The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AEGERION PHARMACEUTICALS INC | COM | 00767E102 | 25,994 | 810,044 | SH | DFND | 1 | 810,044 | 0 | 0 | |
| AGENUS INC | COM NEW | 00847G705 | 3,803 | 1,181,000 | SH | DFND | 1 | 1,181,000 | 0 | 0 | |
| AMAG PHARMACEUTICALS INC | COM | 00163U106 | 40,627 | 1,960,775 | SH | DFND | 1 | 1,960,775 | 0 | 0 | |
| ANACOR PHARMACEUTICALS INC | COM | 032420101 | 25,588 | 1,443,220 | SH | DFND | 1 | 1,443,220 | 0 | 0 | |
| ANGIODYNAMICS INC | COM | 03475V101 | 48,508 | 2,970,510 | SH | DFND | 1 | 2,970,510 | 0 | 0 | |
| ANTARES PHARMA INC | COM | 036642106 | 8,144 | 3,050,000 | SH | DFND | 1 | 3,050,000 | 0 | 0 | |
| ANTHERA PHARMACEUTICALS INC | COM NEW | 03674U201 | 2,598 | 766,329 | SH | DFND | 1 | 766,329 | 0 | 0 | |
| AQUINOX PHARMACEUTICALS INC | COM | 03842B101 | 4,814 | 510,500 | SH | DFND | 1 | 510,500 | 0 | 0 | |
| ARATANA THERAPEUTICS INC | COM | 03874P101 | 12,760 | 817,435 | SH | DFND | 1 | 817,435 | 0 | 0 | |
| ATRICURE INC | COM | 04963C209 | 18,108 | 985,193 | SH | DFND | 1 | 985,193 | 0 | 0 | |
| AUXILIUM PHARMACEUTICALS INC | COM | 05334D107 | 6,018 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| BIODEL INC | COM NEW | 09064M204 | 2,873 | 1,330,034 | SH | DFND | 1 | 1,330,034 | 0 | 0 | |
| BIODELIVERY SCIENCES INTL IN | COM | 09060J106 | 40,701 | 3,372,054 | SH | DFND | 1 | 3,372,054 | 0 | 0 | |
| BIOSCRIP INC | COM | 09069N108 | 9,582 | 1,148,885 | SH | DFND | 1 | 1,148,885 | 0 | 0 | |
| BIOTA PHARMACEUTIALS INC | COM | 090694100 | 3,198 | 1,122,133 | SH | DFND | 1 | 1,122,133 | 0 | 0 | |
| BROOKDALE SR LIVING INC | COM | 112463104 | 10,102 | 303,000 | SH | DFND | 1 | 303,000 | 0 | 0 | |
| CARDICA INC | COM | 14141R101 | 10,117 | 8,874,992 | SH | DFND | 1 | 8,874,992 | 0 | 0 | |
| CAREFUSION CORP | COM | 14170T101 | 5,544 | 125,000 | SH | DFND | 1 | 125,000 | 0 | 0 | |
| CAS MED SYS INC | COM PAR $0.004 | 124769209 | 2,864 | 1,424,796 | SH | DFND | 1 | 1,424,796 | 0 | 0 | |
| CATALYST PHARM PARTNERS INC | COM | 14888U101 | 6,072 | 2,400,000 | SH | DFND | 1 | 2,400,000 | 0 | 0 | |
| CELSUS THERAPEUTICS PLC | SPONSORED ADR NE | 15119A202 | 2,919 | 470,877 | SH | DFND | 1 | 470,877 | 0 | 0 | |
| CEMPRA INC | COM | 15130J109 | 10,249 | 955,147 | SH | DFND | 1 | 955,147 | 0 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 6,143 | 1,050,000 | SH | DFND | 1 | 1,050,000 | 0 | 0 | |
