The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| Abbott Laboratories | COM | 002824100 | 15,958 | 381,500 | SH | DFND | 1 | 0 | 0 | 381,500 | |
| Abbvie Inc. | COM | 00287Y109 | 857 | 15,000 | SH | DFND | 1 | 0 | 0 | 15,000 | |
| Acadia Pharmaceuticals, Inc. | COM | 004225108 | 1,258 | 45,000 | SH | DFND | 1 | 0 | 0 | 45,000 | |
| Achillion Pharmaceuticals, Inc. | COM | 00448Q201 | 3,242 | 420,000 | SH | DFND | 1 | 0 | 0 | 420,000 | |
| Aetna Inc. | COM | 00817Y108 | 5,056 | 45,000 | SH | DFND | 1 | 0 | 0 | 45,000 | |
| Agios Pharmaceuticals, Inc. | COM | 00847X104 | 2,192 | 54,000 | SH | DFND | 1 | 0 | 0 | 54,000 | |
| Alder Biopharmaceuticals Inc. | COM | 014339105 | 808 | 33,000 | SH | DFND | 1 | 0 | 0 | 33,000 | |
| Alexion Pharmaceuticals, Inc. | COM | 015351109 | 6,877 | 49,400 | SH | DFND | 1 | 0 | 0 | 49,400 | |
| Alkermes Public Limited Company | SHS | G01767105 | 2,239 | 65,500 | SH | DFND | 1 | 0 | 0 | 65,500 | |
| Alnylam Pharmaceuticals Inc. | COM | 02043Q107 | 1,506 | 24,000 | SH | DFND | 1 | 0 | 0 | 24,000 | |
| AmerisourceBergen Corporation | COM | 03073E105 | 2,943 | 34,000 | SH | DFND | 1 | 0 | 0 | 34,000 | |
| Amgen Inc. | COM | 031162100 | 15,443 | 103,000 | SH | DFND | 1 | 0 | 0 | 103,000 | |
| AngioDynamics, Inc. | COM | 03475V101 | 1,861 | 151,400 | SH | DFND | 1 | 0 | 0 | 151,400 | |
| Anthem, Inc. | COM | 036752103 | 4,170 | 30,000 | SH | DFND | 1 | 0 | 0 | 30,000 | |
| Arbutus Biopharm Corporation | COM | 03879J100 | 516 | 125,000 | SH | DFND | 1 | 0 | 0 | 125,000 | |
| ARIAD Pharmaceuticals, Inc. | COM | 04033A100 | 3,163 | 495,000 | SH | DFND | 1 | 0 | 0 | 495,000 | |
| Asterias Biotherapeutics, Inc. | COM SER A | 04624N107 | 9 | 1,875 | SH | DFND | 1 | 0 | 0 | 1,875 | |
| Auris Medical Holding AG | COM | H03579101 | 7,897 | 2,169,625 | SH | DFND | 1 | 0 | 0 | 2,169,625 | |
| C.R. Bard, Inc. | COM | 067383109 | 5,067 | 25,000 | SH | DFND | 1 | 0 | 0 | 25,000 | |
| Baxter International Inc. | COM | 071813109 | 5,340 | 130,000 | SH | DFND | 1 | 0 | 0 | 130,000 | |
| Becton, Dickinson and Company | COM | 075887109 | 15,216 | 100,225 | SH | DFND | 1 | 0 | 0 | 100,225 | |
| Biogen Inc. | COM | 09062X103 | 19,925 | 76,540 | SH | DFND | 1 | 0 | 0 | 76,540 | |
| BioMarin Pharmaceutical Inc. | COM | 09061G101 | 5,361 | 65,000 | SH | DFND | 1 | 0 | 0 | 65,000 | |
| Biotime Inc. | W EXP 10/01/2018 | 09066L162 | 1 | 2,294 | SH | DFND | 1 | 0 | 0 | 2,294 | |
| Bluebird Bio, Inc. | COM | 09609G100 | 1,233 | 29,000 | SH | DFND | 1 | 0 | 0 | 29,000 | |
