experience, estimated levels of inventory in the distribution channel and, for product discontinuances, estimates of continuing demand.

Sales returns accruals from new products are estimated and primarily based on the historical sales returns experience of similar products, such as those within the same line of product or those within the same or similar therapeutic category. In limited circumstances, where the new product is not an extension of an existing line of product or where the Company has no historical experience with products in a similar therapeutic category, such that the Company cannot reliably estimate expected returns of the new product, the Company defers recognition of revenue until the right of return no longer exists or until the Company has developed sufficient historical experience to estimate sales returns. The Company also considers the shelf life of new products and determines whether it believes an adjustment to the sales return accrual is appropriate. The shelf life in connection with new products tends to be shorter than the shelf life for more established products because the Company may still be developing an optimal manufacturing process for the new product that would lengthen its shelf life. In addition, higher launch quantities may have been manufactured in advance of the launch date to ensure sufficient supply exists to satisfy market demand. In those cases, the Company assesses the reduced shelf life, together with estimated levels of inventory in the distribution channel and projected demand, and determines whether it believes an adjustment to the sales return accrual is appropriate.

F-31

Other adjustments

In addition to the gross-to-net sales adjustments described above, the Company makes other gross-to-net sales adjustments. For example, the Company offers sales discounts, most significantly in its non-U.S. businesses, and also offers consumer coupons and rebates, most significantly in its U.S. Mead Johnson and BioPharmaceuticals businesses. In addition, in a number of countries outside the U.S., including certain major European countries, the Company provides rebates to government entities. The Company generally accounts for these other gross-to-net adjustments by establishing an accrual in an amount equal to the Company’s estimate of the adjustments attributable to a sale. The Company generally determines its estimates of the accruals for these other gross-to-net sales adjustments primarily based on historical experience, performance on commitments to government entities and other relevant factors, including estimated levels of inventory in the distribution channel, and adjusts the accruals periodically throughout each quarter to reflect actual experience.

Use of information from external sources

The Company uses information from external sources to estimate its gross-to-net sales adjustments. The Company’s estimates of inventory at the wholesalers are based on the projected prescription demand-based sales for its products and historical inventory experience, as well as the Company’s analysis of third-party information, including written and oral information obtained from certain wholesalers with respect to their inventory levels and sell-through to customers and third-party market research data, and the Company’s internal information. The inventory information received from wholesalers is a product of their recordkeeping process and excludes inventory held by intermediaries to whom they sell, such as retailers and hospitals. The Company receives information from IMS, a supplier of market research to the pharmaceutical industry, which it uses to project the prescription demand-based sales for many of its U.S. BioPharmaceuticals products. In 2007, IMS refined and improved its NGPS projection methodology and fully rolled out NGPS Version 2.0 of the National Prescription Audit to all subscribers, which resulted in newly revised volume estimates for historic time periods. Therefore, since the first quarter of 2007, the Company has used the new IMS standard NGPS Version 2.0 projection methodology and has applied NGPS Version 2.0 data for reporting prescription growth and market shares to all periods presented in the Annual Report on Form 10-K. The Company has also continued the practice of combining retail and mail prescription volume on a retail-equivalent basis. The Company uses this methodology for its internal demand forecasts. The Company also uses information from external sources to identify prescription trends, patient demand and average selling prices. The Company’s estimates are subject to inherent limitations of estimates that rely on third-party information, as certain third-party information was itself in the form of estimates, and reflect other limitations including lags between the date as of which third-party information is generated and the date on which the Company receives third-party information.

Retirement Benefits

The Company’s pension plans and postretirement benefit plans are accounted for using actuarial valuations. Management is required to make significant subjective judgments about a number of actuarial assumptions, including discount rates, salary growth, long-term return on plan assets, retirement, turnover, health care cost trend rates, and mortality rates. Depending on the assumptions and estimates used, the pension and postretirement benefit expense could vary within a range of outcomes and have a material effect on reported earnings. In addition, the assumptions can materially affect projected benefit obligations and future cash funding.

The Company adopted SFAS No. 158, Employers’ Accounting for Defined Benefit Pension and Other Postretirement Plans—an amendment of FASB Statements No. 87, 88, 106, and 132(R), in the year ended December 31, 2006 and the adoption of this accounting pronouncement resulted in a $1.1 billion reduction of accumulated other comprehensive income in stockholders’ equity, a $767 million reduction in total assets and a $297 million increase in total liabilities. The adoption of SFAS No. 158 did not impact the Company’s results of operations or cash flows.

The Company’s key assumptions used in calculating its cost of pension benefits are the discount rate, the rate of compensation increase, and the expected long-term rate of return on plan assets. The Company, in consultation with its actuaries, evaluates the key actuarial assumptions and other assumptions used in calculating its cost of pension benefits, such as retirement, turnover and mortality rates, based on expectations or actual experience, as appropriate, and determines such assumptions on December 31 of each year to calculate liability information as of that date and pension expense for the following year. Depending on the assumptions used, the pension expense could vary within a range of outcomes and have a material effect on reported earnings. In addition, the assumptions can materially affect projected benefit obligations and future cash funding. Actual results in any given year may differ from those estimated because of economic and other factors.

In determining the discount rate, the Company uses the yield on high quality corporate bonds that coincides with the cash flows of its plans’ estimated payouts. The Citigroup Above Median yield curve is used in determining the discount rate for the U.S. plans. The assumed rate of compensation increase used by the Company for determining future pension obligations reflects an estimate of the change in actual future compensation levels due to general price levels, productivity, seniority and other factors.

F-32

The U.S. plans’ pension expense for 2008 was determined using a 6.75% assumed discount rate and a 3.56% assumed rate of compensation increase. The present value of benefit obligations at December 31, 2008 for the U.S. plans was determined using a 6.5% assumed discount rate and a 3.56% assumed rate of compensation increase. If the assumed discount rate used in determining the U.S. plans’ pension expense for 2008 had been reduced by 0.25%, such expense would have increased by approximately $17 million. If the assumed rate of compensation increase used in determining the U.S. plans’ pension expense for 2008 had been reduced by 0.25%, such expense would have decreased by approximately $9 million. If the assumed discount rate used in determining the projected benefit obligation at December 31, 2008 had been reduced by 0.25%, the projected benefit obligation would have increased by $126 million.

In determining the expected long-term rate of return on plan assets, the Company estimates returns for individual asset classes with input from external advisors. The Company also considers long-term historical returns including actual performance compared to benchmarks for similar investments.

The U.S. plans’ pension expense for 2008 was determined using an 8.75% expected long-term rate of return on plan assets. If the expected long-term rate of return on plan assets used in determining the U.S. plans’ pension expense for 2008 had been reduced by 1%, such expense would have increased by $43 million.

For a more detailed discussion on retirement benefits, see “Financial Statements—Note 24. Pension, Postretirement and Postemployment Liabilities.”

Acquisitions

The Company’s consolidated financial statements and results of operations reflect an acquired business after the completion of the acquisition. Acquired businesses are accounted for using the purchase method of accounting, which requires that the purchase price be allocated to the net assets acquired at their respective fair values. Any excess of the purchase price over the estimated fair values of the net assets acquired is recorded as goodwill. Amounts allocated to acquired IPRD are expensed at the date of acquisition.

The judgments made in determining the estimated fair value assigned to each class of assets acquired and liabilities assumed, as well as asset lives, can materially impact our results of operations.

There are several methods that can be used to determine the fair value of assets acquired and liabilities assumed. For intangible assets, including IPRD, we typically use the “income method.” This method starts with our forecast of all of the expected future net cash flows. These cash flows are then adjusted to present value by applying an appropriate discount rate that reflects the risk factors associated with the cash flow streams. Some of the more significant estimates and assumptions inherent in the income method or other methods include: the amount and timing of projected future cash flows; the amount and timing of projected costs to develop the IPRD into commercially viable products; the discount rate selected to measure the risks inherent in the future cash flows; and the assessment of the asset’s life cycle and the competitive trends impacting the asset, including consideration of any technical, legal, regulatory, or economic barriers to entry, as well as expected changes in standards of practice for indications addressed by the asset.

Determining the useful life of an intangible asset also requires judgment, as different types of intangible assets will have different useful lives. For example, the useful life of the right associated with a pharmaceutical product’s exclusive patent will be finite and will result in amortization expense being recognized in the results of operations over a determinable period.

For a more detailed discussion on acquired in-process research and development, see “Financial Statements—Note 1. Accounting Policies—Acquired In-Process Research and Development.”

Impairment of Long-Lived Assets

The Company periodically evaluates whether current facts or circumstances indicate that the carrying value of its depreciable assets to be held and used may not be recoverable. If such circumstances are determined to exist, an estimate of undiscounted future cash flows produced by the long-lived asset, or the appropriate grouping of assets, is compared to the carrying value to determine whether impairment exists. If an asset is determined to be impaired, the loss is measured based on the difference between the asset’s fair value and its carrying value. An estimate of the asset’s fair value is based on quoted market prices in active markets, if available. If quoted market prices are not available, the estimate of fair value is based on various valuation techniques, including a discounted value of estimated future cash flows. The Company reports an asset to be disposed of at the lower of its carrying value or its estimated net realizable value.

Goodwill is tested at least annually for impairment using a two-step process. The first step is to identify a potential impairment, and the second step measures the amount of the impairment loss, if any. Goodwill is deemed to be impaired if the carrying amount of a reporting unit’s goodwill exceeds its estimated fair value. All other long-lived assets are tested for impairment using a one-step process, which consists of a comparison of the fair value to the carrying value of the asset. Such assets are deemed to be impaired if their net book value exceeds their estimated fair value.

F-33

The estimates of future cash flows, based on reasonable and supportable assumptions and projections, require management’s judgment. Any changes in key assumptions about the Company’s businesses and their prospects, or changes in market conditions, could result in an impairment charge.

Impairment charges of long-lived assets were $63 million in 2008, $104 million in 2007 and $120 million in 2006. For discussions on impairment of long-lived assets, see “Financial Statements—Note 1. Accounting Policies—Impairment of Long-Lived Assets” and “—Goodwill and Other Intangible Assets.”

Equity Investments

The Company reviews its equity investments for impairment based on its determination of whether the decline in market value of the investment below the Company’s carrying value is other than temporary. In making this determination, the Company considers APB Opinion No. 18, The Equity Method of Accounting for Investments in Common Stock and related interpretations, which set forth factors to be evaluated in determining whether a loss in value should be recognized, including the Company’s ability to hold its investment, the market price and market price fluctuations of the investment’s publicly traded shares and inability of the investee to sustain an earnings capacity, which would justify the carrying amount of the investment. The Company’s previous investment in ImClone was subject to this accounting. For a discussion of the Company’s investment in ImClone, see “Financial Statements—Note 2. Alliances and Collaborations.”

For discussions on equity investments, see “Financial Statements—Note 1. Accounting Policies—Investments” and “—Note 2. Alliances and Collaborations.”

Marketable Securities

The Company’s marketable securities at December 31, 2008 consisted of U.S. Treasury Bills, FRS and ARS.

Due to the lack of availability of observable market quotes on the Company’s investment portfolio of FRS and ARS, the Company utilizes valuation models including those that are based on expected cash flow streams and collateral values, including assessments of counterparty credit quality, default risk underlying the security, discount rates and overall capital market liquidity. The valuation is subject to uncertainties that are difficult to predict. Factors that may impact the Company’s valuation include changes to credit ratings of the securities as well as to the underlying assets supporting those securities, rates of default of the underlying assets, underlying collateral value, discount rates, counterparty risk and ongoing strength and quality of market credit and liquidity.

A considerable amount of judgment and estimation is applied in the valuation of FRS and ARS. In addition, the Company also applies judgment in determining whether the marketable securities are other-than-temporarily impaired. The Company typically considers the severity and duration of the decline, future prospects of the issuer and the Company’s ability and intent to hold the security to recovery.

Other-than-temporary impairment charges related to ARS were $305 million and $275 million in 2008 and 2007, respectively. The carrying value of ARS was $94 million at December 31, 2008.

The credit and capital markets have continued to deteriorate in 2009. If uncertainties in these markets continue, these markets deteriorate further or the Company experiences any additional ratings downgrades on any investments in its portfolio (including on ARS), the Company may incur additional impairment charges.

For discussions on marketable securities, FRS and ARS, see “Financial Statements—Note 10. Fair Value Measurement” and “—Note 11. Cash, Cash Equivalents and Marketable Securities.”

Restructuring

To streamline operations and rationalize manufacturing facilities, the Company has periodically recorded restructuring charges. As a result, the Company has made estimates and judgments regarding its future plans, including future termination benefits and other exit costs to be incurred when the restructuring actions take place. Actual results could vary from these estimates. Adjustments to reflect changes in estimates for restructuring actions taken in prior periods resulted in an increase of $1 million in 2008, and a reduction of $6 million in 2007 and $14 million in 2006.

For discussions on restructuring, see “Financial Statements—Note 1. Accounting Policies—Restructuring” and “—Note 3. Restructuring.”

Contingencies

In the normal course of business, the Company is subject to contingencies, such as legal proceedings and claims arising out of its business, that cover a wide range of matters, including, among others, government investigations, shareholder lawsuits, product and environmental liability. In accordance with SFAS No. 5, Accounting for Contingencies, the Company records accruals for such contingencies when it is probable that a liability will be incurred and the amount of the loss can be reasonably estimated. These estimates are subject to uncertainties that are difficult to predict and, as such, actual results could vary from these estimates.

F-34

For discussions on contingencies, see “Financial Statements—Note 1. Accounting Policies—Contingencies,” “—Note 9. Income Taxes” and “—Note 25. Legal Proceedings and Contingencies.”

Income Taxes

The provision for income taxes has been determined using the asset and liability approach of accounting for income taxes. Under this approach, deferred taxes represent the future tax consequences expected to occur when the reported amounts of assets and liabilities are recovered or paid. The provision for income taxes represents income taxes paid or payable for the current year plus the change in deferred taxes during the year. Deferred taxes result from differences between the financial and tax bases of the Company’s assets and liabilities and are adjusted for changes in tax rates and tax laws when changes are enacted. Valuation allowances are recorded to reduce deferred tax assets when it is more likely than not that a tax benefit will not be realized. The assessment of whether or not a valuation allowance is required often requires significant judgment including the long-range forecast of future taxable income and the evaluation of tax planning initiatives. Adjustments to the deferred tax valuation allowances are made to earnings in the period when such assessments are made. The Company had net deferred tax assets of $2.8 billion and $3.5 billion at December 31, 2008 and 2007, respectively, net of valuation allowances of $1.8 billion and $2.0 billion.

The Company establishes liabilities for possible assessments by tax authorities resulting from known tax exposures including, but not limited to, transfer pricing matters, tax credits and deductibility of certain expenses. Such liabilities represent a reasonable provision for taxes ultimately expected to be paid and may need to be adjusted over time as more information becomes known.

For discussions on income taxes, see “Financial Statements—Note 1. Accounting Policies—Income Taxes” and “—Note 9. Income Taxes.”

Special Note Regarding Forward-Looking Statements

This annual report and other written and oral statements the Company makes from time to time contain certain “forward-looking” statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. You can identify these forward-looking statements by the fact they use words such as “should”, “expect”, “anticipate”, “estimate”, “target”, “may”, “project”, “guidance”, “intend”, “plan”, “believe” and other words and terms of similar meaning and expression in connection with any discussion of future operating or financial performance. One can also identify forward-looking statements by the fact that they do not relate strictly to historical or current facts. Such forward-looking statements are based on current expectations and involve inherent risks and uncertainties, including factors that could delay, divert or change any of them, and could cause actual outcomes to differ materially from current expectations. These statements are likely to relate to, among other things, the Company’s goals, plans and projections regarding its financial position, results of operations, cash flows, market position, product development, product approvals, sales efforts, expenses, performance or results of current and anticipated products and the outcome of contingencies such as legal proceedings, and financial results, which are based on current expectations that involve inherent risks and uncertainties, including internal or external factors that could delay, divert or change any of them in the next several years. The Company has included important factors in the cautionary statements included in reports, previously filed with the Securities and Exchange Commission, that the Company believes could cause actual results to differ materially from any forward-looking statement.

Although the Company believes it has been prudent in its plans and assumptions, no assurance can be given that any goal or plan set forth in forward-looking statements can be achieved and readers are cautioned not to place undue reliance on such statements, which speak only as of the date made. The Company undertakes no obligation to release publicly any revisions to forward-looking statements as a result of new information, future events or otherwise.

F-35

QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK.

The Company is exposed to market risk due to changes in currency exchange rates, interest rates and to a lesser extent natural gas pricing. To reduce that risk, the Company enters into certain derivative financial instruments, when available on a cost-effective basis, to hedge its underlying economic exposure. The Company’s primary net foreign currency translation exposures are the euro, Japanese yen, Canadian dollar, Chinese renminbi, and Mexican peso. To manage these exposures, the Company utilizes foreign currency contracts, which are subject to cash flow hedge accounting treatment. These instruments are managed on a consolidated basis to efficiently net exposures and thus take advantage of any natural offsets.

The Company also uses derivative instruments as part of its interest rate risk management strategy. The derivative instruments used are comprised principally of fixed-to-floating rate interest swaps, which are subject to fair-value hedge accounting treatment. In addition, all of the Company’s financial instruments, including derivatives, are subject to counterparty credit risk which the Company considers as part of the overall fair value measurement. Derivative financial instruments are not used for speculative purposes.

Foreign Exchange Risk

A significant portion of the Company’s revenues and earnings is exposed to changes in foreign currency rates. In addition, the Company is exposed to foreign exchange transaction risk that arises from non-functional currency denominated assets and liabilities. In order to manage this risk, the Company uses foreign exchange forward contracts to offset its exposure to certain assets and liabilities and earnings denominated in certain foreign currencies. These foreign exchange forward contracts are not designated as hedges and, therefore, changes in the fair value of these derivatives are recognized in earnings in other expense, net, as they occur. In addition, the Company utilizes foreign currency contracts to manage foreign exchange risk that primarily arises from certain intercompany transactions and designates these derivative instruments as foreign currency cash flow hedges when appropriate.

The notional amounts of the Company’s foreign exchange derivative contracts were $1.2 billion and $1.7 billion at December 31, 2008 and 2007, respectively. For these derivatives, in which the majority qualify as hedges of future anticipated cash flows, the effective portion of changes in fair value is temporarily deferred in accumulated OCI and then recognized in earnings when the hedged item affects earnings. The Company estimates that a 10% appreciation or depreciation in the underlying currencies being hedged from their levels against the U.S. dollar at December 31, 2008, with all other variables held constant, would decrease by $119 million or increase by $109 million, respectively, the fair value of foreign exchange forward contracts held at December 31, 2008.

The Company is also exposed to translation risk on its non-U.S. dollar-denominated net assets. In order to manage this risk the Company uses non-U.S. dollar borrowings, primarily the €500 Million Notes due 2016 and the €500 Million Notes due 2021, to hedge the foreign currency exposures of the Company’s net investment in certain foreign affiliates. These non-U.S. dollar borrowings are designated as hedges of net investments. The effective portion of foreign exchange gains or losses on these hedges is recorded as part of the foreign currency translation component of accumulated OCI.

For additional information, see “Financial Statements—Note 21. Financial Instruments.”

Interest Rate Risk

The Company uses interest rate swaps as part of its interest rate risk management strategy. The interest rate swaps used are principally fixed-to-floating rate swaps, which are designated as fair-value hedges. SFAS No. 133, Accounting for Derivative Instruments and Hedging Activities, requires interest rate swaps that qualify for fair-value hedge accounting, as well as the underlying debt, to be reported at fair value. As such, the swaps and the underlying debt have been revalued resulting in a $647 million increase to non-current other assets and long-term debt at December 31, 2008. Swaps are generally held to maturity and intended to create an appropriate balance of fixed and floating rate debt for the Company. The Company estimates that an increase or decrease of 100 basis points in short-term or long-term interest rates would decrease or increase the fair value of the Company’s interest rate swaps by $455 million, excluding the effects of counterparty credit risk.

For additional information, see “Financial Statements—Note 10. Fair Value Measurements,” “—Note 11. Cash, Cash Equivalents and Marketable Securities,” “—Note 18. Short-Term Borrowings and Long-Term Debt” and “—Note 21. Financial Instruments.”

F-36

MANAGEMENT’S REPORT ON INTERNAL CONTROL OVER FINANCIAL REPORTING

Management is responsible for establishing and maintaining adequate internal control over financial reporting. Under the supervision and with the participation of management, including the chief executive officer and chief financial officer, management assessed the effectiveness of internal control over financial reporting as of December 31, 2008 based on the framework in “Internal Control—Integrated Framework” issued by the Committee of Sponsoring Organizations of the Treadway Commission. Based on that assessment, management has concluded that the Company’s internal control over financial reporting was effective at December 31, 2008 to provide reasonable assurance regarding the reliability of its financial reporting and the preparation of its financial statements for external purposes in accordance with United States generally accepted accounting principles. Due to its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.

Deloitte & Touche LLP, an independent registered public accounting firm, has audited the Company’s financial statements included in this report and issued its February 20, 2009 report on the effectiveness of the Company’s internal control over financial reporting as of December 31, 2008, which is included herein.


James M. Cornelius		Jean-Marc Huet
Chief Executive Officer		Chief Financial Officer

F-37

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

To the Board of Directors and Stockholders of

Bristol-Myers Squibb Company

We have audited the accompanying consolidated balance sheets of Bristol-Myers Squibb Company and subsidiaries (the “Company”) as of December 31, 2008 and 2007, and the related consolidated statements of earnings, comprehensive income and retained earnings, and cash flows for each of the three years in the period ended December 31, 2008. Our audits also included the financial statement schedule listed in the Index at Item 15 of the Company’s Form 10-K filed on February 20, 2009. These financial statements and financial statement schedule are the responsibility of the Company’s management. Our responsibility is to express an opinion on the financial statements and financial statement schedule based on our audits.

We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.

In our opinion, such consolidated financial statements present fairly, in all material respects, the financial position of Bristol-Myers Squibb Company and subsidiaries as of December 31, 2008 and 2007, and the results of their operations and their cash flows for each of the three years in the period ended December 31, 2008, in conformity with accounting principles generally accepted in the United States of America. Also, in our opinion, such financial statement schedule, when considered in relation to the basic consolidated financial statements taken as a whole, presents fairly, in all material respects, the information set forth therein.

As discussed in Note 1 to the consolidated financial statements, on January 1, 2009 the Company adopted Statement of Financial Accounting Standards (“SFAS”) No. 160, Noncontrolling Interests in Consolidated Financial Statements – an amendment of ARB No. 51, and retrospectively adjusted all periods presented in the consolidated financial statements for the change. Additionally, as discussed in Notes 1, 9 and 24 to the consolidated financial statements, the Company adopted Financial Accounting Standards Board Interpretation (“FIN”) No. 48, Accounting for Uncertainty in Income Taxes – an interpretation of FASB Statement No. 109, effective January 1, 2007, and SFAS No. 158, Employers’ Accounting for Defined Benefit Pension and Other Postretirement Plans – an Amendment of FASB Statements No. 87, 88, 106, and 132(R), effective December 31, 2006.

We have also audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), the Company’s internal control over financial reporting as of December 31, 2008, based on the criteria established in Internal Control—Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission and our report dated February 20, 2009 expressed an unqualified opinion on the Company’s internal control over financial reporting.

DELOITTE & TOUCHE LLP

Parsippany, New Jersey

February 20, 2009

(April 28, 2009 as to the effects of the retrospective adoption of SFAS No. 160, Noncontrolling Interests in Consolidated Financial Statements – an amendment of ARB No. 51, as disclosed in Notes 1, 7, 12, and 19, and of the retroactive effect of the new measurement of segment income and reconciliation to pre-tax income as disclosed in Notes 3 and 22)

F-38

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

To the Board of Directors and Stockholders of

Bristol-Myers Squibb Company

We have audited the internal control over financial reporting of Bristol-Myers Squibb Company and subsidiaries (the “Company”) as of December 31, 2008, based on criteria established in Internal Control — Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission. The Company’s management is responsible for maintaining effective internal control over financial reporting and for its assessment of the effectiveness of internal control over financial reporting, included in the accompanying Management’s Report on Internal Control Over Financial Reporting. Our responsibility is to express an opinion on the Company’s internal control over financial reporting based on our audit.

We conducted our audit in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether effective internal control over financial reporting was maintained in all material respects. Our audit included obtaining an understanding of internal control over financial reporting, assessing the risk that a material weakness exists, testing and evaluating the design and operating effectiveness of internal control based on the assessed risk, and performing such other procedures as we considered necessary in the circumstances. We believe that our audit provides a reasonable basis for our opinion.

A company’s internal control over financial reporting is a process designed by, or under the supervision of, the company’s principal executive and principal financial officers, or persons performing similar functions, and effected by the company’s board of directors, management, and other personnel to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A company’s internal control over financial reporting includes those policies and procedures that (1) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the assets of the company; (2) provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the company are being made only in accordance with authorizations of management and directors of the company; and (3) provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use, or disposition of the company’s assets that could have a material effect on the financial statements.

Because of the inherent limitations of internal control over financial reporting, including the possibility of collusion or improper management override of controls, material misstatements due to error or fraud may not be prevented or detected on a timely basis. Also, projections of any evaluation of the effectiveness of the internal control over financial reporting to future periods are subject to the risk that the controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.

In our opinion, the Company maintained, in all material respects, effective internal control over financial reporting as of December 31, 2008, based on the criteria established in Internal Control — Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission.

We have also audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), the consolidated financial statements and financial statement schedule as of and for the year ended December 31, 2008 of the Company and our report dated February 20, 2009 expressed an unqualified opinion on those financial statements and financial statement schedule.

DELOITTE & TOUCHE LLP

Parsippany, New Jersey

February 20, 2009

F-39

BRISTOL-MYERS SQUIBB COMPANY

CONSOLIDATED STATEMENTS OF EARNINGS

Dollars and Shares in Millions, Except Per Share Data


	Year Ended December 31,
	2008			2007			2006
EARNINGS
Net Sales	$	20,597		$	18,193		$	16,208

Costs of products sold		6,396			5,868			5,420
Marketing, selling and administrative		4,792			4,516			4,469
Advertising and product promotion		1,550			1,415			1,304
Research and development		3,585			3,227			2,951
Acquired in-process research and development		32			230			—
Provision for restructuring, net		218			183			59
Litigation expense, net		33			14			302
Gain on sale of product lines and businesses		(159	)		(273	)		(200	)
Equity in net income of affiliates		(617	)		(524	)		(474	)
Gain on sale of ImClone shares		(895	)		—			—
Other expense, net		191			351			292

Total Expenses, net		15,126			15,007			14,123


Earnings from Continuing Operations Before Income Taxes		5,471			3,186			2,085
Provision for income taxes		1,320			682			431

Net Earnings from Continuing Operations		4,151			2,504			1,654


Discontinued Operations:
Earnings, net of taxes		113			424			371
Gain on Disposal, net of taxes		1,979			—			—

Net Earnings from Discontinued Operations		2,092			424			371

Net Earnings		6,243			2,928			2,025


Net Earnings Attributable to Noncontrolling Interest		996			763			440

Net Earnings Attributable to Shareholders	$	5,247		$	2,165		$	1,585


Earnings from Continuing Operations Attributable to Shareholders per Common Share:
Basic	$	1.60		$	0.88		$	0.62
Diluted	$	1.59		$	0.88		$	0.62

Earnings Attributable to Shareholders per Common Share:
Basic	$	2.65		$	1.10		$	0.81
Diluted	$	2.63		$	1.09		$	0.81

Average Common Shares Outstanding:
Basic		1,977			1,970			1,960
Diluted		2,001			1,980			1,963

Dividends declared per common share	$	1.24		$	1.15		$	1.12

The accompanying notes are an integral part of these financial statements.

