UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of the

Securities Exchange Act of 1934 (Amendment No.    )

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x          Definitive Proxy Statement

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¨          Soliciting Material Pursuant to §240.14a-12

QUINTILES TRANSNATIONAL HOLDINGS INC.

(Name of Registrant as Specified In Its Charter)

N/A

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

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2015

Notice of

Annual Meeting &

Proxy Statement

NOTICE OF 2015 ANNUAL MEETING

OF SHAREHOLDERS

To the shareholders of Quintiles Transnational Holdings Inc.:

The 2015 Annual Meeting of Shareholders of Quintiles Transnational Holdings Inc. (the “Company”) will be held on Thursday, May 7, 2015, at 9:00 a.m., local time, at the Sheraton Imperial Hotel & Convention Center, 4700 Emperor Blvd., Durham, North Carolina 27703 to consider and vote upon the following matters and to transact such other business as may be properly brought before the meeting:

Shareholders of record at the close of business on March 5, 2015 are entitled to notice of, and to vote at, the Annual Meeting.

We hope you will attend the Annual Meeting in person. Whether or not you plan to attend the meeting, we urge you to vote as promptly as possible to ensure that your shares are represented at the meeting.

By Order of the Board of Directors

James H. Erlinger III

Executive Vice President,

General Counsel and Secretary

Durham, North Carolina

March 23, 2015

TABLE OF CONTENTS

QUINTILES TRANSNATIONAL HOLDINGS INC.

PROXY STATEMENT

2015 Annual Meeting of Shareholders

May 7, 2015

GENERAL INFORMATION

What are these materials?

The Board of Directors (the “Board”) of Quintiles Transnational Holdings Inc. (we, us, our, Quintiles, or “our Company”) is soliciting your proxy in connection with our Company’s annual meeting of shareholders, or the Annual Meeting, to be held on Thursday, May 7, 2015, at 9:00 a.m., local time, and at any postponements or adjournments thereof. The proxy materials for the Annual Meeting, including this proxy statement and our annual report to shareholders, are being made available to shareholders on or about March 23, 2015. You are invited to attend the Annual Meeting and are requested to vote on the proposals described in this proxy statement. We will hold the Annual Meeting at the Sheraton Imperial Hotel & Convention Center, 4700 Emperor Blvd., Durham, North Carolina 27703.

What items will be voted on at the Annual Meeting?

We will hold the Annual Meeting to vote on the following proposals and conduct such other business as may be properly brought before the meeting:

Proposal One. The election of four Class II directors as set forth in this proxy statement;

Proposal Two. An advisory (nonbinding) vote to approve executive compensation;

Proposal Three. The ratification of the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm for the year ending December 31, 2015.

What are our Board’s voting recommendations?

Our Board recommends that you vote your shares:

“FOR” each of the nominees to our Board (Proposal One);

“FOR” the advisory (nonbinding) vote to approve executive compensation (Proposal Two); and

“FOR” ratification of the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm for the year ending December 31, 2015 (Proposal Three).

How can I obtain electronic access to the proxy materials?

Our proxy materials are available at http://materials.proxyvote.com/74876Y. This website address is included as an inactive textual reference only. Information on this website does not constitute part of this proxy statement.

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Important Notice Regarding the Availability of Proxy Materials

For the Shareholder Meeting to Be Held on May 7, 2015:

The Annual Report and proxy statement will be available free of charge on the Internet at:

http://materials.proxyvote.com/74876Y

Pursuant to rules adopted by the United States Securities and Exchange Commission, or the SEC, we use the Internet as the primary means of furnishing proxy materials to shareholders. Accordingly, beginning on or about March 23, 2015, we are sending a Notice of Internet Availability of Proxy Materials (the “Notice”) to our shareholders. The Notice contains instructions on how you can access our proxy materials, including this proxy statement, over the Internet or request a printed copy of our proxy materials. The Notice also instructs you on how you can vote using the Internet and by telephone.

In addition, the Notice contains instructions on how to request to receive proxy materials in printed form by mail or electronically by e-mail on an ongoing basis. If you choose to follow the instructions in the Notice for making this request, the materials will be sent promptly to you in the manner you select and you will continue to receive these materials via the method selected unless you elect otherwise. We encourage shareholders to take advantage of the availability of the proxy materials on the Internet to help reduce the environmental impact of our annual meetings and reduce printing and mailing costs.

Where are our principal executive offices located and what is our main telephone number?

Our principal executive offices are located at 4820 Emperor Blvd., Durham, North Carolina 27703. Our main telephone number is (919) 998-2000.

Why did my household only receive one paper copy of the Notice? How can I obtain an additional copy of the proxy materials?

We have adopted a procedure approved by the SEC, known as “householding.” Under this procedure, we deliver a single copy of the Notice and, if requested, our proxy materials, to multiple shareholders who share the same address unless we have received contrary instructions from one or more of the shareholders. This procedure reduces our printing and mailing costs and the environmental impact of our annual meetings. Shareholders who participate in householding will continue to be able to access and receive separate proxy cards. Upon written or oral request, we will deliver promptly a separate Notice or a copy of this proxy statement and our annual report to any shareholder at a shared address to which we delivered a single Notice.

To receive free of charge a separate copy of this proxy statement and our annual report, shareholders may write or call our Company at the following:

Quintiles Investor Relations

4820 Emperor Blvd.

Durham, North Carolina 27703

(919) 998-2590

Shareholders who hold shares in “street name” (as described below) may contact their brokerage firm, bank, broker-dealer or other similar organization to request information about householding.

Who may vote at the Annual Meeting?

Only shareholders of record at the close of business on March 5, 2015 are entitled to vote at the Annual Meeting and any postponements or adjournments thereof. At that time, there were 124,797,705 shares of our common stock outstanding, each of which is entitled to one vote on each matter submitted to a vote at the meeting.

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How do I vote my shares?

You may vote shares by proxy or in person using one of the following methods:

Voting by Mail. If you requested printed proxy materials, you can vote using your proxy card by marking, dating and signing the card and returning it by mail in the accompanying postage-paid envelope. You should mail your signed proxy card sufficiently in advance for it to be received by the close of business on Wednesday, May 6, 2015.

Voting in Person. You can vote in person at the meeting if you are the record owner of the shares to be voted. You can also vote in person at the meeting if you present (i) a properly signed proxy that authorizes you to vote shares on behalf of the record owner and (ii) valid picture identification such as a driver’s license or passport. If a broker, bank, custodian or other nominee holds your shares, to vote in person at the meeting you must present a letter or other proxy appointment, signed on behalf of the broker or nominee, granting you authority to vote the shares.

Voting by Internet. You may vote over the Internet by visiting www.proxyvote.com and entering the control number found in the Notice. The deadline for voting over the Internet is Wednesday, May 6, 2015 at 11:50 p.m. Eastern time.

Voting by Telephone. You may vote by calling the following toll-free telephone number: 1-800-454-8683. The deadline for voting by telephone is Wednesday, May 6, 2015 at 11:50 p.m. Eastern time.

If you vote via the Internet or by telephone, your electronic vote authorizes the named proxies in the same manner as if you signed, dated and returned a proxy card. If you are not the holder of record of your shares, the availability of Internet and telephone voting may depend on the voting process of the organization that holds your shares.

How do I vote shares held by a broker or other nominee?

If a broker, bank, custodian or other nominee holds your shares, you may have received a notice or voting instruction form from them. Please follow the directions that your broker, bank, custodian or other nominee provides or contact the firm to determine the voting methods available to you. Brokers are not permitted to vote for Proposals One, or Two, if the broker has not received instructions from the beneficial owner of shares. It is particularly important, if you hold your shares through a broker or other nominee, that you instruct your broker how you wish to vote your shares because brokers will have discretionary voting authority only with respect to Proposal Three if you do not do so.

How do I revoke my proxy and change my vote?

You can revoke your proxy and change your vote by (1) attending the Annual Meeting and properly voting in person, (2) delivering written notice of revocation of your proxy to our Corporate Secretary at any time before voting is closed, (3) timely submitting new voting instructions by telephone or over the internet as described above, or (4) timely submitting a signed proxy card bearing a later date.

How will my proxy be voted?

If you timely submit your proxy as described above and have not revoked it, your shares will be voted or withheld from voting in accordance with the voting instructions you gave. If you timely submit your proxy as described above without giving voting instructions, your shares will be voted “FOR” the election of the director nominees listed in this proxy statement (Proposal One), “FOR” the advisory (nonbinding) vote to approve executive compensation (Proposal Two), and “FOR” ratification of the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm for the year ending December 31, 2015 (Proposal Three).

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What is the quorum requirement for the Annual Meeting?

A quorum must be present at the meeting before business can be conducted. A quorum will be present if a majority of the shares entitled to vote are represented in person or by proxy at the meeting. Shares represented by a proxy that withholds authority to vote or with instructions to abstain from voting on any matter will be considered present for purposes of determining the existence of a quorum. Shares represented by a proxy as to which a broker, bank, custodian or other nominee has indicated that it does not have discretionary authority to vote on certain matters (sometimes referred to as “broker non-votes”) will also be considered present for purposes of determining the existence of a quorum.

What votes are required to approve each proposal?

Proposal One (Election of Directors). Directors will be elected by a plurality of the votes cast. The nominees who receive the most votes will be elected to fill the available positions. Shareholders do not have the right to vote cumulatively in electing directors. Withholding authority in your proxy to vote for a nominee will result in the nominee receiving fewer votes. Because no director’s nomination is contested, all nominees will be elected so long as they receive any votes.

Proposal Two (Advisory Vote to Approve Executive Compensation). With respect to this proposal, our executive compensation will be approved on an advisory basis if the votes cast for approval exceed the votes cast against approval. Because your vote to approve executive compensation is advisory, it will not be binding upon our Board, overrule any decision by our Board, or create or imply any additional fiduciary duties on our Board or any member of our Board. Our Compensation and Talent Development Committee (the “Compensation Committee”) will, however, take into account the outcome of the vote when considering future executive compensation arrangements.

Proposal Three (Ratification of Appointment of Independent Registered Public Accounting Firm). Ratification of the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm for the year ending December 31, 2015 will be approved if the votes cast for approval exceed the votes cast against approval. Although shareholder ratification of the appointment is not required by law or our third amended and restated bylaws, or our bylaws, our Audit Committee has determined that, as a matter of corporate governance, the selection of our independent registered public accounting firm should be submitted to our shareholders for ratification. If the appointment of PricewaterhouseCoopers LLP is not ratified by a majority of the votes cast at the Annual Meeting, our Audit Committee will consider the appointment of other independent registered public accounting firms. Even if the appointment is ratified, our Audit Committee may change the appointment at any time if it determines that the change would be in the best interests of our Company and our shareholders.

Abstentions and broker non-votes will not be counted for purposes of determining whether these proposals have received sufficient votes for approval.

Who is paying the costs of this proxy solicitation?

Our Company is paying the costs of the solicitation of proxies. We will reimburse brokers, banks or other custodians, nominees and fiduciaries for their charges and expenses in forwarding proxy materials to beneficial owners. In addition, certain of our directors, officers and regular employees, without additional compensation, may solicit proxies on our behalf in person, by telephone, or by electronic communication.

How can I obtain additional information about Quintiles?

Our annual report on Form 10-K and other SEC filings may be accessed at www.sec.gov or on our website at www.quintiles.com/investors. Information on our website does not constitute part of this proxy statement. We will provide copies of our 2014 annual report to shareholders, including our annual report on Form 10-K for the year ended December 31, 2014, including the exhibits and schedules hereto, without charge to any shareholder who makes a written request to our Corporate Secretary at 4820 Emperor Blvd., Durham, North Carolina 27703.

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How can I attend the Annual Meeting?

Only shareholders as of the close of business on March 5, 2015 are entitled to attend the Annual Meeting. Admission will begin at 8:30 a.m. local time on the date of the Annual Meeting, and each shareholder must present valid picture identification such as a driver’s license or passport and, if asked, provide proof of stock ownership as of the record date. The use of mobile phones, pagers, recording or photographic equipment, tablets and/or computers is not permitted at the Annual Meeting. Requests for directions to the meeting location may be directed to Investor Relations, Quintiles Transnational Holdings Inc., 4820 Emperor Blvd., Durham, North Carolina 27703.

How can I find out the results of the voting at the Annual Meeting?

One or more persons will be appointed to act as the inspector of election at the Annual Meeting. Voting results will be announced by the filing of a current report on Form 8-K within four business days after the Annual Meeting. If final voting results are unavailable at that time, we will file an amended current report on Form 8-K within four business days of the day the final results are available.

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BACKGROUND

In January 2008, Quintiles Transnational Corp., our wholly owned subsidiary through which we conduct our operations, or Quintiles Transnational, engaged in what we refer to as the Major Shareholder Reorganization, which resulted in our ownership by Dennis B. Gillings, CBE, Ph.D., or Dr. Gillings, and his affiliates, investment funds associated with Bain Capital Investors, LLC, or Bain Capital, affiliates of TPG Global, LLC, or the TPG Funds (we refer to TPG Global, LLC as “TPG Global” and together with its affiliates, as “TPG”), affiliates of 3i Corporation, or 3i, certain other shareholders who participated in our 2003 going private transaction, and various members of our management. We refer to each of the private investment firms of Bain Capital, TPG, and 3i, together with any of their respective affiliates who own our shares, as a “Sponsor.” In connection with the Major Shareholder Reorganization, we entered into a shareholders agreement with certain of our shareholders, or the Shareholders Agreement (as subsequently amended and restated).

