The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ADMA BIOLOGICS INC | COM | 000899104 | 7,800 | 964,193 | SH | DFND | 1 | 964,193 | 0 | 0 | |
| ADVAXIS INC | COM NEW | 007624208 | 15,265 | 1,690,517 | SH | DFND | 1 | 1,690,517 | 0 | 0 | |
| AEGERION PHARMACEUTICALS INC | COM | 00767E102 | 14,838 | 4,010,291 | SH | DFND | 1 | 4,010,291 | 0 | 0 | |
| ALCOBRA LTD | SHS | M2239P109 | 5,901 | 1,557,106 | SH | DFND | 1 | 1,557,106 | 0 | 0 | |
| AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 7,153 | 4,675,216 | SH | DFND | 1 | 4,675,216 | 0 | 0 | |
| ANACOR PHARMACEUTICALS INC | COM | 032420101 | 5,345 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| ANACOR PHARMACEUTICALS INC | COM | 032420101 | 21,380 | 400,000 | SH | Call | DFND | 1 | 400,000 | 0 | 0 |
| ANGIODYNAMICS INC | COM | 03475V101 | 30,707 | 2,498,527 | SH | DFND | 1 | 2,498,527 | 0 | 0 | |
| ANTARES PHARMA INC | COM | 036642106 | 13,126 | 15,085,393 | SH | DFND | 1 | 15,085,393 | 0 | 0 | |
| ANTHERA PHARMACEUTICALS INC | COM NEW | 03674U201 | 4,180 | 1,154,674 | SH | DFND | 1 | 1,154,674 | 0 | 0 | |
| ARALEZ PHARMACEUTICALS INC | COM | 03852X100 | 13,490 | 3,800,000 | SH | DFND | 1 | 3,800,000 | 0 | 0 | |
| ARATANA THERAPEUTICS INC | COM | 03874P101 | 18,927 | 3,428,865 | SH | DFND | 1 | 3,428,865 | 0 | 0 | |
| ARDELYX INC | COM | 039697107 | 1,680 | 216,180 | SH | DFND | 1 | 216,180 | 0 | 0 | |
| BIODELIVERY SCIENCES INTL IN | COM | 09060J106 | 16,760 | 5,188,794 | SH | DFND | 1 | 5,188,794 | 0 | 0 | |
| BIOTA PHARMACEUTICALS INC | COM | 090694100 | 5,230 | 3,486,711 | SH | DFND | 1 | 3,486,711 | 0 | 0 | |
| CARDICA INC | COM NEW | 14141R309 | 3,159 | 887,499 | SH | DFND | 1 | 887,499 | 0 | 0 | |
| CARDIOVASCULAR SYS INC DEL | COM | 141619106 | 15,168 | 1,462,663 | SH | DFND | 1 | 1,462,663 | 0 | 0 | |
| CAS MED SYS INC | COM PAR $0.004 | 124769209 | 3,542 | 2,494,534 | SH | DFND | 1 | 2,494,534 | 0 | 0 | |
| CATALYST PHARMACEUTICALS INC | COM | 14888U101 | 9,594 | 8,200,000 | SH | DFND | 1 | 8,200,000 | 0 | 0 | |
| CIDARA THERAPEUTICS INC | COM | 171757107 | 2,119 | 166,875 | SH | DFND | 1 | 166,875 | 0 | 0 | |
| CONTRAFECT CORP | COM | 212326102 | 2,873 | 844,906 | SH | DFND | 1 | 844,906 | 0 | 0 | |
| CORIUM INTL INC | COM | 21887L107 | 6,956 | 1,802,092 | SH | DFND | 1 | 1,802,092 | 0 | 0 | |
| DERMA SCIENCES INC | COM PAR $.01 | 249827502 | 7,943 | 2,562,104 | SH | DFND | 1 | 2,562,104 | 0 | 0 | |