F-40

BRISTOL-MYERS SQUIBB COMPANY

CONSOLIDATED STATEMENTS OF COMPREHENSIVE

INCOME AND RETAINED EARNINGS

Dollars in Millions


	Year Ended December 31,
	2008			2007			2006
COMPREHENSIVE INCOME

Net Earnings	$	6,243		$	2,928		$	2,025

Other Comprehensive Income/(Loss)
Foreign currency translation		(123	)		240			159
Foreign currency translation reclassified to net earnings due to business divestitures		(12	)		—			—
Foreign currency translation on hedge of a net investment		36			(141	)		(30	)
Derivatives qualifying as cash flow hedges, net of tax of $3 in 2008, $24 in 2007 and $32 in 2006		9			(56	)		(73	)
Derivatives qualifying as cash flow hedges reclassified to net earnings, net of tax of $23 in 2008, $15 in 2007 and $22 in 2006		42			42			34
Minimum pension liability adjustment, net of tax of $44 in 2006		—			—			82
Pension and postretirement benefits, net of tax of $697 in 2008 and $52 in 2007		(1,387	)		130			—
Pension and postretirement benefits reclassified to net earnings, net of tax of $50 in 2008 and $50 in 2007		102			108			—
Available for sale securities, net of tax of $0 in 2008, $19 in 2007 and $6 in 2006		(37	)		(139	)		12
Available for sale securities reclassified to net earnings, net of tax of $6 in 2008		112			—			—

Total Other Comprehensive (Loss)/Income		(1,258	)		184			184

Comprehensive Income		4,985			3,112			2,209


Comprehensive Income Attributable to Noncontrolling Interest		996			763			440

Comprehensive Income Attributable to Shareholders	$	3,989		$	2,349		$	1,769


RETAINED EARNINGS

Retained Earnings at January 1	$	19,762		$	19,845		$	20,464
Cumulative effect of adoption of FIN No. 48		—			27			—
Net Earnings Attributable to Shareholders		5,247			2,165			1,585
Cash dividends declared		(2,460	)		(2,275	)		(2,204	)

Retained Earnings at December 31	$	22,549		$	19,762		$	19,845

The accompanying notes are an integral part of these financial statements.

F-41

BRISTOL-MYERS SQUIBB COMPANY

CONSOLIDATED BALANCE SHEETS

Dollars in Millions, Except Share and Per Share Data


	December 31,
	2008			2007
ASSETS

Current Assets:
Cash and cash equivalents	$	7,976		$	1,801
Marketable securities		289			424
Receivables, net of allowances of $128 and $180		3,644			3,935
Inventories, net		1,765			2,162
Deferred income taxes, net of valuation allowances		703			851
Prepaid expenses		320			310
Assets held for sale		—			560

Total Current Assets		14,697			10,043

Property, plant and equipment, net		5,405			5,650
Goodwill		4,827			4,998
Other intangible assets, net		1,151			1,330
Deferred income taxes, net of valuation allowances		2,137			2,716
Other assets		1,269			1,130

Total Assets	$	29,486		$	25,867


LIABILITIES

Current Liabilities:
Short-term borrowings	$	154		$	1,891
Accounts payable		1,535			1,442
Accrued expenses		2,936			2,951
Deferred income		277			201
Accrued rebates and returns		806			763
U.S. and foreign income taxes payable		347			296
Dividends payable		617			614
Accrued litigation liabilities		38			205
Liabilities related to assets held for sale		—			35

Total Current Liabilities		6,710			8,398

Pension, postretirement, and postemployment liabilities		2,285			782
Deferred income		791			714
U.S. and foreign income taxes payable		466			537
Other liabilities		441			520
Long-term debt		6,585			4,381

Total Liabilities		17,278			15,332


Commitments and contingencies (Note 25)

EQUITY

Shareholders’ Equity
Preferred stock, $2 convertible series, par value of $1 per share: Authorized 10 million shares; issued and outstanding 5,668 in 2008 and 5,815 in 2007, liquidation value of $50 per share		—			—
Common stock, par value of $.10 per share: Authorized 4.5 billion shares; 2.2 billion issued and outstanding in both 2008 and 2007		220			220
Capital in excess of par value of stock		2,828			2,722
Restricted stock		(71	)		(97	)
Accumulated other comprehensive loss		(2,719	)		(1,461	)
Retained earnings		22,549			19,762
Less cost of treasury stock — 226 million common shares in 2008 and 2007		(10,566	)		(10,584	)

Total Shareholders’ Equity		12,241			10,562
Noncontrolling interest		(33	)		(27	)

Total Equity		12,208			10,535

Total Liabilities and Equity	$	29,486		$	25,867

The accompanying notes are an integral part of these financial statements.

F-42

BRISTOL-MYERS SQUIBB COMPANY

CONSOLIDATED STATEMENTS OF CASH FLOWS

Dollars in Millions


	Year Ended December 31,
	2008			2007			2006
Cash Flows From Operating Activities:
Net earnings	$	6,243		$	2,928		$	2,025
Adjustments to reconcile net earnings to net cash provided by operating activities:
Net earnings attributable to noncontrolling interest		(996	)		(763	)		(440	)
Depreciation		562			542			564
Amortization		254			350			363
Deferred income tax expense/(benefits)		1,430			(416	)		(236	)
Stock-based compensation expense		181			133			112
Acquired in-process research and development		32			230			—
Impairment charges		349			379			120
Gain on sale of product lines and businesses		(3,570	)		(273	)		(207	)
(Gain)/loss on debt buyback/restructuring and interest rate swap termination		(57	)		—			220
Loss on sale of property, plant and equipment		36			51			33
Gain on sale of ImClone and other investments		(874	)		(1	)		(7	)
Changes in operating assets and liabilities:
Receivables		(360	)		(458	)		281
Inventories		130			(54	)		78
Deferred income		61			454			27
Accounts payable		253			141			(349	)
U.S. and foreign income taxes receivable/payable		371			(199	)		(91	)
Changes in other operating assets and liabilities		(338	)		109			(410	)

Net Cash Provided by Operating Activities		3,707			3,153			2,083

Cash Flows From Investing Activities:
Proceeds from sale of marketable securities		560			20,634			31,479
Purchases of marketable securities		(422	)		(19,878	)		(30,717	)
Additions to property, plant and equipment and capitalized software		(941	)		(843	)		(785	)
Proceeds from sale of property, plant and equipment and investment in other companies		83			44			2
Proceeds from sale of product lines and businesses		4,756			273			226
Proceeds from sale and leaseback of properties		227			—			281
Milestone payments for intangible assets		—			—			(280	)
Purchase of businesses, net of cash acquired		(191	)		(432	)		—
Proceeds from sale of ImClone shares		1,007			—			—

Net Cash Provided by/(Used in) Investing Activities		5,079			(202	)		206

Cash Flows From Financing Activities:
Short-term (repayments)/borrowings		(1,688	)		(33	)		30
Long-term debt borrowings		1,580			—			2,506
Long-term debt repayments		(229	)		(1,300	)		(3,796	)
Interest rate swap termination		211			—			(62	)
Issuances of common stock under stock plans and excess tax benefits from share-based payment arrangements		5			333			170
Dividends paid		(2,461	)		(2,213	)		(2,199	)

Net Cash Used in Financing Activities		(2,582	)		(3,213	)		(3,351	)

Effect of Exchange Rates on Cash and Cash Equivalents		(29	)		45			30

Increase/(Decrease) in Cash and Cash Equivalents		6,175			(217	)		(1,032	)
Cash and Cash Equivalents at Beginning of Period		1,801			2,018			3,050

Cash and Cash Equivalents at End of Period	$	7,976		$	1,801		$	2,018

The consolidated statements of cash flows include the activities of the discontinued operations.

The accompanying notes are an integral part of these financial statements.

F-43

Note 1 ACCOUNTING POLICIES

Basis of Consolidation

The consolidated financial statements, prepared in conformity with United States (U.S.) generally accepted accounting principles (GAAP), include the accounts of Bristol-Myers Squibb Company (which may be referred to as Bristol-Myers Squibb, BMS or the Company) and all of its controlled majority-owned subsidiaries. All intercompany balances and transactions have been eliminated.

The Company has entered into codevelopment, cocommercialization and license arrangements with other parties for various therapeutic areas with terms including upfront and contingent payments. All such arrangements with other parties were not determined to be with variable interest entities under the requirements of FIN No. 46(R), Consolidation of Variable Interest Entities, primarily due to the Company not providing more than 50% subordinated financial support. As a result, the Company does not consolidate the financial results of any of these parties.

Reclassifications

Certain prior year amounts have been reclassified to conform to the current year presentation. Among other changes, during 2008 the Company reclassified certain receivables on sale of products to alliance partners. The new presentation also changed the previously reported line items within the consolidated statements of cash flows, however, the new presentation did not change net cash provided by operating activities. See “—Note 12. Receivables, Net.”

Effective January 1, 2009, the Company changed its measurement of segment income. Certain items that were previously excluded from segment results are now fully allocated, including among other items, costs attributed to certain corporate administrative functions and programs, stock-based compensation expense and net interest expense. In addition, certain items that were previously included in segment results are now excluded, including among other items, costs attributed to PTI, upfront milestone payments, and acquired in-process research and development. The pre-tax impact attributable to noncontrolling interest is also excluded from the segment results. See further discussion “—Recently Issued Accounting Standards” below and “—Note 22. Segment Information.”

Use of Estimates

The preparation of financial statements requires the use of estimates and assumptions, based on complex judgments that are considered reasonable, that affect the reported amounts of assets and liabilities and disclosure of contingent assets and contingent liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. The most significant assumptions are employed in estimates used in determining values of intangible assets, restructuring charges and accruals, sales rebate and return accruals, legal contingencies, tax assets and tax liabilities, stock-based compensation expense, retirement and postretirement benefits (including the actuarial assumptions), financial instruments with no observable market quotes, as well as in estimates used in applying the revenue recognition policy. Actual results may or may not differ from estimated results.

Revenue Recognition

The Company recognizes revenue when title and substantially all the risks and rewards of ownership have transferred to the customer. Generally, revenue is recognized at time of shipment. However, in the case of certain sales made by the Mead Johnson business and certain non-U.S. businesses within the BioPharmaceuticals segment, revenue is recognized on the date of receipt by the purchaser, see “—Note 2. Alliances and Collaborations” for further discussion of revenue recognition related to alliances. Revenues are reduced at the time of recognition to reflect expected returns that are estimated based on historical experience and business trends. Additionally, provisions are made at the time of revenue recognition for discounts, rebates and estimated sales allowances based on historical experience updated for changes in facts and circumstances, as appropriate. Such provisions are recorded as a reduction of revenue.

In the case of new products for which the product introduction is not an extension of an existing line of product, where the Company determines that there are not products in a similar therapeutic category, or where the Company determines the new product has dissimilar characteristics with existing products such that the Company cannot reliably estimate expected returns of the new product, the Company defers recognition of revenue until the right of return no longer exists or until the Company has developed sufficient historical experience to estimate sales returns.

F-44

Note 1 ACCOUNTING POLICIES (Continued)

Sales Rebate and Return Accruals

Sales rebate and return accruals are established in the same period the related revenue is recognized, resulting in a reduction to sales and the establishment of a liability, which is included in accrued rebates and returns. An accrual is recorded based on an estimate of the proportion of recorded revenue that will result in a rebate or return. Prime vendor charge-back accruals and cash discounts, established in a similar manner, are recorded as a reduction to accounts receivable. The accrued liabilities and reductions to the trade receivables are as follows:


	December 31,
Dollars in Millions	2008		2007
Medicaid rebates	$	133	$	125
Women, Infants and Children (WIC) rebates		195		198
Sales returns		209		178
Managed health care rebates and other contract discounts		154		134
Prime vendor charge-backs		45		70
Cash discounts		31		24
Other adjustments		115		128

Income Taxes

Cash and Cash Equivalents

Cash and cash equivalents consist of U.S. Treasury backed securities, bank deposits, time deposits and money market funds. Cash equivalents are primarily highly liquid investments with original maturities of three months or less at the time of purchase and are recorded at cost, which approximates fair value. The Company maintains cash and cash equivalent balances in U.S. dollars and foreign currencies which are subject to currency rate risk.

Marketable Securities

The Company determined the appropriate classification of all marketable securities was “available for sale” at the time of purchase. As such, all of the Company’s investments in marketable securities were reported at fair value at December 31, 2008 and 2007. Fair value is determined based on observable market quotes or valuation models using assessments of counterparty credit worthiness, credit default risk or underlying security and overall capital market liquidity. Declines in fair value that are considered other than temporary are charged to earnings and those that are considered temporary are reported as a component of accumulated other comprehensive income (OCI) in stockholders’ equity. The Company uses the average cost method of determining the cost basis in computing realized gains and losses on the sale of its available for sale securities. Realized gains and losses are included in other expense, net.

Inventory Valuation

Inventories are generally stated at average cost, not in excess of market.

Capital Assets and Depreciation

Expenditures for additions, renewals and improvements are capitalized at cost. Depreciation is generally computed on a straight-line method based on the estimated useful lives of the related assets. The estimated useful lives of the major classes of depreciable assets are 50 years for buildings and 3 to 40 years for machinery, equipment and fixtures. The Company periodically evaluates whether current events or circumstances indicate that the carrying value of its depreciable assets may not be recoverable.

Impairment of Long-Lived Assets

F-45

Note 1 ACCOUNTING POLICIES (Continued)

Capitalized Software

Certain costs to obtain internal use software for significant systems projects are capitalized and amortized over the estimated useful life of the software, which ranges from three to 10 years. Costs to obtain software for projects that are not significant are expensed as incurred. Capitalized software, net of accumulated amortization, included in other intangible assets, net was $295 million and $248 million at December 31, 2008 and 2007, respectively. Amortization expense was $84 million in 2008, $116 million in 2007 and $124 million in 2006.

Investments

The Company accounts for 50% or less-owned companies over which it has the ability to exercise significant influence using the equity method of accounting, otherwise the cost method is used. The Company’s share of net income or losses of equity investments is included in equity in net income of affiliates in the consolidated statements of earnings. Losses are recognized in other expense, net when a decline in market value is deemed to be other than temporary. The Company reviews its equity investments for impairment based on its determination of whether the decline in market value of the investment below the Company’s carrying value is other than temporary. In making this determination, the Company considers factors to be evaluated in determining whether a loss in value should be recognized, including the Company’s ability to hold its investment, the market price and market price fluctuations of the investment’s publicly traded shares and inability of the investee to sustain an earnings capacity, which would justify the carrying amount of the investment.

Acquisitions

The Company’s consolidated financial statements and results of operations reflect an acquired business after the completion of the acquisition and are not restated. Acquired businesses are accounted for using the purchase method of accounting, which requires that the assets acquired and the liabilities assumed be recorded at the date of acquisition at their respective fair values. Any excess of the purchase price over the estimated fair values of the net assets acquired is recorded as goodwill. Amounts allocated to acquired in-process research and development (IPRD) are expensed at the date of acquisition. Goodwill is not recognized when acquired net assets do not constitute a business.

Goodwill and Other Intangible Assets

Goodwill is tested for impairment annually using a two-step process. The first step is to identify a potential impairment, and the second step measures the amount of the impairment loss, if any. Goodwill is deemed to be impaired if the carrying amount of a reporting unit’s goodwill exceeds its estimated fair value. The BioPharmaceuticals segment includes four separate reporting units based on geography. The Mead Jonson segment consists of one reporting unit. The Company completed its annual goodwill impairment assessment in the first quarter of 2008 and monitored for any potential impairment in the remaining quarters of 2008, none of which indicated an impairment of goodwill.

Other intangible assets, net, consisting of patents/trademarks, licenses, technology and capitalized software, are amortized on a straight-line basis over their useful lives, ranging from two to 17 years. Such intangible assets are deemed to be impaired if their net carrying value exceeds their estimated fair value.

Restructuring

The Company has recognized restructuring charges in connection with activities that streamline operations and rationalize manufacturing facilities. As a result, the Company has made estimates and judgments regarding its future plans, including future termination benefits and other exit costs to be incurred when the restructuring actions take place. Actual results may vary from these estimates.

Product Liability

Accruals for product liability (including associated legal costs) are recorded on an undiscounted basis when it is probable that a liability has been incurred and the amount of the liability can be reasonably estimated based on existing information. These accruals are adjusted periodically as assessment efforts progress or as additional information becomes available. Receivables for related insurance or other third-party recoveries for product liabilities are recorded, on an undiscounted basis, when it is probable that a recovery will be realized and are classified as a reduction of litigation expense, net in the consolidated statements of earnings.

F-46

Note 1 ACCOUNTING POLICIES (Continued)

Contingencies

In the normal course of business, the Company is subject to loss contingencies, such as legal proceedings and claims arising out of its business, that cover a wide range of matters, including, among others, government investigations, shareholder lawsuits, product and environmental liability. The Company records accruals for such loss contingencies when it is probable that a liability will be incurred and the amount of loss can be reasonably estimated. The Company does not recognize gain contingencies until realized. For a discussion of contingencies, see “—Note 25. Legal Proceedings and Contingencies.”

Derivative Financial Instruments

Derivative financial instruments are used by the Company principally in the management of its interest rate and foreign currency exposures. The Company does not hold or issue derivative financial instruments for speculative purposes.

The Company records all derivative instruments on the balance sheet at fair value. Changes in a derivative’s fair value are recognized in earnings unless specific hedge criteria are met. If the derivative is designated as a fair value hedge, the changes in the fair value of the derivative and of the hedged item attributable to the hedged risk are recognized in the consolidated statements of earnings. If the derivative is designated as a cash flow hedge, the effective portions of changes in the fair value of the derivative are recorded in OCI and are subsequently recognized in the consolidated statements of earnings when the hedged item affects earnings; cash flows are classified consistent with the underlying hedged item. For purchased foreign currency options, the entire change in fair value is included in the measurement of hedge effectiveness for cash flow hedges. Ineffective portions of changes in the fair value of cash flow hedges, if any, are recognized as a charge or credit to earnings.

The Company designates and assigns derivatives as hedges of forecasted transactions, specific assets or specific liabilities. When hedged assets or liabilities are sold or extinguished or the forecasted transactions being hedged are no longer expected to occur, the Company immediately recognizes the gain or loss on the designated hedging financial instruments in the consolidated statements of earnings.

Shipping and Handling Costs

The Company typically does not charge customers for shipping and handling costs. Therefore, shipping and handling costs are included in marketing, selling and administrative expenses and were $242 million in 2008, $226 million in 2007 and $211 million in 2006.

Advertising Costs

Advertising costs are expensed as incurred. Advertising expense was $570 million in 2008, $503 million in 2007 and $472 million in 2006.

Research and Development

Research and development costs are expensed as incurred. The Company from time to time will enter into strategic alliances with third parties, which give the Company rights to develop, manufacture, market and/or sell pharmaceutical products, the rights to which are owned by such third parties. As a result of these alliances, the Company may be obligated to make payments to alliance partners in connection with research and development contingent upon the achievement of certain pre-determined criteria. For milestones achieved prior to regulatory approval of the product, such payments are expensed as research and development. Milestone payments made in connection with regulatory approvals, including non-U.S. regulatory approvals and additional indications, are capitalized and amortized to cost of products sold over the remaining useful life of the asset. All capitalized milestone payments are tested for recoverability periodically or whenever events or changes in circumstances indicate that the carrying amounts may not be recoverable. The Company records research and development, net of reimbursements, in connection with collaboration agreements.

Acquired In-Process Research and Development

The fair value of in-process research and development acquired in a business combination is determined based on the present value of each research project’s projected cash flows. An income approach is utilized that is consistent with guidance in the practice aid issued by the American Institute of Certified Public Accountants, Assets Acquired in Business Combinations to Be Used in Research and Development Activities: A Focus on Software, Electronic Devices and Pharmaceutical Industries. Future cash flows are predominately based on the net income forecast of each project, consistent with historical pricing, margins and expense levels of similar products. Revenues are estimated based on relevant market size and growth factors, expected industry trends, individual project life cycles and the life of each research project’s underlying patent. In determining the fair value of each research project, expected revenues are first adjusted for technical risk of completion. The resulting cash flows are then discounted at a rate approximating the Company’s weighted-average cost of capital. Other acquired in-process research and development is expensed as incurred when the underlying product has not received regulatory approval and does not have any future alternative use. In addition, costs that are nonrefundable, related to the acquisition or licensing of products that have not yet received regulatory approval to be marketed and that have no alternative future use, are charged to earnings as incurred.

F-47

Note 1 ACCOUNTING POLICIES (Continued)

Earnings Per Share

Basic earnings per common share are computed using the weighted-average number of shares outstanding during the year. Diluted earnings per common share are computed using the weighted-average number of shares outstanding during the year plus the incremental shares outstanding assuming the exercise of dilutive stock options, restricted stock and convertible instruments.

Foreign Currency Translation

The statements of earnings of the Company’s foreign subsidiaries are translated into U.S. dollars using average exchange rates. The net assets of the Company’s foreign subsidiaries are translated into U.S. dollars using current exchange rates. The U.S. dollar effects that arise from translating the net assets of these subsidiaries at changing rates are recorded in the foreign currency translation adjustment account, which is included in accumulated OCI.

Recently Issued Accounting Standards

Effective January 1, 2008, the Company adopted Emerging Issues Task Force (EITF) Issue No. 07-3, Accounting for Nonrefundable Advance Payments for Goods or Services Received for Use in Future Research and Development Activities. Nonrefundable advance payments for goods or services that will be used or rendered for future research and development activities should be deferred and capitalized. Such amounts should be recognized as an expense as the related goods are delivered or the services are performed, or when the goods or services are no longer expected to be provided. The Company’s adoption of EITF No. 07-3 did not have a material effect on the Company’s consolidated financial statements.

Effective January 1, 2008, the Company adopted Statement of Financial Accounting (SFAS) No. 159, The Fair Value Option for Financial Assets and Financial Liabilities, including an amendment of SFAS No. 115, Accounting for Certain Investments in Debt and Equity Securities, which permits an entity to measure certain financial assets and financial liabilities at fair value. The objective of SFAS No. 159 is to improve financial reporting by allowing entities to mitigate volatility in reported earnings caused by the measurement of related assets and liabilities using different attributes, without having to apply complex hedge accounting provisions. Under SFAS No. 159, entities that elect the fair value option (by instrument) will report unrealized gains and losses in earnings at each subsequent reporting date. The fair value option election is irrevocable, unless a new election date occurs. SFAS No. 159 establishes presentation and disclosure requirements to help financial statement users understand the effect of the entity’s election on its earnings, but does not eliminate disclosure requirements of other accounting standards. Assets and liabilities that are measured at fair value must be displayed on the face of the balance sheet. The Company chose not to elect the fair value option for its financial assets and liabilities existing at January 1, 2008, and did not elect the fair value option on financial assets and liabilities for those assets and liabilities previously not carried at fair value. Therefore, the adoption of SFAS No. 159 had no impact on the Company’s consolidated financial statements.

Effective January 1, 2008, the Company adopted the provisions of SFAS No. 157, Fair Value Measurements, for financial assets and liabilities and any other assets and liabilities carried at fair value. This pronouncement defines fair value, establishes a framework for measuring fair value and expands disclosures about fair value measurements. The implementation of SFAS No. 157 for non-financial assets and liabilities is effective January 1, 2009. The Company’s adoption of SFAS No. 157 relating to financial assets and liabilities did not have a material effect on the Company’s consolidated financial statements. The adoption of SFAS No. 157 with respect to non-financial assets and liabilities in the future is not expected to have a material impact on the Company’s consolidated financial statements.

In March 2008, the FASB issued SFAS No. 161, Disclosures about Derivative Instruments and Hedging Activities, as an amendment to SFAS No. 133, Accounting for Derivative Instruments and Hedging Activities. SFAS No. 161 requires that objectives for using derivative instruments be disclosed in terms of the underlying risk and accounting designation. The fair value of derivative instruments and their gains and losses will need to be presented in tabular format in order to present a more complete picture of the effects of using derivative instruments. SFAS No. 161 is effective for financial statements issued for fiscal years beginning after November 15, 2008. The Company provided the required disclosures in the December 31, 2008 consolidated financial statements.

At its December 2007 meeting, the FASB ratified the consensus reached by the EITF in issue No. 07-1, Accounting for Collaborative Arrangements Related to the Development and Commercialization of Intellectual Property. The EITF concluded that a collaborative arrangement is one in which the participants are actively involved and are exposed to significant risks and rewards that depend on the ultimate commercial success of the endeavor. Revenues and costs incurred with third parties in connection with collaborative arrangements would be presented gross or net based on the criteria in EITF 99-19, Reporting Revenue Gross as a Principal versus Net as an Agent, and other accounting literature. Payments to or from collaborators would be evaluated and presented based on the nature of the arrangement and its terms, the nature of the entity’s business, and whether those payments are within the scope of other accounting literature. The nature and purpose of collaborative arrangements are to be disclosed along with the accounting policies and

F-48

Note 1 ACCOUNTING POLICIES (Continued)

the classification and amounts of significant financial statement amounts related to the arrangements. Activities in the arrangement conducted in a separate legal entity should be accounted for under other accounting literature; however, required disclosure under EITF 07-1 applies to the entire collaborative agreement. This EITF is effective for fiscal years beginning after December 15, 2008, and is to be applied retrospectively to all periods presented for all collaborative arrangements existing as of the effective date. This accounting pronouncement will not have a material effect on the Company’s consolidated financial statements.

The Company adopted SFAS No. 160, Noncontrolling Interests in Consolidated Financial Statements—an amendment of ARB No. 51. SFAS No. 160 establishes accounting and reporting standards that require the ownership interests in subsidiaries held by parties other than the parent to be clearly identified, labeled and presented in the consolidated balance sheets within equity, but separate from the parent’s equity. This pronouncement also requires the amount of consolidated net income attributable to the parent and to the noncontrolling interest to be clearly identified and presented on the face of the consolidated statements of income. Changes in a parent’s ownership interest while the parent retains its controlling financial interest in its subsidiary must be accounted for consistently, and when a subsidiary is deconsolidated, any retained noncontrolling equity investment in the former subsidiary must be initially measured at fair value. The pronouncement also requires entities to provide sufficient disclosures that clearly identify and distinguish between the interests of the parent and the interests of the noncontrolling owners. As a result of adoption the following retroactive adjustments were made: the December 31, 2008 and 2007 noncontrolling interest balance of $33 million and $27 million, respectively, previously presented as $66 million and $59 million of receivables and $33 million and $32 million of non-current other liabilities, has been presented as part of equity. Also, noncontrolling interest has been presented as a reconciling item in the consolidated statements of earnings, the consolidated statements of comprehensive income and retained earnings and the consolidated statements of cash flows.