In December 2009, we completed what we refer to as the Holding Company Reorganization, whereby we formed Quintiles Transnational Holdings Inc. as the parent company of Quintiles Transnational. In May 2013, we returned to the public markets by completing an initial public offering, or IPO, on the New York Stock Exchange LLC, or the NYSE, and our common stock now trades under the stock symbol “Q.”

In November 2014, our Sponsors’ collective ownership of the Company decreased below 50% of our outstanding shares. As a result, we no longer qualify as a “controlled company” within the meaning of the corporate governance standards contained in Section 303A of the NYSE Listed Company Manual. In order to facilitate the transition to full compliance with the applicable NYSE listing rules following our loss of “controlled company” status, we and the Sponsors amended and restated the Shareholders Agreement to, among other things, revise the Sponsors’ rights to designate director nominees and related voting obligations. The changes to the Shareholders Agreement are more fully described below under “Proposal One—Election of Four Class II Directors—Voting Requirements Under the Shareholders Agreement.”

PROPOSAL ONE — ELECTION OF FOUR CLASS II DIRECTORS

In connection with the loss of “controlled company status” and in preparation for transition to full compliance with the NYSE listing rules requiring a majority of independent directors on our Board, we increased the size of our Board from 11 to 13 directors for a transition period through November 2015. Subject to certain limitations that are described below under “—Voting Requirements Under the Shareholders Agreement,” the shareholders party to the Shareholders Agreement have agreed to vote their respective shares in favor of the following nominees to our Board during this transition period:

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On February 5, 2015, the Company appointed John M. Leonard, M.D. to the Board based on the recommendation of the Governance Committee and pursuant to the Shareholders Agreement. The Board intends to fill the remaining vacancy with another independent director as soon as practicable, which may occur before or after the Annual Meeting. Also on February 5, 2015, in connection with the Board’s orderly evolution, Dr. Gillings announced his desire to transition from his role as Executive Chairman to a director role and the Shareholders Agreement provides that he will transition out of his role as Executive Chairman and Chairman of the Board, effective December 31, 2015. We understand that Dr. Gillings plans to continue to serve as a director pursuant to his director nomination right under the Shareholders Agreement.

The directors are divided into three classes (Classes I, II and III), with staggered three-year terms:

Due to our classified Board structure, unless a vacancy occurs within a class of directors, only one class of directors is elected at each annual meeting of shareholders, with the other classes continuing for the remainder of their respective three-year terms. If a vacancy occurs, the director appointed to fill such vacancy serves only until the next annual meeting following his or her appointment.

The Class I directors consist of Dr. Gillings and Messrs. Coslet, Evanisko and Gordon; the Class II directors consist of Drs. Cohen and Leonard and Messrs. Connaughton and Schaeffer; and the Class III directors consist of Dr. Mireille Gillings and Messrs. Greenberg, Pike and Relyea. Information regarding each of our directors set forth below under “—Directors.”

This year, Class II directors will stand for re-election, including Dr. Leonard, who our Board appointed in February 2015 as a new Class II director to fill a vacancy created when the Board increased its size from 11 to 13. Consistent with the requirements of the Shareholders Agreement, our articles of incorporation and our bylaws, our Board has nominated each of our current Class II directors for re-election as Class II directors at the Annual Meeting. If re-elected at the Annual Meeting, each Class II director nominee will hold office until our 2018 annual meeting or until his successor has been duly elected and qualified or until his earlier death, resignation, retirement, disqualification or removal from office.

Our Board of Directors recommends that shareholders vote FOR the election of each of the above named nominees as directors.

Unless there is a contrary indication, shares of common stock represented by valid proxies will be voted FOR the election of all of the nominees. If for any reason a nominee should become unable or unwilling to serve as a director, which is not expected, the shares represented by valid proxies will be voted for the election of such other person as our Board may recommend.

Directors

Information regarding each of our directors, including their age as of March 23, 2015, their tenure on our Board and other information regarding their experience and qualifications, is set forth below. There are no family relationships between any of our executive officers or directors, except for Dr. Dennis Gillings and Dr. Mireille Gillings, who are married.

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Class I Directors

Dennis B. Gillings, CBE, Ph.D., age 70, has served as our Executive Chairman and as a director since he founded our Company in 1982. He also served as our Chief Executive Officer from 1982 to December 2012. Dr. Gillings taught for more than 15 years as a professor at the University of North Carolina at Chapel Hill. Dr. Gillings serves on several other boards and councils, including the International Advisory Council to Singapore, the International Advisory Board for the Scottish Enterprise, and the Advisory Board of the Schaeffer Health Policy Institute at the University of Southern California. He served as the founding Chairman of the Association of Clinical Research Organizations, a Washington-based trade group formed in 2002. He also served as a director of Icagen, Inc., a biopharmaceutical company, from 1997 until June 2011. He was awarded the Commander in The Most Excellent Order of the British Empire in 2004. Dr. Gillings served as Pro Chancellor of the University of Southampton from 2006 to 2011. In 2012, he received the SCRIP Lifetime Achievement Award in recognition of contributions to the pharmaceutical industry. Dr. Gillings received a diploma in Mathematical Statistics from Cambridge University in 1967 and a Ph.D. in Mathematics from the University of Exeter, England, in 1972. During 1996 to 1997, Dr. Gillings received honorary Professorships of Medicine from Beijing University, Peking Union Medical College, Shanghai University and Xian University. Dr. Gillings has also received Honorary Doctorate degrees from the University of Exeter, the University of North Carolina at Chapel Hill, and the University of Southampton. In 2008, he became an Honorary Fellow at Queen Mary, University of London.

Jonathan J. Coslet, age 50, has served as a director since our going private transaction in 2003. Mr. Coslet is a Senior Partner and the Chief Investment Officer of TPG. He is also Chairman of TPG’s Investment Committee and Management Committee and serves as a member of its Holdings Management Committee. Prior to joining TPG in 1993, Mr. Coslet was in the Investment Banking department of Donaldson, Lufkin & Jenrette, specializing in leveraged acquisitions and high yield finance from 1991 to 1993. From 1987 to 1989, Mr. Coslet worked at Drexel Burnham Lambert Incorporated. Mr. Coslet serves on the board of directors of IASIS Healthcare Corporation, an operator of hospitals, PETCO Animal Supplies, Inc., a pet supply retailer, and Biomet, Inc., a medical device company. Mr. Coslet was formerly a director of J Crew Group, Inc., an apparel retailer, Burger King Corporation, a global fast food hamburger restaurant chain, Caesars Entertainment Corporation, a casino-entertainment provider and Neiman Marcus, Inc., an operator of retail stores. Mr. Coslet also serves on the Harvard Business School Advisory Board for the West Coast. Mr. Coslet received his Master of Business Administration from Harvard Business School in 1991, where he was a Baker Scholar and a Loeb Fellow, and his Bachelor of Science in Economics (Finance) from the University of Pennsylvania Wharton School, where he was Valedictorian, summa cum laude, a Gordon Fellow and a Steur Fellow.

Michael J. Evanisko, age 65, has served as a director since May 2010. Mr. Evanisko is currently Chairman of PARx Solutions, Inc., a provider of processing services for physician practices, where he has served as a director and Chairman since June 2012. From September 2010 to December 2012, Mr. Evanisko served on the board of BackChannel Media, Inc., a broadcast technology developer. From July 2008 to May 2011, he served as a consultant to Clarion Healthcare Consulting, LLC, a strategic and organizational consulting firm to pharmaceutical, biotechnology and medical device and diagnostics businesses. From June 2002 to February 2008, Mr. Evanisko served as Executive Chairman of Adheris, Inc., a provider of educational and informational services to patients taking prescription medications. From January 2008 to June 2008, he also served as a consultant to M|C Communications, LLC, a provider of certified medical education to physicians. He received his Bachelor’s degree in Labor Studies from Pennsylvania State University, his Master of Public Administration from Pennsylvania State University, his Master of Arts in Administrative Sciences from Yale University and his Master of Philosophy from Yale University.

Christopher R. Gordon, age 42, has served as a director since November 2009 and has been involved with our Company since the time of Bain Capital’s investment in January 2008. Mr. Gordon is a Managing Director of Bain Capital, which he joined in 1997. Prior to joining Bain Capital, Mr. Gordon was a consultant at Bain & Company, Inc. Mr. Gordon also currently serves as a director of Air Medical Group Holdings, Inc., a provider of air medical services, CRC Health Corporation, a provider of treatment and educational programs related to

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behavioral issues, SunGard Data Systems Inc., a software and technology services company, and Physio-Control, Inc, a provider of emergency medical response technology. Mr. Gordon was formerly a director of Accellent, Inc., a medical manufacturing supply company, and HCA Holdings, Inc., a corporate operator of hospitals and health systems. He is a founding director of the Healthcare Private Equity Association and volunteers for a variety of charitable organizations, serving on the board of directors of Year Up—Boston, as a member of the Boston Medical Center Foundation Board, and the Boston Medical Center Health Plan Board, and also as a Trustee of the Dana-Farber Cancer Institute. Mr. Gordon received his A.B. in Economics from Harvard College and Master of Business Administration from Harvard Business School.

Class II Directors

John P. Connaughton, age 49, has served as a director since January 2008. Since 1997, Mr. Connaughton has been a Managing Director of Bain Capital, which he joined in 1989. Prior to joining Bain Capital, Mr. Connaughton was a consultant at Bain & Company, Inc., where he worked in the healthcare, consumer products and business services industries. Mr. Connaughton also serves as a director of iHeartMedia, Inc., a global media and entertainment company, Air Medical Group Holdings, Inc., a provider of air medical services, Bio Products Laboratory, a United Kingdom based producer of plasma products, Grupo NotreDame Intermedica, a Brazil based healthcare provider, and The Boston Celtics, a National Basketball Association franchise. Mr. Connaughton was formerly a director of SunGard Data Systems Inc., a software and technology services company, Warner Music Group Corp., a music-based content company, Warner Chilcott plc, an international pharmaceutical company, HCA Holdings, Inc., a corporate operator of hospitals and health systems, and CRC Health Corporation, a provider of treatment and educational programs related to behavioral issues. He also volunteers for a variety of charitable organizations, serving as a member of The Berklee College of Music Board of Trustees and the University of Virginia McIntire Foundation Board of Trustees. Mr. Connaughton received a Bachelor of Science in commerce from the University of Virginia and a Master of Business Administration from Harvard Business School, where he was a Baker Scholar.

Fred E. Cohen, M.D., D.Phil., F.A.C.P., age 58, has served as a director since May 8, 2007. Dr. Cohen is a TPG Partner, having joined TPG in 2001, and serves as the head of TPG’s biotechnology group. Dr. Cohen also served as an Adjunct Professor of Cellular and Molecular Pharmacology at the University of California, San Francisco from 1988 until 2014. Dr. Cohen serves as a director of Genomic Health Inc., a company focused on providing actionable genomic health information, BioCryst Pharmaceuticals, Inc., a company focused on designing and developing small-molecule drugs, Veracyte, Inc., a diagnostics company, Five Prime Therapeutics, Inc., a clinical-stage biotechnology company, and Tandem Diabetes Care^®, Inc., a diabetes products company. He is a member of the Institute of Medicine and the American Academy of Arts and Sciences. He has served as a trustee of Autistica, a United Kingdom based charity. Dr. Cohen holds a Bachelor of Science degree in Molecular Biophysics and Biochemistry from Yale University, a D.Phil. in Molecular Biophysics from Oxford University, where he was a Rhodes Scholar, and an M.D. from Stanford University.

John M. Leonard, M.D., age 57, has served as a director since February 5, 2015. Since July 2014, Dr. Leonard has served as the Chief Medical Officer at Intellia Therapeutics, Inc., a biotechnology company involved in gene-based therapy. Dr. Leonard previously served as the Chief Scientific Officer and Senior Vice President of Research and Development at AbbVie Inc., a global pharmaceutical company, from its spin-out from Abbott Laboratories in January 2013 until retiring from those positions at the end of 2013. Prior to the formation of AbbVie, Dr. Leonard served as Senior Vice President of Global Pharmaceutical Research and Development at Abbott from 2008 to 2012. He has over 30 years of combined experience in medicine, research and management, including serving in various roles at Abbott beginning in 1992. Dr. Leonard also serves as a director of Chimerix, Inc., a biopharmaceutical company. Dr. Leonard completed an Internship and Residency in Internal Medicine at Stanford University Hospital followed by a Postdoctoral Fellowship in Molecular Virology at the National Institute of Allergy and Infectious Diseases at the National Institutes of Health. Dr. Leonard earned a Bachelor’s Degree in Biochemistry from the University of Wisconsin at Madison and a Doctorate in Medicine from Johns Hopkins University in Baltimore, MD. Dr. Leonard completed an Internship and Residency in Internal Medicine at Stanford University Hospital followed by a Postdoctoral Fellowship in Molecular Virology at the National Institute of Allergy and Infectious Diseases at the National Institutes of Health.

