The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACCURAY INC | COM | 004397105 | 3,746 | 750,000 | SH | DFND | 1 | 750,000 | 0 | 0 | |
| ADMA BIOLOGICS INC | COM | 000899104 | 8,061 | 964,193 | SH | DFND | 1 | 964,193 | 0 | 0 | |
| ADVAXIS INC | COM NEW | 007624208 | 17,768 | 1,736,834 | SH | DFND | 1 | 1,736,834 | 0 | 0 | |
| AEGERION PHARMACEUTICALS INC | COM | 00767E102 | 31,557 | 2,320,366 | SH | DFND | 1 | 2,320,366 | 0 | 0 | |
| ALCOBRA LTD | SHS | M2239P109 | 9,405 | 1,557,106 | SH | DFND | 1 | 1,557,106 | 0 | 0 | |
| AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 8,058 | 4,175,216 | SH | DFND | 1 | 4,175,216 | 0 | 0 | |
| AMPHASTAR PHARMACEUTICALS IN | COM | 03209R103 | 14,928 | 1,276,979 | SH | DFND | 1 | 1,276,979 | 0 | 0 | |
| AMPLIPHI BIOSCIENCES CORP | COM NEW | 03211P202 | 2,180 | 552,000 | SH | DFND | 1 | 552,000 | 0 | 0 | |
| ANGIODYNAMICS INC | COM | 03475V101 | 31,637 | 2,398,527 | SH | DFND | 1 | 2,398,527 | 0 | 0 | |
| ANTARES PHARMA INC | COM | 036642106 | 14,408 | 8,475,000 | SH | DFND | 1 | 8,475,000 | 0 | 0 | |
| ANTHERA PHARMACEUTICALS ORD | COM | 03674U201 | 7,032 | 1,154,674 | SH | DFND | 1 | 1,154,674 | 0 | 0 | |
| ARATANA THERAPEUTICS INC | COM | 03874P101 | 11,081 | 1,309,865 | SH | DFND | 1 | 1,309,865 | 0 | 0 | |
| ARDELYX INC | COM | 039697107 | 9,492 | 549,290 | SH | DFND | 1 | 549,290 | 0 | 0 | |
| ATRICURE INC | COM | 04963C209 | 8,841 | 403,519 | SH | DFND | 1 | 403,519 | 0 | 0 | |
| BIODEL INC | COM NEW | 09064M204 | 2,268 | 5,155,530 | SH | DFND | 1 | 5,155,530 | 0 | 0 | |
| BIODELIVERY SCIENCES INTL IN | COM | 09060J106 | 26,377 | 4,744,060 | SH | DFND | 1 | 4,744,060 | 0 | 0 | |
| BIODELIVERY SCIENCES INTL IN | COM | 09060J106 | 1,390 | 250,000 | SH | Call | DFND | 1 | 250,000 | 0 | 0 |
| BIOTA PHARMACEUTIALS INC | COM | 090694100 | 6,904 | 3,486,711 | SH | DFND | 1 | 3,486,711 | 0 | 0 | |
| BOVIE MEDICAL CORP | COM | 10211F100 | 1,847 | 947,400 | SH | DFND | 1 | 947,400 | 0 | 0 | |
| CARBYLAN THERAPEUTICS INC | COM | 141384107 | 4,209 | 1,178,941 | SH | DFND | 1 | 1,178,941 | 0 | 0 | |
| CARDICA INC | COM | 14141R101 | 2,396 | 8,874,992 | SH | DFND | 1 | 8,874,992 | 0 | 0 | |
| CARDIOVASCULAR SYS INC DEL | COM | 141619106 | 19,008 | 1,200,000 | SH | DFND | 1 | 19,008 | 0 | 0 | |
| CAS MED SYS INC | COM PAR $0.004 | 124769209 | 3,273 | 2,618,296 | SH | DFND | 1 | 2,618,296 | 0 | 0 | |
| CATALYST PHARMACEUTICALS INC | COM | 14888U101 | 12,550 | 4,183,177 | SH | DFND | 1 | 4,183,177 | 0 | 0 | |
| CIDARA THERAPEUTICS INC | COM | 171757107 | 2,123 | 166,875 | SH | DFND | 1 | 166,875 | 0 | 0 | |
| CONTRAFECT CORP | COM | 212326102 | 6,312 | 1,418,439 | SH | DFND | 1 | 1,418,439 | 0 | 0 | |
| CORIUM INTL INC | COM | 21887L107 | 16,850 | 1,802,092 | SH | DFND | 1 | 1,802,092 | 0 | 0 | |
| CYNAPSUS THERAPEUTICS INC | COM PAR NO PAR | 23257Y859 | 9,052 | 586,117 | SH | DFND | 1 | 586,117 | 0 | 0 | |
| DERMA SCIENCES INC | COM PAR NO PAR | 249827502 | 11,126 | 2,362,104 | SH | DFND | 1 | 2,362,104 | 0 | 0 | |
