The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACELRX PHARMACEUTICALS INC | COM | 00444T100 | 2,262 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| ACHILLION PHARMACEUTICALS IN | COM | 00448Q201 | 3,319 | 1,000,000 | SH | DFND | 1 | 1,000,000 | 0 | 0 | |
| AERIE PHARMACEUTICALS INC | COM | 00771V108 | 7,027 | 391,232 | SH | DFND | 1 | 391,232 | 0 | 0 | |
| ANACOR PHARMACEUTICALS INC | COM | 032420101 | 25,459 | 1,517,231 | SH | DFND | 1 | 1,517,231 | 0 | 0 | |
| ANGIODYNAMICS INC | COM | 03475V101 | 42,849 | 2,497,049 | SH | DFND | 1 | 2,497,049 | 0 | 0 | |
| ANTARES PHARMA INC | COM | 036642106 | 3,577 | 800,000 | SH | DFND | 1 | 800,000 | 0 | 0 | |
| ANTHERA PHARMACEUTICALS INC | COM NEW | 03674U201 | 2,353 | 766,329 | SH | DFND | 1 | 766,329 | 0 | 0 | |
| ATRICURE INC | COM | 04963C209 | 8,172 | 437,495 | SH | DFND | 1 | 437,495 | 0 | 0 | |
| AUXILIUM PHARMACEUTICALS INC | COM | 05334D107 | 19,924 | 961,100 | SH | DFND | 1 | 961,100 | 0 | 0 | |
| BIODEL INC | COM NEW | 09064M204 | 2,280 | 1,000,000 | SH | DFND | 1 | 1,000,000 | 0 | 0 | |
| BIODELIVERY SCIENCES INTL IN | COM | 09060J106 | 13,088 | 2,222,054 | SH | DFND | 1 | 2,222,054 | 0 | 0 | |
| CARDICA INC | COM | 14141R101 | 4,653 | 4,772,672 | SH | DFND | 1 | 4,772,672 | 0 | 0 | |
| CAS MED SYS INC | COM PAR $0.004 | 124769209 | 2,295 | 1,349,796 | SH | DFND | 1 | 1,349,796 | 0 | 0 | |
| CEMPRA INC | COM | 15130J109 | 14,429 | 1,164,547 | SH | DFND | 1 | 1,164,547 | 0 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 5,985 | 1,033,668 | SH | DFND | 1 | 1,033,668 | 0 | 0 | |
| CUTERA INC | COM | 232109108 | 2,198 | 215,962 | SH | DFND | 1 | 215,962 | 0 | 0 | |
| DEPOMED INC | COM | 249908104 | 50,199 | 4,744,772 | SH | DFND | 1 | 4,744,772 | 0 | 0 | |
| DERMA SCIENCES INC | COM PAR $.01 | 249827502 | 9,431 | 871,598 | SH | DFND | 1 | 871,598 | 0 | 0 | |
| DIGIRAD CORP | COM | 253827109 | 831 | 224,481 | SH | DFND | 1 | 224,481 | 0 | 0 | |
| DISCOVERY LABORATORIES INC N | COM NEW | 254668403 | 18,149 | 8,066,000 | SH | DFND | 1 | 8,066,000 | 0 | 0 | |
| DURATA THERAPEUTICS INC | COM | 26658A107 | 2,414 | 188,706 | SH | DFND | 1 | 188,706 | 0 | 0 | |
| DURECT CORP | COM | 266605104 | 9,412 | 5,440,290 | SH | DFND | 1 | 5,440,290 | 0 | 0 | |
| DYNAVAX TECHNOLOGIES CORP | COM | 268158102 | 14,210 | 7,250,000 | SH | DFND | 1 | 7,250,000 | 0 | 0 | |
| EMERGENT BIOSOLUTIONS INC | COM | 29089Q105 | 24,692 | 1,074,048 | SH | DFND | 1 | 1,074,048 | 0 | 0 | |
| EPIZYME INC | COM | 29428V104 | 2,080 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| FLAMEL TECHNOLOGIES SA | SPONSORED ADR | 338488109 | 30,332 | 3,767,911 | SH | DFND | 1 | 3,767,911 | 0 | 0 | |
| HORIZON PHARMA INC | COM | 44047T109 | 32,442 | 4,257,469 | SH | DFND | 1 | 4,257,469 | 0 | 0 | |
| IDERA PHARMACEUTICALS INC | COM NEW | 45168K306 | 16,437 | 3,550,000 | SH | DFND | 1 | 3,550,000 | 0 | 0 | |
| IGI LABS INC | COM | 449575109 | 4,575 | 1,500,000 | SH | DFND | 1 | 1,500,000 | 0 | 0 | |