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Leonard D. Schaeffer, age 69, has served as a director since January 2008. He has served as a TPG Senior Advisor since 2006, and has also served as a partner of North Bristol Partners LLC, a privately held consulting company, since 2006. From 2007 to 2011, Mr. Schaeffer served as the Chairman of the Board of Surgical Care Affiliates, LLC, a privately held company operating a national network of ambulatory surgical centers and surgical hospitals. Mr. Schaeffer formerly served as Chairman of the Board of WellPoint, Inc. (now Anthem, Inc.), then the largest health insurance company in the United States, Chairman and Chief Executive Officer of WellPoint Health Networks Inc. and Chairman and Chief Executive Officer of Blue Cross California and as a director of Allergan, Inc., a publicly traded specialty pharmaceutical company (1993 – 2011), and as a director of Amgen, Inc, a publicly traded biotechnology company (2004 – 2013). While serving in the federal government from 1978 to 1980, Mr. Schaeffer was Administrator of the Health Care Financing Administration (now CMS) and was responsible for the United States Medicare and Medicaid programs. Mr. Schaeffer was named the Judge Widney Professor and Chair at the University of Southern California in 2007 and serves on the board of the Brookings Institution, the RAND Corporation, the University of Southern California, and on the Board of Fellows of Harvard Medical School. He is a member of the Institute of Medicine of the National Academy of Sciences. Mr. Schaeffer received his Bachelor of Arts from Princeton University in 1969.

Class III Directors

Mireille Gillings, Ph.D., age 51, has served as a director since February 2013. Dr. Mireille Gillings has served as Chief Executive Officer, President and a director of HUYA Bioscience International, LLC, or HUYA, an accelerator and co-developer of novel pharmaceutical products originating in China, since founding the company in 2004, and became its Executive Chair in January 2013. She is also the vice chair and co-founder of GHO Capital, a private equity fund specializing in global health. Dr. Mireille Gillings has over 22 years of scientific experience in the biotechnology industry, including in drug development, operational leadership, pre-clinical research design, establishing academic partnering programs and researching neurological diseases, and has considerable expertise in biopharmaceutical innovation in China. She serves on the board of the Pasteur Foundation. Dr. Mireille Gillings also serves on the board of Sente Inc., a privately held specialty aesthetics company. Dr. Mireille Gillings received a Bachelor of Arts degree from Concordia University in Montreal and holds a Ph.D. from Radboud University in Nijmegen in the Netherlands and post-doctoral fellowships at Bordeaux University in France, and Scripps Research Institute.

Jack M. Greenberg, age 72, has served as a director since January 2004. He has served as Chairman of The Western Union Company, a money transfer services firm, since September 2006 and InnerWorkings, Inc., a global marketing supply chain company, since June 2010. He formerly served as Chairman and Chief Executive Officer of McDonald’s Corporation from May 1999 and August 1998, respectively, until his retirement in December 2002. Before becoming its Chief Executive Officer, Mr. Greenberg held various senior positions at McDonald’s, including Vice-Chairman, President and Chairman and Chief Executive Officer of McDonald’s USA, a division of McDonald’s Corporation. Mr. Greenberg also serves as a director of The Allstate Corporation, a property and casualty insurance company, Hasbro, Inc., a publicly traded branded play company. He also served as a director of Manpower Inc., a publicly traded workforce solutions company, from October 2003 to September 2014. He is a member of the American Institute of Certified Public Accountants, the Illinois CPA Society and the Chicago Bar Association. Mr. Greenberg is also a member of the board of trustees of DePaul University (having previously served as its Chairman), The Field Museum and the Institute of International Education, as well as the Chairman of the board of directors of the Metropolitan Pier & Exposition Authority. He formerly served on the executive committee of The Chicago Community Trust. Mr. Greenberg holds a business degree from DePaul University’s School of Commerce and a Juris Doctor from DePaul University’s School of Law.

Thomas H. Pike, age 55, has served as Chief Executive Officer of Quintiles Transnational since April 2012, as a director since August 2012 and as our Chief Executive Officer since January 2013. Mr. Pike served as Chief Executive Officer of Accelion, Inc., a healthcare outsourcing firm, from January 2010 to November 2010. Following his service with Accelion, Inc., Mr. Pike acted as an independent consultant. Mr. Pike previously spent 22 years with Accenture, a global management consulting, technology services and outsourcing company,

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including serving as Chief Risk Officer from September 2009 to January 2010, Managing Director—North America Health and Products Industries from December 2006 to August 2009, Chief Operating Officer—Global Resources Industries from March 2002 to December 2006 and Managing Partner—Growth & Strategy from 1999 until March 2002. Mr. Pike began his career in the consulting industry, including as a Senior Engagement Manager with McKinsey & Company from 1989 to 1992. Mr. Pike received his Bachelor of Science in Accounting from the University of Delaware.

Richard Relyea, age 38, has served as a director since December 2013. Mr. Relyea joined 3i in 2007 as a member of the North America Private Equity team. In this role, he has been involved in 3i’s investments in a number of companies, including Mold-Masters Limited and Hilite International. Prior to joining 3i, Mr. Relyea was a principal at Halyard Capital where he invested in companies in the business services, media and communications sectors. He also served as an associate at Entrade Inc., where he made investments in technology and digital infrastructure businesses. Mr. Relyea began his career at Security Capital Group’s Preferred Growth Private Equity Fund, where he made investments in real estate operating companies and investment trusts. He is actively involved in several non-profit organizations and is president of the New York Private Equity Network. Mr. Relyea received a B.A. in Economics from Williams College.

Executive Officers

Information regarding each of our executive officers (other than Dr. Gillings and Mr. Pike), including their age as of March 23, 2015, their tenure with our Company and other information regarding their experience and qualifications, is set forth below.

Kevin K. Gordon, age 52, has served as our Executive Vice President and Chief Financial Officer since July 2010. Prior to joining us, he spent 13 years with Teleflex Incorporated, a global, publicly traded health care company, serving as Executive Vice President and Chief Financial Officer from March 2007 to January 2010 and serving in various corporate development roles from January 1997 to March 2007. Prior to serving at Teleflex, Mr. Gordon spent 12 years in senior finance positions with Package Machinery Company and KPMG. Mr. Gordon received his Bachelor’s degree in Accounting from the University of Connecticut.

James H. Erlinger III, age 56, has served as our Executive Vice President, General Counsel since January 2013 and as our Secretary since February 2013. Prior to joining us, he spent over 27 years practicing corporate law at Bryan Cave, LLP, a multinational law firm. Mr. Erlinger focused his practice on outsourcing, healthcare, joint ventures, mergers and acquisitions, licensing and capital formation. Mr. Erlinger is a certified public accountant and received his Bachelor’s degree in Finance from the University of Missouri-Columbia, his Master of Business Administration from the University of Missouri-Columbia, College of Business and his Juris Doctor from the University of Missouri-Kansas City School of Law.

Qualifications of Our Board

Our Board of Directors seeks to ensure that its members have experience, qualifications, attributes and skills that will facilitate the effectiveness of our Board’s oversight responsibilities. Our Board has adopted a corporate governance policy that includes broadly defined, nonbinding guidelines for Board membership such as experience, diversity and term limits.

We believe that the individual and collective experience of our current directors adds value to our Board and our Company. With respect to Mr. Pike, we believe that Mr. Pike’s extensive executive experience, as well as his understanding of our business and strategy from his service as our Chief Executive Officer, qualify him for service as a director, bring a valuable perspective to our Board and provide a vital link between management and our Board. Each of the Disinterested Nominees, including the two standing for election at the Annual Meeting, has been nominated by our Governance Committee. With respect to Mr. Evanisko, we believe that Mr. Evanisko’s over 30 years’ experience in management consulting and entrepreneurial ventures in healthcare and his service on our Board since 2010 qualify him for service as a director and bring a valuable perspective to our Board. With respect to Mr. Greenberg, we believe that his previous service as the chairman, chief executive

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officer and chief financial officer of a global company, McDonald’s Corporation, qualifications as a certified public accountant and current or former service on a number of other public company boards, including as chairman, qualify him for service as a director and bring a valuable perspective to our Board. With respect to Mr. Schaeffer, we believe that his substantial health insurance experience as a former chairman of WellPoint, Inc. and chairman and chief executive officer of WellPoint Health Networks Inc. and Blue Cross of California qualify him for service as a director and bring a valuable perspective to our Board. Finally, with respect to Dr. Leonard, we believe that his over 30 years’ experience in medicine, research and management, including serving in various roles at Abbott beginning in 1992 qualify him for service as a director and bring a valuable perspective to our Board.

With respect to our other directors, who were elected to our Board as a consequence of our shareholders’ nomination rights pursuant to the Shareholders Agreement, we are unaware of the specific experience, qualifications, attributes or skills that led to each shareholder’s decision to nominate these directors to our Board. With respect to the value they add to our Board and our Company, however, we note in particular that (1) Dr. Gillings brings the unique perspective of over 30 years of industry experience and continuous leadership of our Company since its founding, which provide valuable insight to and a vital link between management and our Board; (2) Dr. Mireille Gillings, the other Gillings Nominee, has over 20 years’ experience in the biotechnology industry, including, since 2004, as the founder, president, chief executive officer, executive chair and director of HUYA; (3) each of Messrs. Connaughton and Gordon is a Managing Director of Bain Capital, serves on other public company boards and has over 15 years’ experience in the private equity industry, as well as extensive experience in the healthcare industry; (4) each of Dr. Cohen and Mr. Coslet is a TPG Partner or Senior Partner and has over 25 years’ experience, including experience in the pharmaceutical, private equity and/or investment banking industries; and (5) Mr. Relyea has over 15 years’ experience in the private equity industry.

Voting Requirements Under the Shareholders Agreement

Under the Shareholders Agreement, the Sponsors have agreed, until November 2015, to vote their shares in favor of the following 13 Board nominees:

The Company and each Sponsor have agreed to use their best efforts to cause the Board to reduce its size from 13 directors to 9 directors in November 2015, and thereafter, the Sponsors have agreed to vote their shares in favor of the following 9 Board nominees:

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In addition, the Shareholders Agreement requires the Company and each Sponsor to use their reasonable best efforts to cause the Board to appoint a majority of independent directors to each of the Compensation Committee and the Governance Committee (which the Board did at its February 2015 meeting) and to cause those committees to be composed solely of independent directors by November 2015. Following these actions in November 2015, 3i will no longer be a party to the Shareholders Agreement.

After November 2015, if any of Dr. Gillings (together with his affiliates), Bain Capital or the TPG Funds ceases to beneficially own 5% or more of the then outstanding shares of our common stock, then such Sponsor will no longer have the right to designate a nominee to our Board under the Shareholders Agreement nor will that Sponsor be required to vote in accordance with the Shareholders Agreement. Under the Shareholders Agreement, if any Sponsor no longer has the right to designate a nominee, the Sponsor is required to promptly notify the Company in writing. Upon receipt of such notice, the Company’s independent directors will meet to determine whether to request the Sponsor to cause the director designated as its nominee to resign from the Board. If requested in writing by a majority of the independent directors, such Sponsor is required to cause such a director to tender his or her resignation, which must be effective immediately prior to the Company’s next annual meeting of shareholders or earlier in the director’s discretion.

In determining whether to request such a resignation, our independent directors will, as required by our policy for independent director consideration of board resignations, consider the applicable criteria in our Corporate Governance Guidelines, the charter of the Governance Committee, NYSE requirements, good corporate governance practices generally, the availability of additional qualified candidates that may be considered independent, and other information as they may deem relevant.

Director Independence

As described above, we no longer qualify as a “controlled company” for purposes of certain exemptions from the NYSE corporate governance standards. Pursuant to the phase-in periods stipulated by the NYSE rules, we are required to have a majority independent Board by November 10, 2015, which is one year after the date we ceased to qualify as a controlled company. We will have to be in compliance with certain NYSE corporate governance requirements, including the requirements that, within one year of the date of the loss of “control company” status:

Our Board affirmatively determines the independence of directors and director nominees in accordance with the requirements of the NYSE listing rules. Our Board has affirmatively determined that each of Messrs. Greenberg, Schaeffer and Evanisko and Dr. Leonard meets the definition of “independent director” for purposes of the NYSE rules. Our Board has not made any determination regarding the independence of our other directors.

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As such, we believe that our Audit Committee is comprised entirely of independent directors, including the enhanced independence requirements of Rule 10A-3 of the Exchange Act. In addition, our Compensation Committee and our Governance Committee are comprised of a majority of independent directors. See “—Voting Requirements under the Shareholders Agreement.”