| Boston Scientific Corporation | COM | 101137107 | 9,405 | 500,000 | SH | DFND | 1 | 0 | 0 | 500,000 | |
| Bristol-Myers Squibb Company | COM | 110122108 | 3,833 | 60,000 | SH | DFND | 1 | 0 | 0 | 60,000 | |
| Cardinal Health, Inc. | COM | 14149Y108 | 13,082 | 159,630 | SH | DFND | 1 | 0 | 0 | 159,630 | |
| Celgene Corporation | COM | 151020104 | 21,074 | 210,550 | SH | DFND | 1 | 0 | 0 | 210,550 | |
| Celldex Therapeutics, Inc. | COM | 15117B103 | 605 | 160,000 | SH | DFND | 1 | 0 | 0 | 160,000 | |
| Centene Corporation | COM | 15135B101 | 6,519 | 105,880 | SH | DFND | 1 | 0 | 0 | 105,880 | |
| Cerner Corporation | COM | 156782104 | 3,178 | 60,000 | SH | DFND | 1 | 0 | 0 | 60,000 | |
| Cigna Corporation | COM | 125509109 | 6,588 | 48,000 | SH | DFND | 1 | 0 | 0 | 48,000 | |
| Clovis Oncology, Inc. | COM | 189464100 | 1,008 | 52,500 | SH | DFND | 1 | 0 | 0 | 52,500 | |
| Coherus BioSciences, Inc | COM | 19249H103 | 6,093 | 287,000 | SH | DFND | 1 | 0 | 0 | 287,000 | |
| Community Health Systems, Inc. | COM | 203668108 | 3,236 | 174,840 | SH | DFND | 1 | 0 | 0 | 174,840 | |
| Cooper Companies Inc. | COM NEW | 216648402 | 3,618 | 23,500 | SH | DFND | 1 | 0 | 0 | 23,500 | |
| CVS Health Corporation | COM | 126650100 | 8,942 | 86,200 | SH | DFND | 1 | 0 | 0 | 86,200 | |
| Davita Healthcare Partners, Inc. | COM | 23918K108 | 1,468 | 20,000 | SH | DFND | 1 | 0 | 0 | 20,000 | |
| DexCom, Inc. | COM | 252131107 | 1,358 | 20,000 | SH | DFND | 1 | 0 | 0 | 20,000 | |
| Direxion Shares ETF Trust | SP BIOTECH BL NEW | 25490K323 | 553 | 20,175 | SH | DFND | 1 | 0 | 0 | 20,175 | |
| Eagle Pharmaceuticals Inc | COM | 268948106 | 3,783 | 93,400 | SH | DFND | 1 | 0 | 0 | 93,400 | |
| Eiger BioPharmaceuticals, Inc. | COM | 28249U105 | 56 | 3,333 | SH | DFND | 1 | 0 | 0 | 3,333 | |
| Edwards Lifesciences Corporation | COM | 28176E108 | 6,439 | 73,000 | SH | DFND | 1 | 0 | 0 | 73,000 | |
| Endo International PLC | SHS | G30401106 | 4,814 | 171,000 | SH | DFND | 1 | 0 | 0 | 171,000 | |
| Endocyte, Inc. | COM | 29269A102 | 310 | 100,000 | SH | DFND | 1 | 0 | 0 | 100,000 | |
| Esperion Therapeutics Inc. | COM | 29664W105 | 676 | 40,000 | SH | DFND | 1 | 0 | 0 | 40,000 | |
| Exelixis, Inc. | COM | 30161Q104 | 680 | 170,000 | SH | DFND | 1 | 0 | 0 | 170,000 | |
| Express Scripts Holding Company | COM | 30219G108 | 4,025 | 58,600 | SH | DFND | 1 | 0 | 0 | 58,600 | |
| Geron Corporation | COM | 374163103 | 131 | 45,000 | SH | DFND | 1 | 0 | 0 | 45,000 | |
| Gilead Sciences, Inc. | COM | 375558103 | 21,431 | 233,300 | SH | DFND | 1 | 0 | 0 | 233,300 | |
