The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| Achillion Pharmaceuticals Inc | COM | 00448Q201 | 15,999 | 1,622,633 | SH | DFND | 1 | 0 | 0 | 0 | |
| Berkshire Hathaway Inc | COM | 084670702 | 7 | 50 | SH | DFND | 1 | 0 | 0 | 0 | |
| bluebird bio Inc | COM | 09609G100 | 12,077 | 100,000 | SH | DFND | 1 | 0 | 0 | 0 | |
| Coronado Biosciences Inc | COM | 21976U109 | 1,925 | 500,000 | SH | DFND | 1 | 0 | 0 | 0 | |
| CytRx Corp | COM PAR $.001 | 232828509 | 1,900 | 563,814 | SH | DFND | 1 | 0 | 0 | 0 | |
| Dicerna Pharmaceuticals Inc | COM | 253031108 | 23,813 | 990,981 | SH | DFND | 1 | 0 | 0 | 0 | |
| Kite Pharma Inc | COM | 49803L109 | 21,666 | 375,623 | SH | DFND | 1 | 0 | 0 | 0 | |
| Lpath Inc | COM NEW | 548910306 | 148 | 60,000 | SH | DFND | 1 | 0 | 0 | 0 | |
| Targacept Inc | COM | 87611R306 | 7,917 | 2,665,643 | SH | DFND | 1 | 0 | 0 | 0 | |
| Tenax Therapeutics Inc | COM | 88032L100 | 8 | 2,400 | SH | DFND | 1 | 0 | 0 | 0 | |
| Alnylam Pharmaceuticals Inc | COM | 02043Q107 | 37,110 | 355,395 | SH | DFND | 1 | 0 | 0 | 0 | |
| Arrowhead Research Corp | COM NEW | 042797209 | 16,304 | 2,410,000 | SH | DFND | 1 | 0 | 0 | 0 | |
| Assembly Biosciences Inc | COM | 045396108 | 2,701 | 204,000 | SH | DFND | 1 | 0 | 0 | 0 | |
| BioCryst Pharmaceuticals Inc | COM | 09058V103 | 20,420 | 2,261,361 | SH | DFND | 1 | 0 | 0 | 0 | |
| Dyax Corp | COM | 26746E103 | 26,558 | 1,585,098 | SH | DFND | 1 | 0 | 0 | 0 | |
| La Jolla Pharmaceutical Co | COM PAR $.0001 2 | 503459604 | 19,476 | 1,064,247 | SH | DFND | 1 | 0 | 0 | 0 | |
| Lipocine Inc | COM | 53630X104 | 1,444 | 209,333 | SH | DFND | 1 | 0 | 0 | 0 | |
| Relypsa Inc | COM | 759531106 | 1,150 | 31,872 | SH | DFND | 1 | 0 | 0 | 0 | |
| Repros Therapeutics Inc | COM NEW | 76028H209 | 1,970 | 229,364 | SH | DFND | 1 | 0 | 0 | 0 | |
| Taro Pharmaceutical Industries Ltd | SHS | M8737E108 | 1,230 | 8,721 | SH | DFND | 1 | 0 | 0 | 0 | |
| ZS Pharma Inc | COM | 98979G105 | 3,001 | 71,315 | SH | DFND | 1 | 0 | 0 | 0 | |
| Avalanche Biotechnologies In | COM | 05337G107 | 2,079 | 51,300 | SH | DFND | 1 | 0 | 0 | 0 | |
| Presbia Plc | COM | G7234P100 | 2,587 | 350,000 | SH | DFND | 1 | 0 | 0 | 0 | |
| Shake Shack Inc | COM | 819047101 | 25 | 500 | SH | DFND | 1 | 0 | 0 | 0 | |