Executive Sessions

Our Corporate Governance Guidelines provide that non-management directors shall meet at regularly scheduled executive sessions, which will typically occur at regularly scheduled Board meetings, without any member of management present and must so meet at least annually. Our non-management directors fulfilled this requirenment in 2014. In addition, at least annually the independent directors will meet in a separate executive session. Our independent directors met in separate executive sessions in connection with each of our Board meetings in 2014. Our Corporate Governance Guidelines authorize the non-management and independent directors to designate a director to preside at their respective executive sessions. Pursuant to this authority, at each executive session, our non-management and independent directors, as applicable, select from among themselves a “presiding director” for that session depending upon the nature of the subject matter to be considered. Our Corporate Governance Guidelines also provide that the independent and/or non-management directors shall be entitled, acting as a group by vote of a majority of such independent and/or non-management directors, to retain legal counsel, accountants, or other experts, at our Company’s expense, to advise the independent and/or non-management directors concerning issues arising in the exercise of their functions and powers.

Board Committees

Our Board has three standing Board committees: (1) our Audit Committee; (2) our Compensation Committee; and (3) our Governance Committee. The charters for each of these committees are posted on our website at www.quintiles.com/investors. The composition of these committees is determined by our Board, and each Sponsor has agreed to use its reasonable best efforts to cause the Board to appoint a majority of independent directors to each of the Compensation Committee and the Governance Committee, and to cause those committees to be composed solely of independent directors beginning in November 2015.

The following table provides a summary of the committee assignments for each of our directors as of February 2015:

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Audit Committee

We have a separately designated standing audit committee established in accordance with section 3(a)(58)(A) of the Securities Exchange Act of 1934, as amended, or the Exchange Act. Our Board has determined that Mr. Greenberg qualifies as an “audit committee financial expert” under Item 407(d)(5) of Regulation S-K.

Our Audit Committee oversees our corporate accounting and financial reporting processes and the audits of our financial statements. Our Audit Committee also provides oversight with respect to:

Other responsibilities of our Audit Committee include, among other things:

Our Audit Committee consists of Messrs. Greenberg (Chair), Evanisko, and Schaeffer and Dr. Leonard, each of whom our Board has determined meets the definition of “independent director” for purposes of the NYSE rules, including the independence requirements of Rule 10A-3 of the Exchange Act. Our Audit Committee met eight times during 2014.

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Compensation and Talent Development Committee

Our Compensation Committee oversees our corporate compensation and benefit programs. The responsibilities of our Compensation Committee include, among other things:

Our Compensation Committee may delegate to a subcommittee of its members (including alternates) any of its functions, duties and authorities, on such terms and conditions and with such limitations (if any) as the Compensation Committee deems appropriate. Our Compensation Committee may delegate to one or more officers designated by the Compensation Committee the authority to make grants to eligible individuals other than our executive officers or directors, provided that the Compensation Committee must have fixed the exercise price of each such grant (or a formula for determining such exercise price) and the vesting schedule, approved the form of documentation evidencing each such grant, and determined the appropriate number of shares or the basis for determining such number of shares by position, compensation level or category of personnel. Any officers to whom such authority is delegated are required to regularly report to the Compensation Committee the grants so made. Any such delegation may be revoked at any time by the Compensation Committee.

Our Compensation Committee solicits the recommendations of our Chief Executive Officer with respect to the compensation of our executive officers other than himself and factors these recommendations into the determination of compensation, as described in “Compensation Discussion and Analysis.” In addition, the Compensation Committee has engaged Semler Brossy Consulting Group LLC, or Semler Brossy, to provide advice to it regarding the compensation of our executive officers. Semler Brossy focuses on executive compensation and does not provide services other than those related to executive compensation and benefits.

As more fully described in “Compensation Discussion and Analysis,” our Compensation Committee looks to Semler Brossy to periodically review and advise the Compensation Committee regarding the adequacy and appropriateness of our executive compensation plans, programs and practices and, from time to time, to answer specific questions raised by the Compensation Committee or management. A representative from Semler Brossy attends all regularly scheduled meetings of the Compensation Committee in person or by phone and supports the Compensation Committee by providing independent expertise and advice. Semler Brossy may, on occasion, obtain information and input from management to ensure that its recommendations are consistent with our strategy and culture. To ensure Semler Brossy’s independence, Semler Brossy reports directly to our Compensation Committee and works specifically for the Compensation Committee solely on compensation and benefits.

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The current members of our Compensation Committee are Messrs. Evanisko (Chair), Connaughton, Coslet, Greenberg and Schaeffer. Our Compensation Committee met five times during 2014.

Governance, Quality and Nominating Committee

Our Governance Committee assists our Board in:

The current members of our Governance Committee are Messrs. Schaeffer (Chair), Evanisko, Greenberg and Relyea and Drs. Mireille Gillings and Leonard. Our Governance met four times during 2014.

Criteria for Director Nomination

Our Governance Committee makes recommendations to our Board regarding persons to be nominated to serve as our directors. When determining whether to nominate a current director to stand for re-election as a director, our Governance Committee reviews and considers the performance of such director during the prior year using performance criteria established by our Board. Our Governance Committee also considers the requirements of the Shareholders Agreement as it applies to the composition requirements of our Board and its committees.

The Governance Committee has the authority to retain, at the expense of the Company and without prior permission of our Board or management, its own outside advisors. The Governance Committee may, from time to time, retain third-party search firms to assist it in identifying potential director nominees who meet the criteria and priorities established from time to time and facilitate the screening and nomination process for such nominees. During 2014, the Governance Committee engaged Egon Zehnder International, Inc. to assist it in identifying and soliciting potential candidates to join our Board.

In recruiting and evaluating new director candidates and prior to nominating a person to serve as a director, our Governance Committee assesses a candidate’s character, wisdom, judgment, ability to make independent analytical inquiries, business experiences and other background, understanding of our industry and business environment, time commitment, acumen and independence, as well as our Board’s skill needs. We endeavor to have a Board representing diverse backgrounds and experience at policy-making levels in business, education or areas that are relevant to our business. Board members are expected to become and remain informed about our Company, its business and its industry and rigorously prepare for, attend and participate in all Board and applicable committee meetings. In addition, individual directors and any person nominated to serve as a director should demonstrate high ethical standards and integrity in their personal and professional dealings and be willing to act on and remain accountable for their boardroom decisions.

As outlined in our Governance Committee’s charter, specific factors the committee may consider in identifying candidates for membership on our Board include (1) ensuring that our Board, as a whole, is diverse and consists of individuals with relevant technical skills, industry knowledge and experience, financial expertise, and local or community ties, (2) minimum individual qualifications, including strength of character, mature judgment, relevant career experience, independence of thought and an ability to work collegially, (3) questions of independence, possible conflicts of interest and whether a candidate has special interests or a specific agenda that would impair his or her ability to effectively represent the interests of all shareholders, (4) the extent to which the

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candidate would fill a present need on our Board, (5) whether the candidate can make sufficient time available to perform the duties of a director, and (6) the requirements of any shareholders agreement in existence and as may be amended that governs the composition requirements of our Board and its committees.

Consistent with applicable law, the Shareholders Agreement, our bylaws and the criteria set forth in the Corporate Governance Guidelines, our Governance Committee will consider any candidates proposed by any senior executive officer, director or shareholder. Pursuant to our Corporate Governance Guidelines, our Governance Committee will consider candidates recommended by our shareholders on a substantially similar basis as the committee considers other candidates. Shareholders who wish to make nominations for directors for our 2016 annual meeting of shareholders must follow the requirements contained in our bylaws, which are summarized under “Shareholder Proposals and Nominations.”

Shareholder Proposals and Nominations

We must receive proposals submitted by shareholders pursuant to Rule 14a-8 of the Exchange Act for inclusion in the proxy statement for the 2016 annual meeting of shareholders no later than the close of business on December 1, 2015. Please address your proposals to James H. Erlinger III, Executive Vice President, General Counsel and Secretary, Quintiles Transnational Holdings Inc., 4820 Emperor Blvd., Durham, North Carolina 27703. Proposals must comply with all applicable SEC regulations.

Under our bylaws, if you wish to nominate directors for election, or present other business at the Annual Meeting, you must give proper written notice of any such nomination or business to our Corporate Secretary, not after February 5, 2016, and not before January 8, 2016. If the 2016 annual meeting of shareholders is advanced by more than 30 days or delayed by more than 60 days from May 7, 2016, the anniversary date of the Annual Meeting, you must send notice not earlier than the 120th day prior to the 2016 annual meeting and not later than the close of business on the later of the 90th day prior to such annual meeting or the 10th day following the date on which public announcement of the date of the meeting is first made. Your notice must include certain information specified in our bylaws concerning the nomination or the business. A copy of our bylaws may be obtained from our Corporate Secretary at the address noted above.

Board Leadership Structure

Our Corporate Governance Guidelines provide that our Executive Chairman, who is currently Dr. Gillings, will serve as Chairman of our Board. Our Board believes that it is appropriate for Dr. Gillings to serve as our Chairman because, as discussed above, Dr. Gillings has a unique perspective of over 30 years of industry experience and the continuous leadership of our Company since its founding. Our Board determined at the time of appointing Mr. Pike as Chief Executive Officer that it was beneficial to continue to have Dr. Gillings serve as our Chairman and separate the Chairman and Chief Executive Officer roles to allow our Chief Executive Officer to focus on leading our Company’s business and operations and formulating our strategy while our Chairman continued to focus on leading our Board’s oversight of our strategy and performance. In addition, as discussed above under “Executive Sessions,” our non-management and independent directors hold regular executive sessions without the presence of management and, in the case of our independent directors, the other members of our Board, thus providing additional oversight of our Company and its management. Our Board believes that these layers of Board leadership have provided robust oversight over our Company and its management, including with respect to strategy, operations and risk mitigation.

If we do not have an Executive Chairman our Corporate Governance Guidelines provide that our Board will elect a Chairman as set forth in our bylaws. In the discretion of our Board such person could also be our Chief Executive Officer. Although our Board believes that with our Board as presently structured, it is appropriate to separate the roles of Chairman of the Board and Chief Executive Officer, our Board has also affirmatively determined not to adopt a policy on whether the roles of Chairman and Chief Executive Officer should be separated or combined in the event that we do not have an Executive Chairman because our Board believes that there is no single best blueprint for structuring board leadership and that, as circumstances change, the optimal leadership structure may change.

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Dr. Gillings has announced his desire to transition from his role as Executive Chairman to a director role and the Shareholders Agreement provides that he will transition out of his role as Executive Chairman and Chairman of the Board effective December 31, 2015. Dr. Gillings plans to continue to serve as a director pursuant to his director nomination right under the Shareholders Agreement. The Board will commence an orderly process to select a new Chairman of the Board, whom it expects to name in November 2015 to begin service on January 1, 2016.

Board’s Role in Risk Oversight

Our Board actively oversees our enterprise risk management program to ensure that we maintain effective risk management. Our Board’s role in risk oversight is consistent with our overall leadership structure—management is responsible for assessing and managing our risk exposures, and our Board maintains an oversight role, executed through open communication with management and independent oversight of strategic risks. Our Board considers specific risk topics, including risks associated with our strategic plan, our capital structure and our business activities. Risks are identified by management and reviewed with the appropriate Board committee or the full Board for oversight.

While our Board has the ultimate oversight responsibility for the risk management process, our Board’s committees assist it in fulfilling its oversight responsibilities in certain areas of risk. In particular, our Audit Committee focuses on risks associated with our financial statements, internal accounting and financial controls, internal and external audits, and compliance with legal and regulatory matters in connection therewith, including our guidelines and policies with respect to risk assessment and risk management and our major financial risk exposures. Our Compensation Committee focuses on risks associated with our compensation policies and practices, including those for our executive officers. Our Governance Committee focuses on risks associated with our corporate governance policies and practices and our compliance and ethics program.

Each of these committees reports to our Board with respect to the risk categories it oversees. These ongoing discussions enable our Board to monitor our risk exposure and evaluate our risk mitigation efforts. In addition, our risk management function conducts regular interviews and surveys of key employees relating to enterprise risk management and reports the results and analysis of such interviews and surveys to our Board.

Board Meetings and Committees; Policy Regarding Director Attendance at Annual Meetings of Shareholders

During 2014, our Board held nine meetings. All directors attended at least 75% of the meetings of our Board. In addition, all directors attended at least 75% of the meetings of committees of our Board on which the director served that were held during the period for which he served as a director, except for Mr. Coslet, who attended three of the five meetings of the Compensation Committee. It is our policy that directors are strongly encouraged to attend our annual meetings of shareholders. Accordingly, we expect most, if not all, of our directors to be in attendance at the Annual Meeting. All of our then-serving directors attended our 2014 annual meeting of shareholders.

Communications with Our Board

Anyone who would like to communicate with, or otherwise make his or her concerns known directly to, our Board, any committee of our Board, a particular director, or the non-management directors or independent directors as a group may send a letter (signed or anonymous) to: c/o Board of Directors, Quintiles Transnational Holdings Inc., 4820 Emperor Blvd., Durham, North Carolina 27703, Attention: Corporate Secretary. Our Corporate Secretary will forward all such communications to the applicable Board member(s) at least quarterly, except for advertisements or solicitations, which will be discarded. Before any communications will be forwarded, they will be reviewed by the legal department and addressed through our regular procedures for addressing such matters. If the volume of communications becomes such that our Board adopts a process for determining which communications will be relayed to Board members, that process will appear on our website at www.quintiles.com/investors.