| DIPEXIUM PHARMACEUTICALS ORD | COM | 25456J104 | 4,431 | 465,978 | SH | DFND | 1 | 465,978 | 0 | 0 | |
| DISCOVERY LABORATORIES INC N | COM PAR | 254668502 | 1,299 | 777,797 | SH | DFND | 1 | 777,797 | 0 | 0 | |
| DYNAVAX TECHNOLOGIES CORP | COM NEW | 268158201 | 10,540 | 547,810 | SH | DFND | 1 | 547,810 | 0 | 0 | |
| EGALET CORP | COM | 28226B104 | 7,784 | 1,134,750 | SH | DFND | 1 | 1,134,750 | 0 | 0 | |
| ENDOLOGIX INC | COM | 29266S106 | 8,360 | 1,000,000 | SH | DFND | 1 | 1,000,000 | 0 | 0 | |
| EPIRUS BIOPHARMACEUTICALS IN | COM | 29428P107 | 2,904 | 1,079,543 | SH | DFND | 1 | 1,079,543 | 0 | 0 | |
| FLAMEL TECHNOLOGIES SA | SPONSORED ADR | 338488109 | 48,515 | 4,394,464 | SH | DFND | 1 | 4,394,464 | 0 | 0 | |
| HERON THERAPEUTICS INC | COM | 427746102 | 27,829 | 1,465,475 | SH | DFND | 1 | 1,465,475 | 0 | 0 | |
| HORIZON PHARMA PLC | SHS | G4617B105 | 113,063 | 6,823,377 | SH | DFND | 1 | 6,823,377 | 0 | 0 | |
| HORIZON PHARMA PLC | SHS | G4617B105 | 24,855 | 1,500,000 | SH | Call | DFND | 1 | 1,500,000 | 0 | 0 |
| IDERA PHARMACEUTICALS INC | COM NEW | 45168K306 | 6,128 | 3,094,745 | SH | DFND | 1 | 3,094,745 | 0 | 0 | |
| IGNYTA INC | COM | 451731103 | 15,277 | 2,256,546 | SH | DFND | 1 | 2,256,546 | 0 | 0 | |
| ISHARES TR | RUSSELL 2000 ETF | 464287655 | 110,630 | 1,000,000 | SH | Put | DFND | 1 | 1,000,000 | 0 | 0 |
| KEMPHARM INC | COM | 488445107 | 4,346 | 299,695 | SH | DFND | 1 | 299,695 | 0 | 0 | |
| LA JOLLA PHARMACEUTICAL CO | COM PAR $.0001 2 | 503459604 | 24,368 | 1,165,373 | SH | DFND | 1 | 1,165,373 | 0 | 0 | |
| LION BIOTECHNOLOGIES INC | COM | 53619R102 | 10,696 | 2,105,519 | SH | DFND | 1 | 2,105,519 | 0 | 0 | |
| MEDGENICS INC | COM NEW | 58436Q203 | 13,399 | 3,045,306 | SH | DFND | 1 | 3,045,306 | 0 | 0 | |
| MEDIWOUND LTD | ORD SHS | M68830104 | 4,285 | 530,985 | SH | DFND | 1 | 530,985 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 4,149 | 193,863 | SH | DFND | 1 | 193,863 | 0 | 0 | |
| NEVRO CORP | COM | 64157F103 | 37,576 | 667,907 | SH | DFND | 1 | 667,907 | 0 | 0 | |
| NEVRO CORP | COM | 64157F103 | 16,878 | 300,000 | SH | Call | DFND | 1 | 300,000 | 0 | 0 |
| NEXVET BIOPHARMA PUB LTD CO | ORD SHS | G6503X109 | 3,300 | 1,000,000 | SH | DFND | 1 | 1,000,000 | 0 | 0 | |
| NOVADAQ TECHNOLOGIES INC | COM | 66987G102 | 60,609 | 5,465,216 | SH | DFND | 1 | 5,465,216 | 0 | 0 | |
| PARATEK PHARMACEUTICALS INC | COM | 699374302 | 8,044 | 530,282 | SH | DFND | 1 | 530,282 | 0 | 0 | |
