The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
|
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
|
||||||||||||||||
| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACORDA THERAPEUTICS INC | COM | 00484M106 | 12,626 | 604,700 | SH | DFND | 1 | 604,700 | 0 | 0 | |
| ADMA BIOLOGICS INC | COM | 000899104 | 8,060 | 1,113,293 | SH | DFND | 1 | 1,113,293 | 0 | 0 | |
| ADVAXIS INC | COM NEW | 007624208 | 16,726 | 1,564,679 | SH | DFND | 1 | 1,564,679 | 0 | 0 | |
| AEGERION PHARMACEUTICALS INC | COM | 00767E102 | 12,953 | 4,361,291 | SH | DFND | 1 | 4,361,291 | 0 | 0 | |
| ALCOBRA LTD | SHS | M2239P109 | 5,057 | 2,047,449 | SH | DFND | 1 | 2,047,449 | 0 | 0 | |
| AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 10,715 | 3,359,049 | SH | DFND | 1 | 3,359,049 | 0 | 0 | |
| ANGIODYNAMICS INC | COM | 03475V101 | 50,703 | 2,890,679 | SH | DFND | 1 | 2,890,679 | 0 | 0 | |
| ANTARES PHARMA INC | COM | 036642106 | 25,007 | 14,885,393 | SH | DFND | 1 | 14,885,393 | 0 | 0 | |
| ANTHERA PHARMACEUTICALS INC | COM NEW | 03674U201 | 3,637 | 1,154,674 | SH | DFND | 1 | 1,154,674 | 0 | 0 | |
| ARALEZ PHARMACEUTICALS INC | COM | 03852X100 | 21,374 | 4,406,990 | SH | DFND | 1 | 4,406,990 | 0 | 0 | |
| ARATANA THERAPEUTICS INC | COM | 03874P101 | 28,885 | 3,085,979 | SH | DFND | 1 | 3,085,979 | 0 | 0 | |
| AVIRAGEN THERAPEUTICS INC | COM | 053761102 | 6,694 | 3,486,711 | SH | DFND | 1 | 3,486,711 | 0 | 0 | |
| BIODELIVERY SCIENCES INTL IN | COM | 09060J106 | 14,010 | 5,188,794 | SH | DFND | 1 | 5,188,794 | 0 | 0 | |
| CARDIOVASCULAR SYS INC DEL | COM | 141619106 | 5,473 | 230,532 | SH | DFND | 1 | 230,532 | 0 | 0 | |
| CAS MED SYS INC | COM PAR $0.004 | 124769209 | 972 | 562,030 | SH | DFND | 1 | 562,030 | 0 | 0 | |
| CATALYST PHARMACEUTICALS INC | COM | 14888U101 | 8,938 | 8,200,000 | SH | DFND | 1 | 8,200,000 | 0 | 0 | |
| CIDARA THERAPEUTICS INC | COM | 171757107 | 1,911 | 166,875 | SH | DFND | 1 | 166,875 | 0 | 0 | |
| CONTRAFECT CORP | COM | 212326102 | 3,544 | 1,429,109 | SH | DFND | 1 | 1,429,109 | 0 | 0 | |
| CORIUM INTERNATIONAL ORD | COM | 21887L107 | 10,808 | 1,919,721 | SH | DFND | 1 | 1,919,721 | 0 | 0 | |
| DEPOMED INC | COM | 249908104 | 9,475 | 379,474 | SH | DFND | 1 | 379,474 | 0 | 0 | |
| DERMA SCIENCES INC | COM PAR $.01 | 249827502 | 11,965 | 2,562,104 | SH | DFND | 1 | 2,562,104 | 0 | 0 | |
| DEXTERA SURGICAL INC | COM | 252366109 | 1,587 | 844,167 | SH | DFND | 1 | 844,167 | 0 | 0 | |
| DURECT CORP | COM | 266605104 | 8,889 | 6,395,206 | SH | DFND | 1 | 6,395,206 | 0 | 0 | |
| DYNAVAX TECHNOLOGIES CORP | COM NEW | 268158201 | 14,139 | 1,347,810 | SH | DFND | 1 | 1,347,810 | 0 | 0 | |
| EGALET CORP | COM | 28226B104 | 8,635 | 1,134,750 | SH | DFND | 1 | 1,134,750 | 0 | 0 | |
| EGALET CORP | NOTE 5.500% 4/0 | 28226BAB0 | 8,781 | 10,000,000 | PRN | DFND | 1 | 10,000,000 | 0 | 0 | |
| ENDO INTL PLC | SHS | G30401106 | 29,309 | 1,454,538 | SH | DFND | 1 | 1,454,538 | 0 | 0 | |
| ENDOLOGIX INC | COM | 29266S106 | 10,240 | 800,000 | SH | DFND | 1 | 800,000 | 0 | 0 | |
| FLAMEL TECHNOLOGIES SA | SPONSORED ADR | 338488109 | 54,491 | 4,394,464 | SH | DFND | 1 | 4,394,464 | 0 | 0 | |
