The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abaxis, Inc. Common 002567105 988 22,466 SH   SOLE   22,466 0 0
AbbVie Inc. Common 00287Y109 8,932 164,156 SH   SOLE   164,156 0 0
ACADIA Pharmaceuticals Inc. Common 004225108 18,602 562,500 SH   SOLE   562,500 0 0
Accelerate Diagnostics, Inc. Common 00430H102 2,340 144,625 SH   SOLE   144,625 0 0
Achillion Pharmaceuticals Inc Common 00448Q201 3,782 547,300 SH   SOLE   547,300 0 0
Adaptimmune Therapeutics plc Sponsored ADR 00653A107 3,375 281,934 SH   SOLE   281,934 0 0
Aegerion Pharmaceuticals, Inc. Common 00767E102 2,802 206,000 SH   SOLE   206,000 0 0
Aegerion Pharmaceuticals, Inc. Note 2.00% 8/15/19 00767EAB8 36,801 13,000,000 PRN   SOLE   13,000,000 0 0
Aetna, Inc. Common 00817Y108 36,317 331,931 SH   SOLE   331,931 0 0
Aetna, Inc. Common 00817Y108 9,223 84,300 SH Call SOLE   84,300 0 0
Affimed NV Common N01045108 1,407 228,083 SH   SOLE   228,083 0 0
Agilent Technologies, Inc. Common 00846U101 21,822 635,650 SH   SOLE   635,650 0 0
Akorn, Inc. Common 009728106 24,214 849,482 SH   SOLE   849,482 0 0
Alere, Inc. Common 01449J105 14,344 297,901 SH   SOLE   297,901 0 0
Alexion Pharmaceuticals, Inc. Common 015351109 99,590 636,805 SH   SOLE   636,805 0 0
Alexion Pharmaceuticals, Inc. Common 015351109 2,846 18,200 SH Call SOLE   18,200 0 0
Alkermes plc Common G01767105 68,399 1,165,818 SH   SOLE   1,165,818 0 0
Alkermes plc Common G01767105 9,575 163,200 SH Call SOLE   163,200 0 0
Allergan plc Common G0177J108 86,350 317,686 SH   SOLE   317,686 0 0
Allergan plc Common G0177J108 9,676 35,600 SH Call SOLE   35,600 0 0
Allergan plc Preferred Convertible G0177J116 4,717 5,000 SH   SOLE   5,000 0 0
Alliqua BioMedical, Inc. Common 019621200 5,231 1,650,000 SH   SOLE   1,650,000 0 0
Allscripts Healthcare Solutions, Inc. Common 01988P108 22,050 1,778,200 SH   SOLE   1,778,200 0 0
Alnylam Pharmaceuticals, Inc. Common 02043Q107 22,619 281,474 SH   SOLE   281,474 0 0
Alnylam Pharmaceuticals, Inc. Common 02043Q107 2,371 29,500 SH Call SOLE   29,500 0 0
Amgen Inc. Common 031162100 44,489 321,640 SH   SOLE   321,640 0 0
Anacor Pharmaceuticals Inc. Common 032420101 7,698 65,400 SH   SOLE   65,400 0 0
Anacor Pharmaceuticals Inc. Common 032420101 7,698 65,400 SH Call SOLE   65,400 0 0
ARCA biopharma, Inc. Common 00211Y407 4,032 811,227 SH   SOLE   811,227 0 0
Ardelyx, Inc. Common 039697107 11,064 640,270 SH   SOLE   640,270 0 0
Auris Medical Holding AG Common H03579101 7,495 2,105,263 SH   SOLE   2,105,263 0 0
Baxalta Inc. Common 07177M103 10,071 319,600 SH   SOLE   319,600 0 0
Baxter International, Inc. Common 071813109 10,499 319,600 SH   SOLE   319,600 0 0
Bellicum Pharmaceutical, Inc. Common 079481107 872 60,000 SH   SOLE   60,000 0 0
BioDelivery Sciences International, Inc. Common 09060J106 1,390 250,000 SH   SOLE   250,000 0 0
Biogen Inc. Common 09062X103 136,329 467,183 SH   SOLE   467,183 0 0
BioMarin Pharmaceutical Inc. Common 09061G101 60,083 570,477 SH   SOLE   570,477 0 0
BioMarin Pharmaceutical Inc. Common 09061G101 3,739 35,500 SH Call SOLE   35,500 0 0
bluebird bio, Inc. Common 09609G100 8,037 93,945 SH   SOLE   93,945 0 0
bluebird bio, Inc. Common 09609G100 5,766 67,400 SH Call SOLE   67,400 0 0