In December 2007, the FASB issued SFAS No. 141(R), Business Combinations, which replaces SFAS No. 141, Business Combinations, and requires recognition of assets acquired, liabilities assumed, and any noncontrolling interest in the acquiree at the acquisition date, measured at their fair values as of that date. In a business combination achieved in stages, this FASB requires recognition of identifiable assets and liabilities, as well as the non-controlling interest in the acquiree, at the full amounts of their fair values. This FASB also requires the fair value of acquired in-process research and development to be recorded as indefinite lived intangibles, contingent consideration to be recorded on the acquisition date, and restructuring and acquisition-related deal costs to be expensed as incurred. In addition, any excess of the fair value of net assets acquired over purchase price and any subsequent changes in estimated contingencies are to be recorded in earnings. This FASB applies to the Company’s business combinations for which the acquisition date is on or after January 1, 2009.

In July 2006, the FASB issued FASB Interpretation (FIN) No. 48, Accounting for Uncertainty in Income Taxes – an Interpretation of FASB Statement No. 109, which, in the case of the Company, was effective at January 1, 2007. FIN No. 48 clarifies the accounting for uncertainty in income taxes recognized in an enterprise’s financial statements in accordance with SFAS No. 109, Accounting for Income Taxes. FIN No. 48 requires that all tax positions be evaluated using a recognition threshold and measurement attribute for the financial statement recognition and measurement of a tax position taken or expected to be taken in a tax return. Differences between tax positions taken in a tax return and amounts recognized in the financial statements are recorded as adjustments to income taxes payable or receivable, or adjustments to deferred taxes, or both. FIN No. 48 also requires expanded disclosure at the end of each reporting period including a tabular reconciliation of unrecognized tax benefits. The Company adopted FIN No. 48 on January 1, 2007. As a result of the adoption of this accounting pronouncement, the Company recognized $27 million of previously unrecognized tax benefits, which was accounted for as an increase to the opening balance of retained earnings. In May 2007, the FASB issued FASB Staff Position (FSP) FIN No. 48-1, Definition of Settlement in FASB Interpretation No. 48, which is effective retroactively to January 1, 2007. FSP FIN No. 48-1 provides guidance on how to determine whether a tax position is effectively settled for the purpose of recognizing previously unrecognized tax benefits. The adoption of FSP FIN No. 48-1 did not have any effect on the Company’s consolidated financial statements.

F-49

Note 2 ALLIANCES AND COLLABORATIONS

Sanofi

The Company has agreements with Sanofi-Aventis (Sanofi) for the codevelopment and cocommercialization of AVAPRO*/AVALIDE* (irbesartan/irbesartan-hydrochlorothiazide), an angiotensin II receptor antagonist indicated for the treatment of hypertension and diabetic nephropathy, and PLAVIX* (clopidogrel), a platelet aggregation inhibitor. The worldwide alliance operates under the framework of two geographic territories; one in the Americas (principally the U.S., Canada, Puerto Rico and Latin American countries) and Australia and the other in Europe and Asia. Accordingly, two territory partnerships were formed to manage central expenses, such as marketing, research and development and royalties, and to supply finished product to the individual countries. In general, at the country level, agreements either to copromote (whereby a partnership was formed between the parties to sell each brand) or to comarket (whereby the parties operate and sell their brands independently of each other) are in place. The agreements expire on the later of (i) with respect to PLAVIX*, 2013 and, with respect to AVAPRO*/AVALIDE*, 2012 in the Americas and Australia and 2013 in Europe and Asia and (ii) the expiration of all patents and other exclusivity rights in the applicable territory. The Company acts as the operating partner for the territory covering the Americas and Australia and owns a 50.1% majority controlling interest in this territory. Sanofi’s ownership interest in this territory is 49.9%. As such, the Company consolidates all country partnership results for this territory and records Sanofi’s share of the results as a noncontrolling interest, net of taxes, which was $976 million in 2008, $746 million in 2007 and $428 million in 2006. The Company recorded net sales in this territory and in comarketing countries outside this territory (Germany, Italy, Spain and Greece) of $6,893 million in 2008, $5,958 million in 2007 and $4,355 million in 2006.

Cash flows from operating activities of the partnerships in the territory covering the Americas and Australia are recorded as operating activities within the Company’s consolidated statements of cash flows. Distributions of partnership profits to Sanofi and Sanofi’s funding of ongoing partnership operations occur on a routine basis and are also recorded within operating activities on the Company’s consolidated statements of cash flows.

Sanofi acts as the operating partner of the territory covering Europe and Asia and owns a 50.1% majority financial controlling interest within this territory. The Company’s ownership interest in the partnerships within this territory is 49.9%. The Company accounts for the investment in partnership entities in this territory under the equity method and records its share of the results in equity in net income of affiliates in the consolidated statements of earnings. The Company’s share of income from these partnership entities before taxes was $632 million in 2008, $526 million in 2007 and $439 million in 2006.

The Company routinely receives distributions of profits and provides funding for the ongoing operations of the partnerships in the territory covering Europe and Asia. These transactions are recorded as operating activities within the Company’s consolidated statements of cash flows.

The Company and Sanofi have an alliance for the copromotion of irbesartan. The Company recognized other income of $31 million in 2008, $32 million in 2007 and $31 million in 2006, related to the amortization of deferred income associated with Sanofi’s $350 million payment to the Company for their acquisition of an interest in the irbesartan license for the U.S. upon formation of the alliance. The unrecognized portion of the deferred income amounted to $123 million and $154 million at December 31, 2008 and 2007, respectively, and will continue to amortize through 2012, the expected expiration of the license.

The following is the summarized financial information for the Company’s interests in the partnerships with Sanofi for the territory covering Europe and Asia:


	Year Ended December 31,
Dollars in Millions	2008		2007		2006
Net sales	$	3,478	$	3,090	$	2,785
Gross profit		2,634		2,379		2,156
Net income		1,266		1,070		942
Current assets		1,525		1,727		1,595
Current liabilities		1,525		1,727		1,595

Otsuka

The Company has a worldwide commercialization agreement with Otsuka Pharmaceutical Co., Ltd. (Otsuka), to codevelop and copromote with Otsuka ABILIFY* (aripiprazole) for the treatment of schizophrenia, bipolar mania disorder and major depressive disorder, except in Japan, China, Taiwan, North Korea, South Korea, the Philippines, Thailand, Indonesia, Pakistan and Egypt. Under the terms of the agreement, the Company purchases the product from Otsuka and performs finish manufacturing for sale by the Company or Otsuka to third-party customers. The product is currently copromoted with Otsuka in the U.S., United Kingdom (UK), Germany, France and Spain. In the U.S., Germany and Spain, where the product is invoiced to third-party customers by the Company

F-50

Note 2 ALLIANCES AND COLLABORATIONS (Continued)

on behalf of Otsuka, the Company records alliance revenue for its 65% contractual share of third-party net sales and records all expenses related to the product. The Company recognizes this alliance revenue when ABILIFY* is shipped and all risks and rewards of ownership have transferred to third-party customers. In the UK, France and Italy, where the Company is presently the exclusive distributor for the product, the Company records 100% of the net sales and related cost of products sold and expenses. The Company also has an exclusive right to sell ABILIFY* in other countries in Europe, the Americas and a number of countries in Asia. In these countries, the Company records 100% of the net sales and related cost of products sold.

The agreement expires in November 2012 in the U.S. For the entire European Union (EU), the agreement expires in June 2014. In each other country where the Company has the exclusive right to sell ABILIFY*, the agreement expires on the later of the 10th anniversary of the first commercial sale in such country or expiration of the applicable patent in such country.

The Company recorded net sales for ABILIFY* of $2,153 million in 2008, $1,660 million in 2007 and $1,282 million in 2006. Total milestone payments made to Otsuka under the agreement through December 2008 were $217 million, of which $157 million was expensed as acquired in-process research and development in 1999. The remaining $60 million was capitalized in other intangible assets, net and is amortized in cost of products sold over the remaining life of the agreement in the U.S. The Company amortized in cost of products sold $6 million in each of 2008, 2007 and 2006. The unamortized capitalized payment balance was $23 million and $29 million at December 31, 2008 and 2007, respectively.

ImClone

The Company has a commercialization agreement expiring in September 2018 with ImClone Systems Incorporated (ImClone) for the codevelopment and copromotion of ERBITUX* (cetuximab) in the U.S., as well as codevelopment and copromotion rights in Canada and Japan to the extent the product is commercialized in such countries. ERBITUX* is indicated for use in the treatment of patients with metastatic colorectal cancer and for use in the treatment of squamous cell carcinoma of the head and neck. Under the agreement, covering North America, ImClone receives a distribution fee based on a flat rate of 39% of net sales in North America.

In October 2007, the Company and ImClone amended their codevelopment agreement with Merck KGaA to provide for cocommercialization of ERBITUX* in Japan, which expires in 2032. ImClone has the ability to terminate the agreement after 2018 if it determines that it is commercially unreasonable for ImClone to continue. ERBITUX* received marketing approval in Japan in July 2008 for the use of ERBITUX* in treating patients with advanced or recurrent colorectal cancer.

The Company recorded net sales for ERBITUX* of $749 million in 2008, $692 million in 2007 and $652 million in 2006. The Company amortized into cost of products sold $37 million in 2008, $38 million in 2007 and $34 million in 2006, for previously capitalized milestone payments, which were accounted for as a license acquisition. The unamortized portion of the approval payments is recorded in other intangible assets, net, and was $360 million and $397 million at December 31, 2008 and 2007, respectively, and will continue to amortize through 2018, the remaining term of the agreement.

Upon initial execution of the commercialization agreement, the Company acquired an ownership interest in ImClone, which approximated 17% at the time of the transaction noted below, and had been accounting for its investment under the equity method. The Company recorded an equity loss in income of affiliates, which was adjusted for revenue recognized by ImClone for pre-approved milestone payments made by the Company prior to 2004 of $5 million in 2008 and equity in net income of affiliates of $7 million in 2007 and $43 million in 2006. In November 2008, Eli Lilly and Company (Lilly) acquired ImClone and, as a result, the Company sold its shares of ImClone for $1.0 billion and recognized a pre-tax gain of $895 million. The Company will continue to have marketing rights to ERBITUX* and believes it has rights to ImClone’s investigational compound IMC-11F8.

Gilead

The Company and Gilead Sciences, Inc. (Gilead) have a joint venture to develop and commercialize ATRIPLA* (efavirenz 600 mg/ emtricitabine 200 mg/ tenofovir disoproxil fumarate 300 mg), a once-daily single tablet three-drug regimen combining the Company’s SUSTIVA (efavirenz) and Gilead’s TRUVADA* (emtricitabine and tenofovir disoproxil fumarate), in the U.S., Canada and Europe. ATRIPLA* was approved by the FDA in July 2006, Health Canada in October 2007 and by the European Commission in December 2007 for commercialization in the 27 countries of the EU, as well as Norway and Iceland.

Gilead records all ATRIPLA* revenues in the U.S., Canada and most countries in Europe and consolidates the results of the joint venture in its operating results. The Company records revenue for the bulk efavirenz component of ATRIPLA* upon sales of that product by the joint venture to third-party customers. The Company’s net sales for the efavirenz component is determined by applying a percentage to ATRIPLA* revenue, which approximates revenue for the SUSTIVA brand. In a limited number of EU countries, the Company records revenue for ATRIPLA* where the Company agreed to purchase the product from Gilead and distribute it to third-party customers. The Company recorded revenues of $582 million in 2008, $335 million in 2007 and $76 million in 2006 related to ATRIPLA* sales. The Company accounts for its participation in the U.S. joint venture under the equity method of accounting and records its share of the joint venture results in equity in net income of affiliates in the consolidated statements of earnings. The Company recorded an equity loss on the U.S. joint venture with Gilead of $9 million in 2008 and 2007 and $6 million in 2006.

F-51

Note 2 ALLIANCES AND COLLABORATIONS (Continued)

AstraZeneca

In January 2007, the Company entered into two worldwide (except for Japan) codevelopment and cocommercialization agreements with AstraZeneca PLC (AstraZeneca), one for the codevelopment and cocommercialization of saxagliptin, a DPP-IV inhibitor (Saxagliptin Agreement), and one for the codevelopment and cocommercialization of dapagliflozin, a sodium-glucose contransporter-2 (SGLT2) inhibitor (SGLT2 Agreement). Both compounds are being studied for the treatment of diabetes and were discovered by the Company. Under the terms of the agreements, the Company received from AstraZeneca an upfront payment of $100 million in January 2007. In October 2008, the Company received from AstraZeneca a milestone payment of $50 million for the June 2008 filing of the New Drug Application to the Food and Drug Administration (FDA) for ONGLYZA. The companies have proposed the name ONGLYZA which, if approved by the FDA and the European Medicines Evaluation Agency, will serve as the trade name for saxagliptin.

The upfront and milestone payments were deferred and are being recognized over the useful life of the products into other income. The Company amortized into other income $9 million of upfront payments in 2008 and $7 million in 2007. The unamortized portion of the upfront and milestone payments was $134 million at December 31, 2008 and $93 million at December 31, 2007. Additional milestone payments are expected to be received by the Company upon the successful achievement of various development and regulatory events as well as sales-related milestones. Under the Saxagliptin Agreement, the Company could receive up to $300 million if all development and regulatory milestones are met and up to an additional $300 million if all sales-based milestones are met. Under the SGLT2 Agreement, the Company could receive up to $350 million if all development and regulatory milestones are met and up to an additional $300 million if all sales-based milestones are met. Under each agreement, the Company and AstraZeneca also share in development and commercialization costs. The majority of development costs under the initial development plans through 2009 will be paid by AstraZeneca and any additional development costs will generally be shared equally. The Company records development costs related to saxagliptin and dapagliflozin net of AstraZeneca’s share in research and development expenses. Under each agreement, the two companies will jointly develop the clinical and marketing strategy and share commercialization expenses and profits/losses equally on a global basis, excluding Japan, and the Company will manufacture both products.

Pfizer

In April 2007, the Company and Pfizer Inc. (Pfizer) entered into a worldwide codevelopment and cocommercialization agreement for apixaban, an anticoagulant discovered by the Company being studied for the prevention and treatment of a broad range of venous and arterial thrombotic conditions. In accordance with the terms of the agreement, Pfizer made an upfront payment of $250 million to the Company in May 2007, which was deferred and is being recognized over the life of the agreement into other income. In December 2007, the Company and Pfizer agreed to include Japan in the worldwide agreement. In connection with the Japan agreement, Pfizer made an additional upfront payment of $40 million in December 2007 which was deferred and is being recognized over the useful life of the product into other income. The Company amortized into other income $18 million of the two upfront payments in 2008 and $11 million in 2007. The unamortized portion of the upfront payments was $261 million at December 31, 2008 and $279 million at December 31, 2007. Pfizer will fund 60% of all development costs effective January 1, 2007 going forward, and the Company will fund 40%. The Company records apixaban development costs net of Pfizer’s share in research and development expenses. The Company may also receive additional payments of up to $780 million from Pfizer based on development and regulatory milestones. The companies will jointly develop the clinical and marketing strategy, will share commercialization expenses and profits/losses equally on a global basis, and will manufacture product under this arrangement.

Exelixis

In December 2008, the Company and Exelixis, Inc. (Exelixis) entered into a global codevelopment and cocommercialization arrangement for XL-184 (a MET/VEG/RET inhibitor), an oral anti-cancer compound, and a license for XL-281 with utility in RAS and RAF mutant tumors under development by Exelixis. Under the terms of the arrangement, the Company agreed to pay Exelixis $195 million in 2008 upon execution of the agreement and an additional $45 million in 2009. The Company expensed as research and development the $240 million upon execution of the agreement in 2008. Exelixis will fund the first $100 million of development for XL-184. If Exelixis elects to continue sharing development costs and elects to copromote in the U.S., Exelixis will fund 35% of future global development costs (excluding Japan) and share U.S. profits/losses equally; failing such elections, Exelixis receives milestones and royalties. The Company will fund 100% of development costs in Japan. In addition to double-digit royalties on non-U.S. sales, the Company could pay up to $610 million if all development and regulatory milestones are met and up to an additional $300 million if all sales-based milestones are met.

In addition, the Company and Exelixis have a history of collaborations to identify, develop and promote oncology targets. During December 2006, the Company and Exelixis entered into an oncology collaboration and license agreement under which Exelixis is pursuing the development of three small molecule INDs for codevelopment and copromotion. Under the terms of this agreement, the

F-52

Note 2 ALLIANCES AND COLLABORATIONS (Continued)

Company paid Exelixis $60 million of upfront fees in 2006. During 2008, the Company paid Exelixis $40 million in IND acceptance milestones. If Exelixis elects to fund development costs and copromote in the U.S., both parties will equally share development costs and profits. If Exelixis opts out of the codevelopment and copromotion agreement, BMS will take over full development and U.S. commercial rights, and, if successful, will pay Exelixis development and regulatory milestones up to $190 million and up to an additional $90 million of sales-based milestones, as well as double-digit royalties.

Note 3 RESTRUCTURING

In December 2007 and July 2008, the Company announced productivity transformation initiatives (PTI) designed to fundamentally change the way it runs its business to meet the challenges of a changing business environment and to take advantage of the diverse opportunities in the marketplace as the Company is transformed into a next-generation biopharmaceutical company, and to create a total of $2.5 billion in annual productivity cost savings and cost avoidance by 2012. In connection with the PTI, the Company aims to achieve a culture of continuous improvement to enhance its efficiency, effectiveness and competitiveness and substantially improve its cost base.

The charges associated with the previously announced PTI are estimated to be an aggregate range of $1.3 billion to $1.6 billion, which includes $695 million of costs already incurred. The incurred costs are net of $159 million of gains related to the sale of mature product lines and businesses. The exact timing of the recognition of PTI charges cannot be predicted with certainty and will be affected by the existence of triggering events for expense recognition, among other factors. Also, included in these charges are net termination benefits of $174 million in 2008 and $182 million in 2007 and other exit costs of $44 million in 2008 and $1 million in 2007.

The net restructuring charges include termination benefits for workforce reduction of approximately 2,370 in 2008, 2,800 in 2007 and 1,080 in 2006 manufacturing, selling, administrative, and research and development personnel across all geographic regions. The following table presents details of expenses incurred by segment in connection with restructuring activities: The restructuring charges presented below have been excluded from the segment results. However, $214 million, $186 million and $69 million of the charges incurred in 2008, 2007 and 2006, respectively, are attributable to BioPharmaceuticals segment, with the remaining charges attributable to Mead Johnson segment.


	2008						2007								2006
Dollars in Millions	Termination Benefits		Other Exit Costs		Total		Termination Benefits			Other Exit Costs		Total			Termination Benefits			Other Exit Costs			Total
Charges	$	174	$	43	$	217	$	188		$	1	$	189		$	71		$	2		$	73
Changes in estimates		—		1		1		(6	)		—		(6	)		(13	)		(1	)		(14	)

Provision for restructuring, net	$	174	$	44	$	218	$	182		$	1	$	183		$	58		$	1		$	59

The following table represents the reconciliation of restructuring liabilities and spending against those liabilities:


Dollars in Millions	Termination Liability			Other Exit Costs Liability			Total
Liability at January 1, 2006	$	60		$	—		$	60
Charges		71			2			73
Spending		(44	)		—			(44	)
Changes in estimates		(13	)		(1	)		(14	)

Liability at December 31, 2006		74			1			75
Charges		188			1			189
Spending		(88	)		(3	)		(91	)
Changes in estimates		(6	)		—			(6	)

Liability at December 31, 2007		168			(1	)		167
Charges		174			43			217
Spending		(152	)		(22	)		(174	)
Change in estimates		—			1			1
ConvaTec divestiture		(2	)		—			(2	)

Liability at December 31, 2008	$	188		$	21		$	209

In addition to termination and other charges, the Company recognized accelerated depreciation, fixed asset impairment charges and other shutdown costs of $241 million in 2008, $110 million in 2007 and $186 million in 2006. Most of these charges were included in cost of products sold and primarily relate to the rationalization of the Company’s manufacturing network in the BioPharmaceuticals segment. These assets continue to be depreciated until the facility closures are complete.

F-53

Note 3 RESTRUCTURING (Continued)

The remaining costs of PTI were primarily attributed to process standardization activities across the Company and are recognized as incurred.

Note 4 ACQUISITIONS AND DIVESTITURES

In June 2008, the Company completed the acquisition of Kosan Biosciences, Inc. (Kosan), a cancer therapeutics company with a library of novel compounds, including Hsp90 inhibitors for cancer and microtubule stabilizers, which may have additional potential in neurodegenerative diseases, for a net purchase price of approximately $191 million. The transaction was accounted for under the purchase method of accounting. The purchase price was preliminarily allocated to acquired-in-process research and development of $32 million, other net assets of $32 million and goodwill of $127 million.

In October 2007, the Company completed the acquisition of Adnexus Therapeutics, Inc. (Adnexus), a developer of a new therapeutic class of biologics called ADNECTINS, for a net purchase price of $415 million. In addition, in the event that certain future development and regulatory milestones are achieved, the Company is obligated under the terms of the agreement to pay the former stockholders of Adnexus up to an additional $74 million. The transaction was accounted for under the purchase method of accounting. The purchase price was allocated to acquired-in-process research and development of $230 million, other identifiable intangible assets of $27 million (existing process technology to be used in future discovery), other net assets of $9 million and goodwill of $149 million (after reflecting additional deferred tax assets of $7 million in 2008).

The results of operations for these two acquisitions have been included in the accompanying consolidated financial statements from their dates of acquisition. Pro forma supplemental financial information was not included as the impact of the business combinations was not material.

In December 2008, the Company completed the sale of its mature brand business located in Egypt for $209 million in cash to GlaxoSmithKline. As a result of the transaction, the Company recognized a pre-tax gain of $144 million ($88 million net of tax) in the fourth quarter of 2008.

In August 2008, the Company completed the divestiture of its ConvaTec business. In January 2008, the Company completed the divestiture of Bristol-Myers Squibb Medical Imaging. See “—Note 6. Discontinued Operations and Assets Held for Sale” for further discussions of these divestitures.

In July 2007, the Company completed the sale of the BUFFERIN* and EXCEDRIN* brands in Japan, Asia (excluding China and Taiwan) and certain Oceanic countries to Lion Corporation (Japan) for $247 million in cash. As a result of this transaction, the Company recognized a pre-tax gain of $247 million ($144 million net of tax) in the third quarter of 2007.

In January 2006, the Company completed the sale of its inventory, trademark, patent and intellectual property rights in the U.S. related to DOVONEX*, a treatment for psoriasis, to Warner Chilcott Company, Inc. for $200 million in cash. In addition, the Company received a royalty based on 5% of net sales of DOVONEX* through the end of 2007. As a result of this transaction, the Company recognized a pre-tax gain of $200 million ($130 million net of tax) in the first quarter of 2006.

Note 5 MEAD JOHNSON NUTRITION COMPANY INITIAL PUBLIC OFFERING

During February 2009, Mead Johnson Nutrition Company (Mead Johnson) completed an initial public offering (IPO), in which it sold 34.5 million shares of its Class A common stock at $24 per share. Net proceeds received were approximately $780 million, which will be allocated to noncontrolling interest, net of taxes, and capital in excess of par value of stock within the Company’s stockholders’ equity in accordance with SFAS No. 160, Noncontrolling Interests in Consolidated Financial Statements – an amendment of ARB No. 51.

Upon completion of the IPO, the Company held 42.3 million shares of Mead Johnson Class A common stock and 127.7 million shares of Mead Johnson Class B common stock. The rights of the holders of the shares of Class A common stock and Class B common stock are identical, except with regard to voting and conversion. Each share of Class A common stock is entitled to one vote per share. Each share of Class B common stock is entitled to ten votes per share and is convertible at any time at the election of the holder into one share of Class A common stock. The Class B common stock will automatically convert into shares of Class A common stock in certain circumstances.

Upon completion of the IPO, the Company holds an 83.1% interest in Mead Johnson. Mead Johnson will continue to be consolidated for financial reporting purposes. The Company has entered into various agreements relating to the separation of Mead Johnson, including, a separation agreement, a transitional services agreement, a tax matters agreement, a registration rights agreement and an employee matters agreement.

F-54

Note 5 MEAD JOHNSON NUTRITION COMPANY INITIAL PUBLIC OFFERING (Continued)

Note 6 DISCONTINUED OPERATIONS AND ASSETS HELD FOR SALE

In August 2008, the Company completed the divestiture of its ConvaTec business to Cidron Healthcare Limited, an affiliate of Nordic Capital Fund VII and Avista Capital Partners L.P. (Avista) for a gross purchase price of approximately $4.1 billion, resulting in a pre-tax gain of $3.4 billion, $2.0 billion net of tax, which is included in discontinued operations. The gross purchase price includes an estimated post-closing purchase price adjustment based on the Company’s estimate of the closing working capital of the ConvaTec business and therefore the purchase price and transaction gain are subject to future adjustment based on the actual closing working capital of the ConvaTec business, pursuant to the terms of the Stock and Asset Purchase Agreement, dated May 3, 2008. In addition, in 2008, the Company recorded in discontinued operations a curtailment loss of $5 million and special termination benefits of $13 million associated with the re-measurement of the U.S. and Japan pension plans’ obligations and assets triggered by the decision to sell the ConvaTec business. The results of the ConvaTec business, which previously were reported as a separate operating segment, are included in earnings from discontinued operations, net of taxes, for all periods presented.

In January 2008, the Company completed the divestiture of Bristol-Myers Squibb Medical Imaging (Medical Imaging) to Avista for a gross purchase price of approximately $525 million, excluding post closing adjustments, resulting in a pre-tax gain of $25 million and an after-tax loss of $43 million, which are included in discontinued operations. The results of the Medical Imaging business, which previously were included in the former Other Health Care operating segment, are included in earnings from discontinued operations, net of taxes, for all periods presented. The net assets associated with the Medical Imaging business, totaling approximately $525 million, were reclassified to assets and liabilities held for sale at December 31, 2007.

For a period of time, the Company will continue to generate cash flows and to report income statement activity in other expense, net associated with both the ConvaTec and the Medical Imaging businesses. The activities that give rise to these cash flows and income statement activities are transitional in nature and generally result from agreements that are intended to facilitate the orderly transfer of business operations. The agreements include, among others, services for accounting, customer service, distribution and manufacturing. These activities for both the ConvaTec and the Medical Imaging businesses are not expected to be material to the Company’s results of operations or cash flows. The ConvaTec agreements extend for periods generally less than 24 months, with the majority ranging between six and 18 months from the transaction close date, subject in certain cases to limited extensions. The Medical Imaging agreements extend for periods generally less than 24 months, with the majority ranging between three and six months from the transaction close date, subject in certain cases to closing extensions. The transitional service fees, net of identifiable direct costs, are recognized in other expense, net and amounted to $15 million during the year ended December 31, 2008.

The following summarized financial information related to the ConvaTec and Medical Imaging businesses have been segregated from continuing operations and reported as discontinued operations through the date of disposition and does not reflect the costs of certain services provided to ConvaTec and Medical Imaging by the Company. Such costs, which were not allocated by the Company to ConvaTec and Medical Imaging, were for services, which included, without limitation, legal counsel, insurance, external audit fees, payroll processing, certain human resource services and information technology systems support.


