The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
|
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
|
||||||||||||||||
| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACHILLION PHARMACEUTICALS IN | COM | 00448Q201 | 19,877 | 1,622,633 | SH | DFND | 1 | 1,622,633 | 0 | 0 | |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 33,018 | 340,395 | SH | DFND | 1 | 340,395 | 0 | 0 | |
| ARROWHEAD RESH CORP | COM NEW | 042797209 | 19,262 | 2,610,000 | SH | DFND | 1 | 2,610,000 | 0 | 0 | |
| ASSEMBLY BIOSCIENCES INC | COM | 045396108 | 1,603 | 204,000 | SH | DFND | 1 | 204,000 | 0 | 0 | |
| AVALANCHE BIOTECHNOLOGIES IN | COM | 05337G107 | 2,700 | 50,000 | SH | DFND | 1 | 50,000 | 0 | 0 | |
| BIOCRYST PHARMACEUTICALS | COM | 09058V103 | 27,498 | 2,261,361 | SH | DFND | 1 | 2,261,361 | 0 | 0 | |
| CYTRX CORP | COM PAR $.001 | 232828509 | 1,932 | 705,000 | SH | DFND | 1 | 705,000 | 0 | 0 | |
| DICERNA PHARMACEUTICALS INC | COM | 253031108 | 18,380 | 1,115,981 | SH | DFND | 1 | 1,115,981 | 0 | 0 | |
| DYAX CORP | COM | 26746E103 | 29,973 | 2,131,808 | SH | DFND | 1 | 2,131,808 | 0 | 0 | |
| LA JOLLA PHARMACEUTICAL CO | COM PAR $.0001 2 | 503459604 | 19,635 | 1,064,247 | SH | DFND | 1 | 1,064,247 | 0 | 0 | |
| LIPOCINE INC NEW | COM | 53630X104 | 1,101 | 209,333 | SH | DFND | 1 | 209,333 | 0 | 0 | |
| LPATH INC | COM NEW | 548910306 | 169 | 60,000 | SH | DFND | 1 | 60,000 | 0 | 0 | |
| NEVRO CORP | COM | 64157F103 | 594 | 15,356 | SH | DFND | 1 | 15,356 | 0 | 0 | |
| PROTALIX BIOTHERAPEUTICS INC | COM | 74365A101 | 1,553 | 843,851 | SH | DFND | 1 | 843,851 | 0 | 0 | |
| RELYPSA INC | COM | 759531106 | 13,867 | 450,239 | SH | DFND | 1 | 450,239 | 0 | 0 | |
| REPROS THERAPEUTICS INC | COM NEW | 76028H209 | 2,287 | 229,364 | SH | DFND | 1 | 229,364 | 0 | 0 | |
| TARGACEPT INC | COM | 87611R306 | 7,011 | 2,665,643 | SH | DFND | 1 | 2,665,643 | 0 | 0 | |
| TARO PHARMACEUTICAL INDS LTD | SHS | M8737E108 | 39,698 | 267,883 | SH | DFND | 1 | 267,883 | 0 | 0 | |
| VANDA PHARMACEUTICALS INC | COM | 921659108 | 7,160 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |
| XENOPORT INC | COM | 98411C100 | 7,389 | 842,568 | SH | DFND | 1 | 842,568 | 0 | 0 | |
| ZS PHARMA INC | COM | 98979G105 | 15,581 | 374,821 | SH | DFND | 1 | 374,821 | 0 | 0 | |