The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ADMA BIOLOGICS INC | COM | 000899104 | 7,781 | 964,193 | SH | DFND | 1 | 964,193 | 0 | 0 | |
| ADVAXIS INC | COM NEW | 007624208 | 17,007 | 1,690,517 | SH | DFND | 1 | 1,690,517 | 0 | 0 | |
| AEGERION PHARMACEUTICALS INC | COM | 00767E102 | 35,454 | 3,510,291 | SH | DFND | 1 | 3,510,291 | 0 | 0 | |
| AEGERION PHARMACEUTICALS INC | COM | 00767E102 | 5,050 | 500,000 | SH | Call | DFND | 1 | 500,000 | 0 | 0 |
| ALCOBRA LTD | SHS | M2239P109 | 9,779 | 1,557,106 | SH | DFND | 1 | 1,557,106 | 0 | 0 | |
| AMAG PHARMACEUTICALS INC | COM | 00163U106 | 9,057 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 7,891 | 4,175,216 | SH | DFND | 1 | 4,175,216 | 0 | 0 | |
| AMPHASTAR PHARMACEUTICALS IN | COM | 03209R103 | 14,614 | 1,026,979 | SH | DFND | 1 | 1,026,979 | 0 | 0 | |
| AMPLIPHI BIOSCIENCES CORP | COM NEW | 03211P202 | 2,197 | 552,000 | SH | DFND | 1 | 552,000 | 0 | 0 | |
| ANGIODYNAMICS INC | COM | 03475V101 | 30,332 | 2,498,527 | SH | DFND | 1 | 2,498,527 | 0 | 0 | |
| ANTARES PHARMA INC | COM | 036642106 | 13,885 | 11,475,000 | SH | DFND | 1 | 11,475,000 | 0 | 0 | |
| ANTHERA PHARMACEUTICALS INC | COM NEW | 03674U201 | 5,358 | 1,154,674 | SH | DFND | 1 | 1,154,674 | 0 | 0 | |
| ARATANA THERAPEUTICS INC | COM | 03874P101 | 19,133 | 3,428,865 | SH | DFND | 1 | 3,428,865 | 0 | 0 | |
| ARDELYX INC | COM | 039697107 | 6,329 | 349,290 | SH | DFND | 1 | 349,290 | 0 | 0 | |
| ATRICURE INC | COM | 04963C209 | 18,031 | 803,519 | SH | DFND | 1 | 803,519 | 0 | 0 | |
| BIODEL INC | COM NEW | 09064M204 | 685 | 2,000,000 | SH | DFND | 1 | 2,000,000 | 0 | 0 | |
| BIODELIVERY SCIENCES INTL IN | COM | 09060J106 | 22,459 | 4,688,794 | SH | DFND | 1 | 4,688,794 | 0 | 0 | |
| BIODELIVERY SCIENCES INTL IN | COM | 09060J106 | 2,395 | 500,000 | SH | Call | DFND | 1 | 500,000 | 0 | 0 |
| BIOLINERX LTD | SPONSORED ADR | 09071M106 | 4,550 | 3,500,000 | SH | DFND | 1 | 3,500,000 | 0 | 0 | |
| BIOTA PHARMACEUTIALS INC | COM | 090694100 | 6,764 | 3,486,711 | SH | DFND | 1 | 3,486,711 | 0 | 0 | |
| CARBYLAN THERAPEUTICS INC | COM | 141384107 | 4,268 | 1,178,941 | SH | DFND | 1 | 1,178,941 | 0 | 0 | |
| CARDICA INC | COM | 14141R101 | 1,369 | 8,874,992 | SH | DFND | 1 | 8,874,992 | 0 | 0 | |
| CAS MED SYS INC | COM PAR $0.004 | 124769209 | 4,634 | 2,618,296 | SH | DFND | 1 | 2,618,296 | 0 | 0 | |
| CATALYST PHARMACEUTICALS INC | COM | 14888U101 | 10,249 | 4,183,177 | SH | DFND | 1 | 4,183,177 | 0 | 0 | |
| CIDARA THERAPEUTICS INC | COM | 171757107 | 2,864 | 166,875 | SH | DFND | 1 | 166,875 | 0 | 0 | |
| CONTRAFECT CORP | COM | 212326102 | 6,738 | 1,418,439 | SH | DFND | 1 | 1,418,439 | 0 | 0 | |
| CORIUM INTL INC | COM | 21887L107 | 14,633 | 1,802,092 | SH | DFND | 1 | 1,802,092 | 0 | 0 | |
| CYNAPSUS THERAPEUTICS INC | COM PAR NO PAR | 23257Y859 | 8,916 | 583,121 | SH | DFND | 1 | 583,121 | 0 | 0 | |
| DEPOMED INC | COM | 249908104 | 13,155 | 725,600 | SH | DFND | 1 | 725,600 | 0 | 0 | |
| DERMA SCIENCES INC | COM PAR $.01 | 249827502 | 11,709 | 2,562,104 | SH | DFND | 1 | 2,562,104 | 0 | 0 | |