	Year Ended December 31,
	ConvaTec						Medical Imaging
Dollars in Millions	2008		2007		2006		2008			2007		2006
Net sales	$	735	$	1,155	$	1,048	$	34		$	629	$	658


Earnings before incomes taxes	$	193	$	348	$	315	$	2		$	273	$	235
Curtailment losses and special termination benefits		18		—		—		—			—		—
Provision for income taxes		63		121		107		1			76		72

Earnings, net of taxes	$	112	$	227	$	208	$	1		$	197	$	163


Gain on disposal	$	3,387	$	—	$	—	$	25		$	—	$	—
Provision for income taxes		1,365		—		—		68			—		—

Gain/(loss) on disposal, net of taxes	$	2,022	$	—	$	—	$	(43	)	$	—	$	—

The consolidated statements of cash flows includes the ConvaTec and Medical Imaging businesses through the date of disposition. The Company uses a centralized approach to the cash management and financing of its operations and, accordingly, debt was not allocated to these businesses.

F-55

Note 6 DISCONTINUED OPERATIONS AND ASSETS HELD FOR SALE (Continued)

The following table includes Medical Imaging assets and liabilities that have been segregated and classified as assets held for sale and liabilities related to assets held for sale, as appropriate, in the consolidated balance sheets at December 31, 2007. The amounts presented below were adjusted to exclude cash and intercompany receivables and payables between the business held for sale and the Company, which were excluded from the divestiture. In addition, goodwill at December 31, 2007 of $2 million has been excluded from the following summary of net assets held for sale, and was considered in determining the pre-tax gain on sale in the first quarter of 2008. These assets are not generating operating results or cash flows and were included in the consolidated balance sheet as assets held for sale at December 31, 2007.


Dollars in Millions	December 31, 2007
Medical Imaging
Assets
Receivables, net of allowances of $2	$	62
Inventories, net		20
Other assets		31
Property, plant and equipment, net		174
Other intangible assets, net		273

Total assets held for sale		560

Liabilities
Accounts payable	$	12
Accrued liabilities		23

Total liabilities related to assets held for sale		35

Net assets held for sale	$	525

F-56

Note 7 EARNINGS PER SHARE

The numerator for basic earnings per share is net earnings attributable to shareholders. The numerator for diluted earnings per share is net earnings attributable to shareholders with interest expense added back for the assumed conversion of the convertible debt into common stock. The denominator for basic earnings per share is the weighted-average number of common stock outstanding during the period. The denominator for diluted earnings per share is weighted-average shares outstanding adjusted for the effect of dilutive stock options, restricted shares and assumed conversion of the convertible debt into common stock. The computations for basic and diluted earnings per common share were as follows:


	Year Ended December 31,
Dollars in Millions, except per share data	2008			2007			2006
Basic:
Net Earnings from Continuing Operations	$	4,151		$	2,504		$	1,654
Less Net Earnings Attributable to Noncontrolling Interest		(996	)		(763	)		(440	)

Net Earnings from Continuing Operations Attributable to Shareholders		3,155			1,741			1,214
Discontinued Operations:
Earnings, net of taxes		113			424			371
Gain on Disposal, net of taxes		1,979			—			—

Net Earnings Attributable to Shareholders	$	5,247		$	2,165		$	1,585


Basic Earnings Per Share:
Average Common Shares Outstanding - Basic		1,977			1,970			1,960


Net Earnings from Continuing Operations Attributable to Shareholders per Common Share	$	1.60		$	0.88		$	0.62
Discontinued Operations:
Earnings, net of taxes		0.05			0.22			0.19
Gain on Disposal, net of taxes		1.00			—			—

Net Earnings Attributable to Shareholders per Common Share	$	2.65		$	1.10		$	0.81


Diluted:
Net Earnings from Continuing Operations Attributable to Shareholders	$	3,155		$	1,741		$	1,214
Interest expense on conversion of convertible debt, net of taxes		16			—			—

Net Earnings from Continuing Operations Attributable to Shareholders used for Diluted Earnings per Common Share Calculation		3,171			1,741			1,214
Discontinued Operations:
Earnings, net of taxes		113			424			371
Gain on Disposal, net of taxes		1,979			—			—

Net Earnings Attributable to Shareholders	$	5,263		$	2,165		$	1,585


Diluted Earnings Per Share:
Average Common Shares Outstanding - Basic		1,977			1,970			1,960
Conversion of convertible debt		21			—			—
Incremental shares outstanding assuming the exercise/vesting of dilutive stock options/restricted stock		3			10			3

Average Common Shares Outstanding - Diluted		2,001			1,980			1,963


Net Earnings from Continuing Operations Attributable to Shareholders per Common Share	$	1.59		$	0.88		$	0.62
Discontinued Operations:
Earnings, net of taxes		0.05			0.21			0.19
Gain on Disposal, net of taxes		0.99			—			—

Net Earnings Attributable to Shareholders per Common Share	$	2.63		$	1.09		$	0.81

Weighted-average shares issuable upon the exercise of stock options of 139 million in 2008, 107 million in 2007 and 164 million in 2006 were not included in the diluted earnings per share calculation because they were anti-dilutive. In addition, 29 million shares from the assumed conversion of the convertible debt were not included in the diluted earnings per share calculation in 2007 and 2006 because they were anti-dilutive.

F-57

Note 8 OTHER EXPENSE, NET

The components of other expense, net were as follows:


	Year Ended December 31,
Dollars in Millions	2008			2007			2006
Interest expense	$	310		$	422		$	498
Interest income		(130	)		(241	)		(274	)
ARS impairment charge		305			275			—
(Gain)/loss on debt buyback and termination of interest rate swap agreements		(57	)		—			220
Foreign exchange transaction (gains)/losses		(76	)		15			—
Other, net		(161	)		(120	)		(152	)

Other expense, net	$	191		$	351		$	292

Interest expense includes $48 million net interest rate swap gains in 2008 and net interest rate swap losses of $13 million in 2007 and $18 million in 2006. See “—Note 21. Financial Instruments” for additional discussion on terminated swap contracts.

Interest income relates primarily to interest earned on cash, cash equivalents and investments in marketable securities. For further detail on auction rate securities (ARS) impairment see “—Note 11. Cash, Cash Equivalents and Marketable Securities.”

Other, net includes income from third-party contract manufacturing, certain royalty income and expense, gains and losses on the sale of property, plant and equipment, gains and losses on the sale of marketable securities (including a $19 million loss on the sale of ARS in 2008), insurance recoveries, certain litigation charges/recoveries, ConvaTec and Medical Imaging net transitional service fees, and amortization of certain upfront payments related to the Company’s alliances. See “—Note 2. Alliances and Collaborations.”

Note 9 INCOME TAXES

The components of earnings/(loss) from continuing operations before income taxes were as follows:


	Year Ended December 31,
Dollars in Millions	2008		2007		2006
U.S.	$	2,446	$	972	$	(985	)
Non-U.S.		3,025		2,214		3,070

	$	5,471	$	3,186	$	2,085

The above amounts are categorized based on the location of the taxing authorities.

The provision/(benefit) for income taxes attributable to continuing operations consisted of:


	Year Ended December 31,
Dollars in Millions	2008		2007			2006
Current:
U.S.	$	343	$	221		$	33
Non-U.S.		774		683			625

		1,117		904			658

Deferred:
U.S.		127		(160	)		(200	)
Non-U.S.		76		(62	)		(27	)

		203		(222	)		(227	)

	$	1,320	$	682		$	431

F-58

Note 9 INCOME TAXES (Continued)

Effective Tax Rate

The Company’s provision for income taxes in 2008, 2007 and 2006 was different from the amount computed by applying the statutory U.S. Federal income tax rate to earnings from continuing operations before income taxes, as a result of the following:


	% of Earnings Before Income Taxes
Dollars in Millions	2008					2007					2006
Earnings from Continuing Operations Before Income Taxes	$	5,471				$	3,186				$	2,085

U.S. statutory rate		1,915		35.0	%		1,115		35.0	%		730		35.0	%
Foreign tax effect of operations in Ireland, Puerto Rico and Switzerland		(586	)	(10.7	)%		(492	)	(15.4	)%		(616	)	(29.5	)%
State and local taxes (net of valuation allowance)		1		0.0	%		10		0.3	%		42		2.0	%
U.S. Federal and foreign contingent tax matters		(40	)	(0.7	)%		(60	)	(1.9	)%		87		4.2	%
Acquired in-process research and development expense		11		0.2	%		81		2.5	%		—		—
U.S. Federal research and development tax credit		(84	)	(1.5	)%		(98	)	(3.1	)%		(85	)	(4.1	)%
U.S. Federal and foreign valuation allowance		—		—			—		—			(24	)	(1.2	)%
Impairment of financial instruments		51		0.9	%		96		3.0	%		—		—
Foreign and other		52		0.9	%		30		1.0	%		297		14.3	%

	$	1,320		24.1	%	$	682		21.4	%	$	431		20.7	%

The increase in the 2008 effective tax rate from 2007 was primarily due to higher pre-tax income in the U.S. including the gain on sale of ImClone, and earnings mix in high tax jurisdictions in 2008. Partially offsetting these factors were lower non-deductible charges in 2008 for acquired in-process research and development expenses and lower ARS impairment charges with little or no tax benefit. The tax rate in 2008 was favorably impacted by a benefit of $91 million of tax related to the final settlement of the 2002-2003 audit with the Internal Revenue Service.

F-59

Note 9 INCOME TAXES (Continued)

Deferred Taxes and Valuation Allowance

The components of current and non-current deferred income tax assets/(liabilities) were as follows:


	December 31,
Dollars in Millions	2008			2007
Acquired in-process research and development	$	409		$	839
Intercompany profit and other inventory items		213			263
U.S. Federal foreign tax credit carryforwards		451			1,140
Deferred income		272			276
U.S. Federal research and development tax credit carryforwards		271			275
U.S. Federal charitable contribution carryforwards		—			80
State net operating loss carryforwards		319			451
Foreign net operating loss carryforwards		1,419			1,461
Other foreign deferred tax assets		97			146
Pension and postretirement benefits		768			248
Depreciation		(121	)		(131	)
Share-based compensation		96			78
Repatriation of foreign earnings		(5	)		150
Legal settlements		22			47
Tax deductible goodwill		(508	)		(447	)
Milestone payments and license fees		444			333
Other, net		426			224

		4,573			5,433
Valuation allowance		(1,795	)		(1,950	)

Deferred tax assets, net	$	2,778		$	3,483


Recognized as:
Deferred income taxes – current	$	703		$	851
Deferred income taxes – non-current		2,137			2,716
U.S. and foreign income taxes payable		(3	)		(4	)
Other liabilities – non-current		(59	)		(80	)

Total	$	2,778		$	3,483

The Company has established a valuation allowance against deferred tax assets where the Company has determined that it is not more likely than not that the deferred tax assets will be realized. At December 31, 2008, a valuation allowance of $1,795 million has been established for the following items: $77 million of state deferred tax assets, $1,407 million of foreign net operating loss and tax credit carryforwards, $280 million of state net operating loss and tax credit carryforwards, $14 million related to impaired financial instruments, and $17 million of U.S. Federal and state deferred tax assets related to both the Adnexus and Kosan acquisitions that were offset against goodwill.

The Company recognized significant deferred tax assets at December 31, 2008 related to U.S. Federal foreign tax credit carryforwards of $451 million and U.S. Federal research and development tax credit carryforwards of $271 million. The U.S. Federal charitable contribution carryforwards were fully utilized during 2008 due to gains related to the ConvaTec and Medical Imaging divestitures, while the foreign tax credit and research and development tax credit carryforwards expire in varying amounts beginning in 2014. The foreign tax credit and research and development tax credit carryforwards have been reduced due to derecognition under FIN No. 48. The ConvaTec and Medical Imaging divestitures have resulted in a significant reduction to the foreign tax credit and research and development tax credit carryforwards in 2008. The realization of the foreign tax credit and research and development tax credit carryforwards are dependent on generating sufficient domestic-sourced taxable income prior to their expiration. Although realization is not assured, management believes it is more likely than not that these deferred tax assets will be realized.

Income taxes paid during the year were $636 million in 2008, $994 million in 2007 and $741 million in 2006. As discussed above, the tax rate in 2008 was favorably impacted by a benefit of $91 million of tax related to the final settlement of the 2002-2003 audit with the Internal Revenue Service. The final settlement was related to the Joint Committee of Congress approval of a Foreign Tax Credit Carryback Claim to 2000 and 2001. The Company received a $432 million cash refund, including interest, in 2008.

F-60

Note 9 INCOME TAXES (Continued)

The current tax benefit realized upon the exercise of stock options is credited to capital in excess of par value of stock and was $5 million in 2007 and $10 million in 2006.

At December 31, 2008, the Company had approximately $15.4 billion of undistributed earnings of foreign subsidiaries for which taxes have not been provided as the Company has invested or expects to invest these undistributed earnings permanently offshore. If, in the future, these earnings are repatriated to the U.S., or if the Company determines such earnings will be remitted in the foreseeable future, additional tax provisions would be required. Due to complexities in the tax laws and the assumptions that would have to be made, it is not practicable to estimate the amounts of income taxes that would have to be provided.

The Company conducts business in various countries throughout the world and is subject to tax in numerous jurisdictions. As a result of its business activities, the Company files a significant number of tax returns that are subject to examination by various Federal, state and local tax authorities. Tax examinations are often complex, as tax authorities may disagree with the treatment of items reported by the Company and may require several years to resolve. The Company establishes liabilities for possible assessments by tax authorities resulting from known tax exposures including, but not limited to, transfer pricing matters, tax credits and deductibility of certain expenses. Such liabilities represent a reasonable provision for taxes ultimately expected to be paid and may need to be adjusted over time as more information becomes known. The effect of changes in estimates related to contingent tax liabilities is included in the effective tax rate reconciliation above.

The Company adopted the provisions of FIN No. 48 on January 1, 2007, resulting in the recognition of $27 million of previously unrecognized tax benefits which were accounted for as an increase to the opening balance of retained earnings. FIN No. 48 requires expanded disclosure at the end of each annual reporting period including a tabular reconciliation of unrecognized tax benefits and certain information regarding interest and penalty amounts reflected as part of the Company’s uncertain tax positions. A tabular reconciliation of the Company’s changes in uncertain tax positions from January 1, 2007 to December 31, 2007 and January 1, 2008 to December 31, 2008 is as follows:


Dollars in Millions	Unrecognized Federal, State and Foreign Tax Benefits			Interest			Penalties			Unrecognized Income Tax Benefits, Including Interest and Penalties			Deferred Income Tax Benefits			Unrecognized Income Tax Benefits, Including Interest and Penalties, Net of Deferred Income Tax Benefits
Total uncertain tax positions that, if recognized, would impact the effective tax rate at January 1, 2007	$	898		$	72		$	22		$	992		$	(56	)	$	936
Add tax attributable to deferred tax items at January 1, 2007		242			—			—			242			—			242

Balance, gross uncertain tax positions, at January 1, 2007		1,140			72			22			1,234			(56	)		1,178
Gross additions to tax positions related to current year		208			—			1			209			(3	)		206
Gross reductions to tax positions related to current year		(4	)		—			—			(4	)		—			(4	)
Gross additions to tax positions related to prior years		193			79			6			278			(27	)		251
Gross reductions to tax positions related to prior years		(253	)		(20	)		(1	)		(274	)		17			(257	)
Settlements		(240	)		(54	)		(3	)		(297	)		10			(287	)
Reductions to tax positions related to lapse of statute		(1	)		—			(1	)		(2	)		—			(2	)
Cumulative translation adjustment		15			4			3			22			—			22

Balance, gross uncertain tax positions, at December 31, 2007		1,058			81			27			1,166			(59	)		1,107
Less tax attributable to deferred tax items at December 31, 2007		(264	)		—			—			(264	)		—			(264	)


Total uncertain tax positions that, if recognized, would impact the effective tax rate at December 31, 2007	$	794		$	81		$	27		$	902		$	(59	)	$	843


Total uncertain tax positions that, if recognized, would impact the effective tax rate at January 1, 2008	$	794		$	81		$	27		$	902		$	(59	)	$	843
Add tax attributable to deferred tax items at January 1, 2008		264			—			—			264			—			264

Balance, gross uncertain tax positions, at January 1, 2008		1,058			81			27			1,166			(59	)		1,107
Gross additions to tax positions related to current year		67			—			—			67			(1	)		66
Gross reductions to tax positions related to current year		(28	)		—			—			(28	)		—			(28	)
Gross additions to tax positions related to prior years		238			48			5			291			(55	)		236
Gross reductions to tax positions related to prior years		(131	)		(13	)		(5	)		(149	)		27			(122	)
Settlements		(17	)		(6	)		(1	)		(24	)		5			(19	)
Reductions to tax positions related to lapse of statute		(378	)		(41	)		(4	)		(423	)		22			(401	)
Cumulative translation adjustment		(18	)		(5	)		(2	)		(25	)		—			(25	)

Balance, gross uncertain tax positions, at December 31, 2008		791			64			20			875			(61	)		814
Less tax attributable to deferred tax items at December 31, 2008		(116	)		—			—			(116	)		—			(116	)


Total uncertain tax positions that, if recognized, would impact the effective tax rate at December 31, 2008	$	675		$	64		$	20		$	759		$	(61	)	$	698

F-61

Note 9 INCOME TAXES (Continued)

The annual tabular reconciliation required under FIN No. 48 requires a gross presentation of unrecognized tax benefits. On a gross basis (before reductions in deferred tax assets), the Company’s total amount of unrecognized tax benefits as of January 1, 2008, excluding interest and penalties, was $1,058 million.

The uncertain tax benefits at December 31, 2008 are recorded against the Company’s deferred tax assets to the extent the uncertainty directly related to that asset; otherwise, they are recorded as either current or non-current income taxes payable.

The total amount of gross uncertain tax benefits at December 31, 2008, excluding interest and penalties decreased to $791 million. This reduction is primarily due to favorable resolution of uncertain tax positions, partially offset by additional uncertain tax benefits accrued during 2008. Included in gross reductions to tax positions related to prior years is $27 million of uncertain tax positions that are no longer included in the FIN No. 48 table as a result of the disposition of businesses.

Included in the balance of unrecognized tax benefits was $264 million of uncertain tax positions at January 1, 2008 and $116 million at December 31, 2008, for which the ultimate deductibility is highly certain but for which there is uncertainty as to the timing of such deductibility. Because of the impact of deferred tax accounting, other than interest and penalties, if applicable, the disallowance of the shorter deductibility period would not affect the annual effective tax rate, but would accelerate the payment of cash to the taxing authority or utilization of tax attributes to an earlier period.

The amounts of unrecognized tax benefits that, if recognized, would impact the effective tax rate were $794 million at January 1, 2008, and $675 million at December 31, 2008.

The Company classifies interest and penalties related to unrecognized tax benefits as income tax expense. These amounts are reflected separately on the reconciliation above. The total amount of interest and penalties related to uncertain tax positions and recognized in the consolidated statements of earnings for 2008 was a net benefit of $6 million for interest and $4 million for penalties. The net benefit for interest was a result of $48 million of additional accrual and $54 million of reduction in interest. The net benefit for penalties was a result of $5 million of additional accrual and $9 million of reduction in penalties. The total amount of interest and penalties related to uncertain tax positions and recognized in the consolidated balance sheets at December 31, 2008 was $64 million for interest and $20 million for penalties.

The Company is currently under examination by a number of tax authorities, including all of the major tax jurisdictions listed in the table below, which have proposed adjustments to tax for issues such as transfer pricing, certain tax credits and the deductibility of certain expenses. The Company estimates that it is reasonably possible that the total amount of unrecognized tax benefits at December 31, 2008 will decrease in the range of approximately $95 million to $125 million in the next twelve months as a result of the settlement of certain tax audits. Such settlements will involve the payment of additional taxes, the adjustment of certain deferred taxes and/or the recognition of tax benefits. The Company also anticipates that it is reasonably possible that new issues will be raised by tax authorities which may require increases to the balance of unrecognized tax benefits; however, an estimate of such increases cannot reasonably be made. The Company believes that it has adequately provided for all open tax years by tax jurisdiction under FIN No. 48.

The Company files income tax returns in the U.S. Federal jurisdiction and various state and foreign jurisdictions. With few exceptions, the Company is subject to U.S. Federal, state and local, and non-U.S. income tax examinations by tax authorities. The following is a summary of major tax jurisdictions for which tax authorities may assert additional taxes against the Company based upon tax years currently under audit and subsequent years that will likely be audited:


U.S.		2004 to 2008
Canada		2001 to 2008
France		2004 to 2008
Germany		1999 to 2008
Italy		2003 to 2008
Mexico		2003 to 2008

F-62

Note 10 FAIR VALUE MEASUREMENT

As stated in “—Note 1. Accounting Policies,” on January 1, 2008, the Company adopted the methods of fair value as described in SFAS No. 157 to value its financial assets and liabilities. As defined in SFAS No. 157, fair value is based on the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. In order to increase consistency and comparability in fair value measurements, SFAS No. 157 establishes a fair value hierarchy that prioritizes observable and unobservable inputs used to measure fair value into three broad levels, which are described below:

Level 1: Quoted prices (unadjusted) in active markets that are accessible at the measurement date for identical assets or liabilities. The fair value hierarchy gives the highest priority to Level 1 inputs.

Level 2: Observable prices that are based on inputs not quoted on active markets, but corroborated by market data.

Level 3: Unobservable inputs are used when little or no market data is available. The fair value hierarchy gives the lowest priority to Level 3 inputs.

In determining fair value, the Company utilizes valuation techniques that maximize the use of observable inputs and minimize the use of unobservable inputs to the extent possible as well as considers counterparty credit risk in its assessment of fair value.

The Company chose not to elect the fair value option as prescribed by SFAS No. 159 for its financial assets and liabilities that had not been previously carried at fair value. Therefore, material financial assets and liabilities not carried at fair value, such as short- and long-term debt obligations and trade accounts receivable and payable, are still reported at their carrying values. Financial assets and liabilities carried at fair value at December 31, 2008 are classified in the table below in one of the three categories described above:


Dollars in Millions	Level 1		Level 2		Level 3		Total
Available for Sale:
U.S. Treasury Bills	$	180	$	—	$	—	$	180
Equity Securities		21		—		—		21
U.S. Treasury-Backed Securities		—		7,049		—		7,049
Floating Rate Securities		—		—		203		203
Auction Rate Securities		—		—		94		94

Total available for sale assets		201		7,049		297		7,547

Derivatives:
Interest Rate Swap Derivatives		—		647		—		647
Foreign Exchange Derivatives		—		90		—		90

Total derivative assets		—		737		—		737

Total assets at fair value	$	201	$	7,786	$	297	$	8,284


Dollars in Millions	Level 1		Level 2		Level 3		Total
Derivatives:
Foreign Exchange Derivatives	$	—	$	45	$	—	$	45
Natural Gas Contracts		—		7		—		7

Total derivative liabilities		—		52		—		52

Total liabilities at fair value	$	—	$	52	$	—	$	52

The Company’s assets that utilize Level 3 inputs for fair value measurement consist of the auction rate securities and floating rate securities (FRS).

Due to the lack of observable market quotes on the Company’s ARS investment portfolio, the Company utilizes valuation models that rely exclusively on Level 3 inputs including those that are based on expected cash flow streams and collateral values, including assessments of counterparty credit quality, default risk underlying the security, discount rates and overall capital market liquidity. The valuation of the Company’s ARS investment portfolio is subject to uncertainties that are difficult to predict. Factors that may impact the Company’s valuation include changes to credit ratings of the securities as well as to the underlying assets supporting those securities, rates of default of the underlying assets, underlying collateral value, discount rates, counterparty risk and ongoing strength and quality of market credit and liquidity. The Company’s determination of fair value on its ARS investment portfolio at December 31, 2008 included indicative prices received from external banks, internally developed valuations that were based in part on indicative bids received on the underlying assets of the securities, and other non-observable evidence of fair value. Although the ARS continue to pay interest according to their stated terms, due to the continued severity in the capital markets and the length of

F-63

Note 10 FAIR VALUE MEASUREMENT (Continued)

time until the ARS mature, the Company believes that full recovery is no longer probable. For further discussion on the Company’s December 31, 2008 fair value, carrying value and rollforward of ARS activity, including sales and other-than-temporary impairment charge recorded during 2008, see “—Note 11. Cash, Cash Equivalents and Marketable Securities.”

The Company’s FRS are primarily rated ‘A/Baa1’ or better. FRS are long-term debt securities with coupons that are reset periodically against a benchmark interest rate. The underlying assets of the FRS consist primarily of consumer loans, auto loans, collateralized loan obligations, monoline securities, asset-backed securities, and corporate bonds and loans. Since the latter part of 2007, the general FRS market became less liquid or active due to the continuing credit and liquidity concerns. As a result, there is no availability of observable market quotes in the active market (Level 1 inputs) or market quotes on similar or identical assets or liabilities, or inputs that are derived principally from or corroborated by observable market data by correlation or other means (Level 2 inputs). The Company marks-to-market its FRS based on indicative pricing. Those indicative price quotes represent the individual broker’s own assessments based on similar assets as well as using valuation techniques and analyzing the underlying assets of FRS. Due to the current lack of an active market for the Company’s FRS and the general lack of transparency into their underlying assets, the Company also relies on other qualitative analysis including discussions with brokers and fund managers, default risk underlying the security and overall capital market liquidity (Level 3 inputs) to value its FRS portfolio. For further discussion on the Company’s December 31, 2008 fair value, carrying value and rollforward of activity that occurred during 2008, see “—Note 11. Cash, Cash Equivalents and Marketable Securities.”

For financial assets and liabilities that utilize Level 1 and Level 2 inputs, the Company utilizes both direct and indirect observable price quotes, including LIBOR and EURIBOR yield curves, foreign exchange forward prices, NYMEX futures pricing and common stock price quotes. Below is a summary of valuation techniques for Level 1 and Level 2 financial assets and liabilities:

•

U.S. Treasury Bills and Treasury-Backed Securities – valued at the quoted market price from broker or dealer quotations or transparent pricing sources at the reporting date.

•

Equity securities – valued using quoted stock prices from New York Stock Exchange or National Association of Securities Dealers Automated Quotation System at the reporting date.

•

Interest rate swap derivative assets and liabilities – valued using LIBOR and EURIBOR yield curves, less credit valuation adjustments, at the reporting date. Counterparties to these contracts are financial institutions, some of which experienced downgrades during 2008. Valuations may fluctuate considerably from period-to-period due to volatility in underlying interest rates, which is driven by market conditions and the duration of the swap. In addition, a credit valuation adjustment had a significant impact on the valuation of the Company’s interest rate swaps due to changes in counterparty credit ratings and credit default swap spreads.

•

Foreign exchange derivative assets and liabilities – valued using quoted forward foreign exchange prices at the reporting date. Counterparties to these contracts are financial institutions, some of which experienced downgrades during 2008. Valuations may fluctuate considerably from period-to-period due to volatility in the underlying foreign currencies. Due to the short-term maturities of the Company’s foreign exchange derivatives, which are generally 15 months or less, counterparty credit risk is not significant.

