The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACADIA PHARMACEUTICALS INC | COM | 00404A109 | 6,522 | 200,938 | SH | DFND | 1 | 200,938 | 0 | 0 | |
| AKARI THERAPEUTICS PLC | SPONSORED ADR | 00972G108 | 1,887 | 139,899 | SH | DFND | 1 | 139,899 | 0 | 0 | |
| ALDEYRA THERAPEUTICS INC | COM | 01438T106 | 1,657 | 291,230 | SH | DFND | 1 | 291,230 | 0 | 0 | |
| AQUINOX PHARMACEUTICALS INC | COM | 03842B101 | 5,811 | 877,753 | SH | DFND | 1 | 877,753 | 0 | 0 | |
| ARADIGM CORP | COM NO PAR NEW | 038505400 | 4,814 | 1,101,513 | SH | DFND | 1 | 1,101,513 | 0 | 0 | |
| AVEXIS INC | COM | 05366U100 | 5,424 | 142,664 | SH | DFND | 1 | 142,664 | 0 | 0 | |
| BEIGENE LTD | SPONSORED ADR | 07725L102 | 14,710 | 493,630 | SH | DFND | 1 | 493,630 | 0 | 0 | |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 5,446 | 70,000 | SH | DFND | 1 | 70,000 | 0 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 14,279 | 705,159 | SH | DFND | 1 | 705,159 | 0 | 0 | |
| CLOVIS ONCOLOGY INC | COM | 189464100 | 6,174 | 450,000 | SH | DFND | 1 | 450,000 | 0 | 0 | |
| EIGER BIOPHARMACEUTICALS INC | COM | 28249U105 | 1,850 | 93,331 | SH | DFND | 1 | 93,331 | 0 | 0 | |
| ELEVEN BIOTHERAPEUTICS INC | COM | 286221106 | 1,670 | 1,000,000 | SH | DFND | 1 | 1,000,000 | 0 | 0 | |
| ESSA PHARMA INC | COM | 29668H104 | 83 | 28,100 | SH | DFND | 1 | 28,100 | 0 | 0 | |
| INCYTE CORP | COM | 45337C102 | 7,998 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| KURA ONCOLOGY INC | COM | 50127T109 | 1,717 | 633,692 | SH | DFND | 1 | 633,692 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 4,138 | 757,935 | SH | DFND | 1 | 757,935 | 0 | 0 | |
| NABRIVA THERAPEUTICS AG | SPONSORED ADR | 62957M104 | 1,325 | 176,710 | SH | DFND | 1 | 176,710 | 0 | 0 | |
| NEXVET BIOPHARMA PUB LTD CO | ORD SHS | G6503X109 | 720 | 154,840 | SH | DFND | 1 | 154,840 | 0 | 0 | |
| REGENERON PHARMACEUTICALS | COM | 75886F107 | 6,985 | 20,000 | SH | DFND | 1 | 20,000 | 0 | 0 | |
| RIGEL PHARMACEUTICALS INC | COM NEW | 766559603 | 1,561 | 700,000 | SH | DFND | 1 | 700,000 | 0 | 0 | |
| SEATTLE GENETICS INC | COM | 812578102 | 9,399 | 232,600 | SH | DFND | 1 | 232,600 | 0 | 0 | |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 2,307 | 234,220 | SH | DFND | 1 | 234,220 | 0 | 0 | |
| TESARO INC | COM | 881569107 | 6,304 | 75,000 | SH | DFND | 1 | 75,000 | 0 | 0 | |