The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| Achillion Pharmaceuticals Inc | COM | 00448Q201 | 17,629 | 2,551,261 | SH | SOLE | 1 | 2,551,261 | 0 | 0 | |
| ADAPTIMMUNE THERAPEUTICS-ADR | SPONDS ADR | 00653A107 | 83 | 6,923 | SH | SOLE | 1 | 6,923 | 0 | 0 | |
| Agenus Inc | COM | 00847G705 | 9,443 | 2,052,915 | SH | SOLE | 1 | 2,052,915 | 0 | 0 | |
| Allscripts Healthcare Solutions Inc | COM | 01988P108 | 595 | 48,000 | SH | SOLE | 1 | 48,000 | 0 | 0 | |
| Alnylam Pharmaceuticals Inc | COM | 02043Q107 | 42,246 | 525,713 | SH | SOLE | 1 | 525,713 | 0 | 0 | |
| Arrowhead Research Corp | COM NEW | 42797209 | 11,900 | 2,065,962 | SH | SOLE | 1 | 2,065,962 | 0 | 0 | |
| ATARA BIOTHERAPEUTICS, INC. | COM | 46513107 | 8,153 | 259,317 | SH | SOLE | 1 | 259,317 | 0 | 0 | |
| Berkshire Hathaway Inc | CL B | 84670702 | 7 | 50 | SH | SOLE | 1 | 50 | 0 | 0 | |
| BioCryst Pharmaceuticals Inc | COM | 09058V103 | 25,023 | 2,194,989 | SH | SOLE | 1 | 2,194,989 | 0 | 0 | |
| BioCryst Pharmaceuticals Inc | COM | 09058V103 | 425 | 1,971 | SH | Call | SOLE | 1 | 1,971 | 0 | 0 |
| BioPharmX Corp | COM | 09072X101 | 382 | 370,636 | SH | SOLE | 1 | 370,636 | 0 | 0 | |
| bluebird bio Inc | COM | 09609G100 | 12,775 | 149,325 | SH | SOLE | 1 | 149,325 | 0 | 0 | |
| Bristol-Myers Squibb Co | COM | 110122108 | 5,769 | 97,454 | SH | SOLE | 1 | 97,454 | 0 | 0 | |
| Bristol-Myers Squibb Co | COM | 110122108 | 2,588 | 7,500 | SH | Call | SOLE | 1 | 7,500 | 0 | 0 |
| Catalyst Biosciences Inc | COM | 14888D109 | 1,775 | 380,806 | SH | SOLE | 1 | 380,806 | 0 | 0 | |
| Celldex Therapeutics Inc | COM | 15117B103 | 7,462 | 707,957 | SH | SOLE | 1 | 707,957 | 0 | 0 | |
| Corium International Inc | COM | 21887L107 | 5,298 | 566,648 | SH | SOLE | 1 | 566,648 | 0 | 0 | |
| CytRx Corp | COM PAR $.001 | 232828509 | 1,059 | 446,714 | SH | SOLE | 1 | 446,714 | 0 | 0 | |
| DICERNA PHARMACEUTICALS INC | COM | 253031108 | 16,217 | 1,975,229 | SH | SOLE | 1 | 1,975,229 | 0 | 0 | |
| Dyax Corp | COM | 26746E103 | 2,169 | 113,641 | SH | SOLE | 1 | 113,641 | 0 | 0 | |
| Endologix Inc | COM | 29266S106 | 181 | 14,777 | SH | SOLE | 1 | 14,777 | 0 | 0 | |
| FIVEPRIME THERAPEUTICS INC | COM | 33830X104 | 10,823 | 703,267 | SH | SOLE | 1 | 703,267 | 0 | 0 | |
| Genomic Health Inc | COM | 37244C101 | 313 | 14,777 | SH | SOLE | 1 | 14,777 | 0 | 0 | |
| Global Blood Therapeutics Inc | COM | 37890U108 | 3,216 | 76,277 | SH | SOLE | 1 | 76,277 | 0 | 0 | |
| Global Blood Therapeutics Inc | COM | 37890U108 | 623 | 14,783 | SH | SOLE | 1 | 14,783 | 0 | 0 | |
| Incyte Corp | COM | 45337C102 | 32,953 | 298,674 | SH | SOLE | 1 | 298,674 | 0 | 0 | |
| Invuity Inc | COM NEW | 46187J205 | 70 | 5,000 | SH | SOLE | 1 | 5,000 | 0 | 0 | |
| Invuity Inc | COM NEW | 46187J205 | 2,383 | 170,000 | SH | SOLE | 1 | 170,000 | 0 | 0 | |
| KITE PHARMA INC | COM | 49803L109 | 20,593 | 369,850 | SH | SOLE | 1 | 369,850 | 0 | 0 | |
| La Jolla Pharmaceutical Co | COM PAR $.0001 2 | 503459604 | 29,575 | 1,064,247 | SH | SOLE | 1 | 1,064,247 | 0 | 0 | |
| Lipocine Inc | COM | 53630X104 | 2,476 | 209,333 | SH | SOLE | 1 | 209,333 | 0 | 0 | |
| Masimo Corp | COM | 574795100 | 999 | 25,900 | SH | SOLE | 1 | 25,900 | 0 | 0 | |
| Meridian Bioscience Inc | COM | 589584101 | 50 | 1,252 | SH | Call | SOLE | 1 | 1,252 | 0 | 0 |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 16,340 | 474,730 | SH | SOLE | 1 | 474,730 | 0 | 0 | |
| Natera Inc | COM | 632307104 | 339 | 31,236 | SH | SOLE | 1 | 31,236 | 0 | 0 | |
| NewLink Genetics Corp | COM | 651511107 | 999 | 27,870 | SH | SOLE | 1 | 27,870 | 0 | 0 | |
| NIVALIS THERAPEUTICS INC | COM | 65481J109 | 389 | 30,000 | SH | SOLE | 1 | 30,000 | 0 | 0 | |
| Omeros Corp | COM | 682143102 | 5,292 | 482,831 | SH | SOLE | 1 | 482,831 | 0 | 0 | |
| OraSure Technologies Inc | COM | 68554V108 | 1,434 | 322,996 | SH | SOLE | 1 | 322,996 | 0 | 0 | |
| Presbia PLC | SHS | G7234P100 | 1,918 | 350,000 | SH | SOLE | 1 | 350,000 | 0 | 0 | |
| REGENXBIO INC | COM | 75901B107 | 2,169 | 98,439 | SH | SOLE | 1 | 98,439 | 0 | 0 | |
| REGENXBIO INC | COM | 75901B107 | 2,302 | 104,494 | SH | SOLE | 1 | 104,494 | 0 | 0 | |
| Repros Therapeutics Inc | COM NEW | 76028H209 | 1,704 | 229,364 | SH | SOLE | 1 | 229,364 | 0 | 0 | |
| Symmetry Surgical Inc | COM | 87159G100 | 7,079 | 795,422 | SH | SOLE | 1 | 795,422 | 0 | 0 | |
| United States Oil ETF | UNITS | 91232N108 | 42 | 13,850 | SH | Call | SOLE | 1 | 13,850 | 0 | 0 |
| VBI VACCINES | COM | 91790E102 | 1,691 | 640,458 | SH | SOLE | 1 | 640,458 | 0 | 0 | |
| Veracyte Inc | COM | 92337F107 | 117 | 25,000 | SH | SOLE | 1 | 25,000 | 0 | 0 | |