| Globus Medical, Inc. | CL A | 379577208 | 2,083 | 87,700 | SH | DFND | 1 | 0 | 0 | 87,700 | |
| Halozyme Therapeutics, Inc. | COM | 40637H109 | 3,011 | 318,000 | SH | DFND | 1 | 0 | 0 | 318,000 | |
| HCA Holdings, Inc. | COM | 40412C101 | 4,683 | 60,000 | SH | DFND | 1 | 0 | 0 | 60,000 | |
| Healthcare Services Group Inc. | COM | 421906108 | 1,841 | 50,000 | SH | DFND | 1 | 0 | 0 | 50,000 | |
| Heartware International, Inc. | COM | 422368100 | 157 | 5,000 | SH | DFND | 1 | 0 | 0 | 5,000 | |
| Hologic, Inc. | COM | 436440101 | 2,795 | 81,000 | SH | DFND | 1 | 0 | 0 | 81,000 | |
| Horizon Pharma plc | SHS | G4617B105 | 5,137 | 310,000 | SH | DFND | 1 | 0 | 0 | 310,000 | |
| Humana, Inc. | COM | 444859102 | 5,489 | 30,000 | SH | DFND | 1 | 0 | 0 | 30,000 | |
| Illumina, Inc. | COM | 452327109 | 14,853 | 91,625 | SH | DFND | 1 | 0 | 0 | 91,625 | |
| ImmunoGen, Inc. | COM | 45253H101 | 256 | 30,000 | SH | DFND | 1 | 0 | 0 | 30,000 | |
| Impax Laboratories, Inc. | COM | 45256B101 | 3,458 | 108,000 | SH | DFND | 1 | 0 | 0 | 108,000 | |
| Incyte Corporation | COM | 45337C102 | 6,595 | 91,000 | SH | DFND | 1 | 0 | 0 | 91,000 | |
| Infinity Pharmaceuticals, Inc. | COM | 45665G303 | 843 | 160,000 | SH | DFND | 1 | 0 | 0 | 160,000 | |
| Inovio Pharmaceuticals, Inc. | COM NEW | 45773H201 | 2,308 | 265,000 | SH | DFND | 1 | 0 | 0 | 265,000 | |
| Insulet Corporation | COM | 45784P101 | 497 | 15,000 | SH | DFND | 1 | 0 | 0 | 15,000 | |
| Insys Therapeutics, Inc. | COM NEW | 45824V209 | 4,493 | 281,000 | SH | DFND | 1 | 0 | 0 | 281,000 | |
| Intercept Pharmaceuticals, Inc. | COM | 45845P108 | 1,734 | 13,500 | SH | DFND | 1 | 0 | 0 | 13,500 | |
| Intersect Ent, Inc. | COM | 46071F103 | 3,976 | 209,246 | SH | DFND | 1 | 0 | 0 | 209,246 | |
| Intuitive Surgical, Inc. | COM NEW | 46120E602 | 7,814 | 13,000 | SH | DFND | 1 | 0 | 0 | 13,000 | |
| Ionis Pharmaceuticals Inc. | COM | 462222100 | 5,589 | 138,000 | SH | DFND | 1 | 0 | 0 | 138,000 | |
| iSHARES Trust | NASDQ BIOTEC ETF | 464287556 | 652 | 2,500 | SH | DFND | 1 | 0 | 0 | 2,500 | |
| Jazz Pharmaceuticals Public Limited Company | SHS USD | G50871105 | 8,159 | 62,500 | SH | DFND | 1 | 0 | 0 | 62,500 | |
| Johnson & Johnson | COM | 478160104 | 5,410 | 50,000 | SH | DFND | 1 | 0 | 0 | 50,000 | |
| Juniper Pharmaceuticals Inc. | COM | 48203L107 | 331 | 50,000 | SH | DFND | 1 | 0 | 0 | 50,000 | |
| Juno Therapeutics, Inc. | COM | 48205A109 | 1,409 | 37,000 | SH | DFND | 1 | 0 | 0 | 37,000 | |
| Kite Pharma, Inc. | COM | 49803L109 | 643 | 14,000 | SH | DFND | 1 | 0 | 0 | 14,000 | |
