The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
|
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
|
||||||||||||||||
| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACCURAY INC | COM | 004397105 | 3,630 | 500,000 | SH | DFND | 500,000 | 0 | 0 | ||
| AEGERION PHARMACEUTICALS INC | COM | 00767E102 | 33,599 | 1,006,562 | SH | DFND | 1,006,562 | 0 | 0 | ||
| ALLIQUA INC | COM NEW | 019621200 | 5,996 | 1,545,296 | SH | DFND | 1,545,296 | 0 | 0 | ||
| ALMOST FAMILY INC | COM | 020409108 | 6,092 | 224,230 | SH | DFND | 224,230 | 0 | 0 | ||
| AMAG PHARMACEUTICALS INC | COM | 00163U106 | 48,209 | 1,510,775 | SH | DFND | 1,510,775 | 0 | 0 | ||
| AMPHASTAR PHARMACEUTICALS IN | COM | 03209R103 | 23,042 | 1,977,854 | SH | DFND | 1,977,854 | 0 | 0 | ||
| ANACOR PHARMACEUTICALS INC | COM | 032420101 | 19,107 | 780,820 | SH | DFND | 780,820 | 0 | 0 | ||
| ANGIODYNAMICS INC | COM | 03475V101 | 40,820 | 2,975,227 | SH | DFND | 2,975,227 | 0 | 0 | ||
| ANTARES PHARMA INC | COM | 036642106 | 6,771 | 3,700,000 | SH | DFND | 3,700,000 | 0 | 0 | ||
| ANTHERA PHARMACEUTICALS INC | COM NEW | 03674U201 | 2,499 | 1,301,622 | SH | DFND | 1,301,622 | 0 | 0 | ||
| AQUINOX PHARMACEUTICALS INC | COM | 03842B101 | 3,400 | 510,500 | SH | DFND | 510,500 | 0 | 0 | ||
| ARATANA THERAPEUTICS INC | COM | 03874P101 | 14,482 | 1,442,435 | SH | DFND | 1,442,435 | 0 | 0 | ||
| ATRICURE INC | COM | 04963C209 | 13,629 | 925,902 | SH | DFND | 925,902 | 0 | 0 | ||
| BIODEL INC | COM NEW | 09064M204 | 2,221 | 1,330,034 | SH | DFND | 1,330,034 | 0 | 0 | ||
| BIODELIVERY SCIENCES INTL IN | COM | 09060J106 | 34,734 | 2,032,435 | SH | DFND | 2,032,435 | 0 | 0 | ||
| BIOTA PHARMACEUTIALS INC | COM | 090694100 | 6,451 | 2,611,711 | SH | DFND | 2,611,711 | 0 | 0 | ||
| BROOKDALE SR LIVING INC | COM | 112463104 | 9,763 | 303,000 | SH | DFND | 303,000 | 0 | 0 | ||
| CARDICA INC | COM | 14141R101 | 9,496 | 8,873,992 | SH | DFND | 8,873,992 | 0 | 0 | ||
| CAS MED SYS INC | COM PAR $0.004 | 124769209 | 3,721 | 1,918,296 | SH | DFND | 1,918,296 | 0 | 0 | ||
| CATALYST PHARM PARTNERS INC | COM | 14888U101 | 4,648 | 1,400,000 | SH | DFND | 1,400,000 | 0 | 0 | ||
| CELSUS THERAPEUTICS PLC | SPONSORED ADR NE | 15119A202 | 2,872 | 470,877 | SH | DFND | 470,877 | 0 | 0 | ||
| CEMPRA INC | COM | 15130J109 | 10,468 | 955,147 | SH | DFND | 955,147 | 0 | 0 | ||
| CHEMOCENTRYX INC | COM | 16383L106 | 3,600 | 800,000 | SH | DFND | 800,000 | 0 | 0 | ||
| CONMED CORP | COM | 207410101 | 5,526 | 150,000 | SH | DFND | 150,000 | 0 | 0 | ||
| CORIUM INTL INC | COM | 21887L107 | 8,596 | 1,400,000 | SH | DFND | 1,400,000 | 0 | 0 | ||
| DEPOMED INC | COM | 249908104 | 35,145 | 2,313,702 | SH | DFND | 2,313,702 | 0 | 0 | ||
| DERMA SCIENCES INC | COM PAR $.01 | 249827502 | 15,197 | 1,824,377 | SH | DFND | 1,824,377 | 0 | 0 | ||
| DIGIRAD CORP | COM | 253827109 | 1,307 | 332,480 | SH | DFND | 332,480 | 0 | 0 | ||
| DIPEXIUM PHARMACEUTICALS INC | COM | 25456J104 | 4,726 | 475,000 | SH | DFND | 475,000 | 0 | 0 | ||
| DISCOVERY LABORATORIES INC N | COM NEW | 254668403 | 14,841 | 8,066,000 | SH | DFND | 8,066,000 | 0 | 0 | ||
| DURECT CORP | COM | 266605104 | 6,475 | 4,404,495 | SH | DFND | 4,404,495 | 0 | 0 | ||
| DYNAVAX TECHNOLOGIES CORP | COM | 268158102 | 10,954 | 7,660,100 | SH | DFND | 7,660,100 | 0 | 0 | ||
| ELEVEN BIOTHERAPEUTICS INC | COM | 286221106 | 9,555 | 857,715 | SH | DFND | 857,715 | 0 | 0 | ||
| EMERGENT BIOSOLUTIONS INC | COM | 29089Q105 | 44,336 | 2,080,519 | SH | DFND | 2,080,519 | 0 | 0 | ||
| FLAMEL TECHNOLOGIES SA | SPONSORED ADR | 338488109 | 71,630 | 5,005,613 | SH | DFND | 5,005,613 | 0 | 0 | ||