| DIPEXIUM PHARMACEUTICALS INC | COM | 25456J104 | 5,219 | 465,978 | SH | DFND | 1 | 465,978 | 0 | 0 | |
| DISCOVERY LABORATORIES INC N | COM NEW | 254668403 | 2,329 | 10,889,166 | SH | DFND | 1 | 10,889,166 | 0 | 0 | |
| DYNAVAX TECHNOLOGIES CORP | COM NEW | 268158201 | 15,214 | 629,710 | SH | DFND | 1 | 629,710 | 0 | 0 | |
| EGALET CORP | COM | 28226B104 | 12,505 | 1,134,750 | SH | DFND | 1 | 1,134,750 | 0 | 0 | |
| EMERGENT BIOSOLUTIONS INC | COM | 29089Q105 | 26,924 | 672,922 | SH | DFND | 1 | 672,922 | 0 | 0 | |
| ENDOLOGIX INC | COM | 29266S106 | 9,900 | 1,000,000 | SH | DFND | 1 | 1,000,000 | 0 | 0 | |
| EPIRUS BIOPHARMACEUTICALS IN | COM | 29428P107 | 4,249 | 1,375,000 | SH | DFND | 1 | 1,375,000 | 0 | 0 | |
| FATE THERAPEUTICS INC | COM | 31189P102 | 3,754 | 1,113,986 | SH | DFND | 1 | 1,113,986 | 0 | 0 | |
| FLAMEL TECHNOLOGIES SA | SPONSORED ADR | 338488109 | 53,656 | 4,394,464 | SH | DFND | 1 | 4,394,464 | 0 | 0 | |
| GENOCEA BIOSCIENCES INC | COM | 372427104 | 4,460 | 846,243 | SH | DFND | 1 | 846,243 | 0 | 0 | |
| HERON THERAPEUTICS INC | COM | 427746102 | 59,594 | 2,232,001 | SH | DFND | 1 | 2,232,001 | 0 | 0 | |
| HORIZON PHARMA PLC | SHS | G4617B105 | 176,205 | 8,131,310 | SH | DFND | 1 | 8,131,310 | 0 | 0 | |
| HORIZON PHARMA PLC | SHS | G4617B105 | 10,835 | 500,000 | SH | Call | DFND | 1 | 500,000 | 0 | 0 |
| IDERA PHARMACEUTICALS INC | COM NEW | 45168K306 | 9,563 | 3,094,745 | SH | DFND | 1 | 3,094,745 | 0 | 0 | |
| IGNYTA INC | COM | 451731103 | 30,238 | 2,256,546 | SH | DFND | 1 | 2,256,546 | 0 | 0 | |
| ISHARES TR | RUSSELL 2000 ETF | 464287655 | 129,513 | 1,150,000 | SH | Put | DFND | 1 | 1,150,000 | 0 | 0 |
| KEMPHARM INC | COM | 488445107 | 14,544 | 732,338 | SH | DFND | 1 | 732,338 | 0 | 0 | |
| LA JOLLA PHARMACEUTICAL CO | COM PAR $.0001 2 | 503459604 | 31,465 | 1,165,373 | SH | DFND | 1 | 1,165,373 | 0 | 0 | |
| LION BIOTECHNOLOGIES INC | COM | 53619R102 | 16,255 | 2,105,519 | SH | DFND | 1 | 2,105,519 | 0 | 0 | |
| MEDGENICS INC | COM NEW | 58436Q203 | 18,333 | 3,045,306 | SH | DFND | 1 | 3,045,306 | 0 | 0 | |
| MEDIWOUND LTD | ORD SHS | M68830104 | 4,535 | 530,985 | SH | DFND | 1 | 530,985 | 0 | 0 | |
| MELA SCIENCES INC | COM NEW | 55277R308 | 1,414 | 1,274,297 | SH | DFND | 1 | 1,274,297 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 7,453 | 235,870 | SH | DFND | 1 | 235,870 | 0 | 0 | |
| NEVRO CORP | COM | 64157F103 | 81,112 | 1,201,480 | SH | DFND | 1 | 1,201,480 | 0 | 0 | |
| NEXVET BIOPHARMA PUB LTD CO | ORD SHS | G6503X109 | 2,461 | 721,595 | SH | DFND | 1 | 721,595 | 0 | 0 | |
| NOVADAQ TECHNOLOGIES INC | COM | 66987G102 | 46,922 | 3,683,013 | SH | DFND | 1 | 3,683,013 | 0 | 0 | |
| NOVADAQ TECHNOLOGIES INC | COM | 66987G102 | 6,370 | 500,000 | SH | Call | DFND | 1 | 500,000 | 0 | 0 |
| ORASURE TECHNOLOGIES INC | COM | 68554V108 | 4,415 | 685,528 | SH | DFND | 1 | 685,528 | 0 | 0 | |
| PALATIN TECHNOLOGIES INC | COM PAR $ .01 | 696077403 | 908 | 1,368,085 | SH | DFND | 1 | 1,368,085 | 0 | 0 | |