Bristol-Myers Squibb Co. Common 110122108 31,686 535,240 SH   SOLE   535,240 0 0
Bristol-Myers Squibb Co. Common 110122108 10,490 177,200 SH Call SOLE   177,200 0 0
Care Capital Properties, Inc. Common 141624106 2,777 84,316 SH   SOLE   84,316 0 0
Celgene Corporation Common 151020104 185,364 1,713,634 SH   SOLE   1,713,634 0 0
Celgene Corporation Common 151020104 10,092 93,300 SH Call SOLE   93,300 0 0
Celldex Therapeutics, Inc. Common 15117B103 3,567 338,400 SH   SOLE   338,400 0 0
Cellectis S.A. Sponsored ADS 15117K103 4,175 158,382 SH   SOLE   158,382 0 0
Centene Corporation Common 15135B101 6,508 120,000 SH   SOLE   120,000 0 0
Chimerix Inc. Common 16934W106 1,826 47,800 SH   SOLE   47,800 0 0
Cidara Therapeutics, Inc. Common 171757107 636 50,000 SH   SOLE   50,000 0 0
Cigna Corporation Common 125509109 10,025 74,251 SH   SOLE   74,251 0 0
Cigna Corporation Common 125509109 10,018 74,200 SH Call SOLE   74,200 0 0
Community Health Systems, Inc. Common 203668108 8,963 209,572 SH   SOLE   209,572 0 0
Corsicanto Ltd Note 3.5% 1/15/32 220480AB3 13,506 14,700,000 PRN   SOLE   14,700,000 0 0
Cynapsus Therapeutics, Inc. Common 23257Y859 799 49,322 SH   SOLE   49,322 0 0
DBV Technologies S.A. Sponsored ADR 23306J101 2,335 65,600 SH   SOLE   65,600 0 0
Dynavax Technologies Corporation Common 268158201 6,749 275,000 SH   SOLE   275,000 0 0
DepoMed Inc. Common 249908104 3,770 200,000 SH   SOLE   200,000 0 0
Eli Lilly & Co Common 532457108 7,169 85,667 SH   SOLE   85,667 0 0
Endo International PLC Common G30401106 22,192 320,321 SH   SOLE   320,321 0 0
Endologix Inc. Common 29266S106 6,755 551,000 SH   SOLE   551,000 0 0
Epizyme, Inc. Common 29428V104 3,301 256,700 SH   SOLE   256,700 0 0
Esperion Therapeutics, Inc. Common 29664W105 2,425 102,800 SH   SOLE   102,800 0 0
Esperion Therapeutics, Inc. Common 29664W105 2,425 102,800 SH Call SOLE   102,800 0 0
Flex Pharma, Inc. Common 33938A105 2,794 232,600 SH   SOLE   232,600 0 0
Foamix Pharmaceuticals Ltd. Common M46135105 4,498 613,577 SH   SOLE   613,577 0 0
Forward Pharma A/S Sponsored ADR 34986J105 3,120 132,447 SH   SOLE   132,447 0 0
Galapagos NV Sponsored ADR 36315X101 814 20,000 SH   SOLE   20,000 0 0
GenMark Diagnostics, Inc. Common 372309104 1,693 215,149 SH   SOLE   215,149 0 0
Gilead Sciences, Inc. Common 375558103 218,122 2,221,431 SH   SOLE   2,506,431 0 0
GlaxoSmithKline Plc Sponsored ADR 37733W105 10,958 285,000 SH   SOLE   285,000 0 0
Grifols SA Sponsored ADR 398438408 2,523 83,000 SH   SOLE   83,000 0 0
GW Pharmaceuticals Plc Sponsored ADS 36197T103 8,589 94,000 SH   SOLE   94,000 0 0
GW Pharmaceuticals Plc Common 36197T103 3,783 41,400 SH Call SOLE   41,400 0 0
HCA Holdings, Inc. Common 40412C101 18,813 243,188 SH   SOLE   243,188 0 0
Healthcare Realty Trust, Inc. Common 421946104 4,653 187,224 SH   SOLE   187,224 0 0
Heron Therapeutics, Inc. Common 427746102 5,344 219,000 SH   SOLE   219,000 0 0
Horizon Pharma Plc Common G4617B105 3,229 162,900 SH   SOLE   162,900 0 0
Horizon Pharma Plc Common G4617B105 3,229 162,900 SH Call SOLE   162,900 0 0
Humana, Inc. Common 444859102 23,145 129,300 SH   SOLE   129,300 0 0
