The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AAC HLDGS INC | COM | 000307108 | 33,967 | 1,782,094 | SH | DFND | 1 | 1,782,094 | 0 | 0 | |
| ACCELERON PHARMA INC | COM | 00434H108 | 10,410 | 213,491 | SH | DFND | 1 | 213,491 | 0 | 0 | |
| ACCURAY INC | NOTE 3.750% 8/0 | 004397AB1 | 30,875 | 30,511,000 | PRN | DFND | 1 | 30,511,000 | 0 | 0 | |
| ACHILLION PHARMACEUTICALS IN | COM | 00448Q201 | 17,987 | 1,667,000 | SH | DFND | 1 | 1,667,000 | 0 | 0 | |
| ACURA PHARMACEUTICALS INC | COM PAR $0.01 | 00509L802 | 2,564 | 1,025,641 | SH | DFND | 1 | 1,025,641 | 0 | 0 | |
| ADEPTUS HEALTH INC | CL A | 006855100 | 71,307 | 1,307,908 | SH | DFND | 1 | 1,307,908 | 0 | 0 | |
| AERIE PHARMACEUTICALS INC | COM | 00771V108 | 19,672 | 807,875 | SH | DFND | 1 | 807,875 | 0 | 0 | |
| AETNA INC NEW | COM | 00817Y108 | 63,949 | 591,465 | SH | DFND | 1 | 591,465 | 0 | 0 | |
| AKARI THERAPEUTICS PLC | SPONSORED ADR | 00972G108 | 16,685 | 1,150,700 | SH | DFND | 1 | 1,150,700 | 0 | 0 | |
| ALCOBRA LTD | SHS | M2239P109 | 6,719 | 1,069,914 | SH | DFND | 1 | 1,069,914 | 0 | 0 | |
| ALDEYRA THERAPEUTICS INC | COM | 01438T106 | 4,682 | 690,538 | SH | DFND | 1 | 690,538 | 0 | 0 | |
| ALIMERA SCIENCES INC | COM | 016259103 | 14,225 | 5,878,015 | SH | DFND | 1 | 5,878,015 | 0 | 0 | |
| ALLIQUA BIOMEDICAL INC | COM NEW | 019621200 | 4,023 | 1,880,134 | SH | DFND | 1 | 1,880,134 | 0 | 0 | |
| ALLSCRIPTS HEALTHCARE SOLUTN | NOTE 1.250% 7/0 | 01988PAD0 | 13,412 | 12,400,000 | PRN | DFND | 1 | 12,400,000 | 0 | 0 | |
| ALPHATEC HOLDINGS INC | COM | 02081G102 | 1,495 | 4,982,738 | SH | DFND | 1 | 4,982,738 | 0 | 0 | |
| AMERISOURCEBERGEN CORP | COM | 03073E105 | 311 | 3,000 | SH | DFND | 1 | 3,000 | 0 | 0 | |
| ANTARES PHARMA INC | COM | 036642106 | 4,820 | 3,983,440 | SH | DFND | 1 | 3,983,440 | 0 | 0 | |
| ANTHEM INC | COM | 036752103 | 2,043 | 14,649 | SH | DFND | 1 | 14,649 | 0 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 36,838 | 8,729,361 | SH | DFND | 1 | 8,729,361 | 0 | 0 | |
| ARRAY BIOPHARMA INC | NOTE 3.000% 6/0 | 04269XAA3 | 42,292 | 45,000,000 | PRN | DFND | 1 | 45,000,000 | 0 | 0 | |
| AXOGEN INC | COM | 05463X106 | 16,907 | 3,381,439 | SH | DFND | 1 | 3,381,439 | 0 | 0 | |
| BOVIE MEDICAL CORP | COM | 10211F100 | 1,445 | 688,229 | SH | DFND | 1 | 688,229 | 0 | 0 | |
| CARDIOVASCULAR SYS INC DEL | COM | 141619106 | 15,649 | 1,035,000 | SH | DFND | 1 | 1,035,000 | 0 | 0 | |
| CAREDX INC | COM | 14167L103 | 1,466 | 229,000 | SH | DFND | 1 | 229,000 | 0 | 0 | |
| CAS MED SYS INC | COM PAR $0.004 | 124769209 | 5,664 | 3,200,000 | SH | DFND | 1 | 3,200,000 | 0 | 0 | |
| CATABASIS PHARMACEUTICALS IN | COM | 14875P107 | 5,104 | 643,580 | SH | DFND | 1 | 643,580 | 0 | 0 | |
| CENTENE CORP DEL | COM | 15135B101 | 16,058 | 244,000 | SH | DFND | 1 | 244,000 | 0 | 0 | |