| DIPEXIUM PHARMACEUTICALS INC | COM | 25456J104 | 6,524 | 465,978 | SH | DFND | 1 | 465,978 | 0 | 0 | |
| DISCOVERY LABORATORIES INC N | COM NEW | 254668403 | 2,847 | 9,489,166 | SH | DFND | 1 | 9,489,166 | 0 | 0 | |
| DYNAVAX TECHNOLOGIES CORP | COM NEW | 268158201 | 19,379 | 789,710 | SH | DFND | 1 | 789,710 | 0 | 0 | |
| EGALET CORP | COM NEW | 28226B104 | 14,956 | 1,134,750 | SH | DFND | 1,134,750 | 0 | 0 | ||
| EMERGENT BIOSOLUTIONS INC | COM | 29089Q105 | 46,206 | 1,621,832 | SH | DFND | 1 | 1,621,832 | 0 | 0 | |
| EPIRUS BIOPHARMACEUTICALS IN | COM | 29428P107 | 3,426 | 775,000 | SH | DFND | 1 | 775,000 | 0 | 0 | |
| FATE THERAPEUTICS INC | COM | 31189P102 | 5,938 | 1,113,986 | SH | DFND | 1 | 1,113,986 | 0 | 0 | |
| FLAMEL TECHNOLOGIES SA | SPONSORED ADR | 338488109 | 71,674 | 4,394,464 | SH | DFND | 1 | 4,394,464 | 0 | 0 | |
| FLEXION THERAPEUTICS INC | SPONSORED ADR | 33938J106 | 4,803 | 323,188 | SH | DFND | 1 | 323,188 | 0 | 0 | |
| GENOCEA BIOSCIENCES INC | COM | 372427104 | 7,167 | 1,046,243 | SH | DFND | 1 | 1,046,243 | 0 | 0 | |
| HEARTWARE INTERNATIONAL | COM | 422368100 | 12,537 | 239,675 | SH | DFND | 1 | 239,675 | 0 | 0 | |
| HERON THERAPEUTICS INC | COM | 427746102 | 45,433 | 1,862,001 | SH | DFND | 1 | 1,862,001 | 0 | 0 | |
| HERON THERAPEUTICS INC | COM | 427746102 | 12,200 | 500,000 | SH | Call | DFND | 1 | 500,000 | 0 | 0 |
| HORIZON PHARMA PLC | COM | G4617B105 | 132,108 | 6,665,391 | SH | DFND | 1 | 6,665,391 | 0 | 0 | |
| HORIZON PHARMA PLC | SHS | G4617B105 | 9,910 | 500,000 | SH | Call | DFND | 1 | 500,000 | 0 | 0 |
| IDERA PHARMACEUTICALS INC | SHS | 45168K306 | 17,467 | 5,213,979 | SH | DFND | 5,213,979 | 0 | 0 | ||
| IGI LABS | COM | 449575109 | 14,962 | 2,287,728 | SH | DFND | 1 | 2,287,728 | 0 | 0 | |
| IGNYTA INC | COM NEW | 451731103 | 19,812 | 2,256,546 | SH | DFND | 1 | 2,256,546 | 0 | 0 | |
| IRADIMED CORP | COM | 46266A109 | 5,612 | 230,358 | SH | DFND | 1 | 230,358 | 0 | 0 | |
| ISHARES TR | RUSSELL 2000 ETF | 464287655 | 436,800 | 4,000,000 | SH | Put | DFND | 1 | 4,000,000 | 0 | 0 |
| KEMPHARM INC | COM | 488445107 | 15,500 | 799,788 | SH | DFND | 1 | 799,788 | 0 | 0 | |
| LA JOLLA PHARMACEUTICAL CO | COM PAR $.0001 2 | 503459604 | 30,440 | 1,095,373 | SH | DFND | 1 | 1,095,373 | 0 | 0 | |
| LION BIOTECHNOLOGIES INC | COM | 53619R102 | 12,128 | 2,105,519 | SH | DFND | 1 | 2,105,519 | 0 | 0 | |
| MASIMO ORD | COM | 574795100 | 16,262 | 421,728 | SH | DFND | 1 | 421,728 | 0 | 0 | |
| MEDGENICS INC | COM NEW | 58436Q203 | 12,084 | 1,545,306 | SH | DFND | 1,545,306 | 0 | 0 | ||
| MEDIWOUND LTD | ORD SHS | M68830104 | 3,888 | 509,573 | SH | DFND | 1 | 509,573 | 0 | 0 | |
| MELA SCIENCES INC | COM NEW | 55277R308 | 1,453 | 1,274,297 | SH | DFND | 1 | 1,274,297 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 10,178 | 295,700 | SH | DFND | 1 | 295,700 | 0 | 0 | |
| NEVRO CORP | COM | 64157F103 | 74,553 | 1,607,085 | SH | DFND | 1 | 1,607,085 | 0 | 0 | |
| NEVRO CORP | COM | 64157F103 | 9,278 | 200,000 | SH | Call | DFND | 1 | 200,000 | 0 | 0 |