Humana, Inc. Common 444859102 10,543 58,900 SH Call SOLE   58,900 0 0
ICON PLC Common G4705A100 5,110 72,000 SH   SOLE   72,000 0 0
IDEXX Laboratories, Inc. Common 45168D104 9,827 132,352 SH   SOLE   132,352 0 0
Illumina, Inc. Common 452327109 52,982 301,341 SH   SOLE   301,341 0 0
Impax Laboratories, Inc. Common 45256B101 12,136 344,683 SH   SOLE   344,683 0 0
Incyte Corporation Common 45337C102 97,141 880,461 SH   SOLE   880,461 0 0
Incyte Corporation Common 45337C102 10,338 93,700 SH Call SOLE   93,700 0 0
Inotek Pharmaceuticals Corp. Common 45780V102 3,995 425,000 SH   SOLE   425,000 0 0
Intra-Cellular Therapies, Inc. Common 46116X101 6,006 150,000 SH   SOLE   150,000 0 0
Ishares Nasdaq Biotechnology ETF ETF 464287556 17,493 57,670 SH   SOLE   57,670 0 0
Isis Pharmaceuticals, Inc. Common 464330109 5,942 147,000 SH   SOLE   147,000 0 0
Johnson & Johnson Common 478160104 87,841 940,988 SH   SOLE   940,988 0 0
Juno Therapeutics, Inc. Common 48205A109 7,406 182,000 SH   SOLE   182,000 0 0
Karyopharm Therapeutics Inc. Common 48576U106 9,676 918,866 SH   SOLE   918,866 0 0
Karyopharm Therapeutics Inc. Common 48576U106 3,337 316,900 SH Call SOLE   316,900 0 0
Kite Pharma, Inc. Common 49803L109 351 6,300 SH   SOLE   6,300 0 0
Lexicon Pharmaceuticals, Inc. Common 528872302 3,801 353,900 SH   SOLE   353,900 0 0
Lexicon Pharmaceuticals, Inc. Common 528872302 3,801 353,900 SH Call SOLE   353,900 0 0
LTC Properties Inc. Common 502175102 10,096 236,618 SH   SOLE   236,618 0 0
MacroGenics, Inc. Common 556099109 273 12,743 SH   SOLE   12,743 0 0
Mallinckrodt Plc Common G5785G107 4,655 72,800 SH   SOLE   72,800 0 0
McKesson Corporation Common 58155Q103 12,557 67,862 SH   SOLE   67,862 0 0
Medical Properties Trust, Inc. Common 58463J304 17,299 1,564,060 SH   SOLE   1,564,060 0 0
The Medicines Company Common 58463J304 2,669 70,300 SH Call SOLE   70,300 0 0
The Medicines Company Common 584688105 23,698 624,300 SH   SOLE   624,300 0 0
Medivation, Inc. Common 58501N101 8,730 205,400 SH   SOLE   205,400 0 0
Medtronic PLC Common G5960L103 13,860 207,044 SH   SOLE   207,044 0 0
Medtronic PLC Common G5960L103 5,536 82,700 SH Call SOLE   82,700 0 0
Merck & Co, Inc. Common 58933Y105 33,639 681,097 SH   SOLE   681,097 0 0
Merrimack Pharmaceuticals, Inc. Note 4.50% 7/15/20 590328AA8 2,336 1,485,000 PRN   SOLE   1,485,000 0 0
Merrimack Pharmaceuticals, Inc. Common 590328100 7,266 853,787 SH   SOLE   853,787 0 0
Molina Healthcare, Inc. Common 60855R100 23,953 347,901 SH   SOLE   347,901 0 0
Momenta Pharmaceuticals, Inc. Common 60877T100 2,522 153,700 SH   SOLE   153,700 0 0
Mylan NV Shares Euro N59465109 81,956 2,035,657 SH   SOLE   2,035,657 0 0
Mylan NV Shares Euro N59465109 4,751 118,000 SH Call SOLE   118,000 0 0
Natera, Inc. Common 632307104 8,835 814,300 SH   SOLE   814,300 0 0
Neurocrine Biosciences, Inc. Common 64125C109 14,955 375,860 SH   SOLE   375,860 0 0
Novartis AG Sponsored ADR 66987V109 8,521 92,700 SH   SOLE   92,700 0 0
Novo Nordisk A/S Sponsored ADR 670100205 15,979 294,600 SH   SOLE   294,600 0 0
Omega Healthcare Investors Inc. Common 681936100 14,521 413,116 SH   SOLE   413,116 0 0
Paratek Pharmaceuticals, Inc. Common 699374302 14,489 762,581 SH   SOLE   762,581 0 0
