The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACCURAY INC | COM | 004397105 | 6,510 | 700,000 | SH | DFND | 1 | 700,000 | 0 | 0 | |
| ADMA BIOLOGICS INC | COM | 000899104 | 9,449 | 964,193 | SH | DFND | 1 | 964,193 | 0 | 0 | |
| ADVAXIS INC | COM NEW | 007624208 | 11,639 | 805,994 | SH | DFND | 1 | 805,994 | 0 | 0 | |
| AEGERION PHARMACEUTICALS INC | COM | 00767E102 | 65,492 | 2,502,578 | SH | DFND | 1 | 2,502,578 | 0 | 0 | |
| AEGERION PHARMACEUTICALS INC | COM | 00767E102 | 1,309 | 50,000 | SH | Call | DFND | 1 | 50,000 | 0 | 0 |
| ALCOBRA LTD | SHS | M2239P109 | 8,760 | 1,556,016 | SH | DFND | 1 | 1,556,016 | 0 | 0 | |
| ALERE INC | COM | 01449J105 | 22,123 | 452,423 | SH | DFND | 1 | 452,423 | 0 | 0 | |
| ALLIQUA BIOMEDICAL INC | COM NEW | 019621200 | 1,148 | 220,675 | SH | DFND | 1 | 220,675 | 0 | 0 | |
| AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 2,321 | 991,883 | SH | DFND | 1 | 991,883 | 0 | 0 | |
| AMPHASTAR PHARMACEUTICALS IN | COM | 03209R103 | 31,833 | 2,127,854 | SH | DFND | 1 | 2,127,854 | 0 | 0 | |
| ANACOR PHARMACEUTICALS INC | COM | 032420101 | 10,663 | 184,320 | SH | DFND | 1 | 184,320 | 0 | 0 | |
| ANGIODYNAMICS INC | COM | 03475V101 | 42,670 | 2,398,527 | SH | DFND | 1 | 2,398,527 | 0 | 0 | |
| ANTARES PHARMA INC | COM | 036642106 | 12,737 | 4,700,000 | SH | DFND | 1 | 4,700,000 | 0 | 0 | |
| ANTHERA PHARMACEUTICALS INC | COM NEW | 03674U201 | 10,819 | 2,420,457 | SH | DFND | 1 | 2,420,457 | 0 | 0 | |
| AQUINOX PHARMACEUTICALS INC | COM | 03842B101 | 4,371 | 531,768 | SH | DFND | 1 | 531,768 | 0 | 0 | |
| ARATANA THERAPEUTICS INC | COM | 03874P101 | 18,121 | 1,131,865 | SH | DFND | 1 | 1,131,865 | 0 | 0 | |
| ATRICURE INC | COM | 04963C209 | 10,928 | 533,354 | SH | DFND | 1 | 533,354 | 0 | 0 | |
| BIODEL INC | COM NEW | 09064M204 | 1,583 | 1,330,034 | SH | DFND | 1 | 1,330,034 | 0 | 0 | |
| BIODELIVERY SCIENCES INTL IN | COM | 09060J106 | 23,587 | 2,246,399 | SH | DFND | 1 | 2,246,399 | 0 | 0 | |
| BIOLINERX LTD | SPONSORED ADR | 09071M106 | 6,541 | 3,100,000 | SH | DFND | 1 | 3,100,000 | 0 | 0 | |
| BIOTA PHARMACEUTIALS INC | COM | 090694100 | 6,007 | 2,611,711 | SH | DFND | 1 | 2,611,711 | 0 | 0 | |
| BOVIE MEDICAL CORP | COM | 10211F100 | 2,416 | 1,011,000 | SH | DFND | 1 | 1,011,000 | 0 | 0 | |
| CAPRICOR THERAPEUTICS INC | COM | 14070B101 | 4,868 | 705,882 | SH | DFND | 1 | 705,882 | 0 | 0 | |
| CARDICA INC | COM | 14141R101 | 5,589 | 8,874,992 | SH | DFND | 1 | 8,874,992 | 0 | 0 | |
| CAS MED SYS INC | COM PAR $0.004 | 124769209 | 3,495 | 2,618,296 | SH | DFND | 1 | 2,618,296 | 0 | 0 | |
| CATALYST PHARM PARTNERS INC | COM | 14888U101 | 17,680 | 4,083,177 | SH | DFND | 1 | 4,083,177 | 0 | 0 | |
| CORIUM INTL INC | COM | 21887L107 | 11,376 | 1,736,736 | SH | DFND | 1 | 1,736,736 | 0 | 0 | |
| CONMED CORP | COM | 207410101 | 4,931 | 97,657 | SH | DFND | 1 | 97,657 | 0 | 0 | |
