The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AKARI THERAPEUTICS PLC | SPONSORED ADR | 00972G108 | 1,959 | 139,899 | SH | DFND | 1 | 139,899 | 0 | 0 | |
| ALDEYRA THERAPEUTICS INC | COM | 01438T106 | 265 | 63,146 | SH | DFND | 1 | 63,146 | 0 | 0 | |
| AQUINOX PHARMACEUTICALS INC | COM | 03842B101 | 7,233 | 820,015 | SH | DFND | 1 | 820,015 | 0 | 0 | |
| ARADIGM CORP | COM NO PAR NEW | 038505400 | 4,891 | 1,101,513 | SH | DFND | 1 | 1,101,513 | 0 | 0 | |
| AVEXIS INC | COM | 05366U100 | 2,268 | 83,276 | SH | DFND | 1 | 83,276 | 0 | 0 | |
| BEIGENE LTD | SPONSORED ADR | 07725L102 | 12,219 | 416,879 | SH | DFND | 1 | 416,879 | 0 | 0 | |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 5,774 | 70,000 | SH | DFND | 1 | 70,000 | 0 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 12,728 | 705,159 | SH | DFND | 1 | 705,159 | 0 | 0 | |
| CELATOR PHARMACEUTICALS INC | COM | 15089R102 | 9,215 | 835,408 | SH | DFND | 1 | 835,408 | 0 | 0 | |
| EIGER BIOPHARMACEUTICALS INC | COM | 28249U105 | 1,565 | 93,331 | SH | DFND | 1 | 93,331 | 0 | 0 | |
| ESSA PHARMA INC | COM | 29668H104 | 91 | 28,100 | SH | DFND | 1 | 28,100 | 0 | 0 | |
| INCYTE CORP | COM | 45337C102 | 7,247 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| KURA ONCOLOGY INC | COM | 50127T109 | 2,615 | 645,685 | SH | DFND | 1 | 645,685 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 16,220 | 757,935 | SH | DFND | 1 | 757,935 | 0 | 0 | |
| NABRIVA THERAPEUTICS AG | SPONSORED ADR | 62957M104 | 1,583 | 176,710 | SH | DFND | 1 | 176,710 | 0 | 0 | |
| NEXVET BIOPHARMA PUB LTD CO | ORD SHS | G6503X109 | 511 | 154,840 | SH | DFND | 1 | 154,840 | 0 | 0 | |
| ONCOGENEX PHARMACEUTICALS INC | COM | 68230A106 | 60 | 87,827 | SH | DFND | 1 | 87,827 | 0 | 0 | |
| SEATTLE GENETICS INC | COM | 812578102 | 8,197 | 233,600 | SH | DFND | 1 | 233,600 | 0 | 0 | |
| SOPHIRIS BIO INC | COM NEW | 83578Q209 | 786 | 546,088 | SH | DFND | 1 | 546,088 | 0 | 0 | |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 3,120 | 234,220 | SH | DFND | 1 | 234,220 | 0 | 0 | |
| VITAE PHARMACEUTICALS INC | COM | 92847N103 | 2,089 | 315,025 | SH | DFND | 1 | 315,025 | 0 | 0 | |
| ZOGENIX INC | COM NEW | 98978L204 | 1,552 | 168,000 | SH | DFND | 1 | 168,000 | 0 | 0 | |