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Any person, whether or not an employee, who has a concern about our Company’s conduct, or the conduct of any of our people, including with respect to accounting, internal accounting controls or auditing matters, may, in a confidential or anonymous manner, communicate that concern by writing to: Quintiles Transnational Holdings Inc., 4820 Emperor Blvd., Durham, North Carolina 27703, attention: Chief Compliance Officer, submitting an inquiry to business.ethics@quintiles.com or by calling the toll-free number for the country identified on: www.quintilesethics.com (1-866-267-4479 for the United States). Our Ethics and Compliance Office will report these submissions to our Governance Committee and, as deemed appropriate, our Audit Committee at or prior to the next regularly scheduled meeting of such committee or committees. Our Ethics and Compliance Office will retain copies of all communications received pursuant to these procedures for a period of at least one year.

Corporate Governance Guidelines

We have adopted Corporate Governance Guidelines that we believe reflect our Board’s commitment to a system of governance that enhances corporate responsibility and accountability. Our Corporate Governance Guidelines contain provisions addressing the following matters, among others:

Our Corporate Governance Guidelines are available on our website at www.quintiles.com/investors. We intend to provide any future amendments to our Corporate Governance Guidelines on our website at www.quintiles.com/investors.

Code of Ethics

We have adopted a code of conduct that applies to our directors, officers and employees, including our principal executive officer, principal financial officer, principal accounting officer, controller or persons performing similar functions. A copy of this code of conduct is posted on our website at www.quintiles.com/investors. In the event the code of conduct is revised, or any waiver is granted under the code of conduct with respect to our principal executive officer, principal financial officer, principal accounting officer, controller, or persons performing similar functions, notice of such revision or waiver will be posted on our website or disclosed on a current report on Form 8-K as required. In addition, in 2014 we performed a complete inventory of our corporate policies, created a policy hierarchy and made revisions to harmonize the polices.

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EXECUTIVE AND DIRECTOR COMPENSATION

Compensation Discussion and Analysis

This compensation discussion and analysis provides an overview of our executive compensation policies and practices and describes the details of our 2014 compensation packages for our named executive officers (our “NEOs”). For 2014, the following individuals were our NEOs:

Mr. Mortimer, who retired at the end of 2014, served as an executive officer for part of 2014.

Executive Summary

Evolution of Our Executive Compensation Program

Our compensation strategy has consistently focused on providing total compensation packages that are designed to attract and retain high-caliber executives by incentivizing them to achieve company and individual performance goals and closely aligning these goals with shareholder interests. We emphasize pay for performance and long-term value creation for our shareholders, compensating our executive officers with a combination of base salary, short-term cash incentives and/or long-term equity incentives.

In connection with and following our initial public offering in May 2013 (our “IPO”), we have continued to evaluate our executive compensation program and adopt changes that we feel are appropriate for a publicly traded company and further our compensation strategy, such as issuing equity awards that do not accelerate vesting upon a change of control. In particular, key actions have included the following:

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Financial Performance

We had strong financial results in 2014, exceeding our key objectives and accomplishing strong year-over-year growth.

Reconciliation of the non-GAAP measure, adjusted income from operations, to the corresponding GAAP measure is attached to this proxy statement as Appendix A.

2014 Compensation Decisions

In making compensation decisions for 2014, our Compensation Committee considered a number of factors, including but not limited to, our overall financial performance, achievement of short-term and long-term corporate and individual objectives, individual contributions of our key executives, and our need to reward and retain our top talent. We believe our practice of tying compensation to achievement of both annual and long-term financial and business goals drives strong performance and results in increased shareholder value. That’s why we structure our compensation programs with a focus on variable pay, creating both long and short-term incentives for our executives. Additionally, pay for performance, including long-term equity designed to reward future sustained performance rather than past performance, is an integral part of our executive compensation program and was a driving consideration for 2014 compensation decisions.

We believe that each of our NEOs played a crucial role in our overall success and the Compensation Committee made the following decisions in 2014 to reward that performance:

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Compensation Philosophy

As noted above, our compensation philosophy centers upon a few key objectives.

The key elements of our compensation program combine cash and equity-based compensation to reward the achievement of annual, long-term and strategic goals. Together, these elements are designed to be complementary and collectively serve the overall compensation objectives described above.

Currently, the total compensation for our executive officers, including our NEOs, consists of four primary components: base salary, short-term cash incentive compensation, long-term equity incentive compensation and limited perquisites and other personal benefits.

In addition to the core components of compensation described above, our executive compensation program includes important practices and policies that are reflective of our overall compensation philosophy.

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The Executive Compensation Process

Roles in Compensation Decisions

The Compensation Committee oversees our executive compensation program. The Compensation Committee, with input from management and the advice of outside consultants, makes decisions that are targeted towards implementing compensation arrangements that reward the achievement of annual, long-term and strategic goals and are designed to enhance shareholder value.

Roles and Responsibilities

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Factors Considered in Making Pay Decisions

Our executive compensation program is built on decisions made regarding the total compensation packages, which we intend to be appropriately competitive, and decisions on each individual pay component within that package. Consistent with our compensation philosophy, the Compensation Committee believes that a significant portion of each executive officer’s compensation should be at risk based on continued service and our company’s and the executive officer’s performance.

When making a pay decision for our executive officers, the Compensation Committee considers three primary factors:

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Competitive Market Data

The Compensation Committee does not make any compensation decisions solely based on benchmarks, compensatory formulas or market comparisons. Rather, the Compensation Committee’s process for determining executive compensation balances the three principal factors listed above and includes as one consideration the highly competitive market for executives in the biopharmaceutical and services industries, including an evaluation of companies with similar growth and revenue characteristics within our business segment.

Our business combines, and our peer group derives from, two principal industries: life sciences and services.

2014 Peer Group

The screening process to establish our 2014 peer group included identification of relevant industries, then selection of companies with a similar size and scope to ours. We used service revenue to evaluate the size component, seeking companies with approximately $4.9 billion to $9.8 billion in revenues. To identify companies with a similar scope, we evaluated qualitative factors such as business models, workforce dynamics and competition for talent.

Based on this screening process, the following companies were removed from our 2013 reported peer group: Gilead Sciences, Inc., Biogen Idec Inc., Celgene Corporation, Cephalon, Inc., Varian Medical Systems, Inc., Pharmaceutical Product Development, Inc., Charles River Laboratories International, Inc. and Watson Pharmaceuticals, Inc. The following companies were added to our peer group: Actavis, AECOM Technology Corp., Cognizant Technology Solutions, FTI Consulting, Genpact, Team Health Holdings, Towers Watson & Co., Unisys and Valeant.

In addition to our peer group compensation information, our management reviewed published market survey data with the assistance of Ernst & Young to aid in making compensation recommendations to the Compensation Committee. The surveys that were referenced in our review were furnished by Mercer and Towers Watson. The scope criteria were primarily focused on Life Sciences, Professional Services and Pharmaceuticals/Biotechnology firms with a revenue scope that is similar to the Company. We find published survey data to be a helpful reference point to provide and validate broader industry compensation insights on privately held and publicly traded companies similar to ours in industry focus, size and business complexity.

The comparative compensation information is just one of several analytic tools that are used in setting executive compensation. The Compensation Committee exercises its discretion in determining the nature and extent of market data it reviews to test the reasonableness of our overall executive compensation program. The

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Compensation Committee nevertheless believes that the results of its review demonstrated that our executive compensation was generally competitive for similar senior positions. As noted above, while we believe all of this market data and other information provides a helpful point of reference when making compensation decisions, we do not view this information as the determinative factor for our executives’ compensation or any particular element of the named executive officers’ compensation.

Impact of 2014 Say on Pay Vote

At our 2014 annual meeting of shareholders, 80% of our shareholders who voted on the say-on-pay proposal approved the compensation of our NEOs. The Compensation Committee believes that this vote endorses the Company’s compensation philosophy and programs. The Compensation Committee took this support into account as one of many factors it considered in making decisions throughout the year. The Compensation Committee will continue to monitor shareholder feedback each year as it reviews and establishes future executive compensation plans and determines awards for our executive officers. In view of the loss of controlled company status, the Company is evaluating a more proactive shareholder outreach program to obtain shareholder feedback with respect to our compensation plans and governance matters.

Our 2014 Compensation Program

In making determinations with respect to total direct compensation for our executive officers for 2014, and allocation of that compensation among the core components of our executive compensation program, we sought to provide competitive levels of fixed compensation (base pay) and, through annual and long-term incentives, increased total direct compensation if performance objectives were exceeded and appropriate downward adjustment of total direct compensation if performance objectives were not met.

The differences in total direct compensation levels among our NEOs are primarily due to the Compensation Committee’s assessment of each position’s internal value and the general differences in the range of compensation for similar positions in our peer group and published market survey data.

The following sections describe the decisions the Compensation Committee made with respect to our NEOs for each component of 2014 executive compensation.

Base Salary

The Compensation Committee attempts to maintain base salaries at competitive levels while also reserving a substantial portion of compensation for the other components of compensation that are more directly linked to company and individual performance. Generally, base salaries of the NEOs are reviewed annually. In 2014, the Compensation Committee did not increase the base salaries of any of the NEOs, except for an immaterial adjustment for one NEO for internal alignment.

Short-Term Incentive Compensation

Management Incentive Plan (MIP)

The strategy of the short-term incentive portion of our executive compensation program is to align the level of annual cash incentive compensation received by our executive officers with corporate financial and individual performance results for the year. Adopted by our Board in connection with the IPO, the MIP governs annual cash

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incentive payments to executive officers and other members of senior management as determined by the Compensation Committee. Each of our NEOs, other than Mr. Mortimer, participated in the MIP in 2014.

The Compensation Committee reviews and approves the award targets each year for MIP participants on an annual basis; typically our executive officers participate in the MIP with a target award that is a percentage of their salaries as specified in their employment agreements. Annual award targets for each participating NEO under the MIP were approved by the Compensation Committee in February 2014 as follows:

Funding the Bonus Pool

We fund an overall bonus pool, which we generally use for any bonuses to our non-sales employees, including our NEOs, based on attainment of a company-wide operating surplus targets. The bonus pool is funded when the company meets 80% of its operating surplus targets. For these purposes, operating surplus represented income from operations as reported in our 2014 consolidated statement of income, excluding restructuring costs, share-based compensation, cash bonus expenses and income associated with 2014 acquisitions.

Allocation of the Bonus Pool

If the Company achieves at least 80% of operating surplus, a bonus pool is funded. The bonus pool is then allocated to each business unit based on results versus service revenues and operating surplus targets for each business unit. A funding factor for participating employees within the business unit is created based on relative performance to determine the final allocation.

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As the chart notes, the ultimate size of the MIP bonus pool depends on the extent to which awards are adjusted for the participating executives based on their individual performance achievements for the year. For each participating executive, the Compensation Committee is empowered to reduce awards to 0% of the targeted award amount, and the MIP does not guarantee anyone a bonus. Individual awards are capped at 200% of the targeted award amount, including adjustments based on achievement of the corporate financial measure(s) that fund the bonus pool and adjustments for individual executive performance.

Individual Performance Achievements for 2014

The Committee considers various factors when determining particular awards for participating executive officers, including involvement in leading our business units towards attainment of 2014 financial objectives, each executive’s individual performance and other factors. The following describes specific performance objectives that were set for our NEOs in 2014, which were intended to supplement our key financial objectives to ensure the overall strategic goals of the Company are met, and notable achievements of our executive officers considered by the Committee when determining their MIP payouts:

Dr. Gillings acting in his capacity as Executive Chairman oversaw the overall strategic and financial success of our Company. He exceeded all financial and individual objectives as set forth by our Board. He also oversaw the successful completion of two secondary offerings and began leading our Company out of “controlled company” status, as defined by the corporate governance standards contained in Section 303A of the NYSE Listed Company Manual.

Mr. Pike either met or exceeded all individual goals that were established for 2014 by the Committee. Mr. Pike’s individual goals included leading the Company to exceeding targets for net new business, service revenues, adjusted income from operations, and diluted adjusted earnings per share. Mr. Pike directed the implementation of our strategy to drive shareholder return through restructuring of low cost debt. Mr. Pike also achieved his goal of leading the significant leadership transition for the Company and ensuring we have the right talent in place to achieve our strategy. Mr. Pike achieved his goal in connection with our quality and compliance initiatives, as well as putting strategy in place to drive productivity and process efficiency gains to benefit our customers.

Mr. Gordon exceeded individual objectives that were established for 2014, including goals for leading the Company to exceeding targets for net new business, service revenues, adjusted income from operations, and diluted adjusted earnings per share. He delivered a shared services strategy, which included streamlining our processes and reporting. He successfully led an update to our procurement and vendor management processes. Additionally, our internal compliance and controls, which are under his supervision, were superior, with no material issues identified, and he assumed responsibility for monthly operations reviews from our former Chief Operating Officer that have lead to improvements in our business management system.