| CHARLES RIV LABS INTL INC | COM | 159864107 | 30,322 | 377,188 | SH | DFND | 1 | 377,188 | 0 | 0 | |
| CIDARA THERAPEUTICS INC | COM | 171757107 | 2,050 | 119,456 | SH | DFND | 1 | 119,456 | 0 | 0 | |
| CORSICANTO LTD | NOTE 3.500% 1/1 | 220480AB3 | 901 | 1,000,000 | PRN | DFND | 1 | 1,000,000 | 0 | 0 | |
| CTI BIOPHARMA CORP | COM | 12648L106 | 2,751 | 2,236,832 | SH | DFND | 1 | 2,236,832 | 0 | 0 | |
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 19,743 | 946,022 | SH | DFND | 1 | 946,022 | 0 | 0 | |
| DAVITA HEALTHCARE PARTNERS I | COM | 23918K108 | 57,302 | 822,000 | SH | DFND | 1 | 822,000 | 0 | 0 | |
| DBV TECHNOLOGIES S A | SPONSORED ADR | 23306J101 | 16,770 | 461,869 | SH | DFND | 1 | 461,869 | 0 | 0 | |
| DYAX CORP | COM | 26746E103 | 84,347 | 2,242,073 | SH | DFND | 1 | 2,242,073 | 0 | 0 | |
| EGALET CORP | COM | 28226B104 | 5,258 | 477,123 | SH | DFND | 1 | 477,123 | 0 | 0 | |
| EHEALTH INC | COM | 28238P109 | 32,581 | 3,264,588 | SH | DFND | 1 | 3,264,588 | 0 | 0 | |
| ENDOCHOICE HLDGS INC | COM | 29272U103 | 15,225 | 1,823,309 | SH | DFND | 1 | 1,823,309 | 0 | 0 | |
| ENDOLOGIX INC | NOTE 2.250%12/1 | 29266SAA4 | 34,602 | 40,941,000 | PRN | DFND | 1 | 40,941,000 | 0 | 0 | |
| ENDOLOGIX INC | NOTE 3.250%11/0 | 29266SAB2 | 32,548 | 30,000,000 | PRN | DFND | 1 | 30,000,000 | 0 | 0 | |
| ESSA PHARMA INC | COM | 29668H104 | 8,499 | 1,859,282 | SH | DFND | 1 | 1,859,282 | 0 | 0 | |
| FIVE PRIME THERAPEUTICS INC | COM | 33830X104 | 28,220 | 680,000 | SH | DFND | 1 | 680,000 | 0 | 0 | |
| FLAMEL TECHNOLOGIES SA | SPONSORED ADR | 338488109 | 49,729 | 4,072,809 | SH | DFND | 1 | 4,072,809 | 0 | 0 | |
| FLUIDIGM CORP DEL | NOTE 2.750% 2/0 | 34385PAA6 | 17,603 | 27,715,000 | PRN | DFND | 1 | 27,715,000 | 0 | 0 | |
| FOAMIX PHARMACEUTICALS LTD | SHS | M46135105 | 7,696 | 948,934 | SH | DFND | 1 | 948,934 | 0 | 0 | |
| GALAPAGOS NV | SPON ADR | 36315X101 | 11,507 | 183,000 | SH | DFND | 1 | 183,000 | 0 | 0 | |
| GENESIS HEALTHCARE INC | CL A COM | 37185X106 | 3,344 | 963,564 | SH | DFND | 1 | 963,564 | 0 | 0 | |
| GENOCEA BIOSCIENCES INC | COM | 372427104 | 4,412 | 837,257 | SH | DFND | 1 | 837,257 | 0 | 0 | |
| GENOMIC HEALTH INC | COM | 37244C101 | 28,492 | 809,432 | SH | DFND | 1 | 809,432 | 0 | 0 | |
| GILEAD SCIENCES INC | COM | 375558103 | 53,833 | 532,000 | SH | Call | DFND | 1 | 532,000 | 0 | 0 |
| GLAXOSMITHKLINE PLC | SPONSORED ADR | 37733W105 | 67,602 | 1,675,385 | SH | DFND | 1 | 1,675,385 | 0 | 0 | |
| GLOBAL BLOOD THERAPEUTICS IN | COM | 37890U108 | 37,626 | 1,163,811 | SH | DFND | 1 | 1,163,811 | 0 | 0 | |
| GW PHARMACEUTICALS PLC | ADS | 36197T103 | 21,535 | 310,122 | SH | DFND | 1 | 310,122 | 0 | 0 | |
| HEALTHWAYS INC | COM | 422245100 | 31,725 | 2,465,042 | SH | DFND | 1 | 2,465,042 | 0 | 0 | |
