The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACCURAY INC | COM | 004397105 | 5,285 | 700,000 | SH | DFND | 1 | 700,000 | 0 | 0 | |
| ADMA BIOLOGICS INC | COM | 000899104 | 4,347 | 389,193 | SH | DFND | 1 | 389,193 | 0 | 0 | |
| AEGERION PHARMACEUTICALS INC | COM | 00767E102 | 53,373 | 2,548,863 | SH | DFND | 1 | 2,548,863 | 0 | 0 | |
| AEGERION PHARMACEUTICALS INC | COM | 00767E102 | 3,141 | 150,000 | SH | Call | DFND | 1 | 1,500 | 0 | 0 |
| ALLIQUA INC | COM NEW | 019621200 | 6,206 | 1,170,910 | SH | DFND | 1 | 1,170,910 | 0 | 0 | |
| ALMOST FAMILY INC | COM | 020409108 | 3,730 | 128,841 | SH | DFND | 1 | 128,841 | 0 | 0 | |
| AMAG PHARMACEUTICALS INC | COM | 00163U106 | 24,444 | 573,530 | SH | DFND | 1 | 573,530 | 0 | 0 | |
| AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 2,188 | 2,233,746 | SH | DFND | 1 | 2,233,746 | 0 | 0 | |
| AMPHASTAR PHARMACEUTICALS IN | COM | 03209R103 | 24,704 | 2,127,854 | SH | DFND | 1 | 2,127,854 | 0 | 0 | |
| ANACOR PHARMACEUTICALS INC | COM | 032420101 | 16,264 | 504,320 | SH | DFND | 1 | 504,320 | 0 | 0 | |
| ANGIODYNAMICS INC | COM | 03475V101 | 50,770 | 2,670,703 | SH | DFND | 1 | 2,670,703 | 0 | 0 | |
| ANTARES PHARMA INC | COM | 036642106 | 12,079 | 4,700,000 | SH | DFND | 1 | 4,700,000 | 0 | 0 | |
| ANTHERA PHARMACEUTICALS INC | COM NEW | 03674U201 | 2,818 | 1,783,812 | SH | DFND | 1 | 1,783,812 | 0 | 0 | |
| AQUINOX PHARMACEUTICALS INC | COM | 03842B101 | 3,988 | 531,768 | SH | DFND | 1 | 531,768 | 0 | 0 | |
| ARATANA THERAPEUTICS INC | COM | 03874P101 | 22,444 | 1,259,471 | SH | DFND | 1 | 1,259,471 | 0 | 0 | |
| ATRICURE INC | COM | 04963C209 | 16,485 | 825,902 | SH | DFND | 1 | 825,902 | 0 | 0 | |
| AUSPEX PHARMACEUTICALS INC | COM | 05211J102 | 5,248 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| BIODEL INC | COM NEW | 09064M204 | 1,769 | 1,330,034 | SH | DFND | 1 | 1,330,034 | 0 | 0 | |
| BIODELIVERY SCIENCES INTL IN | COM | 09060J106 | 28,805 | 2,396,399 | SH | DFND | 1 | 2,396,399 | 0 | 0 | |
| BIOTA PHARMACEUTIALS INC | COM | 090694100 | 5,850 | 2,611,711 | SH | DFND | 1 | 2,611,711 | 0 | 0 | |
| CARDICA INC | COM | 14141R101 | 6,212 | 8,874,992 | SH | DFND | 1 | 8,874,992 | 0 | 0 | |
| CAS MED SYS INC | COM PAR $0.004 | 124769209 | 3,165 | 1,918,296 | SH | DFND | 1 | 1,918,296 | 0 | 0 | |
| CATALYST PHARM PARTNERS INC | COM | 14888U101 | 7,128 | 2,400,000 | SH | DFND | 1 | 2,400,000 | 0 | 0 | |
| CELSUS THERAPEUTICS PLC | SPONSORED ADR NE | 15119A202 | 2,260 | 470,877 | SH | DFND | 1 | 470,877 | 0 | 0 | |
