The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ALKERMES PLC | SHS | G01767105 | 17,208 | 600,000 | SH | DFND | 1 | 600,000 | 0 | 0 | |
| ANACOR PHARMACEUTICALS INC | COM | 032420101 | 9,637 | 1,724,028 | SH | DFND | 1 | 1,724,028 | 0 | 0 | |
| ANGIODYNAMICS INC | COM | 03475V101 | 30,757 | 2,726,651 | SH | DFND | 1 | 2,726,651 | 0 | 0 | |
| ANTHERA PHARMACEUTICALS INC | COM | 03674U102 | 1,945 | 4,200,000 | SH | DFND | 1 | 4,200,000 | 0 | 0 | |
| ARTHROCARE CORP | COM | 043136100 | 9,171 | 265,585 | SH | DFND | 1 | 265,585 | 0 | 0 | |
| ATRICURE INC | COM | 04963C209 | 7,522 | 791,841 | SH | DFND | 1 | 791,841 | 0 | 0 | |
| AUXILIUM PHARMACEUTICALS INC | COM | 05334D107 | 13,305 | 800,000 | SH | DFND | 1 | 800,000 | 0 | 0 | |
| BIODEL INC | COM NEW | 09064M204 | 1,922 | 459,771 | SH | DFND | 1 | 459,771 | 0 | 0 | |
| BIODELIVERY SCIENCES INTL IN | COM | 09060J106 | 8,616 | 2,122,054 | SH | DFND | 1 | 2,122,054 | 0 | 0 | |
| CARDICA INC | COM | 14141R101 | 4,868 | 4,385,715 | SH | DFND | 1 | 4,385,715 | 0 | 0 | |
| CAS MED SYS INC | COM PAR $0.004 | 124769209 | 368 | 220,544 | SH | DFND | 1 | 220,544 | 0 | 0 | |
| CEMPRA INC | COM | 15130J109 | 12,083 | 1,555,147 | SH | DFND | 1 | 1,555,147 | 0 | 0 | |
| CUTERA INC | COM | 232109108 | 1,900 | 215,962 | SH | DFND | 1 | 215,962 | 0 | 0 | |
| DEPOMED INC | COM | 249908104 | 31,596 | 5,622,023 | SH | DFND | 1 | 5,622,023 | 0 | 0 | |
| DERMA SCIENCES INC | COM PAR $.01 | 249827502 | 10,346 | 775,000 | SH | DFND | 1 | 775,000 | 0 | 0 | |
| DISCOVERY LABORATORIES INC N | COM NEW | 254668403 | 2,532 | 1,666,000 | SH | DFND | 1 | 1,666,000 | 0 | 0 | |
| DURATA THERAPEUTICS INC | COM | 26658A107 | 2,759 | 383,227 | SH | DFND | 1 | 383,227 | 0 | 0 | |
| DURECT CORP | COM | 266605104 | 6,299 | 5,999,100 | SH | DFND | 1 | 5,999,100 | 0 | 0 | |
| EMERGENT BIOSOLUTIONS INC | COM | 29089Q105 | 15,491 | 1,074,248 | SH | DFND | 1 | 1,074,248 | 0 | 0 | |
| FLAMEL TECHNOLOGIES SA | SPONSORED ADR | 338488109 | 19,268 | 3,139,131 | SH | DFND | 1 | 3,139,131 | 0 | 0 | |
| GLOBUS MED INC | CL A | 379577208 | 4,194 | 248,767 | SH | DFND | 1 | 248,767 | 0 | 0 | |
| GW PHARMACEUTICALS PLC | ADS | 36197T103 | 2,467 | 280,000 | SH | DFND | 1 | 280,000 | 0 | 0 | |
| HI-TECH PHARMACAL INC | COM | 42840B101 | 9,071 | 273,232 | SH | DFND | 1 | 273,232 | 0 | 0 | |
| IMPAX LABORATORIES INC | COM | 45256B101 | 27,884 | 1,398,543 | SH | DFND | 1 | 1,398,543 | 0 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 1,897 | 117,172 | SH | DFND | 1 | 117,172 | 0 | 0 | |
| INSMED INC | COM PAR $.01 | 457669307 | 3,489 | 291,740 | SH | DFND | 1 | 291,740 | 0 | 0 | |