| Laboratory Corporation of America Holdings | COM NEW | 50540R409 | 1,171 | 10,000 | SH | DFND | 1 | 0 | 0 | 10,000 | |
| Lannett Inc. | COM | 516012101 | 1,933 | 107,810 | SH | DFND | 1 | 0 | 0 | 107,810 | |
| Ligand Pharmaceuticals Incorporated | COM NEW | 53220K504 | 8,763 | 81,830 | SH | DFND | 1 | 0 | 0 | 81,830 | |
| Lilly Eli & Co. | COM | 532457108 | 2,520 | 35,000 | SH | DFND | 1 | 0 | 0 | 35,000 | |
| Macrogenics, Inc. | COM | 556099109 | 1,556 | 83,000 | SH | DFND | 1 | 0 | 0 | 83,000 | |
| Mallinckrodt public limited company | SHS | G5785G107 | 5,393 | 88,000 | SH | DFND | 1 | 0 | 0 | 88,000 | |
| Masimo Corporation | COM | 574795100 | 3,138 | 75,000 | SH | DFND | 1 | 0 | 0 | 75,000 | |
| McKesson Corporation | COM | 58155Q103 | 6,762 | 43,000 | SH | DFND | 1 | 0 | 0 | 43,000 | |
| Medivation, Inc. | COM | 58501N101 | 2,897 | 63,000 | SH | DFND | 1 | 0 | 0 | 63,000 | |
| Medtronic, Inc. | COM | 585055106 | 20,738 | 276,500 | SH | DFND | 1 | 0 | 0 | 276,500 | |
| Merck & Co., Inc. | COM | 58933Y105 | 3,175 | 60,000 | SH | DFND | 1 | 0 | 0 | 60,000 | |
| Mylan Inc. | COM | 628530107 | 10,197 | 220,000 | SH | DFND | 1 | 0 | 0 | 220,000 | |
| Myriad Genetics, Inc. | COM | 62855J104 | 524 | 14,000 | SH | DFND | 1 | 0 | 0 | 14,000 | |
| Nektar Therapeutics | COM | 640268108 | 2,970 | 216,000 | SH | DFND | 1 | 0 | 0 | 216,000 | |
| Neurocrine Biosciences, Inc. | COM | 64125C109 | 2,571 | 65,000 | SH | DFND | 1 | 0 | 0 | 65,000 | |
| Nevro Corp. | COM | 64157F103 | 422 | 7,500 | SH | DFND | 1 | 0 | 0 | 7,500 | |
| Novadaq Technologies Inc. | COM | 66987G102 | 2,994 | 270,000 | SH | DFND | 1 | 0 | 0 | 270,000 | |
| Novavax, Inc. | COM | 670002104 | 1,677 | 325,000 | SH | DFND | 1 | 0 | 0 | 325,000 | |
| Nuvasive, Inc. | COM | 670704105 | 2,919 | 60,000 | SH | DFND | 1 | 0 | 0 | 60,000 | |
| Penumbra, Inc. | COM | 70975L107 | 368 | 8,000 | SH | DFND | 1 | 0 | 0 | 8,000 | |
| Perrigo Company plc | SHS | G97822103 | 4,171 | 32,600 | SH | DFND | 1 | 0 | 0 | 32,600 | |
| Pfizer Inc. | COM | 717081103 | 3,260 | 110,000 | SH | DFND | 1 | 0 | 0 | 110,000 | |
| ProShares Trust | PSHS ULT NASB | 74347R214 | 736 | 18,000 | SH | DFND | 1 | 0 | 0 | 18,000 | |
| Prothena Corporation plc | SHS | G72800108 | 1,276 | 31,000 | SH | DFND | 1 | 0 | 0 | 31,000 | |
| PTC Therapeutics Inc. | COM | 69366J200 | 225 | 35,000 | SH | DFND | 1 | 0 | 0 | 35,000 | |
| Qiagen NV | REG SHS | N72482107 | 2,044 | 91,500 | SH | DFND | 1 | 0 | 0 | 91,500 | |
| Quotient Limited | SHS | G73268107 | 880 | 100,000 | SH | DFND | 1 | 0 | 0 | 100,000 | |