| CORIUM INTL INC | COM | 21887L107 | 10,878 | 1,400,000 | SH | DFND | 1 | 1,400,000 | 0 | 0 | |
| DEPOMED INC | COM | 249908104 | 34,357 | 2,471,692 | SH | DFND | 1 | 2,471,692 | 0 | 0 | |
| DERMA SCIENCES INC | COM PAR $.01 | 249827502 | 21,090 | 1,824,377 | SH | DFND | 1 | 1,824,377 | 0 | 0 | |
| DIGIRAD CORP | COM | 253827109 | 1,184 | 332,480 | SH | DFND | 1 | 332,480 | 0 | 0 | |
| DIPEXIUM PHARMACEUTICALS INC | COM | 25456J104 | 4,608 | 475,000 | SH | DFND | 1 | 475,000 | 0 | 0 | |
| DISCOVERY LABORATORIES INC N | COM NEW | 254668403 | 14,357 | 8,066,000 | SH | DFND | 1 | 8,066,000 | 0 | 0 | |
| DURECT CORP | COM | 266605104 | 8,016 | 4,404,495 | SH | DFND | 1 | 4,404,495 | 0 | 0 | |
| DYNAVAX TECHNOLOGIES CORP | COM | 268158102 | 12,256 | 7,660,100 | SH | DFND | 1 | 7,660,100 | 0 | 0 | |
| ELEVEN BIOTHERAPEUTICS INC | COM | 286221106 | 11,305 | 857,715 | SH | DFND | 1 | 857,715 | 0 | 0 | |
| EMERGENT BIOSOLUTIONS INC | COM | 29089Q105 | 46,728 | 2,080,519 | SH | DFND | 1 | 2,080,519 | 0 | 0 | |
| FLAMEL TECHNOLOGIES SA | SPONSORED ADR | 338488109 | 79,019 | 5,267,911 | SH | DFND | 1 | 5,267,911 | 0 | 0 | |
| FLEXION THERAPEUTICS INC | COM | 33938J106 | 3,548 | 263,204 | SH | DFND | 1 | 263,204 | 0 | 0 | |
| HAEMONETICS CORP | COM | 405024100 | 127 | 3,600 | SH | DFND | 1 | 3,600 | 0 | 0 | |
| HERON THERAPEUTICS INC | COM | 427746102 | 34,597 | 2,808,173 | SH | DFND | 1 | 2,808,173 | 0 | 0 | |
| HORIZON PHARMA INC | COM | 44047T109 | 68,868 | 4,353,214 | SH | DFND | 1 | 4,353,214 | 0 | 0 | |
| IDERA PHARMACEUTICALS INC | COM NEW | 45168K306 | 10,225 | 3,525,700 | SH | DFND | 1 | 3,525,700 | 0 | 0 | |
| IGI LABS INC | COM | 449575109 | 11,151 | 2,100,000 | SH | DFND | 1 | 2,100,000 | 0 | 0 | |
| IGNYTA INC | COM | 451731103 | 5,833 | 225,000 | SH | DFND | 1 | 225,000 | 0 | 0 | |
| IMPAX LABORATORIES INC | COM | 45256B101 | 18,262 | 608,929 | SH | DFND | 1 | 608,929 | 0 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 443 | 1,500 | SH | Call | DFND | 1 | 1,500 | 0 | 0 |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 18,326 | 1,438,484 | SH | DFND | 1 | 1,438,484 | 0 | 0 | |
| LA JOLLA PHARMACEUTICAL CO | COM PAR $.0001 2 | 503459604 | 3,559 | 387,721 | SH | DFND | 1 | 387,721 | 0 | 0 | |
| LIBERATOR MEDICAL HLDGS INC | COM | 53012L108 | 11,470 | 3,058,644 | SH | DFND | 1 | 3,058,644 | 0 | 0 | |