Mr. Erlinger exceeded objectives that were established, including goals relating to the leadership of the Office of General Counsel. He was essential in the Company’s ability to successfully complete two secondary offerings, an acquisition and two debt restructurings. Mr. Erlinger led the revisions to harmonize our corporate polices and developed global contracting standards. He also managed efforts to improve and broaden our insurance coverage while achieving reduced cost for the coverage. He also exceeded objectives that were established for workforce metrics in connection with the Office of General Counsel, including but not limited to attraction, retention and succession planning goals.

Summary of MIP Payouts to NEOs for 2014

After determining the funding of the bonus pool and evaluating the extent of the participating executives’ achievement of individual objectives, the Compensation Committee determined final payouts under the MIP for 2014. The table below presents, with respect to each participating NEO, (i) the target award amount (determined as discussed in “Management Incentive Plan,” above), (ii) the baseline award amount (determined by multiplying

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the target award amount by 109.6%, which was the funding factor based on our exceeding our operating surplus targets), (iii) the percentage adjustment to the award for each such executive (determined by the Compensation Committee’s assessment of achievement of individual objectives and contributions to our success), and (iv) the actual award amount approved by the Compensation Committee and paid to each such executive under the MIP for 2014.

Long-Term Incentive Compensation

Stock Incentive Plan Compensation

We believe superior returns for our shareholders are achieved through a culture that focuses on long-term performance by our executive officers and other senior management. By providing our senior management long-term incentives and placing a significant equity opportunity in their hands, we believe we are better able to align the interests of our executive officers and our shareholders.

The objectives of the long-term incentive portion of our executive compensation program include the following:

Our Board and shareholders adopted the 2013 Stock Incentive Plan in connection with the IPO, and we do not expect to make any further awards under our prior stock incentive plans. Awards under the 2013 Stock Incentive Plan represent our principal form of long-term incentive compensation.

Although the Compensation Committee does not utilize formal wealth accumulation analyses, it does consider existing stock ownership and prior awards in determining the size and mix of long-term incentive awards to our executive officers. In particular, the Compensation Committee recognized that Dr. Gillings has made a significant personal investment in the Company and therefore has elected to compensate him for his service as Executive Chairman other than with long-term equity incentives. The Compensation Committee also considered the large amount of stock options previously awarded to Mr. Pike pursuant to his employment agreement, how they vest over time and provisions in his employment agreement in determining to not award any equity grants to Mr. Pike in 2014.

The Compensation Committee awarded long-term incentive awards in 2014 to our NEOs other than Dr. Gillings, Mr. Pike and Mr. Mortimer, who retired at the end of 2014, under the terms of the 2013 Stock Incentive Plan. Mr. Gordon’s award was determined by targeting an award value equivalent to the median of our

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peer group to ensure a market competitive grant. Mr. Erlinger’s award was determined using a compilation of market surveys to target an award with a value equivalent to the median at companies with a comparable position to ensure a market competitive grant. The surveys were furnished by Mercer and Towers Watson and a list of the companies that participated in the surveys can be found in Appendix B. We used the survey data focused on Life Sciences, Professional Services and Pharmaceuticals/Biotechnology firms with a revenue scope that is similar to the Company in determining Mr. Erlinger’s award. For both awards, the Compensation Committee also took into consideration the executives’ strong performance and individual contributions to our success. Mr. Gordon’s and Mr. Erlinger’s awards placed them at approximately the 50th percentile, relative to our peer group for Mr. Gordon and the survey data for Mr. Erlinger.

For both awards, 75% of the awards were delivered in non-qualified stock options and 25% were delivered in RSUs. The non-qualified stock options are time vested, 25% equally over four years. The RSUs are also time vested, with 1/3 of the units vesting after three years and 2/3 vesting after four years. Non-qualified stock option awards are granted with an exercise price equivalent to the fair value on the date of the grant.

In 2014, we decided to move away from granting 100% stock options in favor of a multi-vehicle strategy of awarding a mix of RSUs and stock options, which is more consistent with the practices of public companies and our peer group. When we made our annual equity awards in March 2015, we moved away from awarding RSUs in favor of awarding PUs, whose ultimate value will vary depending on the Company’s achievement of certain performance measures over a specified time period. All grants made to named executive officers in March 2015 consisted of 75% non-qualified stock options and 25% PUs. The PUs we awarded to each of our executive officers in March 2015 have a three year cumulative performance period beginning on January 1, 2015 and ending on December 31, 2017, and will vest, if at all, based on the degree to which the Company achieves certain cumulative total adjusted earnings per share (as defined in the award agreements) goals during this performance period.

Benefits and Perquisites

Executive Benefits

Our employees generally, including our NEOs, are eligible for certain benefits, such as group health and disability insurance, employer contributions to our 401(k) plan and basic life insurance premiums. These benefits are intended to provide competitive and appropriate protection in case of sickness, disability or death. The 401(k) plan provides our employees the opportunity to save for retirement on a tax-deferred basis. NEOs may elect to participate in the 401(k) plan on the same basis as all other employees. We may provide a discretionary matching contribution to eligible 401(k) plan participants in an amount determined annually prior to the beginning of a plan year. For 2014, as in prior recent years, our discretionary matching contribution matched the first 3% of employee contributions at 100% and the next 3% of contributions at 50%. Our discretionary matching contributions under the 401(k) plan vest 50% after one year of service and 100% after two years of service.

The Compensation Committee believes that perquisites should not constitute a significant part of our executive compensation program. From time to time, we may provide limited perquisites to our executive officers on an individual basis as appropriate under the circumstances. For example, in connection with new hires, we have covered legal fees and relocation expenses for our executives. In addition, we have covered the installation or enhancement of home security systems for several of our senior executives (including certain of our NEOs). To offset unintended increased taxable income effects and to provide these perquisites and benefits on a “tax-neutral” basis, we also provided tax gross-ups with respect to some of these benefits and perquisites.

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Friends and family members of certain of our NEOs have, in limited circumstances, accompanied such executives on business travel on the airplane owned and operated by GF Management Company, LLC, or GFM, a company controlled by Dr. Gillings. We pay a flat hourly rate for the use of the airplane, so any such travel is at no additional incremental cost to us. See “Certain Relationships and Related Person Transactions—Other Transactions.”

Expatriate Benefits

For those employees, including our executive officers, who are assigned to an international location outside their home country, we also provide reasonable and customary expatriate benefits, including relocation expenses, housing allowance and other out-of-pocket expenses related to overseas assignment. The expatriate benefits we provided in 2014 to Mr. Mortimer, who continued a multi-year assignment to provide executive leadership in our EMEA (or Europe, Middle East and Africa) region of operations from our regional headquarters in the United Kingdom and to be the chairman of the EMEA management board, are reflected as “All Other Compensation” in the Summary Compensation Table.

Executives who are on international assignment also fall under our tax equalization policy. Under our tax equalization policy, assignees are held responsible for a “hypothetical” home country tax on their compensation (excluding assignment allowances) and personal income as if they had remained in the home country and not gone on an international assignment. We use a “hypothetical tax” withholding model, where we deduct withholdings from the executive’s pay which represent the taxes that the executive would have been responsible for in his home country. We then pay taxes on behalf of the executive in the host location and any residual actual home country taxes. Accordingly, from a tax perspective, the executives do not benefit nor do they suffer economically. We engage a third party accounting firm to prepare an annual tax equalization settlement which reconciles the executive’s hypothetical tax obligation against the amounts withheld.

We believe these benefits are standard in our industry and they generally apply to non-management expatriate employees as well. We believe the level of tax benefit provided is reasonable and not excessive. Further, we believe the cost to our Company of providing this benefit is reasonable in light of the benefits our Company receives in having certain employees assigned internationally.

Supplemental Elements of the Compensation Program

Equity Grant Policy

In February 2015, the Compensation Committee approved an updated Equity Grant Policy which outlines the delegation of authority set forth to appropriate parties to approve grants, as well as our approach to determining grant date and grant price. The Compensation Committee has the authority to make equity awards to officers and employees of the Company or to delegate the authority to make equity awards to one or more officers designated by the Compensation Committee to eligible individuals other than members of the Board of Directors or executive officers. Any grants made by an officer or officers pursuant to the delegation of authority by the Compensation Committee shall be regularly reported to the Compensation Committee. In the case of equity grants that are subject to approval by the Compensation Committee, each equity award will be granted with an effective date as of the date of the approval by the Compensation Committee. In the case of equity grants approved by any officer or officers of the company pursuant to the delegation of authority described above, each equity award will be granted with an effective date of the first trading day of the month following the date of approval. If the effective date determined under the preceding phrases would fall during a Company specified “Blackout Period” as defined by the Office of the General Counsel, then such award will be granted with an effective grant date as of the first permitted trading date following such Blackout Period.

Recoupment Policy

Effective January 1, 2015, we have implemented a formal recoupment, or “clawback” policy for the recovery of incentive-based compensation paid to current and former executive officers on the basis of financial results that are subsequently restated as a result of misconduct or material noncompliance with financial reporting requirements

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under GAAP and SEC rules. The Board has the sole discretion to invoke the policy and direct the Company to recover incentive-based compensation received by such persons on the basis of the restatement.

Share Ownership Guidelines

Our Board believes that management’s ownership of our equity demonstrates a commitment to the long-term profitability of our Company, benefiting shareholders and employees alike. Employees covered by our Share Ownership Guidelines, or the Guidelines, are expected to acquire and maintain a minimum level of ownership in our equity. In order to align management’s long-term interests with our Company’s long-term interests, our Board adopted the Guidelines as outlined below.

Employees who joined our Company after January 1, 2010, must achieve the minimum level of ownership within five years of becoming subject to the Guidelines. In calculating the required holding amounts, we include: 100% of shares owned outright, 100% of vested and non-vested restricted stock, RSUs, phantom stock and similar instruments, and 50% of shares underlying vested and non-vested stock options, stock appreciation rights and other similar instruments and any of the above equity held by immediate family members.

As of December 31, 2014, all of our NEOs and our independent directors were in compliance with the Guidelines.

Payments upon Termination Events

As noted above, we have entered into employment agreements with all of our NEOs, which provide, among other things, for various benefits upon a termination of their employment under various scenarios. These agreements generally provide for severance benefits of varying periods that are triggered in the event we terminate an executive “without cause” or the executive terminates for “good reason” or due to our material breach, with provisions that define the nature of employment, compensation and benefits while employed, compensation and benefits upon termination, and restrictive covenants relating to trade secrets, confidential information, company property and competitive business activities. These provisions, which (with the exception of certain terms of our employment relationship with Dr. Gillings and Mr. Pike) generally mirror each other, are designed to promote stability and continuity of senior management. We believe that reasonable severance benefits are appropriate in order to be competitive in our executive retention efforts. We believe protections afforded by post-termination severance payments allow management to focus their attention and energy on making objective business decisions that are in our best interest without allowing personal considerations to cloud the decision-making process.

Dr. Gillings’ employment agreement provides for severance payments to be paid following termination of his employment under various circumstances, including if he is terminated in connection with a sale of our Company meeting certain conditions, so long as Dr. Gillings does not trigger the sale transaction or vote in favor of it. We and our Sponsors (who have two representatives on the Compensation Committee) believe that providing Dr. Gillings, our founder and Executive Chairman, with long-term stability of income and other benefits is an important aspect of retaining his services. In connection with Dr. Gillings’ announcement that he intends to transition out of his role as an executive at the end of 2015, we would be obligated to pay Dr. Gillings non-compete payments for so as long as we decide to enforce the non-compete provisions of his employment agreement. See “—Employment Agreement with Dr. Gillings” below for a more detailed discussion of amounts owed to Dr. Gillings following a separation.

None of our unvested options or unvested RSUs held by our NEOs automatically accelerate upon a change in control, with the exception of certain options issued pursuant to the employment agreements with Dr. Gillings

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and Messrs. Pike and Gordon. Currently all of the options held by Dr. Gillings are vested and would not be effected by a change in control. Mr. Pike holds 604,287 unvested options whose vesting would be accelerated upon a change in control, which represent 100% of his unvested options. Mr. Gordon holds 60,000 unvested options whose vesting would be accelerated upon a change in control, which represent 23% of his unvested options. With regard to our other unvested awards, the Compensation Committee has the discretion to determine whether awards will vest in the event of a sale of the Company (as defined in the 2013 Stock Incentive Plan).

See “Payments Made Upon Death or Permanent Disability” and “Potential Payments Made Upon Termination” below for a more detailed discussion of these agreements.

Executive Compensation Deferral Program

In addition to our standard 401(k) retirement savings plan available to all United States employees, we have established an elective nonqualified deferred compensation plan for certain of our United States-based senior employees, including our NEOs. The plan generally allows eligible employees to defer up to 90% of their base salaries as of the first day of the calendar year or partial year and up to 100% of any cash bonus payable to the participant with respect to that year. Contributions consist solely of participants’ elective deferral contributions with no matching or other employer contributions. The terms of the plan are intended to comply with Section 409A of the Code.