| Radius Health Inc. | COM NEW | 750469207 | 1,258 | 40,000 | SH | DFND | 1 | 0 | 0 | 40,000 | |
| Regeneron Pharmaceuticals, Inc. | COM | 75886F107 | 11,678 | 32,400 | SH | DFND | 1 | 0 | 0 | 32,400 | |
| ResMed Inc. | COM | 761152107 | 463 | 8,000 | SH | DFND | 1 | 0 | 0 | 8,000 | |
| Seattle Genetics, Inc. | COM | 812578102 | 2,386 | 68,000 | SH | DFND | 1 | 0 | 0 | 68,000 | |
| Shire PLC | SPONSORED ADR | 82481R106 | 5,824 | 33,880 | SH | DFND | 1 | 0 | 0 | 33,880 | |
| St. Jude Medical, Inc. | COM | 790849103 | 6,710 | 122,000 | SH | DFND | 1 | 0 | 0 | 122,000 | |
| Stryker Corporation | COM | 863667101 | 13,411 | 125,000 | SH | DFND | 1 | 0 | 0 | 125,000 | |
| Supernus Pharmaceuticals, Inc. | COM | 868459108 | 6,725 | 441,000 | SH | DFND | 1 | 0 | 0 | 441,000 | |
| Surgery Partners, Inc. | COM | 86881A100 | 133 | 10,000 | SH | DFND | 1 | 0 | 0 | 10,000 | |
| Team Health Holdings Inc. | COM | 87817A107 | 627 | 15,000 | SH | DFND | 1 | 0 | 0 | 15,000 | |
| Teleflex Incorporated | COM | 879369106 | 1,572 | 10,010 | SH | DFND | 1 | 0 | 0 | 10,010 | |
| Tenet Healthcare Corporation | COM NEW | 88033G407 | 289 | 10,000 | SH | DFND | 1 | 0 | 0 | 10,000 | |
| Tetraphase Pharmaceuticals, Inc. | COM | 88165N105 | 102 | 22,000 | SH | DFND | 1 | 0 | 0 | 22,000 | |
| Teva Pharmaceuticals Industries Ltd | ADR | 881624209 | 10,450 | 195,290 | SH | DFND | 1 | 0 | 0 | 195,290 | |
| Theravance Biopharma, Inc. | COM | G8807B106 | 215 | 11,248 | SH | DFND | 1 | 0 | 0 | 11,248 | |
| Thermo Fisher Scientific Inc. | COM | 883556102 | 2,832 | 20,000 | SH | DFND | 1 | 0 | 0 | 20,000 | |
| Ultragenyx Pharmaceuticals Inc. | COM | 90400D108 | 633 | 10,000 | SH | DFND | 1 | 0 | 0 | 10,000 | |
| United Therapeutics Corporation | COM | 91307C102 | 2,325 | 19,300 | SH | DFND | 1 | 0 | 0 | 19,300 | |
| UnitedHealth Group Incorporated | COM | 91324P102 | 11,988 | 93,000 | SH | DFND | 1 | 0 | 0 | 93,000 | |
| Varian Medical Systems, Inc. | COM | 92220P105 | 2,961 | 37,000 | SH | DFND | 1 | 0 | 0 | 37,000 | |
| Vertex Pharmaceuticals Incorporated | COM | 92532F100 | 5,246 | 66,000 | SH | DFND | 1 | 0 | 0 | 66,000 | |
| Wright Medical Group Inc. | ORD SHS 0.03 PAR | N96617118 | 1,167 | 70,309 | SH | DFND | 1 | 0 | 0 | 70,309 | |
| XOMA Corporation | COM | 98419J107 | 174 | 225,000 | SH | DFND | 1 | 0 | 0 | 225,000 | |
| Zafgen, Inc. | COM | 98885E103 | 134 | 20,000 | SH | DFND | 1 | 0 | 0 | 20,000 | |
| Zeltiq Aesthetics Inc. | COM | 98933Q108 | 2,037 | 75,000 | SH | DFND | 1 | 0 | 0 | 75,000 | |
| Zimmer Biomet Holdings, Inc. | COM | 98956P102 | 9,192 | 86,200 | SH | DFND | 1 | 0 | 0 | 86,200 | |