Exhibit 99.1

Press Release

I-many Reports Second Quarter 2007 Financial Results

EDISON, N.J., July 31, 2007 – I-many, Inc. (NASDAQ:IMNY), the leading provider of advanced Contract Lifecycle Management (CLM) solutions for managing corporate commitments, reported financial results for the second quarter ended June 30, 2007.

Q2 2007 Financial Highlights

Financial Results for Q2 2007

On a generally accepted accounting principles (GAAP) basis, net revenues totaled $10 million, an increase of 20% from $8.4 million reported in the prior quarter, and an increase of 45% from $6.9 million reported the same period a year ago. Net loss was $(0.06) per share, which was an improvement from a net loss of $(0.09) per share in both the previous quarter and same period a year ago.

Net revenues and loss exclude the portion of the gross value of license and service contracts booked during the quarter which the company cannot recognize until future periods, such as a portion of those related to multi-year software subscriptions. For additional analysis of the company’s performance, see the discussion of non-GAAP financial results, below.

Starting Q1 2007, the company began reporting net revenue divided among three new categories: Recurring revenue, which comprises revenue from software subscriptions, maintenance, support, and hosting; Services revenue, which comprises revenue from professional services; and License revenue, which represents one-time perpetual license fees from product sales. Management expects this will provide better transparency, particularly into the growth of I-many’s expanding stream of recurring revenues.

Recurring revenue for the quarter totaled $4.8 million, an increase of 7% from $4.4 million in the prior quarter and an increase of 23% from $3.9 million reported in the same quarter a year ago.

Services revenue totaled $3.2 million, an increase of 6% from $3.0 million reported in the prior quarter and an increase of 5% from $3.0 million reported in the same period a year ago.

License revenue totaled $2.1 million, an increase of 123% from the prior quarter of $940,000 and an increase from $16,000 reported in the same period a year ago.

Research and development expense remained at elevated levels as planned for the first half of the year, totaling $4.1 million in the second quarter. This was a decrease of 5% from $4.3 million spent in the previous quarter and up 29% from $3.2 million in the same period a year ago.

Quarter-end cash, restricted cash and short-term investments totaled $14.2 million, as compared to $15.7 million at the previous quarter end and $15.8 million a year ago.

Non-GAAP Financial Results

Management believes certain non-GAAP financial results may present a useful picture of the company’s progress as it continues to change its licensing mix to include software subscriptions. (See “Use of Non-GAAP Financial Information,” below.) These non-GAAP results includes the gross value of license contracts signed, which the company calls “bookings” and which totaled $5.2 million in the second quarter of 2007. This represents an increase of 44% from $3.6 million signed in the prior quarter and an increase of 13% from $4.6 million signed in the second quarter of 2006.

These new contracts increased the amount of unamortized software subscriptions to be recognized over the next five years to a record $18.2 million, up 16% from $15.7 million at the end of the prior quarter and an increase of 41% from $12.9 million at end of the second quarter of 2006. (The company defines “unamortized software subscriptions” as the remaining portion of non-cancellable subscription contracts that have been signed but not yet recognized into revenue.)

The combined amount of deferred revenue and unamortized software subscriptions reached a record $33 million at the end of the quarter, an increase of 3% from $32 million in the prior quarter and up 30% from $26 million at the end of the second quarter 2006.

Reflecting the increasing contribution of subscription revenue, the amount of recurring revenue generated from subscription contracts signed in prior periods and recorded in the second quarter of 2007 reached a record $1.1 million, an increase of 15% from $944,000 recorded in the previous quarter and up 90% from $569,000 recorded in the second quarter of 2006.

Other Q2 2007 Highlights

Significant events in the second quarter of 2007 included:

“The launch of I-many Contract Management Suite for Life Sciences was not only a major highlight for the quarter,” said John A. Rade, I-many’s chairman, president and CEO, “it was also one of the greatest events in our company’s history. The release of this product was a culmination of nearly two years and more than $35 million in research and development, and propels I-many far head of the competition. Within the same quarter we also delivered this new product to some of the world’s largest pharmaceutical companies. So now, after peaking in the prior quarter, our R&D expense ticked down this quarter, indicating the beginning of a trend toward lower R&D expense and reflecting the completion of several major projects and installations. We anticipate the most substantial R&D reduction will appear in the fourth quarter as we bring it closer to industry norms and we have updated our guidance accordingly.”

Continued Rade, “While our R&D expenses are lowering, our sales force has now been set loose to drive revenues higher with a long-anticipated new product that is designed to fulfill a promise of more efficient development, higher margins and greater recurring revenues for I-many and, for our customers, faster ROI, more powerful capabilities and the assurance they are enjoying the best and most comprehensive solution for contract management and compliance in the industry.