| CEMPRA INC | COM | 15130J109 | 6,692 | 284,625 | SH | DFND | 1 | 284,625 | 0 | 0 | |
| CONMED CORP | COM | 207410101 | 11,240 | 250,000 | SH | DFND | 1 | 250,000 | 0 | 0 | |
| CORIUM INTL INC | COM | 21887L107 | 10,594 | 1,736,736 | SH | DFND | 1 | 1,736,736 | 0 | 0 | |
| DEPOMED INC | COM | 249908104 | 27,608 | 1,713,702 | SH | DFND | 1 | 1,713,702 | 0 | 0 | |
| DERMA SCIENCES INC | COM PAR $.01 | 249827502 | 17,288 | 1,856,877 | SH | DFND | 1 | 1,856,877 | 0 | 0 | |
| DIPEXIUM PHARMACEUTICALS INC | COM | 25456J104 | 5,408 | 475,000 | SH | DFND | 1 | 475,000 | 0 | 0 | |
| DISCOVERY LABORATORIES INC N | COM NEW | 254668403 | 9,357 | 8,066,000 | SH | DFND | 1 | 8,066,000 | 0 | 0 | |
| DURECT CORP | COM | 266605104 | 3,476 | 4,404,495 | SH | DFND | 1 | 4,404,495 | 0 | 0 | |
| DYNAVAX TECHNOLOGIES CORP | COM NEW | 268158201 | 12,915 | 766,010 | SH | DFND | 1 | 766,010 | 0 | 0 | |
| ELEVEN BIOTHERAPEUTICS INC | COM | 286221106 | 11,483 | 108,900 | SH | DFND | 1 | 108,900 | 0 | 0 | |
| EMERGENT BIOSOLUTIONS INC | COM | 29089Q105 | 56,277 | 2,066,719 | SH | DFND | 1 | 3,500,000 | 0 | 0 | |
| FLAMEL TECHNOLOGIES SA | SPONSORED ADR | 338488109 | 88,274 | 5,153,190 | SH | DFND | 1 | 5,153,190 | 0 | 0 | |
| FLEXION THERAPEUTICS INC | COM | 33938J106 | 8,343 | 413,204 | SH | DFND | 1 | 413,204 | 0 | 0 | |
| HEARTWARE INTL INC | COM | 422368100 | 3,672 | 50,000 | SH | DFND | 1 | 50,000 | 0 | 0 | |
| HERON THERAPEUTICS INC | COM | 427746102 | 28,250 | 2,808,173 | SH | DFND | 1 | 2,808,173 | 0 | 0 | |
| HORIZON PHARMA PLC | SHS | G4617B105 | 114,953 | 8,917,975 | SH | DFND | 1 | 8,917,975 | 0 | 0 | |
| HORIZON PHARMA PLC | SHS | G4617B105 | 3,867 | 300,000 | SH | Call | DFND | 1 | 3,000 | 0 | 0 |
| IDERA PHARMACEUTICALS INC | COM NEW | 45168K306 | 15,548 | 3,525,700 | SH | DFND | 1 | 3,525,700 | 0 | 0 | |
| IGI LABS INC | COM | 449575109 | 8,578 | 974,810 | SH | DFND | 1 | 974,810 | 0 | 0 | |
| IGNYTA INC | COM | 451731103 | 4,396 | 225,000 | SH | DFND | 1 | 225,000 | 0 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 7,601 | 386,612 | SH | DFND | 1 | 386,612 | 0 | 0 | |
| IRADIMED CORP | COM | 46266A109 | 4,655 | 360,884 | SH | DFND | 1 | 360,884 | 0 | 0 | |
| KINDRED HEALTHCARE INC | COM | 494580103 | 20,185 | 1,110,300 | SH | DFND | 1 | 1,110,300 | 0 | 0 | |
| LA JOLLA PHARMACEUTICAL CO | COM PAR $.0001 2 | 503459604 | 20,689 | 1,121,370 | SH | DFND | 1 | 1,121,370 | 0 | 0 | |
| LIGAND PHARMACEUTICALS INC | COM NEW | 53220K504 | 10,589 | 199,000 | SH | DFND | 1 | 199,000 | 0 | 0 | |
| MASIMO CORP | COM | 574795100 | 2,579 | 97,900 | SH | DFND | 1 | 97,900 | 0 | 0 | |