•

Natural gas forward contracts – valued using NYMEX futures prices for natural gas at the reporting date. Counterparties to these contracts are financial institutions, some of which experienced downgrades during 2008. Valuations may fluctuate considerably from period-to-period due to volatility in the underlying natural gas prices. Due to the short-term maturities of the Company’s natural gas derivatives, which are 15 months or less, counterparty credit risk is not significant.

Increases or decreases to the aggregate fair value of financial assets and liabilities measured at fair value would not have a significant impact on the Company’s liquidity or financial flexibility. Approximately 87% of the fair value of net financial assets is U.S. Treasury Bills and U.S. Treasury-backed securities.

Although the Company has not elected the fair value option for financial assets and liabilities existing at January 1, 2008 or transacted during 2008, any future transacted financial asset or liability will be evaluated for the fair value election as prescribed by SFAS No. 159 and will be fair valued under the provisions of SFAS No. 157. The Company did not elect the fair value option for its $1.6 billion Senior Notes issued on May 1, 2008.

F-64

Note 11 CASH, CASH EQUIVALENTS AND MARKETABLE SECURITIES

Cash and cash equivalents at December 31, 2008 of $7,976 million primarily consisted of U.S. Treasury-backed securities. Cash and cash equivalents at December 31, 2007 of $1,801 million primarily consisted of bank deposits, time deposits and money market funds. Cash equivalents are primarily highly liquid investments with original maturities of three months or less at the time of purchase and are recorded at cost, which approximates fair value. The Company maintains cash and cash equivalent balances in U.S. dollars and foreign currencies which are subject to currency rate risk.

Marketable securities at December 31, 2008 primarily consisted of U.S. Treasury Bills and U.S. dollar-denominated FRS. During 2008, the Company’s FRS holdings have been downgraded from December 31, 2007 ratings, which were primarily ‘AAA/Aaa’, to ratings that ranged from ‘AAA/Aaa’ to ‘A/Baa1’ at December 31, 2008. FRS are long-term debt securities with coupons that are reset periodically against a benchmark interest rate. The underlying assets of the Company’s FRS consist primarily of consumer loans, auto loans, collateralized loan obligations, monoline securities, asset-backed securities, and corporate bonds and loans. The Company accounts for its marketable securities in accordance with SFAS 115, Accounting for Certain Investments in Debt and Equity Securities, and classifies them as “available for sale.” Non-current FRS are classified as non-current other assets at December 31, 2008.

The following tables summarize the Company’s current and non-current marketable securities at December 31, 2008 and 2007, which include U.S. dollar-denominated FRS and ARS, both of which are accounted for as “available for sale” debt securities:


December 31, 2008 Dollars in Millions	Cost		Fair Value		Carrying Value		Unrealized (Loss)/Gain in Accumulated OCI
Current:
Available for sale
Floating rate securities	$	115	$	109	$	109	$	(6	)
U.S. Treasury Bills		179		180		180		1
Other		—		—		—		—

Total current	$	294	$	289	$	289	$	(5	)

Non-current:
Available for sale
Auction rate securities⁽¹⁾	$	169	$	94	$	94	$	—
Floating rate securities		139		94		94		(45	)

Total non-current	$	308	$	188	$	188	$	(45	)


December 31, 2007 Dollars in Millions	Cost		Fair Value		Carrying Value		Unrealized (Loss)/Gain in Accumulated OCI
Current:
Available for sale
Floating rate securities	$	362	$	337	$	337	$	(25	)
Other		87		87		87		—

Total current	$	449	$	424	$	424	$	(25	)

Non-current:
Available for sale
Auction rate securities⁽¹⁾	$	811	$	419	$	419	$	(117	)

Total non-current	$	811	$	419	$	419	$	(117	)

⁽¹⁾	The Company recognized a pre-tax other-than-temporary impairment charge of $305 and $275 million during 2008 and 2007, respectively, and a $19 million loss on the sale of certain of these securities.

F-65

Note 11 CASH, CASH EQUIVALENTS AND MARKETABLE SECURITIES (Continued)

On December 31, 2007, the Company’s principal value in FRS amounted to $337 million. During 2008, the Company received $108 million of principal at par primarily on FRS that matured in March 2008 and temporarily reduced the fair value of the remaining FRS by $26 million to $203 million as an unrealized loss in accumulated OCI. In addition, during 2008, the Company reclassified $94 million of the remaining FRS with maturity dates beyond 2009 from current assets to non-current other assets due to liquidity concerns and the continued uncertainty in the capital markets.

During 2008, the Company received $118 million in connection with the sale of ARS with a carrying value of $137 million, resulting in a loss of $19 million. In addition, a $305 million other-than-temporary impairment charge was recognized, including $117 million that was previously determined to be temporary at December 31, 2007. The 2008 impairment charge was required after an analysis of other-than-temporary impairment factors, including the severity and the duration of the decline in value, future prospects of the issuer and the Company’s ability and intent to hold the security to recovery. The ARS sold were securities generally backed by sub-prime mortgages, collateralized debt obligations and structured credit. The ARS remaining at December 31, 2008 primarily represents interests in insurance securitizations and to a lesser extent, structured credits.

The following table summarizes the activity for those financial assets where fair value measurements are estimated utilizing Level 3 inputs (ARS and FRS):


				Non-current
Dollars in Millions	Current FRS			FRS			ARS			Total
Carrying value at January 1, 2008	$	337		$	—		$	419		$	756
Settlements		(106	)		(2	)		(118	)		(226	)
Transfers between current and non-current		(104	)		104			—			—
Total losses
Included in earnings		—			—			(324	)		(324	)
Included in other comprehensive income		(18	)		(8	)		117			91

Carrying value at December 31, 2008	$	109		$	94		$	94		$	297

For a discussion on the fair value of financial instruments, including ARS and FRS, see “—Note 10. Fair Value Measurement.”

The contractual maturities of the carrying value of the “available for sale” debt securities at December 31, 2008 were as follows:


Dollars in Millions	Within 1 Year		Over 1 to 5 Years		Over 5 to 10 Years		Over 10 Years		Total
Available for Sale
Floating Rate Securities	$	109	$	94	$	—	$	—	$	203
Auction Rate Securities		—		—		—		94		94
U.S. Treasury Bills		180		—		—		—		180

Total Available for Sale	$	289	$	94	$	—	$	94	$	477

Note 12 RECEIVABLES, NET

The major categories of receivables were as follows:


	December 31,
Dollars in Millions	2008		2007
Trade receivables	$	2,545	$	2,781
Alliance Partner receivables		804		543
Income tax refund claims		64		472
Miscellaneous receivables		359		319

		3,772		4,115
Less allowances		128		180

Receivables, net	$	3,644	$	3,935

Receivables are netted with deferred income on sales of product to alliance partners until recognition of revenue. As a result, a corresponding reclassification was made which reduced Alliance Partner receivables and deferred income by $566 million and $246 million at December 31, 2008 and 2007, respectively. For additional information on the Company’s alliance partners, see “—Note 2. Alliances and Collaborations.”

In the aggregate, receivables due from three pharmaceutical wholesalers in the U.S. represented 35% and 29% of total trade receivables at December 31, 2008 and 2007, respectively.

F-66

Note 13 INVENTORIES, NET

The major categories of inventories were as follows:


	December 31,
Dollars in Millions	2008		2007
Finished goods	$	707	$	904
Work in process		738		834
Raw and packaging materials		320		424

Inventories, net	$	1,765	$	2,162

Inventories expected to remain on-hand beyond one year were $185 million and $73 million at December 31, 2008 and 2007, respectively, and were included in non-current other assets.

Note 14 PROPERTY, PLANT AND EQUIPMENT, NET

The major categories of property, plant and equipment were as follows:


	December 31,
Dollars in Millions	2008		2007
Land	$	149	$	185
Buildings		4,506		4,696
Machinery, equipment and fixtures		4,007		4,418
Construction in progress		787		915

		9,449		10,214
Less accumulated depreciation		4,044		4,564

Property, plant and equipment, net	$	5,405	$	5,650

Capitalized interest was $23 million in 2008, $27 million in 2007 and $18 million in 2006.

Note 15 GOODWILL

The changes in the carrying amount of goodwill by segment for the years ended December 31, 2008 and 2007 were as follows:


Dollars in Millions	BioPharmaceuticals Segment			Mead Johnson Segment		ConvaTec/ Medical Imaging			Total
Balance at January 1, 2007	$	4,445		$	113	$	271		$	4,829
Acquisition of Adnexus		156			—		—			156
Other adjustments		2			—		11			13

Balance at January 1, 2008	$	4,603		$	113	$	282		$	4,998
Sale of Medical Imaging		—			—		(2	)		(2	)
Sale of ConvaTec		—			—		(280	)		(280	)
Sale of mature brand business in Egypt		(9	)		—		—			(9	)
Acquisition of Kosan		127			—		—			127
Adnexus purchase price adjustment		(7	)		—		—			(7	)

Balance at December 31, 2008	$	4,714		$	113	$	—		$	4,827

See “— Note 4. Acquisitions and Divestitures” for further detail.

F-67

Note 16 OTHER INTANGIBLE ASSETS, NET

At December 31, 2008 and 2007, other intangible assets consisted of the following:


	Patents/ Trademarks				Licenses				Technology				Capitalized Software				Total Other Intangible Assets
Dollars in Millions	2008		2007		2008		2007		2008		2007		2008		2007		2008		2007
Gross carrying amount	$	156	$	179	$	650	$	663	$	1,107	$	1,214	$	1,040	$	917	$	2,953	$	2,973
Less accumulated amortization		103		99		250		215		704		660		745		669		1,802		1,643

Other intangible assets, net	$	53	$	80	$	400	$	448	$	403	$	554	$	295	$	248	$	1,151	$	1,330

The change in the carrying amount of other intangible assets for the years ended December 31, 2008 and 2007 were as follows:


	Total Other Intangible Assets
Dollars in Millions	2008			2007
Other intangible assets, net carrying amount at January 1	$	1,330		$	1,852
Additions		138			74
Acquisition of Adnexus		—			27
Amortization		(254	)		(350	)
Medical Imaging – assets held for sale		—			(273	)
Sale of ConvaTec		(21	)		—
Impairment charges		(40	)		—
Other		(2	)		—

Other intangible assets, net carrying amount at December 31	$	1,151		$	1,330

Impairment charges in 2008 relate to certain patent and product rights acquired from Dupont in 2001 and results from development programs that were abandoned and license terminations. Amortization expense for other intangible assets was $254 million in 2008, $350 million in 2007 and $363 million in 2006. Amortization expense for other intangible assets related to ConvaTec and Medical Imaging reflected in discontinued operations was $4 million in 2008, $69 million in 2007 and $71 million in 2006.

Expected amortization expense related to the current net carrying amount of other intangible assets follows:


Years Ending December 31,	Dollars in Millions
2009	$	219
2010		228
2011		211
2012		172
2013		90
Later Years		231

Note 17 ACCRUED EXPENSES

The major categories of accrued expenses were as follows:


	December 31,
Dollars in Millions	2008		2007
Employee compensation and benefits	$	784	$	784
Royalties		515		492
Accrued research and development		466		399
Restructuring – current		158		105
Pension and postretirement benefits		90		85
Other		923		1,086

	$	2,936	$	2,951

F-68

Note 18 SHORT-TERM BORROWINGS AND LONG-TERM DEBT

Short-term borrowings were $154 million and $1,891 million at December 31, 2008 and 2007, respectively.

In September 2008, the Company repaid $1,150 million principal amount of the $1,200 million aggregate principal amount of Floating Rate Convertible Senior Debentures due 2023, as a result of a partial redemption by the note holders. All or a portion of the remaining balance of $50 million can be redeemed by the holders at par on September 15, 2013 and 2018, or if a fundamental change in ownership of the Company occurs. All or part of the remaining debt is callable at par at any time by the issuer. The Debentures have a conversion price of $41.28, or a conversion rate of 24.2248 shares, subject to certain anti-dilutive adjustments. The maximum conversion rate is 38.7597 shares. The Debentures pay interest quarterly at an annual rate equal to the three month LIBOR, reset quarterly, minus 0.50% (the yield never to be less than zero).

In August 2008 and February 2008, the Company repaid the $400 million 4.00% Notes due 2008 and $117 million of the 1.10% Yen Notes due 2008, respectively.

The components of long-term debt were as follows:


Dollars in Millions	December 31, 2008			December 31, 2007
*Principal Value*
5.875% Notes due 2036	$	1,023		$	1,250
6.125% Notes due 2038		1,000			—
4.375% Euro Notes due 2016		698			725
4.625% Euro Notes due 2021		698			725
5.45% Notes due 2018		600			—
5.25% Notes due 2013		597			600
6.80% Debentures due 2026		350			350
7.15% Debentures due 2023		339			350
6.88% Debentures due 2097		287			300
Floating Rate Convertible Senior Debentures due 2023		50			—
5.75% Industrial Revenue Bonds due 2024		35			35
1.81% Yen Notes due 2010		39			31
Variable Rate Industrial Revenue Bonds due 2030		15			15
Other		6			9

Subtotal	$	5,737		$	4,390

*Adjustments to Principal Value*
Fair value of interest rate swaps⁽¹⁾		647			(24	)
Unamortized proceeds from swap terminations		233			37
Unamortized bond discounts		(32	)		(22	)

	$	6,585		$	4,381

⁽¹⁾	For further discussion on Company’s interest rate swaps refer to “—Note 21. Financial Instruments.”

F-69

Note 18 SHORT-TERM BORROWINGS AND LONG-TERM DEBT (continued)

In November and December 2008, the Company repurchased approximately $254 million principal amount of debt and terminated $241 million notional amount of interest rate swaps, resulting in a gain of $57 million reported in other expense, net. The table below summarizes the debt repurchase and related activity:


Dollars in Millions	Principal Amount		Repurchase Price		Gain on Repurchase		Swap Termination Proceeds		Other			Earnings Impact
5.875% Notes due 2036	$	227	$	201	$	26	$	32	$	(3	)	$	55
6.88% Debentures due 2097		13		13		—		—		—			—
7.15% Debentures due 2023		11		11		—		2		—			2
5.25% Notes due 2013		3		3		—		—		—			—

Total	$	254	$	228	$	26	$	34	$	(3	)	$	57

On May 1, 2008, the Company issued $600 million aggregate principal amount of 5.45% Notes due 2018 and $1.0 billion aggregate principal amount of 6.125% Notes due 2038 (collectively, the “May 1, 2008 Issued Notes”) in a registered public offering. Interest payments are made May 1 and November 1 of each year, beginning on November 1, 2008. The May 1, 2008 Issued Notes are senior unsecured obligations of the Company and rank equally in right of payment with all of the Company’s existing and future senior unsecured indebtedness. The Company may redeem the May 1, 2008 Issued Notes, in whole or in part, at any time at a redemption price equal to the greater of par value or an amount calculated based upon the sum of the present values of the remaining scheduled payments as set forth in the prospectus supplement dated April 28, 2008.

In December 2008, the Company terminated $550 million notional amount of its 2036 and 2038 fixed-to-floating interest rate swap agreements related to its Notes due 2036 and 2038 and received proceeds of $197 million. These proceeds are being recognized against interest expense over the remaining life of the underlying debt.

In September 2005, the Company terminated $350 million notional amount of its 2026 fixed-to-floating interest rate swap agreements related to its $350 million 6.80% Debentures due 2026 and received proceeds of $39 million. These proceeds are being recognized against interest expense over the remaining life of the underlying debt, of which approximately $1 million, pre-tax, was recognized in each of the years 2008, 2007 and 2006. For further discussion on the Company’s swap terminations refer to “—Note 21. Financial Instruments.”

Including payments due to interest rate swaps, cash payments for interest were $539 million in 2008, $610 million in 2007 and $682 million in 2006. Cash receipts from interest rate swaps were $236 million in 2008, $210 million in 2007 and $205 million in 2006 and were excluded from cash payments for interest.

The Company’s principal value of long-term debt obligations were $5,737 million at December 31, 2008 of which $45 million is due in 2010, $647 million is due in 2013, and the remaining $5,045 million is due later than 2013.

At December 31, 2008, the Company provided a total of $168 million financial guarantees in the form of stand-by letters of credit and performance bonds. The stand-by letters of credit are with insurance companies in support of third-party liability programs. The performance bonds have been issued to support a range of ongoing operating activities, including sale of Company products to hospitals and foreign ministries of health, bonds for customs, duties and value added tax and guarantees related to miscellaneous legal actions. A significant majority of the Company’s outstanding financial guarantees will expire within the year and are not expected to be funded.

F-70

Note 19 EQUITY

Changes in common shares, treasury stock, capital in excess of par value of stock and restricted stock were as follows:


Dollars and Shares in Millions	Common Shares Issued	Treasury Stock		Cost of Treasury Stock			Capital in Excess of Par Value of Stock		Restricted Stock
Balance at January 1, 2006	2,205	248		$	(11,168	)	$	2,528	$	(71	)
Employee stock compensation plans	—	(10	)		241			98		(57	)

Balance at December 31, 2006	2,205	238			(10,927	)		2,626		(128	)
Employee stock compensation plans	—	(12	)		343			96		31

Balance at December 31, 2007	2,205	226			(10,584	)		2,722		(97	)
Employee stock compensation plans	—	—			18			106		26

Balance at December 31, 2008	2,205	226		$	(10,566	)	$	2,828	$	(71	)

Each share of the Company’s preferred stock is convertible into 16.96 shares of common stock and is callable at the Company’s option. The reductions in the number of issued shares of preferred stock in 2008, 2007 and 2006 were due to conversions into shares of common stock.

The accumulated balances related to each component of OCI, net of taxes, were as follows:


Dollars in Millions	Foreign Currency Translation			Derivatives Qualifying as Cash Flow Hedges			Minimum Pension Liability			Pension and Other Postretirement Benefits			Available for Sale Securities			Accumulated Other Comprehensive Income/(Loss)
Balance at January 1, 2006	$	(553	)	$	16		$	(229	)	$	—		$	1		$	(765	)
Other comprehensive income/(loss)		129			(39	)		82			—			12			184
Adjustments on adoption of SFAS No. 158		—			—			147			(1,211	)		—			(1,064	)

Balance at December 31, 2006		(424	)		(23	)		—			(1,211	)		13			(1,645	)
Other comprehensive income/(loss)		99			(14	)		—			238			(139	)		184

Balance at December 31, 2007		(325	)		(37	)		—			(973	)		(126	)		(1,461	)
Other comprehensive income/(loss)		(99	)		51			—			(1,285	)		75			(1,258	)

Balance at December 31, 2008	$	(424	)	$	14		$	—		$	(2,258	)	$	(51	)	$	(2,719	)

The reconciliation of noncontrolling interest was as follows:


	Noncontrolling Interest
	2008			2007			2006
Balance at January 1	$	(27	)	$	50		$	(134	)
Noncontrolling interest		1,468			1,132			628
Distributions		(1,474	)		(1,209	)		(444	)

Balance at December 31	$	(33	)	$	(27	)	$	50

Noncontrolling interest is primarily related to the Company’s partnerships with Sanofi for the territory covering the Americas for sales of PLAVIX*. Net earnings attributable to noncontrolling interest is presented net of taxes of $472 million in 2008, $369 million in 2007 and $188 million in 2006 in the consolidated statements of earnings with a corresponding increase to the provision for income taxes. Distribution of the partnership profits to Sanofi and Sanofi’s funding of ongoing partnership operations occur on a routine basis and are included within operating activities in the consolidated statements of cash flows. The above activity includes the pre-tax earnings and distributions related to these partnerships.

F-71

Note 20 EMPLOYEE STOCK BENEFIT PLANS

Employee Stock Plans

On May 1, 2007, the stockholders approved the Company’s 2007 Stock Award and Incentive Plan (the 2007 Plan). The 2007 Plan replaced the 2002 Stock Incentive Plan (the 2002 Plan) that expired on May 31, 2007. The 2007 Plan provides for 42 million new shares of common stock reserved for delivery to participants, plus shares remaining available for new grants under the 2002 Plan and shares recaptured from outstanding awards under the 2002 Plan. Only the number of shares actually delivered to participants in connection with an award after all restrictions have lapsed will be counted against the number of shares reserved. Shares tendered in a prior year to pay the purchase price of options and the number of shares previously utilized to satisfy withholding tax obligations upon exercise continue to be available and reserved. At December 31, 2008 and 2007, 350 million and 352 million shares of common stock, respectively, were reserved for issuance pursuant to stock plans, options and conversions of preferred stock. There were 100 million and 98 million shares available to be granted for the active plans at December 31, 2008 and 2007, respectively, adjusted for the combination of plans.

Under the Company’s 2007 Plan and the 2002 Plan, executive officers and key employees may be granted options to purchase the Company’s common stock at no less than 100% of the market price on the date the option is granted. Options generally become exercisable in installments of 25% per year on each of the first through the fourth anniversaries of the grant date and have a maximum term of 10 years. Generally, the Company issues shares for the stock option exercise from treasury stock. Additionally, the plan provides for the granting of stock appreciation rights whereby the grantee may surrender exercisable rights and receive common stock and/or cash measured by the excess of the market price of the common stock over the option exercise price. At December 31, 2008 there were 202 thousand stock appreciation rights outstanding, all treated as liability awards.

The 2007 Plan and the 2002 Plan provide for the granting of common stock to key employees, subject to restrictions as to continuous employment. Restrictions generally expire over a four year period from date of grant. Compensation expense is recognized over the restricted period. During the first quarter of 2007, the Company began granting restricted stock units instead of restricted stock. A stock unit is a right to receive stock at the end of the specified vesting period. A stock unit has no voting rights.

The 2007 Plan and the 2002 Plan also incorporate the Company’s long-term performance awards. These awards, which are delivered in the form of a target number of performance shares, have a three year cycle. For 2008 to 2010 and 2007 to 2009, the awards have annual goals set at the beginning of each performance period and are based 50% on earnings per share and 50% on sales. Maximum performance will result in a maximum payout of 165% for the 2008 to 2010 award and 220% for the 2007 to 2009 award. In addition, a one-time special performance award was granted for the 2008 to 2010 performance period. This special performance award has annual goals, set at the beginning of each performance period, based 50% on pre-tax operating margin and 50% on operating cash flow. Maximum performance will result in a maximum payout of 165%. The goals for the 2005 through 2007 and the 2006 through 2008 awards are set for the three year period and are based 50% on cumulative earnings per share and 50% on cumulative sales, with the ultimate payout modified by the Company’s total stockholder return versus the 11 companies in its proxy peer group. Maximum performance for all three measures will result in a maximum payout of 253% of target. If threshold targets are not met for the performance period, no payment will be made under the plan.

Under the TeamShare Stock Option Plan, which terminated on January 3, 2005, full-time employees, excluding key executives, were granted options to purchase the Company’s common stock at the market price on the date the options were granted. The Company authorized 66 million shares for issuance under the plan. Individual grants generally became exercisable evenly on the third, fourth and fifth anniversary of the grant date and have a maximum term of 10 years. Options on 36 million shares have been exercised under the plan at December 31, 2008.

The Company’s results of operations for the years ended December 31, 2008, 2007 and 2006 reflect the impact of SFAS No. 123(R), Share-Based Payment, which includes the impact of the expensing of stock options. The Company has elected the alternative method as provided in FSP No. 123(R)-3, Transition Election Related To Accounting For The Tax Effects of Share-Based Payment Awards, in determining the Company’s pool of excess tax benefits. The following tables summarize stock-based compensation expense related to employee stock options, restricted stock and long-term performance awards for the years ended December 31, 2008, 2007 and 2006:


	Years Ended December 31,
Dollars in Millions	2008		2007		2006
Stock options	$	79	$	72	$	80
Restricted stock		82		53		34
Long-term performance shares		20		8		(2	)

Total stock-based compensation expense	$	181	$	133	$	112

F-72

Note 20 EMPLOYEE STOCK BENEFIT PLANS (continued)

Stock-based compensation expense was recognized in the consolidated statements of earnings as follows:


	Years Ended December 31,
Dollars in Millions	2008		2007		2006
Cost of products sold	$	18	$	13	$	11
Marketing, selling and administrative		109		80		67
Research and development		54		40		34

Total stock-based compensation expense		181		133		112
Deferred tax benefit		59		45		39

Stock-based compensation expense, net of taxes	$	122	$	88	$	73

Stock-based compensation expense of $5 million in 2008, $7 million in 2007 and $6 million in 2006 is included in discontinued operations.

Stock Options

A summary of stock option activities were as follows:


Shares in Millions	Shares of Common Stock Issued Under Plan		Weighted-Average Exercise Price of Shares
Balance at January 1, 2006	164		$	38.45
Granted	16			23.18
Exercised	(8	)		21.00
Expired or forfeited	(9	)		33.53

Balance at December 31, 2006	163			38.16
Granted	15			26.31
Exercised	(13	)		27.02
Expired or forfeited	(17	)		32.84

Balance at December 31, 2007	148			38.53
Granted	18			22.11
Exercised	—			15.90
Expired or forfeited	(34	)		41.72

Balance at December 31, 2008	132			35.48

Information related to stock option grants and exercises under both the 2007 Plan and the 2002 Plan are summarized as follows:


	Year Ended December 31,
Amounts in Millions, except per share data	2008		2007		2006
Stock options granted		18.4		15.3		15.3
Weighted-average grant-date fair value (per share)	$	4.95	$	6.56	$	4.74
Total intrinsic value of stock options exercised	$	2	$	37	$	17
Cash proceeds from exercise of stock options	$	5	$	345	$	167

At December 31, 2008, there was $100 million of total unrecognized compensation cost related to stock options that is expected to be recognized over a weighted-average period of 2.4 years.

The following tables summarize information concerning the Company’s stock compensation plans and currently outstanding and exercisable options:


Shares in Millions	Number of Securities to be Issued Upon Exercise of Outstanding Options and Rights	Weighted-Average Exercise Price of Outstanding Options and Rights
Plan Category
Equity compensation plans approved by security holders	124	$	35.33
Equity compensation plans not approved by security holders⁽¹⁾	8		37.80

	132		35.48

⁽¹⁾	Shares under this plan are no longer being issued.

F-73

Note 20 EMPLOYEE STOCK BENEFIT PLANS (continued)

The following table summarizes significant ranges of outstanding and exercisable options at December 31, 2008 (amounts in millions, except per share data):


	Options Outstanding						Options Exercisable
Range of Exercise Prices	Number Outstanding	Weighted- Average Remaining Contractual Life (in Years)	Weighted- Average Exercise Price Per Share		Aggregate Intrinsic Value (in millions)		Number Exercisable	Weighted- Average Remaining Contractual Life (in Years)	Weighted- Average Exercise Price Per Share		Aggregate Intrinsic Value (in millions)
$1 - $20	—	8.22	$	4.80	$	8	—	8.08	$	3.79	$	3
$20 - $30	85	6.56		25.00		25	53	5.44		25.73		5
$30 - $40	—	7.32		30.93		—	—	5.75		30.61		—
$40 - $50	20	2.27		45.60		—	19	2.27		45.60		—
$50 - $60	10	2.24		58.47		—	10	2.25		58.34		—
$60 and up	17	0.48		63.28		—	17	0.48		63.28		—

	132	4.82		35.48	$	33	99	3.67		39.16	$	8


Vested or expected to vest	130	4.77		35.63	$	32

The aggregate intrinsic value in the preceding table represents the total pre-tax intrinsic value, based on the Company’s closing stock price of $23.25 on December 31, 2008, which would have been received by the option holders had all option holders exercised their options as of that date. The total number of in-the-money options exercisable at December 31, 2008 was 17 million. At December 31, 2007, 113 million outstanding options were exercisable and the weighted-average exercise price was $42.21.