| FLEXION THERAPEUTICS INC | COM | 33938J106 | 3,893 | 213,204 | SH | DFND | 213,204 | 0 | 0 | ||
| HERON THERAPEUTICS INC | COM | 427746102 | 23,392 | 2,808,173 | SH | DFND | 2,808,173 | 0 | 0 | ||
| HORIZON PHARMA PLC | COM | G4617B105 | 62,491 | 5,088,883 | SH | DFND | 5,088,883 | 0 | 0 | ||
| HORIZON PHARMA PLC | COM | G4617B105 | 450 | 2,000 | SH | Call | DFND | 2,000 | 0 | 0 | |
| IDERA PHARMACEUTICALS INC | COM NEW | 45168K306 | 8,074 | 3,525,700 | SH | DFND | 3,525,700 | 0 | 0 | ||
| IGI LABS INC | COM | 449575109 | 10,576 | 1,134,810 | SH | DFND | 1,134,810 | 0 | 0 | ||
| IGNYTA INC | COM | 451731103 | 5,172 | 225,000 | SH | DFND | 225,000 | 0 | 0 | ||
| IMPAX LABORATORIES INC | COM | 45256B101 | 15,623 | 658,929 | SH | DFND | 658,929 | 0 | 0 | ||
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 495 | 1,500 | SH | Call | DFND | 1,500 | 0 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 11,466 | 854,384 | SH | DFND | 854,384 | 0 | 0 | ||
| IRADIMED CORP | COM | 46266A109 | 2,880 | 410,884 | SH | DFND | 410,884 | 0 | 0 | ||
| KINDRED HEALTHCARE INC | COM | 494580103 | 9,609 | 495,300 | SH | DFND | 495,300 | 0 | 0 | ||
| LA JOLLA PHARMACEUTICAL CO | COM PAR $.0001 2 | 503459604 | 10,639 | 1,107,046 | SH | DFND | 1,107,046 | 0 | 0 | ||
| LIBERATOR MEDICAL HLDGS INC | COM | 53012L108 | 3,602 | 1,150,837 | SH | DFND | 1,150,837 | 0 | 0 | ||
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 3,235 | 184,756 | SH | DFND | 184,756 | 0 | 0 | ||
| NATUS MEDICAL INC DEL | COM | 639050103 | 13,720 | 464,915 | SH | DFND | 464,915 | 0 | 0 | ||
| NOVADAQ TECHNOLOGIES INC | COM | 66987G102 | 2,475 | 195,017 | SH | DFND | 195,017 | 0 | 0 | ||
| ONCOTHYREON INC | COM | 682324108 | 2,880 | 1,500,000 | SH | DFND | 1,500,000 | 0 | 0 | ||
| PERNIX THERAPEUTICS HLDGS IN | COM | 71426V108 | 26,880 | 3,500,000 | SH | DFND | 3,500,000 | 0 | 0 | ||
| PROGENICS PHARMACEUTICALS IN | COM | 743187106 | 46,457 | 8,951,169 | SH | DFND | 8,951,169 | 0 | 0 | ||
| QLT INC | COM | 746927102 | 5,178 | 1,145,527 | SH | DFND | 1,145,527 | 0 | 0 | ||
| RECRO PHARMA INC | COM | 75629F109 | 3,470 | 1,172,195 | SH | DFND | 1,172,195 | 0 | 0 | ||
| REDHILL BIOPHARMA LTD | SPONSORED ADS | 757468103 | 3,466 | 263,160 | SH | DFND | 263,160 | 0 | 0 | ||
| RETROPHIN INC | COM | 761299106 | 22,884 | 2,558,854 | SH | DFND | 2,558,854 | 0 | 0 | ||
| RIGEL PHARMACEUTICALS INC | COM NEW | 766559603 | 11,636 | 5,998,019 | SH | DFND | 5,998,019 | 0 | 0 | ||
| RITE AID CORP | COM | 767754104 | 8,107 | 1,675,000 | SH | DFND | 1,675,000 | 0 | 0 | ||
| RXI PHARMACEUTICALS CORP NEW | COM NEW | 74979C303 | 2,253 | 1,126,482 | SH | DFND | 1,126,482 | 0 | 0 | ||
| SYNERON MEDICAL LTD | ORD SHS | M87245102 | 10,072 | 1,005,221 | SH | DFND | 1,005,221 | 0 | 0 | ||
| TENAX THERAPEUTICS INC | COM | 88032L100 | 7,737 | 1,968,631 | SH | DFND | 1,968,631 | 0 | 0 | ||
| TETRAPHASE PHARMACEUTICALS I | COM | 88165N105 | 19,137 | 959,247 | SH | DFND | 959,247 | 0 | 0 | ||
| THORATEC CORP | COM NEW | 885175307 | 13,365 | 500,000 | SH | DFND | 500,000 | 0 | 0 | ||
| TONIX PHARMACEUTICALS HLDG C | COM NEW | 890260201 | 1,893 | 276,394 | SH | DFND | 276,394 | 0 | 0 | ||
| TREVENA INC | COM | 89532E109 | 3,852 | 600,000 | SH | DFND | 600,000 | 0 | 0 | ||
| UNIVERSAL AMERN CORP NEW | COM | 91338E101 | 15,118 | 1,880,359 | SH | DFND | 1,880,359 | 0 | 0 | ||
| VOLCANO CORPORATION | COM | 928645100 | 10,585 | 994,854 | SH | DFND | 994,854 | 0 | 0 | ||
| XENCOR INC | COM | 98401F105 | 7,017 | 753,683 | SH | DFND | 753,683 | 0 | 0 | ||
| ZOGENIX INC | COM | 98978L105 | 6,483 | 5,637,645 | SH | DFND | 5,637,645 | 0 | 0 | ||