| PERNIX THERAPEUTICS HLDGS IN | COM | 71426V108 | 6,395 | 6,090,829 | SH | DFND | 1 | 6,090,829 | 0 | 0 | |
| PERNIX THERAPEUTICS HLDGS IN | DEBT 4.250% 4/0 | 71426VAJ7 | 5,287 | 15,500,000 | SH | DFND | 1 | 15,500,000 | 0 | 0 | |
| PROGENICS PHARMACEUTICALS IN | COM | 743187106 | 39,027 | 8,951,169 | SH | DFND | 1 | 8,951,169 | 0 | 0 | |
| PROTALIX BIOTHERAPEUTICS INC | COM | 74365A101 | 2,846 | 3,386,285 | SH | DFND | 1 | 3,386,285 | 0 | 0 | |
| QLT INC | COM | 746927102 | 8,847 | 4,445,527 | SH | DFND | 1 | 4,445,527 | 0 | 0 | |
| RAPTOR PHARMACEUTICAL CORP | COM | 75382F106 | 32,200 | 7,000,000 | SH | DFND | 1 | 7,000,000 | 0 | 0 | |
| RECRO PHARMA INC | COM | 75629F109 | 12,299 | 2,060,086 | SH | DFND | 1 | 2,060,086 | 0 | 0 | |
| REDHILL BIOPHARMA LTD | SPONSORED ADS | 757468103 | 10,024 | 818,265 | SH | DFND | 1 | 818,265 | 0 | 0 | |
| RETROPHIN INC | COM | 761299106 | 40,431 | 2,959,790 | SH | DFND | 1 | 2,959,790 | 0 | 0 | |
| RITTER PHARMACEUTICALS INC | COM | 767836109 | 879 | 778,000 | SH | DFND | 1 | 778,000 | 0 | 0 | |
| RXI PHARMACEUTICALS ORD | COM NEW | 74979C303 | 1,355 | 5,018,409 | SH | DFND | 1 | 5,018,409 | 0 | 0 | |
| SCYNEXIS INC | COM | 811292101 | 3,036 | 753,373 | SH | DFND | 1 | 753,373 | 0 | 0 | |
| SEASPINE HLDGS CORP | COM | 81255T108 | 14,640 | 1,000,007 | SH | DFND | 1 | 1,000,007 | 0 | 0 | |
| SPECTRANETICS CORP | COM | 84760C107 | 1,054 | 72,615 | SH | DFND | 1 | 72,615 | 0 | 0 | |
| STRATA SKIN SCIENCES INC | COM | 86272A107 | 953 | 1,008,297 | SH | DFND | 1 | 1,008,297 | 0 | 0 | |
| STRONGBRIDGE BIOPHARMA PLC | SHS USD | G85347105 | 7,555 | 1,656,705 | SH | DFND | 1 | 1,656,705 | 0 | 0 | |
| SYNERON MEDICAL LTD | ORD SHS | M87245102 | 6,360 | 870,013 | SH | DFND | 1 | 870,013 | 0 | 0 | |
| TELIGENT INC NEW | COM | 87960W104 | 11,210 | 2,287,728 | SH | DFND | 1 | 2,287,728 | 0 | 0 | |
| TENAX THERAPEUTICS INC | COM | 88032L100 | 4,036 | 1,968,631 | SH | DFND | 1 | 1,968,631 | 0 | 0 | |
| TONIX PHARMACEUTICALS HLDG C | COM NEW | 890260201 | 1,991 | 825,986 | SH | DFND | 1 | 825,986 | 0 | 0 | |
| TREVENA INC | COM | 89532E109 | 6,720 | 812,579 | SH | DFND | 1 | 812,579 | 0 | 0 | |
| VERACYTE INC | COM | 92337F107 | 525 | 97,298 | SH | DFND | 1 | 97,298 | 0 | 0 | |
| XENOPORT INC | COM | 98411C100 | 7,180 | 1,592,067 | SH | DFND | 1 | 1,592,067 | 0 | 0 | |
| ZOGENIX INC | COM NEW | 98978L204 | 8,153 | 882,312 | SH | DFND | 1 | 882,312 | 0 | 0 | |