“We also see a more favorable climate emerging for the industry at large,” added Rade, “like the movement within the U.S. Congress seeking Medicare Part D reform, which we expect can only create more demand for our compliance solutions. These positive factors, plus the continued ramp up in our sales efforts and further realization of our deferred revenue stream, keep us on course to reaching our goals for 2007.”

Conference Call

I-many will host a conference call to discuss these first quarter results today at 4:30 p.m. Eastern Time. A brief presentation by management will be followed by a question and answer period. The dial-in number for the conference call is 1-888-694-4728 or 1-973-582-2745, passcode #9021017. A web simulcast of the call can be accessed via I-many’s web site at www.imany.com.

A replay of the call will be available after 7:30 p.m. today and until August 31, 2007, and can be accessed by dialing 1-877-519-4471 or 1-973-341-3080, conference ID #9021017. A replay of the webcast will also be available at www.imany.com.

Use of Non-GAAP Financial Information

The company supplements its GAAP financial statements in this release and in its annual report on Form 10-K with a reconciliation of the non-GAAP gross value of license transactions to its reported GAAP license revenues. This non-GAAP financial information is provided as additional information for investors and is not in accordance with or an alternative to GAAP. Following the balance sheet and income statement, management has included a table that shows the results for the second quarter 2007 compared to the comparable periods in 2006 for new license transactions including subscription contracts, the recognition into reportable license revenue of deferred non-subscription license transactions, and the reconciliation of those numbers to total license revenue according to GAAP. Management believes its inclusion can enhance an overall understanding of the company’s past operational performance and also its prospects for the future. This reconciliation of license revenues is made with the intent of providing both management and investors a more complete understanding of the revenue performance of the company, as opposed to GAAP revenue results, which do not include the impact of newly-executed subscription agreements and other deferred revenue arrangements that are material to the ongoing performance of the company’s business. This information quantifies the various components comprising current license revenue, which in each quarter consists of revenues from licenses sold in current periods plus revenues deferred from prior periods, less revenue deferred from licenses sold in current periods. Management uses this information as a basis for planning and forecasting core business activity in future periods and believes it is useful in understanding our results of operations. The presentation of this additional revenue information is not meant to be considered in isolation or as a substitute for revenues reported in accordance with generally accepted accounting principles in the United States.

About I-many

I-many (NASDAQ:IMNY) is the leading provider of advanced Contract Lifecycle Management solutions for managing corporate commitments. Designed to extend beyond the traditional contract management capabilities, I-many ContractSphere^® offers an end-to-end solution, from pre-contract processes and contract management to transaction compliance. Ultimately, this provides companies with the visibility and control needed to manage any type of commitment—from contracts and obligations to payments and collections. The result is increased revenue, minimized risk and dramatically reduced operating costs, which deliver improved profitability with hard return on investment. More than 280 customers across 21 industries worldwide have implemented and realized the value of I-many business solutions. For more information, please visit www.imany.com.

This news release contains forward-looking statements, and actual results may vary from those expressed or implied herein. Factors that could affect these results include the risk of unforeseen technical or practical impediments to planned software development, which could affect the company’s product release timetable; the risk that the ratio of subscription license sales to perpetual license sales could be higher than anticipated, possibly leading to lower GAAP revenue in current periods and less cash than predicted in the near term; the risk of lower demand for the company’s new products than management anticipates; the inherent risks of large software implementation projects, which can cause customer disagreements that could affect I-many’s ability to collect both services and license revenue, whether recognized or deferred; the possibility that customers could cancel maintenance and support services at the time of annual renewal, which could decrease I-many’s base of recurring revenue; the possibility that extraordinary events outside the company’s control could extend the length of the sales cycle for the company’s products or make the market for the company’s products more unpredictable; the risk that the company will not be successful in opening new markets for its products; and other risk factors set forth from time to time in the company’s filings with the Securities and Exchange Commission.

I-MANY, INC. AND SUBSIDIARIES

Condensed Consolidated Statements of Operations

(in thousands, except per share amounts)

(Unaudited)

I-MANY, INC. AND SUBSIDIARIES

Condensed Consolidated Balance Sheets

(in thousands)

Reconciliation of Gross Value of License Bookings to Reportable Product Revenue

Note: Consistent with the company’s reclassification of subscription revenues, which are now included in Recurring revenue, subscription revenues are no longer included in the amounts in the line item titled, “Add license revenue recorded in current quarter from contracts sold in prior periods.” The results have been updated with this reclassification for both the current and comparable periods. This line item will still include fees from perpetual license sales which had not been fully recognized as revenue at the time of the sale.

Company Contacts

I-many, Inc.

Kevin Harris, CFO

732-452-1515

kharris@Imany.com

or

Investor Relations:

Liolios Group, Inc. 949-574-3860

Ron Both, ron@liolios.com

Geoffrey Plank, geoffrey@liolios.com

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