| HEALTHWAYS INC | NOTE 1.500% 7/0 | 422245AB6 | 49,087 | 51,925,000 | PRN | DFND | 1 | 51,925,000 | 0 | 0 | |
| HEARTWARE INTL INC | COM | 422368100 | 8,062 | 159,961 | SH | DFND | 1 | 159,961 | 0 | 0 | |
| HEARTWARE INTL INC | NOTE 3.500%12/1 | 422368AA8 | 37,364 | 39,226,000 | PRN | DFND | 1 | 39,226,000 | 0 | 0 | |
| HORIZON PHARMA PLC | SHS | G4617B105 | 253,210 | 11,684,801 | SH | DFND | 1 | 11,684,801 | 0 | 0 | |
| IMMUNOMEDICS INC | COM | 452907108 | 3,296 | 1,073,640 | SH | DFND | 1 | 1,073,640 | 0 | 0 | |
| IMPRIVATA INC | COM | 45323J103 | 13,633 | 1,206,418 | SH | DFND | 1 | 1,206,418 | 0 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 33,797 | 4,305,288 | SH | DFND | 1 | 4,305,288 | 0 | 0 | |
| INVUITY INC | COM NEW | 46187J205 | 9,510 | 1,078,218 | SH | DFND | 1 | 1,078,218 | 0 | 0 | |
| JAZZ INVESTMENTS I LTD | NOTE 1.875% 8/1 | 472145AB7 | 5,223 | 5,000,000 | PRN | DFND | 1 | 5,000,000 | 0 | 0 | |
| KEMPHARM INC | COM | 488445107 | 28,211 | 1,420,497 | SH | DFND | 1 | 1,420,497 | 0 | 0 | |
| LOXO ONCOLOGY INC | COM | 548862101 | 7,141 | 251,000 | SH | DFND | 1 | 251,000 | 0 | 0 | |
| MACROGENICS INC | COM | 556099109 | 16,040 | 517,920 | SH | DFND | 1 | 517,920 | 0 | 0 | |
| MCKESSON CORP | COM | 58155Q103 | 28,529 | 144,646 | SH | DFND | 1 | 144,646 | 0 | 0 | |
| MYLAN N V | SHS EURO | N59465109 | 57,098 | 1,056,000 | SH | DFND | 1 | 1,056,000 | 0 | 0 | |
| MYOKARDIA INC | COM | 62857M105 | 5,498 | 375,000 | SH | DFND | 1 | 375,000 | 0 | 0 | |
| NANOSTRING TECHNOLOGIES INC | COM | 63009R109 | 12,954 | 880,622 | SH | DFND | 1 | 880,622 | 0 | 0 | |
| NEOS THERAPEUTICS INC | COM | 64052L106 | 6,563 | 458,332 | SH | DFND | 1 | 458,332 | 0 | 0 | |
| NIVALIS THERAPEUTICS INC | COM | 65481J109 | 28,889 | 3,732,412 | SH | DFND | 1 | 3,732,412 | 0 | 0 | |
| NXSTAGE MEDICAL INC | COM | 67072V103 | 100,545 | 4,589,000 | SH | DFND | 1 | 4,589,000 | 0 | 0 | |
| OXFORD IMMUNOTEC GLOBAL PLC | ORD SHS | G6855A103 | 5,976 | 519,670 | SH | DFND | 1 | 519,670 | 0 | 0 | |
| PACIFIC BIOSCIENCES CALIF IN | COM | 69404D108 | 18,224 | 1,388,000 | SH | DFND | 1 | 1,388,000 | 0 | 0 | |
| PACIRA PHARMACEUTICALS INC | COM | 695127100 | 28,489 | 371,000 | SH | DFND | 1 | 371,000 | 0 | 0 | |
| PALATIN TECHNOLOGIES INC | COM PAR $ .01 | 696077403 | 1,328 | 2,000,000 | SH | DFND | 1 | 2,000,000 | 0 | 0 | |
| PORTOLA PHARMACEUTICALS INC | COM | 737010108 | 35,179 | 683,749 | SH | DFND | 1 | 683,749 | 0 | 0 | |
| POZEN INC | COM | 73941U102 | 305 | 44,583 | SH | DFND | 1 | 44,583 | 0 | 0 | |
| PRONAI THERAPEUTICS INC | COM | 74346L101 | 26,940 | 1,791,255 | SH | DFND | 1 | 1,791,255 | 0 | 0 | |
| PROTEON THERAPEUTICS INC | COM | 74371L109 | 19,625 | 1,265,343 | SH | DFND | 1 | 1,265,343 | 0 | 0 | |