The fair value of employee stock options granted were estimated on the date of the grant using the Black-Scholes option pricing model for stock options with a service condition, and the Monte Carlo simulation model for options with service and market conditions. The following table presents the weighted-average assumptions used in the valuation:


	Year Ended December 31,
	2008		2007		2006
Expected volatility	31.1	%	28.9	%	26.7	%
Risk-free interest rate	3.3	%	4.7	%	4.6	%
Dividend yield	4.3	%	4.5	%	4.8	%
Expected life	6.7 yrs		6.2 yrs		6.3 yrs

The Company derived the expected volatility assumption required in the Black-Scholes model by calculating a 10-year historical volatility and weighting that equally with the derived implied volatility. The selection of the blended historical and implied volatility approach was based on the Company’s assessment that this calculation of expected volatility is more representative of future stock price trends than using only historical volatility.

The risk-free interest rate assumption is based upon the U.S. Treasury yield curve in effect at the time of grant. The dividend yield assumption is based on the Company’s history and expectation of dividend payouts.

The expected life of employee stock options represents the weighted-average period the stock options are expected to remain outstanding and is a derived output of a lattice-binomial model. The expected life of employee stock options is impacted by all of the underlying assumptions and calibration of the Company’s model. The lattice-binomial model assumes that employees’ exercise behavior is a function of the option’s remaining vested life and the extent to which the option is in-the-money. The lattice-binomial model estimates the probability of exercise as a function of these two variables based on the entire history of exercises and cancellations on all past option grants made by the Company.

Stock-based compensation expense is based on awards ultimately expected to vest. Forfeitures were estimated based on historical experience at the time of grant and revised in subsequent periods if actual forfeitures differ from those estimates.

The Company acquired Adnexus on October 19, 2007. As part of the acquisition agreement, the Company assumed 24 million shares of Adnexus incentive stock options (ISOs) and replaced them with 0.6 million shares of Company ISOs. The converted options retain their original vesting schedules, including the vesting commencement date, as well as the expiration date. A Black-Scholes model was used to determine the expected term and the individual ISOs valuations. The result was a weighted-average expected term of 5.2 years and a weighted-average fair value on October 19, 2007 of $20.34.

F-74

Note 20 EMPLOYEE STOCK BENEFIT PLANS (continued)

Restricted Stock Awards and Restricted Stock Units

The fair value of nonvested shares of the Company’s common stock is determined based on the average trading price of the Company’s common stock on the grant date.

Restricted share activities were as follows:


Shares in Thousands	Number of Shares		Weighted-Average Grant-Date Fair Value
Nonvested shares at January 1, 2006	4,162		$	27.36
Granted	4,295			23.45
Vested	(645	)		32.48
Forfeited	(921	)		26.64

Nonvested shares at December 31, 2006	6,891			24.58
Granted	3,584			27.14
Vested	(1,360	)		25.51
Forfeited	(892	)		25.13

Nonvested shares at December 31, 2007	8,223			25.48
Granted	5,468			22.22
Vested	(3,310	)		25.37
Forfeited	(1,650	)		24.22

Nonvested shares at December 31, 2008	8,731			23.73

Expected to vest	8,270			23.73

At December 31, 2008, there was $153 million of total unrecognized compensation cost related to nonvested restricted stock and that cost is expected to be recognized over a weighted-average period of 2.6 years. The total fair value of nonvested shares and share units granted that was recognized as compensation expense was $82 million in 2008, $53 million in 2007 and $34 million in 2006. The total fair value of shares and share units that vested in 2008 was $84 million.

Long-Term Performance Awards

Since the adoption of SFAS No. 123(R), the fair value of the 2006 through 2008 performance award was estimated on the date of grant using a Monte Carlo simulation model due to a market condition. The Monte Carlo simulation model utilizes multiple input variables that determine the probability of satisfying each market condition stipulated in the award grant and calculates the fair market value for the long-term performance awards. For the 2008 to 2010 and the 2007 to 2009 performance awards, because theses awards do not contain a market condition, the fair value was based on the closing trading price of the Company’s common stock on the grant date.

The valuation model for the 2006 through 2008 award used the following assumptions:


Grant Year	Grant Date	Weighted-Average Expected Volatility		Expected Dividend Yield		Risk-Free Interest Rate
2006	3/7/2006	20.4	%	4.9	%	4.4	%

Weighted-average expected volatility is based on the three year historical volatility levels on the Company’s common stock. Expected dividend yield is based on historical dividend payments. Risk-free interest rate reflects the yield on five year zero coupon U.S. Treasury bonds, based on the performance shares’ contractual term. The fair value of the performance awards is amortized over the performance period of the award.

F-75

Note 20 EMPLOYEE STOCK BENEFIT PLANS (continued)

Information related to performance awards under both the 2007 Plan and the 2002 Plan is summarized as follows:


Shares in Thousands Grant Date					Performance Shares Outstanding
Shares in Thousands Grant Date	Performance Cycle Measurement Date	Shares Granted	Weighted-Average Grant-Date Fair Value		December 31, 2008	December 31, 2007
3/1/05	12/31/07	1,087	$	25.45	—	830
3/7/06	12/31/08	640		20.00	348	415
3/6/07	Annually on 12/31	219		27.01	176	209
5/1/07	Annually on 12/31	57		28.68	57	57
3/19/08	Annually on 12/31	878		21.46	786	—
3/25/08	Annually on 12/31	279		21.60	224	—
3/31/08	Annually on 12/31	15		21.30	15	—
4/7/08	Annually on 12/31	15		22.00	15	—

Total outstanding					1,621	1,511

Unrecognized compensation cost related to the performance share plan was $24 million at December 31, 2008 and is expected to be recognized over a weighted-average period of 1.7 years.

Accuracy of Fair Value Estimates

The Company’s determination of fair value of stock-based payment awards on the date of grant using an option-pricing model is affected by the Company’s stock price, as well as assumptions regarding a number of highly complex and subjective variables. These variables include, but are not limited, to the Company’s expected stock price volatility over the term of the awards and actual and projected employee stock option exercise behaviors. Option-pricing models were developed for use in estimating the value of traded options that have no vesting or hedging restrictions and are fully transferable. Because the Company’s employee stock options have certain characteristics that are significantly different from traded options, and because changes in the subjective assumptions can materially affect the estimated value, in management’s opinion, the existing valuation models may not provide an accurate measure of the fair value of the Company’s employee stock options. Although the fair value of employee stock options is determined in accordance with SFAS No. 123(R) and Staff Accounting Bulletin (SAB) No. 107, Share-Based Payment, using an option-pricing model, that value may not be indicative of the fair value observed in a willing buyer/willing seller market transaction.

Note 21 FINANCIAL INSTRUMENTS

Cash Flow Hedges

Foreign Exchange contracts

The Company utilizes foreign currency contracts to hedge anticipated transactions, primarily intercompany transactions, on certain foreign currencies and designates these derivative instruments as foreign currency cash flow hedges when appropriate. The notional amounts of the Company’s foreign exchange derivative contracts at December 31, 2008 and 2007 were $1,151 million and $1,225 million, respectively. For these derivatives, in which the majority qualify as hedges of future anticipated cash flows, the effective portion of changes in fair value is temporarily deferred in accumulated OCI and then recognized in earnings when the hedged item affects earnings.

The table below summarizes the Company’s outstanding foreign exchange forward contracts at December 31, 2008. The fair value of all foreign exchange forward contracts is based on year-end currency rates. The fair value of foreign exchange forward contracts should be viewed in relation to the fair value of the underlying hedged transactions and the overall reduction in exposure to adverse fluctuations in foreign currency exchange rates.

F-76

Note 21 FINANCIAL INSTRUMENTS (Continued)


Dollars in Millions, except currency rates	Weighted-Average Strike Price		Notional Amount		Fair Value Asset/(Liability)			Maturity
Foreign Exchange Forwards:
Cash Flow Hedges
Australian dollar	$	0.79	$	56	$	7		2009
Brazilian real		2.44		9		—		2009
British pound		1.83		94		19		2009
Canadian dollar		1.09		107		12		2009
Euro		1.42		486		11		2009
Japanese yen		101.05		225		(27	)	2009
Japanese yen		88.55		10		—		2010
Mexican peso		11.27		100		21		2009
Polish zloty		2.73		30		2		2009
Swedish krona		6.31		14		3		2009
Swiss franc		1.02		20		1		2009

Total Cash Flow Hedges			$	1,151	$	49

At December 31, 2007 the total notional and fair market value for contracts to buy Japanese yen was $145 million and $1 million, respectively, which are fully offset by the total notional and fair market value for sell contracts of $145 million and $1 million, respectively. At December 31, 2008, the Company did not hold any foreign exchange option contracts to buy or sell Japanese yen.

At December 31, 2008, the balance of deferred gains on foreign exchange forward contracts that qualified for cash flow hedge accounting included in accumulated OCI on a pre-tax basis was $45 million ($35 million net of tax), all of which is expected to be reclassified into earnings within the next 14 months.

SFAS No. 133, Accounting for Derivative Instruments and Hedging Activities, requires that the Company perform periodic assessments of hedge effectiveness. The Company assesses effectiveness at the inception of the hedge and on a quarterly basis. These assessments determine whether derivatives designated as qualifying hedges continue to be highly effective in offsetting changes in the cash flows of hedged items. Any ineffective portion of fair value can no longer be deferred in accumulated OCI and is included in current period earnings. For the years ended December 31, 2008, 2007 and 2006, the impact of hedge ineffectiveness on earnings was not significant. Additionally, for the years ended December 31, 2008, 2007 and 2006, the impact of discontinued hedges was a pre-tax gain of $6 million and a pre-tax loss of $12 million and $10 million, respectively.

Natural Gas contracts

The Company utilizes forward contracts to hedge anticipated purchase of natural gas, and designates these derivative instruments as cash flow hedges when appropriate. For these derivatives, in which the majority qualify as hedges of future anticipated cash flows, the effective portion of changes in fair value is temporarily deferred in accumulated OCI and then recognized in earnings when the hedged item affects earnings. For the year ended December 31, 2008, the impact of discontinued natural gas hedges was a pre-tax loss of $4 million and was not material for the year ended December 31, 2007.

Non-Qualifying Foreign Exchange Contracts

In addition to the foreign exchange contracts noted above, the Company utilizes forward contracts to hedge foreign currency-denominated monetary assets and liabilities. The primary objective of these forward contracts is to protect the U.S. dollar value of foreign currency-denominated monetary assets and liabilities from the effects of volatility in foreign exchange rates that might occur prior to their receipt or settlement in U.S. dollars. These forward contracts are not designated as hedges and are mark-to-market through other expense, net. The notional and fair value amounts of purchased and sold foreign exchange forward contracts at December 31, 2008 and 2007 were not material.

Furthermore, the Company uses foreign exchange forward contracts to offset its exposure to certain assets and liabilities and earnings denominated in certain foreign currencies. These foreign exchange forward contracts are not designated as hedges and, therefore, changes in the fair value of these derivatives are recognized in earnings in other expense, net, as they occur. The notional and fair value amounts of these foreign exchange forward contracts at December 31, 2008 and 2007 were not material.

F-77

Note 21 FINANCIAL INSTRUMENTS (Continued)

Hedge of Net Investment

The Company uses non-U.S. dollar borrowings, primarily the €500 Million Notes due 2016 and the €500 Million Notes due 2021, to hedge the foreign currency exposures of the Company’s net investment in certain foreign affiliates. These non-U.S. dollar borrowings are designated as hedges of net investments. The effective portion of foreign exchange gains or losses on these hedges is recorded as part of the foreign currency translation component of accumulated OCI.

The Company had unhedged exposures to net foreign currency-denominated assets and liabilities of approximately $1,074 million and $1,902 million at December 31, 2008 and 2007, respectively, primarily in Japan, China, Mexico, Australia, the UK and Thailand.

Fair Value Hedges

Interest Rate contracts

The Company uses derivative instruments as part of its interest rate risk management strategy. The derivative instruments used are comprised principally of fixed-to-floating rate interest rate swaps, which are subject to fair-value hedge accounting treatment. In November 2006, in connection with the funding of the retirement of the 2011 fixed rate debt, the Company executed several fixed-to-floating interest rate swaps to convert $1.3 billion and €1 billion ($1.3 billion at inception) of the Company’s newly-issued fixed rate debt to be paid in 2016, 2021, and 2036 to variable rate debt. In 2008, the Company executed additional fixed-to-floating interest rate swaps to convert $1.2 billion of the Company’s newly-issued fixed rate debt to be paid in 2018 and 2038 to variable rate. The total notional amounts of outstanding interest rate swaps were $2.6 billion and €1 billion ($1.4 billion) at December 31, 2008, $2.6 billion and €1.0 billion ($1.5 billion) at December 31, 2007 and $2.6 billion and €1 billion ($1.3 billion) at December 31, 2006. The Company recognized a net decrease in interest expense of $48 million in 2008, and a net increase of $13 million and $18 million in 2007 and 2006, respectively.

The swaps, as well as the underlying debt being hedged, are recorded at fair value. Swaps are generally held to maturity and are intended to create an appropriate balance of fixed and floating rate debt for the Company. Swaps that qualify as fair value hedges that are terminated prior to their maturity dates are reported as part of the carrying value of the underlying debt and are amortized to earnings over the remaining life of the debt. Swaps that qualify as cash flow hedges that are terminated are reported in accumulated OCI and amortized to earnings over the remaining life of the debt. At December 31, 2008, the balance of deferred losses on forward starting swaps included in accumulated OCI was $19 million, which will be reclassified into earnings over the remaining life of the debt.

In November and December 2008, the Company repurchased approximately $254 million principal amount of debt and terminated $241 million notional amount of interest rate swaps resulting in a gain of $57 million, reported in other expense, net. Also in 2008, the Company terminated $550 million notional amount of fixed-to-floating interest rate swap agreements for total proceeds of $197 million. The proceeds from this swap termination are being recognized against interest expense over the remaining life of the underlying debt. For further discussion on the Company’s debt buyback refer to “—Note 18. Short-Term Borrowings and Long-Term Debt.”

F-78

Note 21 FINANCIAL INSTRUMENTS (Continued)

The following tables summarize the interest rate swaps outstanding at December 31, 2008 and the earnings impact from terminated interest rate swaps for 2008, 2007 and 2006:

Interest Rate Swaps Outstanding


Interest Rate Swaps	Notional Amount of Underlying Debt		Variable Rate Received	Year of Transaction	Maturity	Fair Value
Dollars in Millions
Swaps associated with:
5.25% Notes due 2013	$	597	1 month U.S. $ LIBOR +0.42%	2003	2013	$	71
5.45% Notes due 2018		600	1 month U.S. $ LIBOR +1.065%	2008	2018		87
4.375% €500 Million Notes due 2016		698	3 month EUR € EURIBOR +0.40%	2006	2016		17
4.625% €500 Million Notes due 2021		698	3 month EUR € EURIBOR +0.56%	2006	2021		9
7.15% Notes due 2023		339	1 month U.S. $ LIBOR +1.66%	2004	2023		98
5.875% Notes due 2036		573	1 month U.S. $ LIBOR +0.62%	2006	2036		200
6.125% Notes due 2038		300	1 month U.S. $ LIBOR +1.3255%	2008	2038		95
6.125% Notes due 2038		200	1 month U.S. $ LIBOR +1.292%	2008	2038		70

	$	4,005				$	647

Earnings Impact from Terminated Interest Rate Swaps


		Unrecognized Gains/(Losses)					Pre-Tax Income/ (Expense) Recognized
Interest Rate Swaps	Year of Termination	Long-term Debt		Other Comprehensive Loss			2008		2007		2006
Dollars in Millions
Interest rate swap lock associated with:
5.75% Notes due 2011	2001	$	—	$	—		$	—	$	—	$	(37	)
6.125% Notes due 2038	2008		—		(19	)		—		—		—
Swaps associated with:
5.75% Notes due 2011	2005		—		—			—		—		(21	)
6.80% Notes due 2026	2005		36					1		1		1
5.75% Notes due 2011	2006		—		—			—		—		(62	)
5.25% Notes due 2013	2008		—		—			—		—		—
7.15% Notes due 2023	2008		—		—			3		—		—
5.875% Notes due 2036	2008		—		—			31		—		—
5.875% Notes due 2036	2008		172		—			—		—		—
5.75% Notes due 2038	2008		25		—			—		—		—

		$	233	$	(19	)	$	35	$	1	$	(119	)

F-79

Note 21 FINANCIAL INSTRUMENTS (Continued)

The following table summarizes the Company’s fair value of outstanding derivatives at December 31, 2008 and 2007:


Dollars in Millions	Balance Sheet Location	2008		2007		Balance Sheet Location	2008			2007
Derivatives designated as hedging instruments:
Interest rate contracts	Other assets	$	647	$	72	Accrued expenses	$	—		$	(96	)
Foreign exchange contracts	Other assets		89		8	Accrued expenses		(40	)		(64	)
Hedge of net investments			—		—	Short-term borrowings		—			(108	)
Hedge of net investments			—		—	Long-term debt		(1,319	)		(1,450	)
Natural gas contracts			—		—	Accrued expenses		(7	)		—

			736		80			(1,366	)		(1,718	)

Derivatives not designated as hedging instruments:
Foreign exchange contracts	Other assets		1		12	Accrued expenses		(5	)		(3	)

Total Derivatives		$	737	$	92		$	(1,371	)	$	(1,721	)

The impact on earnings from interest rate swaps that qualified as fair value hedges for the years ended December 31, 2008 and 2007 was as follows:


Dollars in Millions	2008		2007
Interest income/(expense)	$	49	$	(12	)
Terminated – gain recognized in other expense, net		34		—

Total	$	83	$	(12	)

The impact on OCI and earnings from foreign exchange and natural gas forwards that qualified as cash flow hedges was as follows:


	Foreign Exchange Contracts						Natural Gas Contracts					Forward Starting Swap					Total Impact
Dollars in Millions	2008			2007			2008			2007		2008			2007		2008			2007
Gain/(loss) recognized in OCI at December 31 (effective portion)	$	45		$	(54	)	$	(3	)	$	—	$	(19	)	$	—	$	23		$	(54	)
Loss reclassified from OCI to cost of products sold (effective portion)		(65	)		(56	)		(2	)		—		—			—		(67	)		(56	)
Gain/(loss) recognized in other expense, net (discontinued and ineffective portion)		6			(12	)		(4	)		—		—			—		2			(12	)

The impact on OCI and earnings from non-derivative debt designated as a hedge of net investment for the years ended December 31, 2008 and 2007 was as follows:


	Net Investment Hedges
Dollars in Millions	2008			2007
Loss recognized in OCI (effective portion)	$	(131	)	$	(168	)
Gain recognized in other expense, net (ineffective portion and amount excluded from effectiveness testing)		9			—

F-80

Note 21 FINANCIAL INSTRUMENTS (Continued)

The impact on earnings from non-qualifying derivatives for the years ended December 31, 2008 and 2007 was as follows:


Dollars in Millions	2008		2007
Gain recognized in other expense, net	$	5	$	4

For a discussion on the fair value of financial instruments, see “—Note 10. Fair Value Measurement.” For a discussion on cash, cash equivalents and marketable securities, see “—Note 11. Cash, Cash Equivalents and Marketable Securities.” For long-term debt, the difference between the fair value and carrying value is not material.

On January 13, 2009, the Company terminated fixed-to-floating interest rate swaps with a notional amount of $1,061 million resulting in a $187 million gain which will be amortized over the remaining life of the debt.

Note 22 SEGMENT INFORMATION

Segment information is consistent with how management reviews the businesses, makes investing and resource allocation decisions and assesses operating performance. The Company reports financial and operating information in two segments—BioPharmaceuticals and Mead Johnson. The BioPharmaceuticals segment is comprised of the global BioPharmaceuticals and international consumer medicines businesses. The Mead Johnson segment consists of Mead Johnson Nutrition Company, primarily an infant formula business and children’s nutrition business.

Effective January 1, 2009, the Company changed its measurement of segment income for all the periods presented. The following summarizes the most significant changes from the previously reported amounts.

•

Certain items that were previously excluded from segment results are now fully included, including among other items, costs attributed to certain corporate administrative functions and programs, stock-based compensation expense and net interest expense;

•

Certain items that were previously included in segment results are now excluded, including among other items, costs attributed to PTI, upfront milestone payments and acquired in-process research and development; and

•

The pre-tax income attributable to noncontrolling interest is excluded from the segment results.

In January and August 2008, the Company completed the divestiture of its Medical Imaging and ConvaTec businesses, respectively. The results of the Medical Imaging and ConvaTec businesses, previously included in the former Other Health Care and ConvaTec operating segments, respectively, are included in discontinued operations. For additional information on the divestitures of Medical Imaging and ConvaTec, see “—Note 4. Acquisitions and Divestitures” and “—Note 6. Discontinued Operations and Assets Held for Sale.”

The Company’s products are sold principally to the wholesale and retail trade, both nationally and internationally. Certain products are also sold to other drug manufacturers, hospitals, clinics, government agencies and the medical profession. Gross sales to three pharmaceutical wholesalers in the U.S. accounted for approximately 20%, 16% and 12% of the Company’s total gross sales in 2008, 18%, 15% and 11% of the Company’s total gross sales in 2007 and 17%, 15% and 10% of the Company’s total gross sales in 2006.

The Company’s selected geographic area information was as follows:


	Net Sales						Year-End Assets
Dollars in Millions	2008		2007		2006		2008		2007
United States	$	12,042	$	10,422	$	8,785	$	19,968	$	16,949
Europe, Middle East and Africa		4,514		4,036		3,979		4,592		5,198
Other Western Hemisphere		1,622		1,628		1,517		3,467		2,300
Pacific		2,419		2,107		1,927		1,459		1,420

Total	$	20,597	$	18,193	$	16,208	$	29,486	$	25,867

F-81

Note 22 SEGMENT INFORMATION (continued)

Net sales and reconciliation of the Company’s segment results to earnings from continuing operations before income taxes are as follows:


	Net Sales						Segment Results									Year-End Assets
Dollars in Millions	2008		2007		2006		2008			2007			2006			2008		2007
BioPharmaceuticals	$	17,715	$	15,622	$	13,861	$	3,581		$	2,234		$	1,469		$	28,125	$	24,566
Mead Johnson		2,882		2,571		2,347		692			659			649			1,361		1,301

	$	20,597	$	18,193	$	16,208		4,273			2,893			2,118		$	29,486	$	25,867

Reconciliation of segment results to earnings from continuing operations before income taxes:
Productivity transformation initiative								(403	)		(292	)		—
ARS impairment charges and loss on sale								(324	)		(275	)		—
Downsizing and streamlining of worldwide operations								—			(44	)		(59	)
Accelerated depreciation, asset impairment and contract termination								(40	)		(100	)		(186	)
Gain on sale of properties and product line and business								—			282			200
Debt buyback and retirement cost and swap terminations								57			—			(220	)
Upfront and milestone payments and acquired in-process research and development								(380	)		(392	)		(70	)
Litigation settlement, insurance recovery and product liability								(31	)		(18	)		(326	)
Mead Johnson charges								(44	)		—			—
Gain on sale of ImClone shares								895			—			—
Noncontrolling interest—pre-tax								1,468			1,132			628

Earnings from continuing operations before income taxes							$	5,471		$	3,186		$	2,085

Net sales of the Company’s key products were as follows:


	Net Sales by Products
Dollars in Millions	2008		2007		2006
BioPharmaceuticals
PLAVIX*	$	5,603	$	4,755	$	3,257
AVAPRO/AVALIDE		1,290		1,204		1,097
PRAVACHOL		203		443		1,197
REYATAZ		1,292		1,124		931
SUSTIVA Franchise (total revenue)		1,149		956		791
BARACLUDE		541		275		83
ERBITUX*		749		692		652
TAXOL		385		422		563
SPRYCEL		310		158		25
IXEMPRA		101		15		—
ABILIFY*		2,153		1,660		1,282
ORENCIA		441		231		89
Other BioPharmaceuticals		3,498		3,687		3,894

Total BioPharmaceuticals		17,715		15,622		13,861

Mead Johnson
ENFAMIL		1,157		1,082		1,007
Other		1,725		1,489		1,340

Total Mead Johnson		2,882		2,571		2,347

Total	$	20,597	$	18,193	$	16,208


	Capital Expenditures						Depreciation
Dollars in Millions	2008		2007		2006		2008		2007		2006
BioPharmaceuticals	$	686	$	723	$	611	$	518	$	501	$	526
Mead Johnson		81		78		69		44		41		38

Total	$	767	$	801	$	680	$	562	$	542	$	564

F-82

Note 23 LEASES

Minimum rental commitments under all non-cancelable operating leases, primarily real estate and motor vehicles, in effect at December 31, 2008, were as follows:


Years Ending December 31,	Dollars in Millions
2009	$	136
2010		110
2011		93
2012		79
2013		73
Later years		183

Total minimum payments		674
Less total minimum sublease rentals		36

Net minimum rental commitments	$	638

Operating lease rental expense was $179 million in 2008, $166 million in 2007 and $149 million in 2006 (net of sublease rental income of $16 million in 2008, $17 million in 2007 and $21 million in 2006).

In February 2008, the Company completed the sale and leaseback of an administrative facility in Paris, France for $227 million (€155 million), resulting in a pre-tax gain from the transaction of $111 million, of which $102 million was deferred and will reduce future lease rental costs over the lease period of 9 years.

In December 2006, the Company completed the sale and leaseback of several administrative facilities in New Jersey for $283 million, resulting in a pre-tax gain from the transaction of $154 million, of which $145 million was deferred and will reduce future lease rental costs over the lease periods ranging from 8 to 12 years.

F-83

Note 24 PENSION, POSTRETIREMENT AND POSTEMPLOYMENT LIABILITIES

The Company and certain of its subsidiaries have defined benefit pension plans, defined contribution plans and termination indemnity plans for regular full-time employees. The principal pension plan is the Bristol-Myers Squibb Retirement Income Plan in the U.S. which represents approximately 70% of the Company’s total pension plan assets and obligations. The funding policy is to contribute amounts to provide for current service and to fund past service liability. Plan benefits are based primarily on the participant’s years of credited service and compensation. Plan assets consist principally of equity and fixed-income securities.

The Company also provides comprehensive medical and group life benefits for substantially all U.S. retirees who elect to participate in its comprehensive medical and group life plans. The medical plan is contributory. Contributions are adjusted periodically and vary by date of retirement and the original retiring Company. The life insurance plan is noncontributory. Plan assets consist principally of equity and fixed-income securities. Similar plans exist for employees in certain countries outside of the U.S.