| INSYS THERAPEUTICS INC NEW | COM NEW | 45824V209 | 4,152 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| INTEGRA LIFESCIENCES HLDGS C | COM NEW | 457985208 | 18,422 | 502,914 | SH | DFND | 1 | 502,914 | 0 | 0 | |
| INTELLIPHARMACEUTICS INTL IN | COM | 458173101 | 3,333 | 1,960,779 | SH | DFND | 1 | 1,960,779 | 0 | 0 | |
| LANNET INC | COM | 516012101 | 21,703 | 1,822,258 | SH | DFND | 1 | 1,822,258 | 0 | 0 | |
| MASIMO CORP | COM | 574795100 | 5,318 | 250,837 | SH | DFND | 1 | 250,837 | 0 | 0 | |
| MERIT MED SYS INC | COM | 589889104 | 3,721 | 333,734 | SH | DFND | 1 | 333,734 | 0 | 0 | |
| NATUS MEDICAL INC DEL | COM | 639050103 | 35,367 | 2,590,992 | SH | DFND | 1 | 2,590,992 | 0 | 0 | |
| NOVADAQ TECHNOLOGIES INC | COM | 66987G102 | 16,372 | 1,219,634 | SH | DFND | 1 | 1,219,634 | 0 | 0 | |
| NOVADAQ TECHNOLOGIES INC | COM | 66987G102 | 10,281 | 763,808 | SH | DFND | 1 | 763,808 | 0 | 0 | |
| NPS PHARMACEUTICALS INC | COM | 62936P103 | 25,638 | 1,696,754 | SH | DFND | 1 | 1,696,754 | 0 | 0 | |
| ORASURE TECHNOLOGIES INC | COM | 68554V108 | 1,940 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |
| ORTHOFIX INTL N V | COM | N6748L102 | 6,725 | 250,000 | SH | DFND | 1 | 250,000 | 0 | 0 | |
| PAIN THERAPEUTICS INC | COM | 69562K100 | 2,210 | 1,000,000 | SH | DFND | 1 | 1,000,000 | 0 | 0 | |
| POZEN INC | COM | 73941U102 | 3,211 | 641,000 | SH | DFND | 1 | 641,000 | 0 | 0 | |
| PROGENICS PHARMACEUTICALS IN | COM | 743187106 | 15,613 | 3,500,615 | SH | DFND | 1 | 3,500,615 | 0 | 0 | |
| QLT INC | COM | 746927102 | 3,446 | 784,893 | SH | DFND | 1 | 784,893 | 0 | 0 | |
| RIGEL PHARMACEUTICALS INC | COM NEW | 766559603 | 10,187 | 3,050,000 | SH | DFND | 1 | 3,050,000 | 0 | 0 | |
| ROCKWELL MED INC | COM | 774374102 | 1,906 | 528,065 | SH | DFND | 1 | 528,065 | 0 | 0 | |
| SOLTA MED INC | COM | 83438K103 | 8,956 | 3,928,135 | SH | DFND | 1 | 3,928,135 | 0 | 0 | |
| SPECTRANETICS CORP | COM | 84760C107 | 2,591 | 138,720 | SH | DFND | 1 | 138,720 | 0 | 0 | |
| TETRAPHASE PHARMACEUTICALS I | COM | 88165N105 | 10,041 | 1,428,314 | SH | DFND | 1 | 1,428,314 | 0 | 0 | |
| TEVA PHARMACEUTICAL INDS LTD | ADR | 881624209 | 33,839 | 863,236 | SH | DFND | 1 | 863,236 | 0 | 0 | |
| TEVA PHARMACEUTICAL INDS LTD | ADR | 881624209 | 83 | 3,000 | SH | Call | DFND | 1 | 3,000 | 0 | 0 |
| TRIUS THERAPEUTICS INC | COM | 89685K100 | 3,276 | 404,427 | SH | DFND | 1 | 404,427 | 0 | 0 | |
| VENTRUS BIOSCIENCES INC | COM | 922822101 | 4,440 | 1,849,839 | SH | DFND | 1 | 1,849,839 | 0 | 0 | |
| ZOGENIX INC | COM | 98978L105 | 1,827 | 1,068,493 | SH | DFND | 1 | 1,068,493 | 0 | 0 | |