| LIPOCINE INC NEW | COM | 53630X104 | 1,614 | 264,532 | SH | DFND | 1 | 264,532 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 3,695 | 184,756 | SH | DFND | 1 | 184,756 | 0 | 0 | |
| NATUS MEDICAL INC DEL | COM | 639050103 | 19,230 | 764,915 | SH | DFND | 1 | 764,915 | 0 | 0 | |
| NOVADAQ TECHNOLOGIES INC | COM | 66987G102 | 19,803 | 1,201,617 | SH | DFND | 1 | 1,201,617 | 0 | 0 | |
| OXYGEN BIOTHERAPEUTICS INC | COM PAR $0.0001 | 69207P308 | 8,032 | 1,968,631 | SH | DFND | 1 | 1,968,631 | 0 | 0 | |
| PERNIX THERAPEUTICS HLDGS IN | COM | 71426V108 | 25,144 | 3,500,000 | SH | DFND | 1 | 3,500,000 | 0 | 0 | |
| POZEN INC | COM | 73941U102 | 5,496 | 659,730 | SH | DFND | 1 | 659,730 | 0 | 0 | |
| PROGENICS PHARMACEUTICALS IN | COM | 743187106 | 28,602 | 6,636,169 | SH | DFND | 1 | 6,636,169 | 0 | 0 | |
| QLT INC | COM | 746927102 | 8,209 | 1,328,392 | SH | DFND | 1 | 1,328,392 | 0 | 0 | |
| RECRO PHARMA INC | COM | 75629F109 | 5,384 | 672,195 | SH | DFND | 1 | 672,195 | 0 | 0 | |
| REDHILL BIOPHARMA LTD | SPONSORED ADS | 757468103 | 4,603 | 263,160 | SH | DFND | 1 | 263,160 | 0 | 0 | |
| RETROPHIN INC | COM | 761299106 | 24,885 | 1,675,251 | SH | DFND | 1 | 1,675,251 | 0 | 0 | |
| RIGEL PHARMACEUTICALS INC | COM NEW | 766559603 | 20,321 | 5,598,019 | SH | DFND | 1 | 5,598,019 | 0 | 0 | |
| RITE AID CORP | COM | 767754104 | 11,472 | 1,600,000 | SH | DFND | 1 | 1,600,000 | 0 | 0 | |
| RXI PHARMACEUTICALS CORP NEW | COM NEW | 74979C303 | 3,402 | 1,126,482 | SH | DFND | 1 | 1,126,482 | 0 | 0 | |
| SAGENT PHARMACEUTICALS INC | COM | 786692103 | 8,539 | 330,188 | SH | DFND | 1 | 330,188 | 0 | 0 | |
| SYNERON MEDICAL LTD | ORD SHS | M87245102 | 10,374 | 1,005,221 | SH | DFND | 1 | 1,005,221 | 0 | 0 | |
| TETRAPHASE PHARMACEUTICALS I | COM | 88165N105 | 28,541 | 2,115,747 | SH | DFND | 1 | 2,115,747 | 0 | 0 | |
| TEVA PHARMACEUTICAL INDS LTD | ADR | 881624209 | 210 | 4,000 | SH | Put | DFND | 1 | 4,000 | 0 | 0 |
| TONIX PHARMACEUTICALS HLDG C | COM NEW | 890260201 | 6,711 | 467,639 | SH | DFND | 1 | 467,639 | 0 | 0 | |
| TREVENA INC | COM | 89532E109 | 3,390 | 600,000 | SH | DFND | 1 | 600,000 | 0 | 0 | |
| UNIVERSAL AMERN CORP NEW | COM | 91338E101 | 20,712 | 2,486,459 | SH | DFND | 1 | 2,486,459 | 0 | 0 | |
| XENCOR INC | COM | 98401F105 | 9,004 | 774,881 | SH | DFND | 1 | 774,881 | 0 | 0 | |
| ZOGENIX INC | COM | 98978L105 | 10,327 | 5,137,645 | SH | DFND | 1 | 5,137,645 | 0 | 0 | |