Tax and Accounting Implications

Our executive compensation arrangements are designed to take account of and to avoid excise taxes under Section 409A of the Code, and include provisions addressing requirements that apply only after the IPO. Prior to the IPO, we were not subject to the Section 162(m) limitation on deductions for certain executive compensation. Now that we are public, we intend to claim the benefit of a special exemption rule that applies to compensation paid (or compensation in respect of equity awards such as stock options or restricted stock granted) during a transition period that may extend until our annual meeting of shareholders scheduled to be held in 2017, unless the transition period is terminated earlier under the Section 162(m) post-offering transition rules. At such time as we are subject to the deduction limitations, we expect that the Compensation Committee will take the deductibility limitations of Section 162(m) into account in its compensation decisions; however, the Compensation Committee may, in its judgment, authorize compensation payments that are not exempt under Section 162(m) when it believes that such payments are appropriate. Further, we cannot guarantee that awards or other forms of compensation will satisfy 162(m) requirements.

Compensation Policies and Practices as They Relate to Risk Management

We have reviewed our compensation policies and practices for all employees and concluded that any risks arising from our policies and programs are not reasonably likely to have a material adverse effect on our Company.

Compensation and Talent Development Committee Report

The Compensation Committee has reviewed and discussed with management the foregoing Compensation Discussion and Analysis. Based on such review and discussions, the Compensation Committee recommended to our Board that the Compensation Discussion and Analysis be included in this proxy statement for the annual meeting of shareholders in 2015.

THE COMPENSATION AND TALENT

DEVELOPMENT COMMITTEE

Michael J. Evanisko (Chairman)

John P. Connaughton

Jonathan J. Coslet

Jack M. Greenberg

Leonard D. Schaeffer

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2014 Summary Compensation Table

The following table presents summary information regarding the total compensation awarded to, earned by, or paid to each of our named executive officers for services rendered in all capacities for the fiscal years ended December 31, 2014 and 2013.

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2014 All Other Compensation

The following table details the components of the amounts reflected in the “All Other Compensation” column of the Summary Compensation Table for each of our named executive officers for the fiscal year ended December 31, 2014.

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2014 Grants of Plan-Based Awards

The following table provides information with respect to awards made to our named executive officers during 2014 pursuant to the MIP and the 2013 Stock Incentive Plan.

Narrative Disclosure Relating to Summary Compensation Table and Grants of Plan-Based Awards Table

Employment Agreements

We have entered into employment agreements with each of our named executive officers which contain provisions that define the nature of employment, compensation and benefits while employed, compensation and benefits upon termination, and restrictive covenants relating to trade secrets, confidential information, company property and competitive business activities.

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Employment Agreement with Dr. Gillings

In connection with our privatization in September 2003, Dr. Gillings entered into an employment agreement with us and our parent company at the time, Pharma Services Holding, Inc., or Pharma Services, replacing his prior employment agreement. Quintiles Transnational assumed all rights and obligations of Pharma Services pursuant to this agreement in March 2006. Amendments to Dr. Gillings’ employment agreement were made and entered into on February 1, 2008, December 12, 2008, December 31, 2008, December 14, 2009 and April 18, 2013. These amendments were primarily tied to the successful completion of significant corporate events. The 2009 amendment was implemented in connection with the Holding Company Reorganization in 2009 to clarify that the provisions would continue, unchanged, with respect to shares of Quintiles common stock (as opposed to shares of Quintiles Transnational stock). In connection with our IPO, we amended the terms of his agreement to reduce certain compensation and benefits provided to Dr. Gillings and to provide for other modifications necessary to comply with certain provisions of Section 409A of the Code.

The current term of this employment agreement will continue until it is terminated pursuant to its terms. Dr. Gillings served as our Executive Chairman during 2014 and was entitled to the following compensation and benefits during 2014 under the terms of his employment agreement in effect as of December 31, 2014:

We also have agreed to reimburse GFM for expenses, at the current rate of $13,502 per hour, related to the use of its airplane for business-related travel. Subject to a limit of $2.5 million per year during the term of the employment agreement, in 2014, we reimbursed GFM approximately $1.8 million for the use of its airplane. See “Certain Relationships and Related Person Transactions—Other Transactions.”

Additional material terms of our employment agreement with Dr. Gillings are described under “Potential Payments Upon Events of Termination” below.

Employment Agreement with Mr. Pike

Quintiles Transnational entered into an employment agreement with Mr. Pike in April 2012 in connection with him joining our Company. The term of the employment agreement began on April 30, 2012 and continues until terminated as set forth in the agreement. Our agreement with Mr. Pike, as in effect on December 31, 2014, generally provides for the following compensation and benefits:

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As previously discussed, the Compensation Committee determined to fold the remaining portion of Mr. Pike’s executive allowance into his base salary in February 2013.

In addition, if either we terminate Mr. Pike without Cause or he terminates for Good Reason (each as defined in Mr. Pike’s employment agreement and outlined below), Mr. Pike’s 604,287 unvested options will continue to vest over the 24-month period beginning on the termination date, contingent upon his executing a customary release of all claims against us arising out of his employment. Furthermore, in the event of a change in control (as defined in Mr. Pike’s employment agreement and outlined below), then all of his options become vested and exercisable.

Under the terms of our agreement with Mr. Pike, the following events constitute a change in control:

Additional material terms of our employment agreement with Mr. Pike are described under “Potential Payments Upon Events of Termination” below.

Agreements with Other NEOs

We have entered into the following agreements with Messrs. Gordon, Erlinger and Mortimer:

Each of these NEOs, other than Mr. Mortimer, currently holds the same position with Quintiles Transnational Holdings Inc. and Quintiles Transnational, and Mr. Mortimer held the same position at Quintiles

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Transnational Holdings Inc. and Quintiles Transnational until he resigned as an officer as of May 12, 2014, although he continued as an employee until June 30, 2014. Mr. Mortimer provided consulting services to the Company as an independent contractor from July 1, 2014 until December 31, 2014, at which time Mr. Mortimer retired. Material terms of the employment agreements in effect as of December 31, 2014 with Messrs. Gordon and Erlinger have substantially the same provisions except as noted in the following:

Term. The term of our employment agreement with Mr. Gordon will continue until it is terminated pursuant to its terms, which include termination by us for Cause or by Mr. Gordon for Good Reason. The term of our employment agreement with Mr. Erlinger will continue until it is terminated pursuant to its terms, which include termination by us for Cause or by Mr. Erlinger for Material Breach (as defined below). Either party to the agreements with Messrs. Gordon and Erlinger may terminate the employment relationship without cause at any time upon giving the other party 60 days prior written notice.

Compensation. These employment agreements generally provide for and specify:

Other Provisions.

None of the employment agreements with our NEOs, other than Dr. Gillings and Messrs. Pike and Gordon (as discussed below), provide for any specific benefits in the event of a change in control. However, the Compensation Committee has the discretion to determine whether awards will accelerate in the event of a sale of the Company (as defined in the 2013 Stock Incentive Plan).

Additional material terms of our employment agreements with these NEOs are described under “Potential Payments Upon Events of Termination” below.

As noted above, on May 12, 2014, we entered into a consulting and general release agreement with Mr. Mortimer, pursuant to which he continued as an employee until June 30, 2014 and provided consulting services as an independent contractor until December 31, 2014, at which time he retired. Pursuant to his consulting agreement, we agreed to pay Mr. Mortimer the following amounts: (i) a lump sum payment in cash of $350,000 as a bonus for the 2014 performance year, less applicable withholdings; provided, however, that if we did not pay out to the other participants in the MIP 100% of the bonus pool for 2014, then the amount due Mr. Mortimer would have been reduced by the same percentage that our payout of the MIP bonus pool is below 100%; (ii) monthly consulting fees of $50,000 per month from July 1, 2014 until December 31, 2014; (iii) from June 30, 2014 through December 31, 2014, (a) continued provision of benefits equivalent to those to which Mr. Mortimer would have been entitled under our expatriate benefit package had Mr. Mortimer remained employed, provided that, in lieu of any relocation expenses or benefits related to a relocation back to the United States provided for in such package, we shall pay to Mr. Mortimer, on or before December 31, 2014, a lump sum payment of $600,000; such expatriate benefits shall be grossed-up for income taxes consistent with prior practices to put Mr. Mortimer in the same after-tax position as had such benefits and payments not constituted taxable income; and (b) provision of medical, dental and vision insurance benefits substantially equivalent to those he had prior to his resignation; and (iv) tax preparation services for the 2014 and 2015 tax years.

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2014 Outstanding Equity Awards

The following table provides information regarding all outstanding equity awards previously granted to the named executive officers as of December 31, 2014.

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2014 Option Exercises and Stock Vested

The following table sets forth information regarding options exercised by our named executive officers during fiscal year 2014. None of the outstanding restricted stock units held by our named executive officers vested during fiscal year 2014.

Equity Awards Outstanding under Existing Stock Incentive Plans

All of the equity awards outstanding at the end of 2014 are governed by the 2003 Stock Incentive Plan, the 2008 Stock Incentive Plan or the 2013 Stock Incentive Plan, in addition to the terms of the award agreement covering a particular grant. All equity awards made after our IPO have been issued under the terms of the 2013 Stock Incentive Plan. We expect to grant all equity-based awards under the 2013 Stock Incentive Plan going forward. Under our 2013 Stock Incentive Plan, we may generally grant the following types of awards: stock options (including both incentive stock options and nonqualified options), stock appreciation rights, restricted stock and restricted stock units, performance shares and performance units, cash-based awards and other stock-based awards, in each case generally subject to annual award limits set forth in the 2013 Stock Incentive Plan. In 2014, our equity awards issued to our named executive officers under the 2013 Stock Incentive Plan were limited to stock options and restricted stock units.

All awards granted under these stock incentive plans to date are (or were) subject to service-based vesting, which typically ranged from four to five years. All option awards are exercisable for shares of our common stock and are

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nonqualified stock options. Each option will terminate upon the tenth anniversary of the date of grant. Each restricted stock unit represents the right to receive one share of our common stock shortly after vesting. Except as provided for in a grant award or certificate, or (as discussed below) in an employment agreement, in the event of termination of employment for any reason, all unvested awards immediately terminate. Vested options will remain exercisable for up to 90 days following termination, except they will remain exercisable for up to 365 days if termination is due to death or a disability, retirement or redundancy that is approved by the Compensation Committee. In the event termination of employment is for “Cause” (which under the terms of these stock incentive plans is deemed to mirror the definition of “Cause” found in the employment agreement we have entered into with each of our named executive officers), or if an executive breaches a restrictive covenant, all outstanding awards will be forfeited in their entirety.

2014 Nonqualified Deferred Compensation

Pursuant to our elective nonqualified deferred compensation plan, certain eligible employees, including our named executive officers, may defer up to 90% of their base salaries as of the first day of the calendar year or partial year and up to 100% of awards earned under the MIP for 2014 and certain cash bonuses and/or commissions payable. Deferral elections are made by eligible employees before the beginning of the calendar year for which the compensation is payable. Contributions to the elective nonqualified deferred compensation plan consist solely of participants’ elective deferral contributions with no matching or other employer contributions. None of the named executive officers elected to defer any portion of their salaries or cash bonuses during 2014.

Eligible employees are permitted to make individual investment elections that will determine the rate of return on their deferral amounts under the elective nonqualified deferred compensation plan. Participants may change their investment elections at any time. Deferrals are only deemed to be invested in the investment options selected. Participants have no ownership interest in any of the funds as investment elections are used only as an index for crediting gains or losses to participants’ accounts. The investment options consist of a variety of well-known mutual funds including certain non-publicly traded mutual funds available through variable insurance products. Investment experience in the funds is credited to the participants’ accounts daily, net of investment option related expenses. The plan does not operate in a manner to provide any above-market returns or preferential earnings to participants. For 2014, participants were able to choose among a total of 30 investment options, however, the named executive officers only elected to invest in the following investment options in 2014:

Distributions of amounts credited to the account of a named executive officer under the elective nonqualified deferred compensation plan will generally commence six months after the date of the executive’s separation from service. NEOs may also elect to receive in-service distributions of such amounts at the time they make their deferral elections. In addition, upon a showing of an unforeseeable emergency, an executive may be allowed to access funds in his deferred compensation account before he otherwise would have been eligible to. Benefits can generally be received either as a lump sum payment or in annual installments over a period not to exceed 15 years, or a combination thereof, except in the case of in-service distributions, which are always paid in a lump sum.

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The following table provides information related to the potential benefits payable to each of our NEOs under our elective nonqualified deferred compensation plan.

Payments Made Upon Death or Permanent Disability

In the event of death or permanent disability of an NEO, in addition to amounts disclosed below under “Potential Payments Upon Events of Termination,” each NEO will receive benefits under our long-term disability plan or payments under our life and accidental death insurance plans, as appropriate. These payments are generally available to all employees; however, the amounts paid may differ by employee based upon individual base salary and plan limitations on benefits. For example, Dr. Gillings and the other NEOs are eligible for two times the amount of base salary at death (up to $1,000,000). In the event of accidental death, an additional benefit of up to two times the amount of base salary at that time (up to $1,000,000) is also available. Therefore, if such benefits were triggered for the NEOs on December 31, 2014 under our life insurance plans, the legally designated beneficiary(ies) of each named executive officer, other than Mr. Erlinger, would have received $1,000,000 from life insurance, plus an additional $1,000,000 if death was accidental (excluding any voluntary supplemental coverage elected and paid for by the named executive officer under our life insurance program). Mr. Erlinger would have received $870,000.

