The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ALKERMES PLC | SHS | G01767105 | 15,129 | 450,000 | SH | DFND | 1 | 450,000 | 0 | 0 | |
| ANACOR PHARMACEUTICALS INC | COM | 032420101 | 18,454 | 1,737,669 | SH | DFND | 1 | 1,737,669 | 0 | 0 | |
| ANGIODYNAMICS INC | COM | 03475V101 | 37,312 | 2,826,651 | SH | DFND | 1 | 2,826,651 | 0 | 0 | |
| ANTHERA PHARMACEUTICALS INC | COM NEW | 03674U201 | 2,864 | 712,499 | SH | DFND | 1 | 712,499 | 0 | 0 | |
| ATRICURE INC | COM | 04963C209 | 7,439 | 677,543 | SH | DFND | 1 | 677,543 | 0 | 0 | |
| AUXILIUM PHARMACEUTICALS INC | COM | 05334D107 | 14,762 | 811,100 | SH | DFND | 1 | 811,100 | 0 | 0 | |
| BIODEL INC | COM NEW | 09064M204 | 3,150 | 1,000,000 | SH | DFND | 1 | 1,000,000 | 0 | 0 | |
| BIODELIVERY SCIENCES INTL IN | COM | 09060J106 | 11,523 | 2,122,054 | SH | DFND | 1 | 2,122,054 | 0 | 0 | |
| CARDICA INC | COM | 14141R101 | 6,204 | 4,772,672 | SH | DFND | 1 | 4,772,672 | 0 | 0 | |
| CAS MED SYS INC | COM PAR $0.004 | 124769209 | 1,743 | 1,300,896 | SH | DFND | 1 | 1,300,896 | 0 | 0 | |
| CEMPRA INC | COM | 15130J109 | 16,001 | 1,391,357 | SH | DFND | 1 | 1,391,357 | 0 | 0 | |
| CUBIST PHARMACEUTICALS INC | COM | 229678107 | 1,589 | 25,000 | SH | DFND | 1 | 25,000 | 0 | 0 | |
| CUTERA INC | COM | 232109108 | 1,922 | 215,962 | SH | DFND | 1 | 215,962 | 0 | 0 | |
| DEPOMED INC | COM | 249908104 | 41,997 | 5,622,023 | SH | DFND | 1 | 5,622,023 | 0 | 0 | |
| DERMA SCIENCES INC | COM PAR $.01 | 249827502 | 9,552 | 771,598 | SH | DFND | 1 | 771,598 | 0 | 0 | |
| DIGIRAD CORP | COM | 253827109 | 460 | 182,480 | SH | DFND | 1 | 182,480 | 0 | 0 | |
| DISCOVERY LABORATORIES INC N | COM NEW | 254668403 | 4,245 | 2,166,000 | SH | DFND | 1 | 2,166,000 | 0 | 0 | |
| DURATA THERAPEUTICS INC | COM | 26658A107 | 3,464 | 383,227 | SH | DFND | 1 | 383,227 | 0 | 0 | |
| DURECT CORP | COM | 266605104 | 7,548 | 5,632,977 | SH | DFND | 1 | 5,632,977 | 0 | 0 | |
| EMERGENT BIOSOLUTIONS INC | COM | 29089Q105 | 20,464 | 1,074,248 | SH | DFND | 1 | 1,074,248 | 0 | 0 | |
| FLAMEL TECHNOLOGIES SA | SPONSORED ADR | 338488109 | 24,717 | 3,767,911 | SH | DFND | 1 | 3,767,911 | 0 | 0 | |
| FOREST LABS INC | COM | 345838106 | 2,140 | 50,000 | SH | DFND | 1 | 50,000 | 0 | 0 | |
| GLOBUS MED INC | CL A | 379577208 | 4,343 | 248,767 | SH | DFND | 1 | 248,767 | 0 | 0 | |
| GW PHARMACEUTICALS PLC | ADS | 36197T103 | 5,694 | 328,387 | SH | DFND | 1 | 328,387 | 0 | 0 | |
| GW PHARMACEUTICALS PLC | ADS | 36197T103 | 6 | 4,549 | SH | DFND | 1 | 4,549 | 0 | 0 | |
| HEALTH NET INC | COM | 42222G108 | 63 | 2,000 | SH | DFND | 1 | 2,000 | 0 | 0 | |
| HEARTWARE INTL INC | COM | 422368100 | 1,830 | 25,000 | SH | DFND | 1 | 25,000 | 0 | 0 | |
| HORIZON PHARMA INC | COM | 44047T109 | 6,298 | 1,880,000 | SH | DFND | 1 | 1,880,000 | 0 | 0 | |
| IDERA PHARMACEUTICALS INC | COM NEW | 45168K306 | 7,874 | 4,525,000 | SH | DFND | 1 | 4,525,000 | 0 | 0 | |