Perrigo Company PLC Common G97822103 2,972 18,900 SH   SOLE   18,900 0 0
Pfizer, Inc. Common 717081103 56,610 1,802,291 SH   SOLE   1,802,291 0 0
Physicians Realty Trust Common 71943U104 18,572 1,230,772 SH   SOLE   1,230,772 0 0
Pieris Pharmaceuticals, Inc. Common 720795103 7,042 3,848,191 SH   SOLE   3,848,191 0 0
Puma Biotechnology, Inc. Common 74587V107 7,174 95,200 SH   SOLE   95,200 0 0
Puma Biotechnology, Inc. Common 74587V107 3,421 45,400 SH Call SOLE   45,400 0 0
Regeneron Pharmaceuticals, Inc. Common 75886F107 71,755 154,266 SH   SOLE   154,266 0 0
Sabra Health Care REIT Inc. Common 78573L106 10,574 456,190 SH   SOLE   456,190 0 0
Sage Therapeutics, Inc. Common 78667J108 4,139 97,800 SH   SOLE   97,800 0 0
Sage Therapeutics, Inc. Common 78667J108 3,504 82,800 SH Call SOLE   82,800 0 0
Sagent Pharmaceuticals, Inc. Common 786692103 6,278 409,500 SH   SOLE   409,500 0 0
Senior Housing Properties Trust Common 81721M109 10,862 670,504 SH   SOLE   670,504 0 0
Shire plc Sponsored ADR 82481R106 10,162 49,513 SH   SOLE   49,513 0 0
Spectrum Pharmaceuticals, Inc. Note 2.75% 12/15/18 84763AAB4 4,453 5,000,000 PRN   SOLE   5,000,000 0 0
St Jude Medical, Inc. Common 790849103 10,190 161,510 SH   SOLE   161,510 0 0
Stryker Corporation Common 863667101 11,663 123,940 SH   SOLE   123,940 0 0
Supernus Pharmaceuticals, Inc. Note 7.50% 5/1/19 868459AB4 5,548 2,000,000 PRN   SOLE   2,000,000 0 0
Tenet Healthcare Corporation Common 88033G407 6,073 164,500 SH   SOLE   164,500 0 0
TetraLogic Pharmaceuticals Corporation Note 8.00% 6/15/19 88165UAB5 2,360 4,500,000 PRN   SOLE   4,500,000 0 0
Tetraphase Pharmaceuticals Inc. Common 88165N105 1,435 192,322 PRN   SOLE   192,322 0 0
Teva Pharmaceutical Industries Ltd. ADR 881624209 78,231 1,385,594 SH   SOLE   1,385,594 0 0
Thermo Fisher Scientific Inc. Common 883556102 10,564 86,395 SH   SOLE   86,395 0 0
Trillium Therapeutics Inc. Common 89620X506 847 65,000 SH   SOLE   65,000 0 0
Trovagene, Inc. Common 897238309 3,130 550,000 SH   SOLE   550,000 0 0
Ultragenyx Pharmaceutical Inc. Common 90400D108 8,514 88,400 SH   SOLE   88,400 0 0
UniQure NV Common N90064101 2,102 102,800 SH   SOLE   102,800 0 0
UniQure NV Common N90064101 2,102 102,800 SH Call SOLE   102,800 0 0
United Therapeutics Corporation Common 91307C102 23,964 182,600 SH   SOLE   182,600 0 0
UnitedHealth Group, Inc. Common 91324P102 36,265 312,600 SH   SOLE   312,600 0 0
UnitedHealth Group, Inc. Common 91324P102 10,406 89,700 SH Call SOLE   89,700 0 0
Ventas Inc. Common 92276F100 20,701 369,266 SH   SOLE   369,266 0 0
Verastem, Inc. Common 92337C104 895 500,000 SH   SOLE   500,000 0 0
Vertex Pharmaceuticals Incorporated Common 92532F100 105,171 1,009,903 SH   SOLE   1,009,903 0 0
WellCare Health Plans Inc. Common 94946T106 7,640 88,652 SH   SOLE   88,652 0 0
Welltower, Inc. Preferred 95040Q203 12,146 200,000 SH   SOLE   200,000 0 0
Wright Medical Group Inc. Common 98235T107 3,281 156,100 SH   SOLE   156,100 0 0
Xencor, Inc. Common 98401F105 245 20,000 SH   SOLE   20,000 0 0
Zafgen, Inc. Common 98885E103 425 13,307 SH   SOLE   13,307 0 0
Zimmer Biomet Holdings, Inc. Common 98956P102 9,609 102,300 SH   SOLE   102,300 0 0