The net periodic benefit cost of the Company’s defined benefit pension and postretirement benefit plans included the following components:


	Pension Benefits									Other Benefits
Dollars in Millions	2008			2007			2006			2008			2007			2006
Service cost — benefits earned during the year	$	227		$	249		$	238		$	7		$	8		$	9
Interest cost on projected benefit obligation		389			352			326			38			36			34
Expected return on plan assets		(469	)		(442	)		(410	)		(28	)		(25	)		(22	)
Amortization of prior service cost/(benefit)		10			11			12			(3	)		(3	)		(3	)
Amortization of net actuarial loss		98			140			166			5			6			4
Amortization of transitional obligation		—			—			1			—			—			—

Net periodic benefit cost		255			310			333			19			22			22
Curtailments		1			—			—			(2	)		—			—
Settlements		36			—			—			—			—			—
Special termination benefits		14			3			(1	)		2			1			—

Total net periodic benefit cost	$	306		$	313		$	332		$	19		$	23		$	22

Total net periodic benefit costs have been recognized as follows:


	Pension Benefits						Other Benefits
Dollars in Millions	2008		2007		2006		2008		2007		2006
Continuing operations	$	275	$	280	$	297	$	19	$	22	$	21
Discontinued operations		31		33		35		—		1		1

Total net periodic benefit cost	$	306	$	313	$	332	$	19	$	23	$	22

The estimated net actuarial loss and prior service cost that will be amortized from accumulated OCI into net periodic benefit cost in 2009 are:


Dollars in Millions	Pension Benefits		Other Benefits
Amortization of net actuarial loss	$	156	$	11
Amortization of prior service cost/(benefit)		9		(3	)

	$	165	$	8

F-84

Note 24 PENSION, POSTRETIREMENT AND POSTEMPLOYMENT LIABILITIES (Continued)

Changes in benefit obligations, plan assets, funded status and amounts recognized on the balance sheet as of and for the years ended December 31, 2008 and 2007, for the Company’s defined benefit and postretirement benefit plans, were as follows:


	Pension Benefits						Other Benefits
Dollars in Millions	2008			2007			2008			2007
Benefit obligation at beginning of year	$	6,184		$	6,186		$	646		$	651
Service cost—benefits earned during the year		227			249			8			9
Interest cost on projected benefit obligation		389			352			38			36
Plan participants’ contributions		5			4			22			16
Curtailments and settlements		(124	)		(28	)		(3	)		(2	)
Actuarial assumptions losses/(gains)		189			(179	)		(62	)		11
Plan amendments and other		—			2			—			—
Retiree Drug Subsidy received		—			—			10			5
Benefits paid		(622	)		(496	)		(87	)		(87	)
Special termination benefits		13			4			2			2
Exchange rate (gains)/losses		(193	)		90			(5	)		5

Benefit obligation at end of year	$	6,068		$	6,184		$	569		$	646


Fair value of plan assets at beginning of year	$	6,019		$	5,658		$	320		$	291
Actual return on plan assets		(1,451	)		458			(91	)		29
Employer contribution		426			323			56			66
Plan participants’ contributions		5			4			22			16
Settlements		(63	)		(9	)		—			—
Retiree Drug Subsidy received		—			—			10			5
Benefits paid		(622	)		(496	)		(87	)		(87	)
Exchange rate (losses)/gains		(162	)		81			—			—

Fair value of plan assets at end of year	$	4,152		$	6,019		$	230		$	320


Funded status	$	(1,916	)	$	(165	)	$	(339	)	$	(326	)


Amounts recognized in the consolidated balance sheets consist of:
Other assets	$	26		$	291		$	—		$	—
Accrued expenses		(33	)		(27	)		(57	)		(58	)
Pension and other postretirement liabilities (accrued benefit cost)		(1,909	)		(429	)		(282	)		(268	)

Net amount recognized	$	(1,916	)	$	(165	)	$	(339	)	$	(326	)


Amounts recognized in accumulated other comprehensive loss:
Net actuarial loss	$	3,248		$	1,358		$	169		$	117
Net obligation at adoption		2			2			—			—
Prior service cost/(benefit)		32			46			(16	)		(20	)

Net amount recognized	$	3,282		$	1,406		$	153		$	97

The impact of the Medicare Prescription Drug Improvement and Modernization Act of 2003 was $96 million in 2008, $98 million in 2007 and $94 million in 2006 and was reflected as a reduction in accumulated postretirement benefit obligation.

The accumulated benefit obligation for all defined benefit pension plans was $5,418 million and $5,417 million at December 31, 2008 and 2007, respectively.

Information related to the Company’s pension plans at December 31 was as follows:


Dollars in Millions	2008		2007
Pension plans with projected benefit obligations in excess of plan assets:
Projected benefit obligation	$	5,865	$	1,376
Fair value of plan assets		3,923		921
Pension plans with accumulated benefit obligations in excess of plan assets:
Accumulated benefit obligation	$	5,179	$	352
Fair value of plan assets		3,869		62

F-85

Note 24 PENSION, POSTRETIREMENT AND POSTEMPLOYMENT LIABILITIES (Continued)

Actuarial assumptions

Weighted-average assumptions used to determine benefit obligations at December 31 were as follows:


	Pension Benefits				Other Benefits
	2008		2007		2008		2007
Discount rate	6.33	%	6.46	%	7.00	%	6.46	%
Rate of compensation increase	3.63	%	3.67	%	3.55	%	3.60	%

Weighted-average actuarial assumptions used to determine net periodic benefit cost for the years ended December 31 were as follows:


	Pension Benefits						Other Benefits
	2008		2007		2006		2008		2007		2006
Discount rate	6.47	%	5.74	%	5.49	%	6.46	%	5.73	%	5.49	%
Expected long-term return on plan assets	8.29	%	8.30	%	8.39	%	8.75	%	8.75	%	8.75	%
Rate of compensation increase	3.70	%	3.63	%	3.60	%	3.60	%	3.60	%	3.61	%

The Company uses the yield on high quality corporate bonds that matches the duration of the benefit obligations in determining the discount rate. The Citigroup Above Median yield curve is used in developing the discount rate for the U.S. plans.

The Company considers several factors in developing the expected return on plan assets, such as its long-term historical returns and input from external advisors. Individual asset class return forecasts were developed based upon market conditions, for example, price-earnings levels and yields and long-term growth expectations. The expected long-term rate of return is the weighted-average of target asset allocation of each individual asset class. The long-term expected rate of return on plan assets for the U.S. plans included an active management premium of approximately 1% over projected market returns received from external advisors. The Company’s long-term expected annualized returns for U.S. pension plans were as follows:


	2008		2007		2006
10 years	3.4	%	8.2	%	9.3	%
15 years	7.1	%	10.4	%	10.1	%
20 years	8.3	%	10.6	%	10.5	%

The expected return on plan assets was determined using the expected rate of return and a calculated value of assets, referred to as the “market-related value.” The market-related value exceeds the fair value of plan assets by approximately $1.1 billion at December 31, 2008 and was less than the fair value of plan assets by approximately $100 million at December 31, 2007. The change was primarily driven by the significant losses incurred on plan assets in 2008 due to current market conditions. Differences between the assumed and actual returns are amortized to the market-related value on a straight-line basis over a three year period.

Gains and losses have resulted from changes in actuarial assumptions (such as changes in the discount rate) and from differences between assumed and actual experience (such as differences between actual and assumed returns on plan assets). These gains and losses (except those differences being amortized to the market-related value) are only amortized to the extent they exceed 10% of the higher of the market-related value or the projected benefit obligation for each respective plan. As a result, approximately $1.7 billion related to pension benefits is not expected to be amortized during 2009. The remaining actuarial losses are amortized over the expected remaining service periods of active participants.

Assumed health care cost trend rates at December 31 were as follows:


	2008		2007		2006
Health care cost trend rate assumed for next year	8.91	%	9.37	%	9.87	%
Rate to which the cost trend rate is assumed to decline (the ultimate trend rate)	4.52	%	4.49	%	4.49	%
Year that the rate reaches the ultimate trend rate	2017		2018		2018

F-86

Note 24 PENSION, POSTRETIREMENT AND POSTEMPLOYMENT LIABILITIES (Continued)

Assumed health care cost trend rates have an effect on the amounts reported for the health care plans. A one-percentage-point change in assumed health care cost trend rates would have the following effects:


Dollars in Millions	1-Percentage- Point Increase		1-Percentage- Point Decrease
Effect on total of service and interest cost	$	5	$	(2	)
Effect on postretirement benefit obligation		39		(25	)

Plan assets

The Company’s asset allocation at December 31 was as follows:


	Pension Benefits				Other Benefits
	2008		2007		2008		2007
Publicly traded equity securities	59	%	65	%	63	%	67	%
Debt securities (including cash)	30	%	27	%	23	%	24	%
Private equity	10	%	7	%	13	%	9	%
Other	1	%	1	%	1	%	—

Total	100	%	100	%	100	%	100	%

The Company’s investment strategy emphasizes equities in order to achieve high expected returns and, in the long run, low expense and low required cash contributions. For the U.S. pension plans, a target asset allocation of 70% public equity (58% U.S., 12% international), 8% private equity and 22% fixed income is maintained and cash flow (i.e., cash contributions, benefit payments) is used to rebalance back to the targets as necessary. Investments are well diversified within each of the three major asset categories. Approximately 83% of the U.S. equity investments are actively managed. Investment strategies for international pension plans are typically similar, although the asset allocations are usually more conservative.

Private equity is valued on a three month lag. Bristol–Myers Squibb Company common stock represents less than 1% of the plan assets at December 31, 2008 and 2007.

Contributions

Contributions to the U.S. pension plans were $250 million in 2008, $238 million in 2007 and $235 million in 2006. Contributions to the U.S. pension plans are expected to be approximately $550 million during 2009, of which $400 million was contributed in January 2009.

Contributions to the international pension plans were $176 million in 2008, $85 million in 2007 and $90 million in 2006. Contributions to the international plans are expected to be in the range of $120 million to $140 million in 2009.

Estimated Future Benefit Payments

The following benefit payments for mainly the U.S. pension plans, which reflect expected future service, as appropriate, are expected to be paid:


			Other Benefits
Dollars in Millions	Pension Benefits		Gross		Medicare Subsidy		Net
2009	$	359	$	67	$	9	$	58
2010		371		68		10		58
2011		394		68		11		57
2012		423		67		11		56
2013		443		66		12		54
Years 2014 – 2018		2,543		308		56		252

F-87

Note 24 PENSION, POSTRETIREMENT AND POSTEMPLOYMENT LIABILITIES (Continued)

Adoption of SFAS No. 158

The Company adopted SFAS No. 158, Employers’ Accounting for Defined Benefit Pension and Other Postretirement Plans—an amendment of FASB Statements No. 87, 88, 106, and 132(R), in the year ended December 31, 2006, resulting in a $1,064 million reduction of accumulated OCI in stockholders’ equity, a $767 million reduction in total assets and a $297 million increase in total liabilities. The impact of the adoption in 2006 is summarized as follows:


	SFAS No. 158 Adjustments
Dollars in Millions	Pre-SFAS No. 158			Pre-tax			Tax			Net			Post- SFAS No. 158
Current assets:
Deferred income taxes	$	573		$	—		$	76		$	76		$	649
Non-current assets:
Deferred income taxes		2,139			—			438			438			2,577
Prepaid pension		1,324			(1,324	)		—			(1,324	)		—
Other assets		299			43			—			43			342
Current liabilities:
Accrued expenses		2,251			81			—			81			2,332
U.S. and foreign income taxes payable		445			—			(1	)		(1	)		444
Non-current liabilities:
Other liabilities		327			269			(52	)		217			544
Stockholders’ equity:
Accumulated other comprehensive loss		(581	)		(1,631	)		567			(1,064	)		(1,645	)

Savings Plan

The principal defined contribution plan is the Bristol-Myers Squibb Savings and Investment Program. The Company’s contribution is based on employee contributions and the level of Company match. The Company’s contributions to the plan were $58 million in 2008, $60 million in 2007 and $56 million in 2006.

Post Employment Benefit Plan

The Company offers long-term disability benefits to certain employees. These post employment liabilities were $94 million and $87 million at December 31, 2008 and 2007, respectively. The expense related to these benefits was $26 million in 2008, $17 million in 2007 and $25 million in 2006.

Termination Indemnity Plans

The Company operates in certain jurisdictions, primarily in Europe, which require the recording of statutory termination obligations. These obligations are recognized on an undiscounted basis assuming employee termination at each measurement date. The total pension liability recorded for these obligations was $62 million at December 31, 2008 and $70 million at December 31, 2007.

F-88

Note 25 LEGAL PROCEEDINGS AND CONTINGENCIES

Various lawsuits, claims, proceedings and investigations are pending involving the Company and certain of its subsidiaries. In accordance with SFAS No. 5, Accounting for Contingencies, the Company records accruals for such contingencies when it is probable that a liability will be incurred and the amount of loss can be reasonably estimated. These matters involve antitrust, securities, patent infringement, pricing, sales and marketing practices, environmental, health and safety matters, consumer fraud, employment matters, product liability and insurance coverage. Significant litigation charges were $33 million in 2008, $14 million in 2007 and $302 million in 2006, net of revised estimates to previously accrued amounts. Cash payments related to significant litigation were $210 million in 2008, $318 million in 2007 and $272 million in 2006. The most significant of these matters are described below.

There can be no assurance that there will not be an increase in the scope of pending matters or that any future lawsuits, claims, proceedings or investigations will not be material.

INTELLECTUAL PROPERTY

PLAVIX* Litigation

PLAVIX* is currently the Company’s largest product ranked by net sales. The PLAVIX* patents are subject to a number of challenges in the U.S., including the litigation with Apotex Inc. and Apotex Corp. (Apotex) described below, and in other less significant markets for the product. It is not possible reasonably to estimate the impact of these lawsuits on the Company. However, loss of market exclusivity of PLAVIX* and sustained generic competition in the U.S. would be material to the Company’s sales of PLAVIX*, results of operations and cash flows, and could be material to the Company’s financial condition and liquidity. The Company and its product partner, Sanofi, (the Companies) intend to vigorously pursue enforcement of their patent rights in PLAVIX*.

PLAVIX* Litigation – U.S.

Patent Infringement Litigation against Apotex and Related Matters

As previously disclosed, the Company’s U.S. territory partnership under its alliance with Sanofi is a plaintiff in a pending patent infringement lawsuit instituted in the United States District Court for the Southern District of New York (District Court) entitled Sanofi-Synthelabo, Sanofi-Synthelabo, Inc. and Bristol-Myers Squibb Sanofi Pharmaceuticals Holding Partnership v. Apotex. The suit is based on U.S. Patent No. 4,847,265 (the ‘265 Patent), a composition of matter patent, which discloses and claims, among other things, the hydrogen sulfate salt of clopidogrel, a medicine made available in the U.S. by the Companies as PLAVIX*. Also, as previously reported, the District Court has upheld the validity and enforceability of the ‘265 Patent, maintaining the main patent protection for PLAVIX* in the U.S. until November 2011. The District Court also ruled that Apotex’s generic clopidogrel bisulfate product infringed the ‘265 Patent and permanently enjoined Apotex from engaging in any activity that infringes the ‘265 Patent, including marketing its generic product in the U.S. until after the patent expires.

Apotex appealed the District Court’s decision and on December 12, 2008, the United States Court of Appeals for the Federal Circuit (Circuit Court) affirmed the District Court’s ruling sustaining the validity of the ‘265 patent. Apotex has filed a petition with the Circuit Court for a rehearing en banc, which petition is pending. The District Court has stayed certain antitrust counterclaims brought by Apotex pending the final outcome of the appeal.

As previously disclosed, the Company’s U.S. territory partnership under its alliance with Sanofi is also a plaintiff in five additional pending patent infringement lawsuits against Dr. Reddy’s Laboratories, Inc. and Dr. Reddy’s Laboratories, LTD (Dr. Reddy’s), Teva Pharmaceuticals USA, Inc. (Teva), Cobalt Pharmaceuticals Inc. (Cobalt), Watson Pharmaceuticals, Inc. and Watson Laboratories, Inc. (Watson) and Sun Pharmaceuticals (Sun). The lawsuits against Dr. Reddy’s, Teva and Cobalt relate to the ‘265 Patent. A trial date for the action against Dr. Reddy’s has not been set. On January 24, 2008, the court entered an order that requires Dr. Reddy’s to give the Company 10 business days notice of its intent to launch. The patent infringement actions against Teva and Cobalt were stayed pending resolution of the Apotex litigation, and the parties to those actions agreed to be bound by the outcome of the litigation against Apotex, although Teva and Cobalt can appeal the outcome of the litigation. Consequently, on July 12, 2007, the District Court entered judgments against Cobalt and Teva and permanently enjoined Cobalt and Teva from engaging in any activity that infringes the ‘265 Patent until after the Patent expires. Cobalt and Teva have each filed an appeal. The lawsuit against Watson, filed in October 2004, is based on U.S. Patent No. 6,429,210 (the ‘210 Patent), which discloses and claims a particular crystalline or polymorph form of the hydrogen sulfate salt of clopidogrel, which is marketed as PLAVIX*. In December 2005, the court permitted Watson to pursue its declaratory judgment counterclaim with respect to U.S. Patent No. 6,504,030. In January 2006, the Court approved the parties’ stipulation to stay this case pending the outcome of the trial in the Apotex matter. In April 2007, Pharmastar filed a request for inter partes reexamination of the ‘210 Patent. The U.S. Patent and Trademark Office granted this request in July of 2007. Thus, the ‘210 Patent is currently under reexamination. The lawsuit against Sun, filed on July 11, 2008, is based on infringement of the ‘265 patent and the ‘210 Patent. With respect to the ‘265 Patent, Sun has agreed to be bound by the outcome of the Apotex litigation, although Sun, like Teva and Cobalt, can appeal the outcome of the litigation. Each of Dr. Reddy’s, Teva, Cobalt, Watson and Sun have filed an aNDA with the FDA, and all exclusivity periods and statutory stay periods under the Hatch-Waxman Act have expired. Accordingly, final approval by the FDA would provide each company authorization to distribute a generic clopidogrel bisulfate product in the U.S., subject to various legal remedies for which the Companies may apply including injunctive relief and damages.

F-89

Note 25 LEGAL PROCEEDINGS AND CONTINGENCIES (Continued)

As previously disclosed, in March 2007, the Company was served with a Civil Investigative Demand by the FTC requesting documents and information related to the proposed settlement. The Company and the FTC are currently in discussions regarding potential resolution of this matter. In addition, as previously disclosed, in April 2007, the Company received a subpoena from the New York State Attorney General’s Office — Antitrust Bureau (NYAG) for documents related to the proposed settlement. On December 22, 2008, the Company entered into a settlement agreement with the NYAG on behalf of all states pursuant to which the Company agreed to pay $1.1 million to resolve the states’ claims.

It is not possible at this time reasonably to assess the outcomes of the appeal by Apotex of the Circuit court’s decision, or the other PLAVIX* patent litigations or the timing of any renewed generic competition for PLAVIX* from Apotex or additional generic competition for PLAVIX* from other third-party generic pharmaceutical companies. However, if Apotex were to prevail in an appeal of the patent litigation, the Company would expect to face renewed generic competition for PLAVIX* promptly thereafter. Loss of market exclusivity for PLAVIX* and/or sustained generic competition would be material to the Company’s sales of PLAVIX*, results of operations and cash flows, and could be material to the Company’s financial condition and liquidity. Additionally, it is not possible at this time reasonably to assess the amount of damages that could be recovered by the Company and Apotex’s ability to pay such damages in the event the Company prevails in Apotex’s appeal of the District court decision.

Additionally, on November 13, 2008, Apotex filed the lawsuit in New Jersey Superior Court entitled Apotex Inc., et al. v. Sanofi-Aventis, et al., seeking payment of $60 million, plus interest, related to the break-up of the proposed settlement agreement. On December 31, 2008, the defendants removed the case to the Federal District Court for New Jersey. Apotex has moved to remand the case back to state court.

PLAVIX* Litigation – International

PLAVIX* – Canada (Apotex, Inc.)

As previously disclosed, Sanofi-Synthelabo and Sanofi-Synthelabo Canada Inc. instituted a prohibition action in the Federal Court of Canada against Apotex and the Minister of Health in response to a Notice of Allegation (NOA) from Apotex directed against Canadian Patent No. 1,336,777 (the ‘777 Patent) covering clopidogrel bisulfate. Apotex’s NOA indicated that it had filed an Abbreviated New Drug Submission (ANDS) for clopidogrel bisulfate tablets and that it sought approval (a Notice of Compliance) of that ANDS before the expiration of the ‘777 Patent, which is scheduled for August 12, 2012. Apotex’s NOA further alleged that the ‘777 Patent was invalid or not infringed. In March 2005, the Canadian Federal Court of Ottawa rejected Apotex’s challenge to the Canadian PLAVIX* patent and held that the asserted claims are novel, not obvious and infringed, and granted Sanofi’s application for an order of prohibition against the Minister of Health and Apotex. That order of prohibition precludes approval of Apotex’s ANDS until the patent expires in 2012, unless the Federal Court’s decision is reversed on appeal. Apotex filed an appeal and in December 2006, the Federal Court of Appeal dismissed Apotex’s appeal and upheld the Federal Court’s issuance of the order of prohibition. In February 2007, Apotex filed leave to appeal this decision to the Supreme Court of Canada, which was granted in July 2007. BIOTECanada, the Canadian Generic Pharmaceutical Association and Canada’s Research-Based Pharmaceutical Companies were granted leave to intervene. On November 6, 2008, the Supreme Court of Canada dismissed Apotex’s appeal of the Federal Court of Appeal decision and upheld the validity of the ‘777 Patent and the order of prohibition.

Also, as previously disclosed, in April 2007, Apotex filed a lawsuit in Canada in the Ontario Superior Court of Justice entitled Apotex Inc., et al. v. Sanofi-Aventis, et al., seeking a payment of $60 million, plus interest, related to the break-up of the proposed settlement agreement. In January 2008, the Court granted defendants’ motions to dismiss on the grounds of forum non conveniens and subject matter jurisdiction. Apotex appealed the decision to the Court of Appeal for Ontario. On October 10, 2008, the Court of Appeal dismissed the lawsuit. Apotex did not appeal to the Supreme Court of Canada. Instead, on November 13, 2008, Apotex filed the lawsuit in New Jersey Superior Court described above.

PLAVIX* – Canada (Cobalt)

As previously disclosed, Sanofi and Sanofi-Synthelabo Canada instituted a prohibition action in the Federal Court of Canada against Cobalt and the Minister of Health in response to a NOA from Cobalt directed against the ‘777 Patent and Canadian Patent No. 2,334,870 (the ‘870 Patent). Cobalt’s NOA indicated that it has filed an ANDS for clopidogrel bisulfate tablets and that it sought a Notice of Compliance for that ANDS before the expiration of the ‘777 and ‘870 Patents. Cobalt alleged that the ‘777 Patent was invalid and that the ‘870 Patent was invalid and not infringed. Following the Supreme Court of Canada decision in Apotex Inc. v. Sanofi-Synthelabo Canada Inc., 2008 SCC 61, dismissing Apotex’s appeal and upholding the validity of the ‘777 Patent as described above, the Federal Court of Canada granted Sanofi’s application for an order of prohibition against the Minister of Health and Cobalt precluding approval of Cobalt’s ANDS until the ‘777 Patent expires in 2012. Sanofi did not pursue the prohibition action with respect to the ‘870 Patent.

F-90

Note 25 LEGAL PROCEEDINGS AND CONTINGENCIES (Continued)

PLAVIX* – Korea

As previously disclosed, in June 2006, the Korean Intellectual Property Tribunal (KIPT) invalidated all claims of Sanofi’s Korean Patent No. 103,094, including claims directed to clopidogrel and pharmaceutically acceptable salts and to clopidogrel bisulfate, and Sanofi appealed. In January 2008, the Patent Court affirmed the KIPT decision. The Company and Sanofi have filed an appeal to the Supreme Court of Korea. Sanofi has also commenced infringement actions against generic pharmaceutical companies, which have launched generic clopidogrel bisulfate, or received approval for alternate salt forms of clopidogrel, in Korea. It is not possible at this time reasonably to assess the outcome of these lawsuits or the impact on the Company.

PLAVIX* – Australia

As previously disclosed, Sanofi was notified that, in August 2007, GenRx Proprietary Limited (GenRx) obtained regulatory approval of an application for clopidogrel bisulfate 75mg tablets in Australia. GenRx, formerly a subsidiary of Apotex, has since changed its name to Apotex. In August 2007, Apotex filed an application in the Federal Court of Australia seeking revocation of Sanofi’s Australian Patent No. 597784 (Case No. NSD 1639 of 2007). Sanofi filed counterclaims of infringement and sought an injunction. On September 21, 2007, the Australian court granted Sanofi’s injunction. A subsidiary of the Company was subsequently added as a party to the proceedings. In February 2008, a second company, Spirit Pharmaceuticals Pty. Ltd., also filed a revocation suit against the same patent. This case was consolidated with the Apotex case and a trial occurred in April. On August 12, 2008, the Federal Court of Australia held that claims of Patent No. 597784 covering clopidogrel bisulfate, hydrochloride, hydrobromide, and taurocholate salts are valid. The Federal Court also held that the process claims, pharmaceutical composition claims, and claim directed to clopidogrel and its pharmaceutically acceptable salts are invalid. In view of this decision, it is possible a generic company could develop and seek registration in Australia for an alternate salt form of clopidogrel (other than bisulfate, hydrochloride, hydrobromide, or taurocholate). The Company and Sanofi filed notices of appeal in the Full Court of the Federal Court of Australia appealing the holding of invalidity of the claim covering clopidogrel and its pharmaceutically acceptable salts, process claims, and pharmaceutical composition claims which have stayed the Federal Court’s ruling. Apotex filed a notice of appeal appealing the holding of validity of the clopidogrel bisulfate, hydrochloride, hydrobromide, and taurocholate claims. A hearing on the appeals occurred in February 2009 and a decision is pending.

PLAVIX* – Germany

As previously disclosed, in 2007, YES Pharmaceutical Development Services GmbH (YES Pharmaceutical) filed an application for marketing authorization in Germany for an alternate salt form of clopidogrel. This application relied on data from studies that were originally conducted by Sanofi and BMS for PLAVIX*. In May 2008, the German health authority (Bfarm) granted marketing authorization to the YES Pharmaceutical product. Data protection for PLAVIX* did not expire until July 2008. Sanofi and BMS filed an objection to the grant of the marketing authorization on the grounds that their data exclusivity rights had been infringed. YES Pharmaceutical and its partners sought immediate enforcement of the marketing authorization, which was denied by Bfarm. YES Pharmaceutical and its partners then filed a legal motion for immediate enforcement before the administrative court, which was granted. YES Pharmaceutical’s partners, Hexal and Ratiopharm, began and continue to market the product in Germany. Sanofi and BMS appealed the decision of the administrative court, but this appeal has been rejected by the administrative appeal court. The third-party objection before Bfarm was dismissed by Bfarm. Sanofi and BMS have appealed this decision to the administrative court in Cologne. This matter is currently pending. YES Pharmaceutical and its partners have announced that they plan to seek marketing authorization in other EU countries in addition to Germany. Also, the Company believes that other companies have filed for approvals in the EU of a clopidogrel containing product. These applications are pending.