| PSIVIDA CORP | COM | 74440J101 | 5,891 | 1,222,110 | SH | DFND | 1 | 1,222,110 | 0 | 0 | |
| REGENXBIO INC | COM | 75901B107 | 19,406 | 1,169,042 | SH | DFND | 1 | 1,169,042 | 0 | 0 | |
| RELYPSA INC | COM | 759531106 | 25,514 | 900,281 | SH | DFND | 1 | 900,281 | 0 | 0 | |
| RENNOVA HEALTH INC | *W EXP 12/22/202 | 759757115 | 285 | 645,161 | SH | DFND | 1 | 645,161 | 0 | 0 | |
| RENNOVA HEALTH INC | COM | 759757107 | 755 | 559,431 | SH | DFND | 1 | 559,431 | 0 | 0 | |
| RIGEL PHARMACEUTICALS INC | COM NEW | 766559603 | 7,266 | 2,397,855 | SH | DFND | 1 | 2,397,855 | 0 | 0 | |
| RITE AID CORP | COM | 767754104 | 19,543 | 2,492,772 | SH | DFND | 1 | 2,492,772 | 0 | 0 | |
| SAGE THERAPEUTICS INC | COM | 78667J108 | 34,913 | 598,854 | SH | DFND | 1 | 598,854 | 0 | 0 | |
| SCYNEXIS INC | COM | 811292101 | 4,324 | 696,281 | SH | DFND | 1 | 696,281 | 0 | 0 | |
| SPECTRANETICS CORP | MTNF 2.625% 6/0 | 84760CAA5 | 22,537 | 29,831,000 | PRN | DFND | 1 | 29,831,000 | 0 | 0 | |
| STEADYMED LTD | SHS | M84920103 | 4,390 | 1,346,744 | SH | DFND | 1 | 1,346,744 | 0 | 0 | |
| STREAMLINE HEALTH SOLUTIONS | COM | 86323X106 | 935 | 662,971 | SH | DFND | 1 | 662,971 | 0 | 0 | |
| TEVA PHARMACEUTICAL INDS LTD | ADR | 881624209 | 53,497 | 815,000 | SH | DFND | 1 | 815,000 | 0 | 0 | |
| TEVA PHARMACEUTICAL INDS LTD | ADR | 881624209 | 36,102 | 550,000 | SH | Call | DFND | 1 | 550,000 | 0 | 0 |
| TONIX PHARMACEUTICALS HLDG C | COM NEW | 890260201 | 10,090 | 1,315,551 | SH | DFND | 1 | 1,315,551 | 0 | 0 | |
| TRACON PHARMACEUTICALS INC | COM | 89237H100 | 4,481 | 485,000 | SH | DFND | 1 | 485,000 | 0 | 0 | |
| TRILLIUM THERAPEUTICS INC | COM NEW | 89620X506 | 2,173 | 172,307 | SH | DFND | 1 | 172,307 | 0 | 0 | |
| TRINITY BIOTECH PLC | SPON ADR NEW | 896438306 | 2,893 | 246,000 | SH | DFND | 1 | 246,000 | 0 | 0 | |
| TRUPANION INC | COM | 898202106 | 10,367 | 1,062,214 | SH | DFND | 1 | 1,062,214 | 0 | 0 | |
| UNIVERSAL AMERN CORP NEW | COM | 91338E101 | 33,523 | 4,789,027 | SH | DFND | 1 | 4,789,027 | 0 | 0 | |
| VANDA PHARMACEUTICALS INC | COM | 921659108 | 55,829 | 5,996,691 | SH | DFND | 1 | 5,996,691 | 0 | 0 | |
| VERACYTE INC | COM | 92337F107 | 2,823 | 392,147 | SH | DFND | 1 | 392,147 | 0 | 0 | |
| VERSARTIS INC | COM | 92529L102 | 6,077 | 490,503 | SH | DFND | 1 | 490,503 | 0 | 0 | |
| VOYAGER THERAPEUTICS INC | COM | 92915B106 | 5,153 | 235,294 | SH | DFND | 1 | 235,294 | 0 | 0 | |
| WALGREENS BOOTS ALLIANCE INC | COM | 931427108 | 32,909 | 386,457 | SH | DFND | 1 | 386,457 | 0 | 0 | |
| XENCOR INC | COM | 98401F105 | 18,372 | 1,256,612 | SH | DFND | 1 | 1,256,612 | 0 | 0 | |
| XENOPORT INC | COM | 98411C100 | 34,518 | 6,287,374 | SH | DFND | 1 | 6,287,374 | 0 | 0 | |
| ZAFGEN INC | COM | 98885E103 | 5,307 | 843,665 | SH | DFND | 1 | 843,665 | 0 | 0 | |