| DEPOMED INC | COM | 249908104 | 15,804 | 705,204 | SH | DFND | 1 | 705,204 | 0 | 0 | |
| DERMA SCIENCES INC | COM PAR $.01 | 249827502 | 18,045 | 2,130,477 | SH | DFND | 1 | 2,130,477 | 0 | 0 | |
| DIPEXIUM PHARMACEUTICALS INC | COM | 25456J104 | 6,479 | 475,000 | SH | DFND | 1 | 475,000 | 0 | 0 | |
| DISCOVERY LABORATORIES INC N | COM NEW | 254668403 | 9,606 | 8,072,500 | SH | DFND | 1 | 8,072,500 | 0 | 0 | |
| DURECT CORP | COM | 266605104 | 7,458 | 3,904,495 | SH | DFND | 1 | 3,904,495 | 0 | 0 | |
| DYNAVAX TECHNOLOGIES CORP | COM NEW | 268158201 | 17,182 | 766,010 | SH | DFND | 1 | 766,010 | 0 | 0 | |
| ELEVEN BIOTHERAPEUTICS INC | COM | 286221106 | 8,617 | 966,057 | SH | DFND | 1 | 966,057 | 0 | 0 | |
| EMERGENT BIOSOLUTIONS INC | COM | 29089Q105 | 52,071 | 1,810,519 | SH | DFND | 1 | 1,810,519 | 0 | 0 | |
| EPIRUS BIOPHARMACEUTICALS IN | COM | 29428P107 | 6,936 | 775,000 | SH | DFND | 1 | 775,000 | 0 | 0 | |
| FATE THERAPEUTICS INC | COM | 31189P102 | 344 | 70,428 | SH | DFND | 1 | 70,428 | 0 | 0 | |
| FLAMEL TECHNOLOGIES SA | SPONSORED ADR | 338488109 | 84,865 | 4,719,959 | SH | DFND | 1 | 4,719,959 | 0 | 0 | |
| FLEXION THERAPEUTICS INC | COM | 33938J106 | 7,842 | 348,204 | SH | DFND | 1 | 348,204 | 0 | 0 | |
| GENOCEA BIOSCIENCES INC | COM | 372427104 | 12,275 | 1,035,000 | SH | DFND | 1 | 1,035,000 | 0 | 0 | |
| GENOMIC HEALTH INC | COM | 37244C101 | 2,291 | 75,000 | SH | DFND | 1 | 75,000 | 0 | 0 | |
| HERON THERAPEUTICS INC | COM | 427746102 | 40,859 | 2,808,173 | SH | DFND | 1 | 2,808,173 | 0 | 0 | |
| HORIZON PHARMA PLC | SHS | G4617B105 | 183,179 | 7,053,504 | SH | DFND | 1 | 7,053,504 | 0 | 0 | |
| HORIZON PHARMA PLC | SHS | G4617B105 | 12,985 | 500,000 | SH | Call | DFND | 1 | 500,000 | 0 | 0 |
| IDERA PHARMACEUTICALS INC | COM NEW | 45168K306 | 21,013 | 5,663,845 | SH | DFND | 1 | 5,663,845 | 0 | 0 | |
| IGI LABS INC | COM | 449575109 | 8,160 | 1,000,000 | SH | DFND | 1 | 1,000,000 | 0 | 0 | |
| IGNYTA INC | COM | 451731103 | 17,330 | 1,741,700 | SH | DFND | 1 | 1,741,700 | 0 | 0 | |
| IRADIMED CORP | COM | 46266A109 | 5,443 | 357,364 | SH | DFND | 1 | 357,364 | 0 | 0 | |
| LA JOLLA PHARMACEUTICAL CO | COM PAR $.0001 2 | 503459604 | 12,874 | 703,470 | SH | DFND | 1 | 703,470 | 0 | 0 | |
| LION BIOTECHNOLOGIES INC | COM | 53619R102 | 12,866 | 1,062,419 | SH | DFND | 1 | 1,062,419 | 0 | 0 | |
| MEDGENICS INC | COM NEW | 58436Q203 | 8,262 | 1,025,000 | SH | DFND | 1 | 1,025,000 | 0 | 0 | |
| MELA SCIENCES INC | COM NEW | 55277R308 | 1,511 | 587,915 | SH | DFND | 1 | 587,915 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 8,985 | 306,463 | SH | DFND | 1 | 306,463 | 0 | 0 | |
| NOVADAQ TECHNOLOGIES INC | COM | 66987G102 | 5,260 | 323,863 | SH | DFND | 1 | 323,863 | 0 | 0 | |
| OHR PHARMACEUTICAL INC | COM NEW | 67778H200 | 4,509 | 1,775,000 | SH | DFND | 1 | 1,775,000 | 0 | 0 | |
