The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Achillion Pharmaceuticals Inc COM 00448Q201 17,896 2,589,818 SH   SOLE   0 0 0
Agenus Inc COM NEW 00847G705 9,587 2,084,142 SH   SOLE   0 0 0
Atara Biotherapeutics Inc. COM 46513107 8,269 262,995 SH   SOLE   0 0 0
Berkshire Hathaway Inc CL B NEW 84670702 7 50 SH   SOLE   0 0 0
bluebird bio Inc COM 09609G100 12,969 151,594 SH   SOLE   0 0 0
Catalyst Biosciences Inc COM ADDED 14888D109 1,775 380,806 SH   SOLE   0 0 0
Celldex Therapeutics Inc NEW COM 15117B103 7,575 718,729 SH   SOLE   0 0 0
CytRx Corp COM PAR $.001 232828509 1,075 453,465 SH   SOLE   0 0 0
Dicerna Pharmaceuticals Inc COM 253031108 16,463 2,005,238 SH   SOLE   0 0 0
Five Prime Therapeutics Inc COM 33830X104 10,988 713,954 SH   SOLE   0 0 0
Incyte Corp COM 45337C102 33,453 303,212 SH   SOLE   0 0 0
Kite Pharma Inc COM 49803L109 20,907 375,476 SH   SOLE   0 0 0
Mirati Therapeutics Inc COM 60468T105 16,593 482,069 SH   SOLE   0 0 0
NewLink Genetics Corp COM 651511107 1,014 28,291 SH   SOLE   0 0 0
Omeros Corp COM 682143102 5,370 490,000 SH   SOLE   0 0 0
OraSure Technologies Inc COM 68554V108 1,434 322,996 SH   SOLE   0 0 0
Allscripts Healthcare Solutions Inc COM 01988P108 595 48,000 SH   SOLE   0 0 0
Endologix Inc COM 29266S106 184 15,000 SH   SOLE   0 0 0
Genomic Health Inc COM 37244C101 317 15,000 SH   SOLE   0 0 0
Natera Inc COM ADDED 632307104 344 31,693 SH   SOLE   0 0 0
Veracyte Inc COM 92337F107 117 25,000 SH   SOLE   0 0 0
Alnylam Pharmaceuticals Inc COM 02043Q107 42,885 533,660 SH   SOLE   0 0 0
Arrowhead Research Corp COM NEW 42797209 12,080 2,097,185 SH   SOLE   0 0 0
BioCryst Pharmaceuticals Inc COM 09058V103 25,402 2,228,206 SH   SOLE   0 0 0
Bristol-Myers Squibb Co COM 110122108 6,064 102,425 SH   SOLE   0 0 0
Corium International Inc COM 21887L107 5,378 575,212 SH   SOLE   0 0 0
Dyax Corp COM 26746E103 2,202 115,358 SH   SOLE   0 0 0
Global Blood Therapeutics Inc COM ADDED 37890U108 3,896 92,399 SH   SOLE   0 0 0
Invuity Inc COM NEW 46187J205 2,454 175,000 SH   SOLE   0 0 0
La Jolla Pharmaceutical Co COM PAR $.0001 2 503459604 30,022 1,080,331 SH   SOLE   0 0 0
Lipocine Inc NEW COM 53630X104 2,514 212,497 SH   SOLE   0 0 0
Repros Therapeutics Inc COM NEW 76028H209 1,730 232,830 SH   SOLE   0 0 0
Symmetry Surgical Inc COM 87159G100 7,186 807,442 SH   SOLE   0 0 0
Adaptimmune Therapeutics-adr SPONDS ADR 00653A107 84 7,028 SH   SOLE   0 0 0
Biopharmx Corp COM 09072X101 382 370,636 SH   SOLE   0 0 0
Nivalis Therapeutics Inc COM 65481J109 389 30,000 SH   SOLE   0 0 0
Presbia Plc SHS G7234P100 1,918 350,000 SH   SOLE   0 0 0
Regenxbio Inc COM ADDED 75901B107 4,505 204,494 SH   SOLE   0 0 0
Masimo Corp COM 574795100 999 25,900 SH   SOLE   0 0 0
USO 01/15/2016 CALL 25 UNITS 91232N108 42 13,850 SH Call SOLE   0 0 0
VIVO 01/15/2016 CALL 20 COM 589584101 50 1,252 SH Call SOLE   0 0 0
BCRX 12/18/2015 CALL 12 COM 09058V103 431 2,000 SH Call SOLE   0 0 0
BMY 01/15/2016 CALL 60 COM 110122108 2,588 7,500 SH Call SOLE   0 0 0
Vbi Vaccines Inc COM 91790E102 1,716 650,000 SH   SOLE   0 0 0