OTHER INTELLECTUAL PROPERTY LITIGATION

ABILIFY*

As previously disclosed, Otsuka has filed patent infringement actions against Teva, Barr Pharmaceuticals, Inc. (Barr), Sandoz Inc. (Sandoz), Synthon Laboratories, Inc (Synthon), Sun Pharmaceuticals (Sun) and Apotex relating to U.S. Patent No. 5,006,528, which covers aripiprazole and expires in October 2014. Aripiprazole is comarketed by the Company and Otsuka in the U.S. as ABILIFY*. The lawsuits are currently pending in the U.S. District Court for the District of New Jersey.

It is not possible at this time reasonably to assess the outcome of these lawsuits or their impact on the Company.

ERBITUX*

As previously disclosed, in February 2007, Abbott Laboratories (Abbott) filed suit against ImClone in the U.S. District Court for the District of Massachusetts alleging that ImClone’s manufacture and sale of ERBITUX* infringe U.S. Patent No. 5,665,578 (the ‘578 Patent), and seeking damages for that alleged infringement. Pursuant to settlement and sublicensing agreements executed by ImClone and Repligen Corporation (Repligen) announced on September 10, 2007, Repligen granted ImClone a royalty-free, irrevocable worldwide sublicense for the future use of other patented technology, including the ‘578 Patent, owned by Abbott and licensed to

F-91

Note 25 LEGAL PROCEEDINGS AND CONTINGENCIES (Continued)

Repligen under an agreement between Abbott and Repligen. On September 23, 2008, ImClone and Abbott executed a written settlement agreement ending the litigation pending between the parties. Under the terms of the settlement agreement, ImClone paid Abbott $17.5 million for full and final settlement of all claims and counterclaims. The Company’s commercial agreements with ImClone include provisions pursuant to which certain financial consequences to the Company resulting from the settlement and sublicensing agreements would be the responsibility of ImClone.

It is not possible at this time to assess the outcome of this lawsuit or the potential impact on the Company.

ENFAMIL

On September 15, 2008, the Company and its wholly-owned subsidiary Mead Johnson & Co. filed a patent infringement lawsuit against Abbott Laboratories and Abbott Nutrition (Abbott) in U.S. District Court for the Southern District of Indiana for infringement of its U.S. Patent No. 7,040,500. The companies allege that Abbott’s sale of certain cans of SIMILAC* infant formula powder infringes the ‘500 patent. In February 2009, the companies entered into a settlement agreement resolving this matter.

GENERAL COMMERCIAL LITIGATION

Clayworth Litigation

As previously disclosed, the Company, together with a number of other pharmaceutical manufacturers, was named as a defendant in an action filed in California State Superior Court in Oakland, James Clayworth et al. v. Bristol-Myers Squibb Company, et al., alleging that the defendants conspired to fix the prices of pharmaceuticals by agreeing to charge more for their drugs in the U.S. than they charge outside the U.S., particularly Canada, and asserting claims under California’s Cartwright Act and unfair competition law. The plaintiffs sought trebled monetary damages, injunctive relief and other relief. In December 2006, the Court granted the Company and the other manufacturers’ motion for summary judgment based on the pass-on defense, and judgment was then entered in favor of defendants. In July 2008, judgment in favor of defendants was affirmed by the California Court of Appeals. In November 2008, the California Supreme Court granted the plaintiffs’ petition for review. It is not possible at this time reasonably to assess the outcome of this lawsuit or its impact on the Company in the event plaintiffs are successful on appeal.

RxUSA Wholesale Litigation

As previously disclosed, in July 2006, a complaint was filed by drug wholesaler RxUSA Wholesale, Inc. in the U.S. District Court for the Eastern District of New York against the Company, 15 other drug manufacturers, five drug wholesalers, two officers of defendant McKesson and a wholesale distribution industry trade group, RxUSA Wholesale, Inc. v. Alcon Labs., Inc., et al. The complaint alleges violations of Federal and New York antitrust laws, as well as various other laws. Plaintiff claims that defendants allegedly engaged in anti-competitive acts that resulted in the exclusion of plaintiff from the relevant market and seeks $586 million in damages before any trebling, and other relief. The Company, together with the other manufacturer defendants, filed a motion to dismiss the case in November 2006. That motion remains pending before the Court. It is not possible at this time reasonably to estimate the outcome of this lawsuit or the impact on the Company.

ANTITRUST LITIGATION

As previously disclosed, 18 lawsuits comprised of both individual suits and purported class actions have been filed against the Company in U.S. District Court, Southern District of Ohio, Western Division, by various plaintiffs, including pharmacy chains (individually and as assignees, in whole or in part, of certain wholesalers), various health and welfare benefit plans/funds and individual residents of various states. These lawsuits allege, among other things, that the purported settlement with Apotex of the patent infringement litigation violated the Sherman Act and related laws. Plaintiffs are seeking, among other things, permanent injunctive relief barring the Apotex settlement and/or monetary damages. The putative class actions filed on behalf of direct purchasers have been consolidated under the caption In re: Plavix Direct Purchaser Antitrust Litigation, and the putative class actions filed on behalf of indirect purchasers have been consolidated under the caption In re: Plavix Indirect Purchaser Antitrust Litigation. Amended complaints were filed on October 19, 2007. Defendants filed a consolidated motion to dismiss on December 11, 2007, which remains pending. It is not possible at this time reasonably to assess the outcome of these lawsuits or their impact on the Company.

SHAREHOLDER DERIVATIVE ACTIONS

As previously disclosed, on July 31, 2007, certain members of the Board of Directors, current and former officers and the Company were named in two derivative actions filed in the New York State Supreme Court, John Frank v. Peter Dolan, et al. (07-602580) and Donald Beebout v. Peter Dolan, et al. (07-602579), and one derivative action filed in the federal district court, Steven W. Sampson v. James D. Robinson, III, et al. (07-CV-6890). The complaints allege breaches of fiduciary duties for allegedly failing to disclose material information relating to efforts to settle the PLAVIX* patent infringement litigation with Apotex. Plaintiffs seek monetary damages on behalf of the Company, contribution and indemnification. By decision filed on December 13, 2007, the state court granted motions to dismiss the complaints, Frank and Beebout, relating to certain members of the Board of Directors, but did not

F-92

Note 25 LEGAL PROCEEDINGS AND CONTINGENCIES (Continued)

dismiss the complaints as to the former officers. By decision dated August 20, 2008, the federal district court granted the Company’s motion to dismiss the Sampson action. Plaintiffs have appealed the district court’s decision to the U.S. Circuit Court of Appeals for the Second Circuit, which is pending.

SECURITIES LITIGATION

In Re Bristol-Myers Squibb Co. Securities Litigation

As previously disclosed, in June and July 2007, two putative class action complaints, Minneapolis Firefighters’ Relief Assoc. v. Bristol-Myers Squibb Co., et al. (07 CV 5867) and Jean Lai v. Bristol-Myers Squibb Company, et al., were filed in the U.S. District for the Southern District of New York against the Company, the Company’s former Chief Executive Officer, Peter Dolan and former Chief Financial Officer, Andrew Bonfield. The complaints allege violations of securities laws for allegedly failing to disclose material information relating to efforts to settle the PLAVIX* patent infringement litigation with Apotex. On September 20, 2007, the Court dismissed the Lai case without prejudice, changed the caption of the case to In re Bristol-Myers Squibb, Co. Securities Litigation, and appointed Ontario Teachers’ Pension Plan Board as lead plaintiff. On October 15, 2007, Ontario Teachers’ Pension Plan Board filed an amended complaint making similar allegations as the earlier filed complaints, naming an additional former officer but no longer naming Andrew Bonfield as a defendant. By decision dated August 20, 2008, the federal district court denied defendants’ motions to dismiss.

The Company intends to defend itself vigorously in this litigation. It is not possible at this time to reasonably assess the outcome of these lawsuits, or the potential impact on the Company.

PRICING, SALES AND PROMOTIONAL PRACTICES LITIGATION AND INVESTIGATIONS

AWP Litigation

As previously disclosed, the Company, together with a number of other pharmaceutical manufacturers, is a defendant in a number of private class actions as well as suits brought by the attorneys general of various states. In these actions, plaintiffs allege that defendants caused the Average Wholesale Prices (AWPs) of their products to be inflated, thereby injuring government programs, entities and persons who reimbursed prescription drugs based on AWPs. The Company remains a defendant in five state attorneys’ general suits pending in federal and state courts around the country.

As previously reported, one set of class actions, together with a suit by the Arizona attorney general, have been consolidated in the U.S. District Court for the District of Massachusetts (AWP MDL). The Court in the AWP MDL has certified three classes of persons and entities who paid for or reimbursed for seven of the Company’s physician-administered drugs. In June 2007, the Company settled in principle the claims of Class 1 (Medicare Part B beneficiaries nationwide) for $13 million, plus half the costs of class notice up to a maximum payment of $1 million and the parties are finalizing the terms of the settlement. A hearing will be scheduled for preliminary approval of the Class 1 settlement. In June 2007, in a non-jury trial in the AWP MDL, the Court found the Company liable for violations of Massachusetts’ consumer protection laws with respect to certain oncology drugs for certain years and awarded damages in the amount of $183 thousand plus interest for Class 3 (private third-party payors) and instructed the parties to apply the Court’s opinion to determine damages for Class 2 (Medigap insurers). In August, 2007, the Court found damages of $187 thousand plus interest for Class 2. The Company has appealed the June 2007 decision to the U.S. Court of Appeals for the First Circuit and oral arguments were heard on November 4, 2008. In September 2008, the Court in the AWP MDL issued an order certifying multi-state classes for Class 2 and Class 3.

It is not possible at this time reasonably to assess the outcome of the litigation matters described above, or their potential impact on the Company.

California 340B Litigation

As previously disclosed, in August 2005, the County of Santa Clara filed a purported class action against the Company and numerous other pharmaceutical manufacturers on behalf of itself and a putative class of other cities and counties in California, as well as the covered entities that purchased drugs pursuant to the 340B drug discount program. In July 2006, the U.S. District Court for the Northern District of California dismissed the lawsuit with prejudice for failure to state a claim and plaintiff appealed to the U.S. Court of Appeals for the Ninth Circuit. In September 2008, the Ninth Circuit reversed the District Court’s dismissal and reinstated the lawsuit.

It is not possible at this time to reasonably assess the outcome of this lawsuit, or its potential impact on the Company.

PRODUCT LIABILITY LITIGATION

The Company is a party to various product liability lawsuits. In addition to lawsuits, the Company also faces unfiled claims involving other products. At this time, the Company does not believe that any of the on-going lawsuits will likely result in a material effect on the Company’s financial results or operations. However, the Company is also aware of potential unfiled claims. It is not possible at this time to reasonably assess the outcome of any additional lawsuits that might be filed or their potential impact on the Company.

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Note 25 LEGAL PROCEEDINGS AND CONTINGENCIES (Continued)

The Company and certain affiliates of Sanofi are defendants in a number of individual lawsuits claiming personal injury allegedly sustained after using PLAVIX*, most of which appear before the United States District Court for the District of New Jersey (NJ District Court). The NJ District Court ordered an administrative termination of these cases pending resolution of potentially related issues before the United State Supreme Court in cases involving prescription drugs and preemption. The defendants have executed tolling agreements with respect to unfiled claims by potential additional plaintiffs. It is not possible at this time to reasonably assess the outcomes of these lawsuits or their impact on the Company.

ENVIRONMENTAL PROCEEDINGS

As previously reported, the Company is a party to several environmental proceedings and other matters, and is responsible under various state, Federal and foreign laws, including the Comprehensive Environmental Response, Compensation and Liability Act, (CERCLA), for certain costs of investigating and/or remediating contamination resulting from past industrial activity at the Company’s current or former sites or at waste disposal or reprocessing facilities operated by third parties.

CERCLA Matters

With respect to CERCLA matters for which the Company is responsible under various state, Federal and foreign laws, the Company typically estimates potential costs based on information obtained from the U.S. Environmental Protection Agency (EPA), or counterpart state agency and/or studies prepared by independent consultants, including the total estimated costs for the site and the expected cost-sharing, if any, with other “potentially responsible parties”, and the Company accrues liabilities when they are probable and reasonably estimable. As of December 31, 2008, the Company estimated its share of the total future costs for these sites to be approximately $62 million, recorded as other liabilities, which represents the sum of best estimates or, where no simple estimate can reasonably be made, estimates of the minimal probable amount among a range of such costs (without taking into account any potential recoveries from other parties, which are not currently expected).

Passaic River (NJ) Remediation and Natural Resource Damages Claims

As previously disclosed, in September 2003, the New Jersey Department of Environmental Protection (NJDEP) issued an administrative enforcement Directive requiring the Company and other companies to perform an assessment of natural resource damages and to implement unspecified interim remedial measures to restore conditions in the Lower Passaic River (LPR). The Directive named the Company due to releases from a nearby bulk chemical reprocessing facility operated by a predecessor of McKesson Corp. Subsequently, the EPA issued notice letters to numerous parties, but not the Company, requesting performance of a Remedial Investigation/Feasibility Study (RI/FS) of conditions in the LPR. Under a consent agreement with EPA in 2004, a group of these other parties committed to pay roughly half of the $20 million estimated for the RI/FS by EPA at that time. The EPA thereafter substantially increased its estimate of the scope and cost of the RI/FS and, as a result, the EPA agreed to allow the group to perform most of the remaining RI/FS tasks. By the group’s estimate, total costs to complete the RI/FS and related tasks now exceed $50 million. The group has negotiated an amended consent agreement with the EPA to conduct the remaining RI/FS work, which became effective in May 2007. As part of that process, the Company and McKesson have bought out of remaining RI/FS tasks.

Separately, the Company has agreed to pay approximately $110 thousand towards RI/FS tasks previously funded by McKesson and work cooperatively going forward, subject to later reallocation. In mid-2007 the EPA announced plans to seek implementation of “early-action” remedial measures to address the most highly-contaminated portions of the LPR while the RI/FS is being completed. The EPA has indicated it expects to select any such actions early in 2009. Also, a sub-group of the cooperating private parties have commenced discussions with federal natural resource trustee agencies concerning an agreement to assess natural resource damages in the LPR. Those discussions are expected to continue until mid-2009. The remaining parties, including the Company and McKesson, have declined to discuss the proposal at least until the scope and cost of the “early-actions” sought by the EPA are most thoroughly understood. The extent of any liability the Company may face for these and related requirements cannot yet be determined.

North Brunswick Township Board of Education

As previously disclosed, in October 2003, the Company was contacted by counsel representing the North Brunswick, NJ Board of Education (BOE) regarding a site where waste materials from E.R. Squibb and Sons may have been disposed from the 1940’s through the 1960’s. Fill material containing industrial waste and heavy metals in excess of residential standards was discovered during an expansion project at the North Brunswick Township High School, as well as at a number of neighboring residential properties and adjacent public park areas. In January 2004, the NJDEP sent the Company and others an information request letter about possible waste disposal at the site, to which the Company responded in March 2004. The BOE and the Township, as the current owners of the school property and the park, are conducting and jointly financing soil remediation work and ground water investigation work under a work plan approved by NJDEP, and has asked the Company to contribute to the cost. The Company is actively monitoring the clean-

F-94

Note 25 LEGAL PROCEEDINGS AND CONTINGENCIES (Continued)

up project, including its costs. To date, neither the school board nor the Township has asserted any claim against the Company. Instead, the Company and the local entities have negotiated an agreement to attempt to resolve the matter by informal means, including mediation and binding allocation as necessary. A central component of the agreement is provision by the Company of interim funding to help defray cleanup costs and assure the work is not interrupted; the Company transmitted an initial interim funding payment in December 2007. The parties have since commenced mediation activities, which are expected to conclude by mid-2009.

ODS Regulatory Compliance

As previously disclosed, the EPA was investigating industrial and commercial facilities throughout the U.S. that use refrigeration equipment containing ozone-depleting substances (ODS) and enforcing compliance with regulations governing the prevention, service and repair of leaks (ODS requirements). In 2004, the Company performed a voluntary corporate-wide audit at its facilities in the U.S. and Puerto Rico that use ODS-containing refrigeration equipment. The Company submitted an audit report to the EPA in November 2004, identifying potential violations of the ODS requirements at several of its facilities. In addition to the matters covered in the Company’s audit report letter to the EPA, the EPA previously sent Mead Johnson a request for information regarding compliance with ODS requirements at its facility in Evansville, Indiana. The Company responded to the request in June 2004, and, as a result, identified potential violations at the Evansville facility. The Company has signed a Consent Decree with the EPA to resolve both the potential violations discovered during the audit and those identified as a result of the EPA request for information to the Evansville facility, which was filed in the Evansville Division of the U.S. District Court for the Southern District of Indiana on July 8, 2008. The Consent Decree requires the Company to pay a civil penalty of $127 thousand and to retire, retrofit or replace 17 ODS-containing refrigeration units by June 2009 located at facilities in New Jersey, Indiana, and Puerto Rico. The Consent Decree also requires the Company to spend at least $2,225 thousand on a Supplemental Environmental Project, which consists of the removal of two ODS-containing comfort cooling devices at the New Brunswick, NJ facility and the tie in of their functions to a new centralized chiller system that does not use ODS as a refrigerant. The Consent Decree has not yet been entered by the court.

New Brunswick Facility – Environmental & Personal Injury Lawsuits

As previously disclosed, in May 2008, approximately 100 lawsuits were filed against the Company in Superior Court, Middlesex County, NJ, by or on behalf of current and former residents of New Brunswick, NJ who live adjacent to the Company’s New Brunswick facility. The complaints allege various personal injuries and property damage resulting from soil and groundwater contamination on their property stemming from historical operations at the New Brunswick facility. The complaints also allege that BMS has failed to remediate contamination at the New Brunswick facility in compliance with state and federal cleanup requirements. The New Brunswick facility is already undergoing environmental remediation as part of a New Jersey Department of Environmental Protection (NJDEP) approved cleanup plan. In addition to the lawsuits, the plaintiffs filed a notice seeking relief under the NJ Environmental Rights Act. In October 2008, the New Jersey Supreme Court granted Mass Tort status to these cases and transferred them to the New Jersey Superior Court in Atlantic County for centralized case management purposes. The Company has filed motions to dismiss these lawsuits, some of which were denied with leave to refile them after discovery has been taken, while others are still pending before the court. The Company intends to defend itself vigorously in this litigation. It is not possible at this time to reasonably assess the outcome of these lawsuits, or the potential impact on the Company.

WAGE & HOUR LITIGATION

As previously disclosed, a putative class action complaint was filed against the Company by former sales representatives. In Beth Amendola v. Bristol-Myers Squibb Company, et al. (Docket No. 07-CV-6088), filed in June 2007 in the District court, the plaintiff alleges that the Company violated the federal Fair Labor Standards Act by, among other things, not paying overtime compensation to her and a putative class of similarly situated sales employees. On June 5, 2008 the Court issued a decision that renders the case a nonclass action lawsuit. The Company settled the lawsuit with the individual plaintiffs. This settlement agreement is not material to the Company and concludes the lawsuit.

OTHER PROCEEDINGS

SEC Germany Investigation

As previously disclosed, in October 2004, the SEC notified the Company that it is conducting an informal inquiry into the activities of certain of the Company’s German pharmaceutical subsidiaries and its employees and/or agents. On October 4, 2006, the SEC informed the Company that its inquiry is now formal. The SEC’s inquiry encompasses matters currently under investigation by the German prosecutor in Munich, Germany. The Company understands the inquiry and investigation concern potential violations of the Foreign Corrupt Practices Act and German law, respectively. The Company is cooperating with both the SEC and the German authorities. The Company has established an accrual with respect to the investigation by the German prosecutor. It is not possible at this time reasonably to assess the outcome of these investigations or their impact on the Company.

F-95

Note 25 LEGAL PROCEEDINGS AND CONTINGENCIES (Continued)

ConvaTec – Italy Investigation

As previously reported, the Italian competition authorities investigated a complaint lodged by a hospital in the Ferrara region of Italy relating to an allegation that four medical device companies, including ConvaTec, boycotted tenders in 2003 and 2004, (the Ferrara tenders). In May 2007, ConvaTec received a statement of objections from the Italian competition authorities, whereby the authorities alleged that four medical device companies, including ConvaTec, acted in a concerted manner with regard not only to the Ferrara tenders, but tenders or pricing discussions in three other regions and acted in such a way to prevent competition throughout Italy. In August 2007, the competition authorities issued their decision, and found that the four medical device companies had infringed Italian anti-trust law by not participating in the Ferrara tenders, and imposed a fine against ConvaTec in an amount that is not material to the Company. (As ConvaTec was a division of BMS Italy prior to its divestiture, the fine was imposed against BMS Italy). ConvaTec appealed the decision to the Administrative Court and the fine imposed against ConvaTec was later reduced. The Company has further appealed the decision to the High Court of Second Instance (Consiglio di Stato) and a hearing occurred on February 17, 2009.

Note 26 SELECTED QUARTERLY FINANCIAL DATA (UNAUDITED)


Dollars in Millions, except per share data	First Quarter			Second Quarter			Third Quarter			Fourth Quarter			Year
2008:
Net Sales	$	4,891		$	5,203		$	5,254		$	5,249		$	20,597
Gross Margin		3,321			3,533			3,620			3,727			14,201
Net Earnings from Continuing Operations		877			963			847			1,464			4,151
Less Net Earnings Attributable to Noncontrolling Interest		(230	)		(241	)		(259	)		(266	)		(996	)
Net Earnings from Continuing Operations Attributable to Shareholders		647			722			588			1,198			3,155
Net Earnings from Discontinued Operations		14			42			1,990			46			2,092
Net Earnings Attributable to Shareholders		661			764			2,578			1,244			5,247
Earnings Attributable to Shareholders per Common Share⁽¹⁾:
Basic:
Continuing Operations	$	0.32		$	0.37		$	0.30		$	0.61		$	1.60
Discontinued Operations, net		0.01			0.02			1.00			0.02			1.05

Net Earnings Attributable to Shareholders per Common Share	$	0.33		$	0.39		$	1.30		$	0.63		$	2.65


Diluted:
Continuing Operations	$	0.32		$	0.36		$	0.30		$	0.61		$	1.59
Discontinued Operations, net		0.01			0.02			0.99			0.02			1.04

Net Earnings Attributable to Shareholders per Common Share	$	0.33		$	0.38		$	1.29		$	0.63		$	2.63


Dividends declared per common share	$	0.31		$	0.31		$	0.31		$	0.31		$	1.24

Cash and cash equivalents	$	2,443		$	4,047		$	7,173		$	7,976		$	7,976
Marketable securities		194			355			258			289			289

Dollars in Millions, except per share data	First Quarter			Second Quarter			Third Quarter			Fourth Quarter			Year
2007:
Net Sales	$	4,063		$	4,471		$	4,601		$	5,058		$	18,193
Gross Margin		2,797			3,063			3,123			3,342			12,325
Net Earnings from Continuing Operations		733			782			964			25			2,504
Less Net Earnings Attributable to Noncontrolling Interest		(141	)		(194	)		(211	)		(217	)		(763	)
Net Earnings/(Loss) from Continuing Operations Attributable to Shareholders		592			588			753			(192	)		1,741
Net Earnings from Discontinued Operations		98			118			105			103			424
Net Earnings/(Loss) Attributable to Shareholders		690			706			858			(89	)		2,165
Earnings/ (Loss) Attributable to Shareholders per Common Share⁽¹⁾:
Basic:
Continuing Operations	$	0.30		$	0.30		$	0.38		$	(0.10	)	$	0.88
Discontinued Operations, net		0.05			0.06			0.05			0.05			0.22

Net Earnings/(Loss) Attributable to Shareholders per Common Share	$	0.35		$	0.36		$	0.43		$	(0.05	)	$	1.10


Diluted:
Continuing Operations	$	0.30		$	0.30		$	0.38		$	(0.10	)	$	0.88
Discontinued Operations, net		0.05			0.06			0.05			0.05			0.21

Net Earnings/(Loss) Attributable to Shareholders per Common Share	$	0.35		$	0.36		$	0.43		$	(0.05	)	$	1.09


Dividends declared per common share	$	0.28		$	0.28		$	0.28		$	0.31		$	1.15

Cash and cash equivalents	$	2,214		$	2,379		$	1,647		$	1,801		$	1,801
Marketable securities		1,798			2,267			1,935			424			424

(1)	Earnings per share for the quarters may not add to the amounts for the year, as each period is computed on a discrete basis.

F-96

Note 26 SELECTED QUARTERLY FINANCIAL DATA (UNAUDITED) (continued)

The Company recorded the following specified expense/(income) items in 2008 and 2007 that affected the comparability of results:


Dollars in Millions	First Quarter			Second Quarter			Third Quarter			Fourth Quarter			Year
2008:
Productivity Transformation Initiative:
Downsizing and streamlining of worldwide operations	$	11		$	30		$	26		$	122		$	189
Accelerated depreciation, asset impairment and other shutdown costs		96			58			53			34			241
Pension settlements/curtailments		—			—			—			17			17
Process standardization implementation costs		15			21			28			45			109
Gain on sale and leaseback of properties		(9	)		—			—			—			(9	)
Termination of lease contracts		—			—			—			15			15
Gain on sale of product lines and businesses		—			—			—			(159	)		(159	)

		113			109			107			74			403
Other:
Litigation settlement		—			2			30			1			33
Insurance recovery		—			—			—			(20	)		(20	)
Mead Johnson charges		—			1			9			34			44
Product liability		16			—			2			—			18
Upfront and milestone payments and acquired in-process research and development		20			63			37			260			380
Asset impairment		—			—			—			40			40
ARS impairment charges and gain/(loss) on sale		25			(2	)		224			77			324
Debt buyback and swap terminations		—			—			—			(57	)		(57	)
Gain on sale of ImClone shares		—			—			—			(895	)		(895	)

		174			173			409			(486	)		270
Income taxes on items above		(33	)		(34	)		(87	)		193			39

Decrease/(Increase) to Net Earnings from Continuing Operations	$	141		$	139		$	322		$	(293	)	$	309


Dollars in Millions	First Quarter			Second Quarter			Third Quarter			Fourth Quarter			Year
2007:
Productivity Transformation Initiative:
Downsizing and streamlining of worldwide operations	$	—		$	—		$	—		$	145		$	145
Accelerated depreciation and asset impairment		—			—			—			110			110
Process standardization implementation costs		—			—			—			37			37

		—			—			—			292			292
Other:
Litigation settlement		—			14			—			—			14
Insurance recovery		—			—			(11	)		—			(11	)
Product liability		—			—			5			10			15
Upfront and milestone payments and acquired in-process research and development		80			17			60			235			392
ARS impairment charges		—			—			—			275			275
Downsizing and streamlining of worldwide operations		37			7			—			—			44
Accelerated depreciation, asset impairment and contract termination		16			13			17			54			100
Gain on sale of properties and product lines and businesses		—			(26	)		(247	)		(9	)		(282	)

		133			25			(176	)		857			839
Income taxes on items above		(40	)		(5	)		82			(70	)		(33	)
Change in estimate for taxes on a prior year specified item		(39	)		—			—			—			(39	)

Decrease/(Increase) to Net Earnings from Continuing Operations	$	54		$	20		$	(94	)	$	787		$	767

F-97