| IMPAX LABORATORIES INC | COM | 45256B101 | 18,451 | 733,929 | SH | DFND | 1 | 733,929 | 0 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 13,755 | 996,000 | SH | DFND | 1 | 996,000 | 0 | 0 | |
| LANNET INC | COM | 516012101 | 44,352 | 1,339,945 | SH | DFND | 1 | 1,339,945 | 0 | 0 | |
| LIBERATOR MEDICAL HLDGS INC | COM | 53012L108 | 9,047 | 2,169,531 | SH | DFND | 1 | 2,169,531 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 3,564 | 214,286 | SH | DFND | 1 | 214,286 | 0 | 0 | |
| MOLINA HEALTHCARE INC | COM | 60855R100 | 7,968 | 229,300 | SH | DFND | 1 | 229,300 | 0 | 0 | |
| NATUS MEDICAL INC DEL | COM | 639050103 | 22,818 | 1,014,116 | SH | DFND | 1 | 1,014,116 | 0 | 0 | |
| NOVADAQ TECHNOLOGIES INC | COM | 66987G102 | 32,479 | 1,969,634 | SH | DFND | 1 | 1,969,634 | 0 | 0 | |
| NPS PHARMACEUTICALS INC | COM | 62936P103 | 12,144 | 400,000 | SH | DFND | 1 | 400,000 | 0 | 0 | |
| NXSTAGE MEDICAL INC | COM | 67072V103 | 5,435 | 543,466 | SH | DFND | 1 | 543,466 | 0 | 0 | |
| OPHTHOTECH CORP | COM | 683745103 | 4,853 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |
| PAIN THERAPEUTICS INC | COM | 69562K100 | 5,978 | 1,230,000 | SH | DFND | 1 | 1,230,000 | 0 | 0 | |
| POZEN INC | COM | 73941U102 | 9,289 | 1,155,323 | SH | DFND | 1 | 1,155,323 | 0 | 0 | |
| PROGENICS PHARMACEUTICALS IN | COM | 743187106 | 21,320 | 4,000,000 | SH | DFND | 1 | 4,000,000 | 0 | 0 | |
| QLT INC | COM | 746927102 | 4,372 | 784,893 | SH | DFND | 1 | 784,893 | 0 | 0 | |
| RIGEL PHARMACEUTICALS INC | COM NEW | 766559603 | 14,122 | 4,955,119 | SH | DFND | 1 | 4,955,119 | 0 | 0 | |
| RITE AID CORP | COM | 767754104 | 2,530 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |
| SAGENT PHARMACEUTICALS INC | COM | 786692103 | 8,157 | 321,388 | SH | DFND | 1 | 321,388 | 0 | 0 | |
| SAREPTA THERAPEUTICS INC | COM | 803607100 | 14,801 | 726,655 | SH | DFND | 1 | 726,655 | 0 | 0 | |
| SOLTA MED INC | COM | 83438K103 | 9,901 | 3,356,391 | SH | DFND | 1 | 3,356,391 | 0 | 0 | |
| ST JUDE MED INC | COM | 790849103 | 6 | 100 | SH | DFND | 1 | 100 | 0 | 0 | |
| SYNERON MEDICAL LTD | ORD SHS | M87245102 | 2,460 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| TARGACEPT INC | COM | 87611R306 | 1,240 | 298,909 | SH | DFND | 1 | 298,909 | 0 | 0 | |
| TETRAPHASE PHARMACEUTICALS I | COM | 88165N105 | 29,654 | 2,193,328 | SH | DFND | 1 | 2,193,328 | 0 | 0 | |
| TEVA PHARMACEUTICAL INDS LTD | ADR | 881624209 | 33,737 | 841,736 | SH | DFND | 1 | 841,736 | 0 | 0 | |
| THERAPEUTICSMD INC | COM | 88338N107 | 11,088 | 2,128,159 | SH | DFND | 1 | 2,128,159 | 0 | 0 | |
| TONIX PHARMACEUTICALS HLDG C | COM NEW | 890260201 | 4,051 | 392,952 | SH | DFND | 1 | 392,952 | 0 | 0 | |
| TORNIER N V | SHS | N87237108 | 282 | 15,000 | SH | DFND | 1 | 15,000 | 0 | 0 | |
| VENTRUS BIOSCIENCES INC | COM | 922822101 | 7,066 | 1,849,839 | SH | DFND | 1 | 1,849,839 | 0 | 0 | |
| XENCOR INC | COM | 98401F105 | 7,988 | 874,000 | SH | DFND | 1 | 874,000 | 0 | 0 | |
| ZOGENIX INC | COM | 98978L105 | 20,211 | 5,875,276 | SH | DFND | 1 | 5,875,276 | 0 | 0 | |