| PARATEK PHARMACEUTICALS INC | COM | 699374302 | 10,059 | 530,283 | SH | DFND | 1 | 530,283 | 0 | 0 | |
| PERNIX THERAPEUTICS HLDGS IN | COM | 71426V108 | 17,968 | 6,090,829 | SH | DFND | 1 | 6,090,829 | 0 | 0 | |
| PERNIX THERAPEUTICS HLDGS IN | DEBT 4.250% 4/0 | 71426VAJ7 | 8,944 | 15,500,000 | SH | DFND | 1 | 15,500,000 | 0 | 0 | |
| PROGENICS PHARMACEUTICALS IN | COM | 743187106 | 54,871 | 8,951,169 | SH | DFND | 1 | 8,951,169 | 0 | 0 | |
| PROTALIX BIOTHERAPEUTICS INC | COM | 74365A101 | 3,405 | 3,338,570 | SH | DFND | 1 | 3,338,570 | 0 | 0 | |
| QLT INC | COM | 746927102 | 11,825 | 4,445,527 | SH | DFND | 1 | 4,445,527 | 0 | 0 | |
| RAPTOR PHARMACEUTICAL CORP | COM | 75382F106 | 12,548 | 2,412,995 | SH | DFND | 1 | 2,412,995 | 0 | 0 | |
| RECRO PHARMA INC | COM | 75629F109 | 18,541 | 2,060,086 | SH | DFND | 1 | 2,060,086 | 0 | 0 | |
| REDHILL BIOPHARMA LTD | SPONSORED ADS | 757468103 | 10,689 | 829,906 | SH | DFND | 1 | 829,906 | 0 | 0 | |
| RETROPHIN INC | COM | 761299106 | 57,094 | 2,959,790 | SH | DFND | 1 | 2,959,790 | 0 | 0 | |
| RIGEL PHARMACEUTICALS INC | COM NEW | 766559603 | 9,470 | 3,125,282 | SH | DFND | 1 | 3,125,282 | 0 | 0 | |
| RITTER PHARMACEUTICALS INC | COM | 767836109 | 1,323 | 778,000 | SH | DFND | 1 | 778,000 | 0 | 0 | |
| RXI PHARMACEUTICALS CORP NEW | COM NEW | 74979C303 | 1,958 | 5,126,482 | SH | DFND | 1 | 5,126,482 | 0 | 0 | |
| SCYNEXIS INC | COM | 811292101 | 4,813 | 775,000 | SH | DFND | 1 | 775,000 | 0 | 0 | |
| SEASPINE HLDGS CORP | COM | 81255T108 | 17,180 | 1,000,007 | SH | DFND | 1 | 1,000,007 | 0 | 0 | |
| SPDR SERIES TRUST | S&P BIOTECH | 78464A870 | 70,200 | 1,000,000 | SH | Put | DFND | 1 | 1,000,000 | 0 | 0 |
| SPECTRANETICS CORP | COM | 84760C107 | 8,510 | 565,079 | SH | DFND | 1 | 565,079 | 0 | 0 | |
| ST JUDE MED INC | COM | 790849103 | 12,354 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| STRONGBRIDGE BIOPHARMA PLC | SHS USD | G85347105 | 10,911 | 1,656,705 | SH | DFND | 1 | 1,656,705 | 0 | 0 | |
| SYNERON MEDICAL LTD | ORD SHS | M87245102 | 8,136 | 1,055,221 | SH | DFND | 1 | 1,055,221 | 0 | 0 | |
| TELIGENT INC NEW | COM | 87960W104 | 20,361 | 2,287,728 | SH | DFND | 1 | 2,287,728 | 0 | 0 | |
| TENAX THERAPEUTICS INC | COM | 88032L100 | 6,457 | 1,968,631 | SH | DFND | 1 | 1,968,631 | 0 | 0 | |
| TITAN PHARMACEUTICALS INC DE | COM NEW | 888314309 | 3,380 | 761,201 | SH | DFND | 1 | 761,201 | 0 | 0 | |
| TONIX PHARMACEUTICALS HLDG C | COM NEW | 890260201 | 6,832 | 890,748 | SH | DFND | 1 | 890,748 | 0 | 0 | |
| TREVENA INC | COM | 89532E109 | 10,500 | 1,000,000 | SH | DFND | 1 | 1,000,000 | 0 | 0 | |
| VALEANT PHARMACEUTICALS INTL | COM | 91911K102 | 91,485 | 900,000 | SH | DFND | 1 | 900,000 | 0 | 0 | |
| VALEANT PHARMACEUTICALS INTL | COM | 91911K102 | 10,165 | 100,000 | SH | Call | DFND | 1 | 100,000 | 0 | 0 |
| VERACYTE INC | COM | 92337F107 | 2,196 | 304,980 | SH | DFND | 1 | 304,980 | 0 | 0 | |
| ZOGENIX INC | COM NEW | 98978L204 | 16,024 | 1,087,112 | SH | DFND | 1 | 1,087,112 | 0 | 0 | |