| ONCOTHYREON INC | COM | 682324108 | 5,705 | 3,500,000 | SH | DFND | 1 | 3,500,000 | 0 | 0 | |
| ORASURE TECHNOLOGIES INC | COM | 68554V108 | 327 | 50,000 | SH | DFND | 1 | 50,000 | 0 | 0 | |
| PARATEK PHARMACEUTICALS INC | COM | 699374302 | 8,136 | 260,283 | SH | DFND | 1 | 260,283 | 0 | 0 | |
| PERNIX THERAPEUTICS HLDGS IN | COM | 71426V108 | 23,179 | 2,168,326 | SH | DFND | 1 | 2,168,326 | 0 | 0 | |
| PROGENICS PHARMACEUTICALS IN | COM | 743187106 | 3,588 | 600,000 | SH | Call | DFND | 1 | 600,000 | 0 | 0 |
| PROGENICS PHARMACEUTICALS IN | COM | 743187106 | 1,794 | 300,000 | SH | Call | DFND | 1 | 300,000 | 0 | 0 |
| PROGENICS PHARMACEUTICALS IN | COM | 743187106 | 53,528 | 8,951,169 | SH | DFND | 1 | 8,951,169 | 0 | 0 | |
| QLT INC | COM | 746927102 | 4,479 | 1,145,527 | SH | DFND | 1 | 1,145,527 | 0 | 0 | |
| RECRO PHARMA INC | COM | 75629F109 | 12,821 | 1,413,533 | SH | DFND | 1 | 1,413,533 | 0 | 0 | |
| REDHILL BIOPHARMA LTD | SPONSORED ADS | 757468103 | 7,046 | 484,281 | SH | DFND | 1 | 484,281 | 0 | 0 | |
| RETROPHIN INC | COM | 761299106 | 70,977 | 2,962,298 | SH | DFND | 1 | 2,962,298 | 0 | 0 | |
| RETROPHIN INC | COM | 761299106 | 11,198 | 500,000 | SH | Call | DFND | 1 | 500,000 | 0 | 0 |
| RIGEL PHARMACEUTICALS INC | COM NEW | 766559603 | 29,439 | 8,246,329 | SH | DFND | 1 | 8,246,329 | 0 | 0 | |
| RXI PHARMACEUTICALS CORP NEW | COM NEW | 74979C303 | 811 | 1,126,482 | SH | DFND | 1 | 1,126,482 | 0 | 0 | |
| SPECTRUM PHARMACEUTICALS INC | COM | 84763A108 | 4,856 | 800,000 | SH | DFND | 1 | 800,000 | 0 | 0 | |
| SYNERON MEDICAL LTD | ORD SHS | M87245102 | 12,445 | 1,005,221 | SH | DFND | 1 | 1,005,221 | 0 | 0 | |
| TANDEM DIABETES CARE INC | COM | 875372104 | 1,287 | 101,957 | SH | DFND | 1 | 101,957 | 0 | 0 | |
| TEARLAB CORP | COM | 878193101 | 1,820 | 914,499 | SH | DFND | 1 | 914,499 | 0 | 0 | |
| TENAX THERAPEUTICS INC | COM | 88032L100 | 6,418 | 1,968,631 | SH | DFND | 1 | 1,968,631 | 0 | 0 | |
| TONIX PHARMACEUTICALS HLDG C | COM NEW | 890260201 | 7,436 | 1,176,639 | SH | DFND | 1 | 1,176,639 | 0 | 0 | |
| TORNIER N V | SHS | N87237108 | 2,622 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| TREVENA INC | COM | 89532E109 | 9,188 | 1,409,153 | SH | DFND | 1 | 1,409,153 | 0 | 0 | |
| UNILIFE CORP NEW | COM | 90478E103 | 4,612 | 1,150,000 | SH | DFND | 1 | 1,150,000 | 0 | 0 | |
| UNIVERSAL AMERN CORP NEW | COM | 91338E101 | 12,111 | 1,133,989 | SH | DFND | 1 | 1,133,989 | 0 | 0 | |
| VERASTEM INC | COM | 92337C104 | 10,679 | 1,050,000 | SH | DFND | 1 | 1,050,000 | 0 | 0 | |
| XOMA CORP DEL | COM | 98419J107 | 5,460 | 1,500,000 | SH | DFND | 1 | 1,500,000 | 0 | 0 | |
| ZOGENIX INC | COM | 98978L105 | 14,711 | 10,737,645 | SH | DFND | 1 | 10,737,645 | 0 | 0 | |
| ZOSANO PHARMA CORP | COM | 98979H103 | 4,903 | 485,000 | SH | DFND | 1 | 485,000 | 0 | 0 | |