| MEDGENICS INC | COM NEW | 58436Q203 | 5,187 | 1,025,000 | SH | DFND | 1 | 1,025,000 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 3,422 | 184,756 | SH | DFND | 1 | 184,756 | 0 | 0 | |
| NOVADAQ TECHNOLOGIES INC | COM | 66987G102 | 5,176 | 311,403 | SH | DFND | 1 | 311,403 | 0 | 0 | |
| ONCOTHYREON INC | COM | 682324108 | 3,800 | 2,000,000 | SH | DFND | 1 | 2,000,000 | 0 | 0 | |
| PARATEK PHARMACEUTICALS INC | COM | 699374302 | 8,027 | 260,283 | SH | DFND | 1 | 260,283 | 0 | 0 | |
| PERNIX THERAPEUTICS HLDGS IN | COM | 71426V108 | 28,640 | 3,050,000 | SH | DFND | 1 | 3,050,000 | 0 | 0 | |
| PROGENICS PHARMACEUTICALS IN | COM | 743187106 | 1,512 | 200,000 | SH | Call | DFND | 1 | 2,000 | 0 | 0 |
| PROGENICS PHARMACEUTICALS IN | COM | 743187106 | 67,671 | 8,951,169 | SH | DFND | 1 | 8,951,169 | 0 | 0 | |
| QLT INC | COM | 746927102 | 4,594 | 1,145,527 | SH | DFND | 1 | 1,145,527 | 0 | 0 | |
| RAPTOR PHARMACEUTICAL CORP | COM | 75382F106 | 164 | 15,558 | SH | DFND | 1 | 15,558 | 0 | 0 | |
| RECRO PHARMA INC | COM | 75629F109 | 4,043 | 1,413,533 | SH | DFND | 1 | 1,413,533 | 0 | 0 | |
| REDHILL BIOPHARMA LTD | SPONSORED ADS | 757468103 | 3,353 | 251,509 | SH | DFND | 1 | 251,509 | 0 | 0 | |
| RETROPHIN INC | COM | 761299106 | 32,544 | 2,658,854 | SH | DFND | 1 | 2,549,874 | 0 | 0 | |
| RIGEL PHARMACEUTICALS INC | COM NEW | 766559603 | 19,299 | 8,501,750 | SH | DFND | 1 | 8,501,750 | 0 | 0 | |
| RXI PHARMACEUTICALS CORP NEW | COM NEW | 74979C303 | 1,802 | 1,126,482 | SH | DFND | 1 | 1,126,482 | 0 | 0 | |
| SALIX PHARMACEUTICALS INC | COM | 795435106 | 11,494 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| SYNERON MEDICAL LTD | ORD SHS | M87245102 | 9,379 | 1,005,221 | SH | DFND | 1 | 1,005,221 | 0 | 0 | |
| TENAX THERAPEUTICS INC | COM | 88032L100 | 7,560 | 1,968,631 | SH | DFND | 1 | 1,968,631 | 0 | 0 | |
| THORATEC CORP | COM NEW | 885175307 | 16,230 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |
| TONIX PHARMACEUTICALS HLDG C | COM NEW | 890260201 | 2,930 | 501,639 | SH | DFND | 1 | 501,639 | 0 | 0 | |
| TREVENA INC | COM | 89532E109 | 8,427 | 1,409,153 | SH | DFND | 1 | 1,409,153 | 0 | 0 | |
| UNIVERSAL AMERN CORP NEW | COM | 91338E101 | 16,106 | 1,735,553 | SH | DFND | 1 | 1,735,553 | 0 | 0 | |
| VOLCANO CORPORATION | COM | 928645100 | 44,608 | 2,494,854 | SH | DFND | 1 | 2,494,854 | 0 | 0 | |
| XENCOR INC | COM | 98401F105 | 8,355 | 520,881 | SH | DFND | 1 | 520,881 | 0 | 0 | |
| ZOGENIX INC | COM | 98978L105 | 8,546 | 6,237,645 | SH | DFND | 1 | 6,237,645 | 0 | 0 | |