| NOVADAQ TECHNOLOGIES INC | COM | 66987G102 | 19,907 | 1,908,648 | SH | DFND | 1 | 1,908,648 | 0 | 0 | |
| ONCOTHYREON | COM | 682324108 | 1,623 | 592,200 | SH | DFND | 1 | 592,200 | 0 | 0 | |
| ORASURE TECHNOLOGIES INC | COM | 68554V108 | 3,044 | 685,528 | SH | DFND | 1 | 685,528 | 0 | 0 | |
| PALATIN TECHNOLOGIES INC | COM PAR $ .01 | 696077403 | 1,108 | 1,368,085 | SH | DFND | 1 | 1,368,085 | 0 | 0 | |
| PARATEK PHARMACEUTICALS INC | COM | 699374302 | 10,075 | 530,283 | SH | DFND | 1 | 530,283 | 0 | 0 | |
| PERNIX THERAPEUTICS HLDGS IN | COM | 71426V108 | 19,247 | 6,090,829 | SH | DFND | 1 | 6,090,829 | 0 | 0 | |
| PERNIX THERAPEUTICS HLDGS IN | DEBT 4.250% 4/0 | 71426VAJ7 | 10,816 | 15,500,000 | SH | DFND | 1 | 15,500,000 | 0 | 0 | |
| PROGENICS PHARMACEUTICALS IN | COM | 743187106 | 51,201 | 8,951,169 | SH | DFND | 1 | 8,951,169 | 0 | 0 | |
| QLT INC | COM | 746927102 | 11,825 | 4,445,527 | SH | DFND | 1 | 4,445,527 | 0 | 0 | |
| RAPTOR PHARMACEUTICAL CORP | COM | 75382F106 | 8,549 | 1,412,995 | SH | DFND | 1 | 1,412,995 | 0 | 0 | |
| RECRO PHARMA INC | COM | 75629F109 | 24,783 | 2,060,086 | SH | DFND | 1 | 2,060,086 | 0 | 0 | |
| REDHILL BIOPHARMA LTD | SPONSORED ADS | 757468103 | 10,714 | 829,906 | SH | DFND | 1 | 829,906 | 0 | 0 | |
| RETROPHIN INC | COM | 761299106 | 52,874 | 2,609,790 | SH | DFND | 1 | 2,609,790 | 0 | 0 | |
| RETROPHIN INC | COM | 761299106 | 10,130 | 500,000 | SH | Call | DFND | 1 | 500,000 | 0 | 0 |
| RIGEL PHARMACEUTICALS INC | COM NEW | 766559603 | 12,659 | 5,125,282 | SH | DFND | 1 | 5,125,282 | 0 | 0 | |
| RITTER PHARMACEUTICALS INC | COM | 767836109 | 1,595 | 778,000 | SH | DFND | 1 | 778,000 | 0 | 0 | |
| RXI PHARMACEUTICALS CORP NEW | COM NEW | 74979C303 | 2,272 | 6,126,482 | SH | DFND | 1 | 6,126,482 | 0 | 0 | |
| SCYNEXIS INC | COM | 811292101 | 5,642 | 775,000 | SH | DFND | 1 | 775,000 | 0 | 0 | |
| SEASPINE HLDGS CORP | COM | 81255T108 | 16,200 | 1,000,007 | SH | DFND | 1 | 1,000,007 | 0 | 0 | |
| SPECTRANETICS CORP | COM | 84760C107 | 10,614 | 900,249 | SH | DFND | 1 | 900,249 | 0 | 0 | |
| SPECTRUM PHARMACEUTICALS | COM | 84763A108 | 15,050 | 2,516,748 | SH | DFND | 1 | 2,516,748 | 0 | 0 | |
| SYNERON MEDICAL LTD | ORD SHS | M87245102 | 7,545 | 1,055,221 | SH | DFND | 1 | 1,055,221 | 0 | 0 | |
| TENAX THERAPEUTICS INC | COM | 88032L100 | 5,906 | 1,968,631 | SH | DFND | 1 | 1,968,631 | 0 | 0 | |
| TETRAPHASE PHARMACEUTICALS | COM | 88165N105 | 1,194 | 160,047 | SH | DFND | 1 | 160,047 | 0 | 0 | |
| TONIX PHARMACEUTICALS HLDG C | COM NEW | 890260201 | 4,712 | 890,748 | SH | DFND | 1 | 890,748 | 0 | 0 | |
| TREVENA INC | COM | 89532E109 | 11,159 | 1,078,132 | SH | DFND | 1 | 1,078,132 | 0 | 0 | |
| VERACYTE INC | COM | 92337F107 | 3,453 | 736,196 | SH | DFND | 1 | 736,196 | 0 | 0 | |
| SPDR SERIES TRUST | S&P BIOTECH | 78464A870 | 62,250 | 1,000,000 | SH | Put | DFND | 1 | 1,000,000 | 0 | 0 |
| ZOGENIX INC | COM NEW | 98978L204 | 14,947 | 1,107,205 | SH | DFND | 1 | 1,107,205 | 0 | 0 | |
| ZOSANO PHARMA CORP | COM | 98979H103 | 1,472 | 371,842 | SH | DFND | 1 | 371,842 | 0 | 0 | |