| IMPAX LABORATORIES INC | COM | 45256B101 | 18,884 | 922,543 | SH | DFND | 1 | 922,543 | 0 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 5,055 | 290,000 | SH | DFND | 1 | 290,000 | 0 | 0 | |
| INSMED INC | COM PAR $.01 | 457669307 | 2,578 | 165,145 | SH | DFND | 1 | 165,145 | 0 | 0 | |
| INTEGRA LIFESCIENCES HLDGS C | COM NEW | 457985208 | 8,911 | 221,391 | SH | DFND | 1 | 221,391 | 0 | 0 | |
| INTELLIPHARMACEUTICS INTL IN | COM | 458173101 | 3,442 | 1,756,260 | SH | DFND | 1 | 1,756,260 | 0 | 0 | |
| LANNET INC | COM | 516012101 | 28,553 | 1,308,561 | SH | DFND | 1 | 1,308,561 | 0 | 0 | |
| MASIMO CORP | COM | 574795100 | 4,418 | 165,837 | SH | DFND | 1 | 165,837 | 0 | 0 | |
| NATUS MEDICAL INC DEL | COM | 639050103 | 35,748 | 2,520,992 | SH | DFND | 1 | 2,520,992 | 0 | 0 | |
| NOVADAQ TECHNOLOGIES INC | COM | 66987G102 | 27,868 | 1,687,090 | SH | DFND | 1 | 1,687,090 | 0 | 0 | |
| NOVAVAX INC | COM | 670002104 | 2,520 | 800,000 | SH | DFND | 1 | 800,000 | 0 | 0 | |
| NPS PHARMACEUTICALS INC | COM | 62936P103 | 14,365 | 451,597 | SH | DFND | 1 | 451,597 | 0 | 0 | |
| NUVASIVE INC | COM | 670704105 | 7,347 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| ORTHOFIX INTL N V | COM | N6748L102 | 3,147 | 151,523 | SH | DFND | 1 | 151,523 | 0 | 0 | |
| PAIN THERAPEUTICS INC | COM | 69562K100 | 2,720 | 1,000,000 | SH | DFND | 1 | 1,000,000 | 0 | 0 | |
| POZEN INC | COM | 73941U102 | 3,673 | 641,000 | SH | DFND | 1 | 641,000 | 0 | 0 | |
| PROGENICS PHARMACEUTICALS IN | COM | 743187106 | 17,466 | 3,479,348 | SH | DFND | 1 | 3,479,348 | 0 | 0 | |
| QLT INC | COM | 746927102 | 3,634 | 784,893 | SH | DFND | 1 | 784,893 | 0 | 0 | |
| QUEST DIAGNOSTICS INC | COM | 74834L100 | 1,545 | 25,000 | SH | DFND | 1 | 25,000 | 0 | 0 | |
| RIGEL PHARMACEUTICALS INC | COM NEW | 766559603 | 12,766 | 3,565,819 | SH | DFND | 1 | 3,565,819 | 0 | 0 | |
| SAGENT PHARMACEUTICALS INC | COM | 786692103 | 1,393 | 68,300 | SH | DFND | 1 | 68,300 | 0 | 0 | |
| SEQUENOM INC | COM NEW | 817337405 | 1,602 | 600,000 | SH | DFND | 1 | 600,000 | 0 | 0 | |
| SOLTA MED INC | COM | 83438K103 | 6,889 | 3,328,135 | SH | DFND | 1 | 3,328,135 | 0 | 0 | |
| SPECTRANETICS CORP | COM | 84760C107 | 8,330 | 495,833 | SH | DFND | 1 | 495,833 | 0 | 0 | |
| TETRAPHASE PHARMACEUTICALS I | COM | 88165N105 | 20,408 | 1,793,328 | SH | DFND | 1 | 1,793,328 | 0 | 0 | |
| TEVA PHARMACEUTICAL INDS LTD | ADR | 881624209 | 24,245 | 641,736 | SH | DFND | 1 | 641,736 | 0 | 0 | |
| THERAPEUTICSMD INC | COM | 88338N107 | 6,236 | 2,128,159 | SH | DFND | 1 | 2,128,159 | 0 | 0 | |
| TONIX PHARMACEUTICALS HLDG C | COM NEW | 890260201 | 1,745 | 478,000 | SH | DFND | 1 | 478,000 | 0 | 0 | |
| VENTRUS BIOSCIENCES INC | COM | 922822101 | 5,346 | 1,849,839 | SH | DFND | 1 | 1,849,839 | 0 | 0 | |
| ZOGENIX INC | COM | 98978L105 | 3,679 | 1,987,645 | SH | DFND | 1 | 1,987,645 | 0 | 0 | |