With respect to coverage in the event of long-term disability, our plan provides a benefit of 66 2/3% of base salary, with a maximum benefit of $15,000 per month, for as long as the individual is medically determined to be disabled and certain other requirements are met. Generally, maximum coverage is limited as follows based on an individual’s age at the time he becomes disabled:

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As a result, if such benefits had been triggered on December 31, 2014 under our long-term disability insurance plan, based on the then-current age of each NEO, each NEO would have been entitled to receive the following amounts for as long as he remained disabled: Dr. Gillings (age 70), $15,000 per month for a maximum of 12 months; Mr. Pike (age 55), $15,000 per month to age 65; Mr. Gordon (age 52), $15,000 per month to age 65; and Mr. Erlinger (56), $15,000 per month to age 65. Mr. Mortimer (age 54) was eligible to receive $15,000 per month to age 65; however this benefit was eliminated upon his retirement from our Company on December 31, 2014.

Potential Payments Upon Events of Termination

As discussed previously, we have entered into employment agreements with each of our NEOs. The information below describes and quantifies certain compensation that would become payable under these agreements and our other existing plans and arrangements for each of our NEOs as if his employment had terminated on December 31, 2014. Except as otherwise discussed below, these benefits are in addition to benefits generally available to salaried employees, such as distributions under the 401(k) plan and disability benefits.

Employment Agreement with Dr. Gillings

Events of Termination

Our employment agreement with Dr. Gillings provides for certain payments and other benefits if his employment with us is terminated, which vary depending on the circumstances of his termination. Except in certain circumstances discussed below, our obligation to compensate Dr. Gillings ceases on the last date of his employment other than with respect to his full salary and any other accrued benefits set forth in the agreement through that date.

In the event Dr. Gillings’ employment is terminated either:

For the purposes of Dr. Gillings’ employment agreement “Cause” means:

In addition, if Dr. Gillings terminates his employment due to our material breach of the agreement, and it is ultimately determined that no reasonable basis existed for Dr. Gillings’ termination on account of our alleged default, such event shall be deemed “Cause” for termination by us.

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For purposes of this discussion, “Good Reason” includes:

In addition, if either:

Dr. Gillings’ severance benefits will not impact any other benefits otherwise payable to him under any of our other compensation or benefit plans in which he participates.

We have agreed to secure the cash severance payment we would owe Dr. Gillings through a letter of credit or similar arrangement, or to deposit the present value of such payments into an escrow arrangement (with protection against claims from our creditors), in a form reasonably acceptable to Dr. Gillings. We will release a portion of the cash severance amounts secured by such arrangements in the event Dr. Gillings is required to recognize income tax as a result thereof and will reimburse Dr. Gillings for any penalties imposed on him, along with any income tax due as the result of such reimbursement, if we fail to release a sufficient portion of the amounts secured to satisfy Dr. Gillings’ income tax liabilities resulting from this arrangement.

Dr. Gillings is not required to mitigate any of the severance benefits we may owe; provided, however, we will no longer be obligated to provide the severance benefits if he breaches any of the restrictive covenants contained in his employment agreement (described below). In addition, our obligation to provide the severance benefits is conditioned upon Dr. Gillings’ execution of a customary release of all claims against us arising out of his employment.

The employment agreement includes restrictive covenants requiring Dr. Gillings to disclose and assign to us any developments conceived, made or suggested by him during his employment or the non-competition period (described below) and generally prohibiting Dr. Gillings from:

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until the latest of (1) three years following the date he ceases to own any equity interest in us or any of our subsidiaries, or (2) three years from the date of his termination of employment. For so long as we require Dr. Gillings to comply with these restrictive covenants, we are required to pay him during the non-competition period monthly amounts equal to the sum of his annual base salary in effect on his termination date plus his most recent annual bonus divided by 12, provided however, that we are not required to make such payments during the three-year period following termination if we are paying Dr. Gillings the severance payments described above. The agreement pursuant to which Dr. Gillings rolled over his equity in the going private transaction in 2003 contains the same non-compete provisions. These restrictions automatically lapse if we release Dr. Gillings from the non-compete under his employment agreement.

Dr. Gillings holds fully vested options to purchase 1,000,000 shares of our common stock granted under the 2008 Stock Incentive Plan. Neither Dr. Gillings’ employment agreement nor his award agreement governing his stock options provide for any specific benefits with respect to Dr. Gillings’ stock options in the event of his termination (for whatever reason) or a change in control.

Potential Payments upon Dr. Gillings’ Termination

The following table sets forth our payment obligations upon termination of Dr. Gillings’ employment pursuant to the terms of his employment agreement and our other compensation plans under the various scenarios described above. The amounts set forth in the table are estimates and assume a termination of employment occurring on December 31, 2014 (the last business day of our last completed fiscal year). Due to the numerous factors involved in estimating these amounts, the actual value of benefits and amounts to be paid can only be determined upon Dr. Gillings’ actual termination of employment.

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Employment Agreement with Mr. Pike

Events of Termination

Our employment agreement with Mr. Pike provides for certain payments and other benefits if his employment with us is terminated, which vary depending on the circumstances of his termination. Except in certain circumstances outlined below, our obligation to compensate Mr. Pike ceases as of the termination date except with respect to any amounts due under the agreement at that time and the amounts subsequently due, if any, under our annual performance incentive plan then in effect.

Either party may terminate the employment relationship without cause at any time upon giving the other party 60 days’ written notice. The agreement automatically terminates upon Mr. Pike’s death. In addition, we may terminate his agreement at any time upon written notice to Mr. Pike due to his disability. In addition, we may terminate our employment relationship with Mr. Pike immediately upon written notice at any time for “Cause,” which is defined in Mr. Pike’s employment agreement to include:

Under the employment agreement, Mr. Pike may terminate his employment for “Good Reason” if any of the following events occurs without his consent;

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Mr. Pike must provide us with written notice of the event constituting Good Reason within 90 days of becoming aware of our actions or inactions giving rise to such Good Reason. Any termination for Good Reason shall become effective 30 days following Mr. Pike’s written notice, provided we have not cured the actions or inactions giving rise to his notice of termination for Good Reason.

Payments Upon Termination

In the event Mr. Pike terminates his employment without Good Reason, his employment is terminated due to death or disability or by our Company for Cause, we must pay Mr. Pike (or his estate) a lump sum equal to any accrued but unpaid base salary, unreimbursed expenses and any earned but unpaid annual incentive bonus (only if Mr. Pike was employed on March 1 of the year following the year which such incentive relates). In addition, in the event of termination by death or disability, we will be obligated to pay any earned but unpaid amount under our annual performance incentive plan for the prior year (which, for these purposes, was the 2013 MIP) and, if such termination occurs after the first quarter of a year, Mr. Pike (or his estate) will also be entitled to a pro rata portion of his annual performance incentive award for the year of termination (which, for these purposes, was the 2014 MIP), based upon actual performance and paid at the time it would be paid if he had continued his employment.

In addition, if either we terminate Mr. Pike without Cause or he terminates for Good Reason, subject to certain conditions outlined below, we will make the following cash severance payments to him:

In addition, if either we terminate Mr. Pike without Cause or he terminates for Good Reason, Mr. Pike’s employment agreement provides that 604,287 of the unvested options issued pursuant to his employment agreement will continue to vest over the 24-month period beginning on the termination date. Furthermore, in the event we terminate Mr. Pike without Cause or he terminates for Good Reason within 24 months after a change in control (as defined in Mr. Pike’s employment agreement and discussed above), then the severance payments otherwise payable over 24 months become payable in a lump sum. In the event of a change in control (as defined in Mr. Pike’s employment agreement) all of his options become vested and exercisable.

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Also, in the event any of his severance payments are deemed to be parachute payments for purposes of Section 280G of the Code, then he will receive the greater of (taking into account all federal, state and local income taxes, as well as the parachute tax under Section 280G): (1) the amount that would result in no portion of the severance payments being subject to the parachute tax under Section 280G to be a parachute payment or (2) the full severance amount.

Mr. Pike’s employment agreement requires, as a precondition to the receipt of the cash severance payments identified in the table below, that Mr. Pike sign a release in which he waives all claims that he might have against us. In addition, his employment agreement requires that he comply with certain provisions of the agreement:

Mr. Pike has also agreed not to take any action which is materially detrimental or otherwise intended to be adverse to our reputation, business relations, prospects and operations.

Potential Payments upon Mr. Pike’s Termination

The following table sets forth our payment obligations upon termination of Mr. Pike’s employment pursuant to the terms of his employment agreement and our other compensation plans under the various scenarios described above. The amounts set forth in the table are estimates and assume a termination of employment occurring on December 31, 2014 (the last business day of our last completed fiscal year). Due to the numerous factors involved in estimating these amounts, the actual value of benefits and amounts to be paid can only be determined upon Mr. Pike’s actual termination of employment.

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Employment Agreements with Other NEOs

Events of Termination

Except in certain circumstances outlined below, our obligation to compensate an executive ceases as of the termination date except with respect to any amounts due under the agreement at that time and the amounts subsequently due, if any, pursuant to our annual cash bonus plans. See “—Agreements with Other NEOs” above for a discussion of amounts owed to Mr. Mortimer following his resignation as an executive officer during 2014. The following discussion pertains to agreements with each of our NEOs other than Dr. Gillings, Mr. Pike and Mr. Mortimer.

Each of the agreements provide that we may terminate an executive’s employment relationship immediately without notice at any time for “Cause.” Except as specified below, the agreements with each of these named executive officers generally mirror each other and define “Cause” to include:

Our agreement with Mr. Gordon provides that he may terminate his employment for “Good Reason” if any of the following events occurs without his consent:

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Mr. Gordon must provide us with written notice of the event constituting Good Reason within 30 days of becoming aware of our actions or inactions giving rise to such Good Reason, subject to a 60-day cure period.

Our agreement with Mr. Erlinger provides that he may terminate his employment for our material breach upon written notice to us, subject to a 90-day cure period. We refer to each of the executive’s right to terminate under these circumstances as “Material Breach.”

If either:

subject to certain conditions outlined below, we will make cash severance payments to the executive officer. The severance amount payable is based on a multiple of monthly salary at the time of termination and then again multiplied by a specified number of months. The following table identifies the severance amounts payable to such named executive officers under their agreements.

The agreements also provide for an additional lump-sum cash payment equal to 24 times our monthly cost of providing medical, dental, vision, long-term disability and term life insurance benefits for Mr. Gordon and 12 times our monthly cost of providing medical, dental, vision, long-term disability and term life insurance benefits for Mr. Erlinger. To the extent any portion of this payment is included as gross income for the executive; the executive will receive an additional amount equal to the federal income tax applicable to such payment. We refer to these payments as the insurance benefits for purposes of the tabular discussion for each of these named executive officers below.

The agreement for Mr. Gordon also provides for an additional $60,000, representing two times his annual executive allowance, to be paid in monthly installments. As previously discussed, while the executive allowance has been folded into base salaries for these executives, the Compensation Committee still treats it as a separate element of compensation for the purposes of the determining amounts payable upon termination by these executives. The employment agreements require, as a precondition to the receipt of the cash severance payments identified in the table below, that the executive sign a release in which he waives all claims that he might have against us and that he complies with certain provisions of the agreement:

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Each of these executives have also agreed not to take any action which is materially detrimental or otherwise intended to be adverse to our reputation, business relations, prospects and operations.

Change in Control

Mr. Gordon’s employment agreement provides that all of the unvested options issued to him in 2010, or 60,000 options, become vested and exercisable upon a change in control, as defined in his employment agreement. Options and RSUs subsequently granted to Mr. Gordon will not automatically accelerate upon a change in control. Under the terms of our employment agreement with Mr. Gordon, the following events constitute a change in control:

None of the employment agreements with our other NEOs (except for Dr. Gillings and Mr. Pike) provide for any specific benefits in the event of a change in control. However, the Compensation Committee has the discretion to determine whether awards will accelerate in the event of a sale of the Company (as defined in the 2013 Stock Incentive Plan).

Equity Awards

Each of our NEOs holds options to purchase shares of our common stock, Messrs. Gordon and Erlinger hold restricted stock units, each granted under our stock incentive plans. Our stock incentive plans do not provide for acceleration of vesting upon termination of employment (for any reason). None of the equity awards held by our NEOs (other than Messrs. Pike and Gordon) automatically accelerate upon a change in control; however, the Compensation Committee has discretion to determine whether awards will accelerate in the event of a sale of the Company (as defined in the 2013 Stock Incentive Plan).

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Potential Payments upon Events of Termination of Other Named Executive Officers

The following table sets forth our payment obligations to each of our other named executive officers upon termination of employment pursuant to the terms of such individual’s employment agreement and our other compensation plans under the various scenarios described above. The amounts set forth in the table are estimates and assume a termination of employment occurring on December 31, 2014 (the last business day of our last completed fiscal year). Due to the numerous factors involved in estimating these amounts, the actual value of benefits and amounts to be paid can only be determined upon an executive’s actual termination of employment.