| HERON THERAPEUTICS INC | COM | 427746102 | 49,105 | 2,850,000 | SH | DFND | 1 | 2,850,000 | 0 | 0 | |
| HERON THERAPEUTICS INC | COM | 427746102 | 5,169 | 300,000 | SH | Call | DFND | 1 | 300,000 | 0 | 0 |
| HORIZON PHARMA PLC | SHS | G4617B105 | 99,773 | 5,503,182 | SH | DFND | 1 | 5,503,182 | 0 | 0 | |
| HORIZON PHARMA PLC | SHS | G4617B105 | 4,533 | 250,000 | SH | Call | DFND | 1 | 250,000 | 0 | 0 |
| HORIZON PHARMA PLC | SHS | G4617B105 | 5,439 | 300,000 | SH | Call | DFND | 1 | 300,000 | 0 | 0 |
| HORIZON PHARMA PLC | SHS | G4617B105 | 9,065 | 500,000 | SH | Call | DFND | 1 | 500,000 | 0 | 0 |
| IDERA PHARMACEUTICALS INC | COM NEW | 45168K306 | 6,215 | 2,427,745 | SH | DFND | 1 | 2,427,745 | 0 | 0 | |
| IGNYTA INC | COM | 451731103 | 14,194 | 2,256,546 | SH | DFND | 1 | 2,256,546 | 0 | 0 | |
| INTERSECT ENT INC | COM | 46071F103 | 10,115 | 638,600 | SH | DFND | 1 | 638,600 | 0 | 0 | |
| LA JOLLA PHARMACEUTICAL CO | COM PAR $.0001 2 | 503459604 | 34,425 | 1,447,053 | SH | DFND | 1 | 1,447,053 | 0 | 0 | |
| LION BIOTECHNOLOGIES INC | COM | 53619R102 | 21,713 | 2,638,259 | SH | DFND | 1 | 2,638,259 | 0 | 0 | |
| MEDGENICS INC | COM NEW | 58436Q203 | 18,773 | 3,370,306 | SH | DFND | 1 | 3,370,306 | 0 | 0 | |
| MEDICINES CO | COM | 584688105 | 9,646 | 255,600 | SH | DFND | 1 | 255,600 | 0 | 0 | |
| MEDIWOUND LTD | ORD SHS | M68830104 | 4,089 | 530,985 | SH | DFND | 1 | 530,985 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 6,610 | 1,000,000 | SH | DFND | 1 | 1,000,000 | 0 | 0 | |
| NEVRO CORP | COM | 64157F103 | 5,277 | 50,555 | SH | DFND | 1 | 50,555 | 0 | 0 | |
| NEXVET BIOPHARMA PUB LTD CO | ORD SHS | G6503X109 | 4,222 | 1,017,255 | SH | DFND | 1 | 1,017,255 | 0 | 0 | |
| NOVADAQ TECHNOLOGIES INC | COM | 66987G102 | 59,866 | 5,174,209 | SH | DFND | 1 | 5,174,209 | 0 | 0 | |
| OPHTHOTECH CORP | COM | 683745103 | 18,913 | 410,000 | SH | DFND | 1 | 410,000 | 0 | 0 | |
| PACIRA PHARMACEUTICALS INC | COM | 695127100 | 5,156 | 150,680 | SH | DFND | 1 | 150,680 | 0 | 0 | |
| PACIRA PHARMACEUTICALS INC | COM | 695127100 | 5,133 | 150,000 | SH | Call | DFND | 1 | 150,000 | 0 | 0 |
| PARATEK PHARMACEUTICALS INC | COM | 699374302 | 10,228 | 786,134 | SH | DFND | 1 | 786,134 | 0 | 0 | |
| PERNIX THERAPEUTICS HLDGS IN | DBCV 4.250% 4/0 | 71426VAK4 | 4,340 | 15,500,000 | PRN | DFND | 1 | 15,500,000 | 0 | 0 | |
| PROGENICS PHARMACEUTICALS IN | COM | 743187106 | 56,661 | 8,951,169 | SH | DFND | 1 | 8,951,169 | 0 | 0 | |
| QLT INC | COM | 746927102 | 10,856 | 5,269,831 | SH | DFND | 1 | 5,269,831 | 0 | 0 | |
| RAPTOR PHARMACEUTICAL CORP | COM | 75382F106 | 5,963 | 664,800 | SH | DFND | 1 | 664,800 | 0 | 0 | |
| RECRO PHARMA INC | COM | 75629F109 | 21,659 | 2,450,086 | SH | DFND | 1 | 2,450,086 | 0 | 0 | |
| REDHILL BIOPHARMA LTD | SPONSORED ADS | 757468103 | 9,962 | 717,203 | SH | DFND | 1 | 717,203 | 0 | 0 | |
| RETROPHIN INC | COM | 761299106 | 77,642 | 3,469,271 | SH | DFND | 1 | 3,469,271 | 0 | 0 | |
| RXI PHARMACEUTICALS CORP NEW | COM | 74979C501 | 585 | 316,010 | SH | DFND | 1 | 316,010 | 0 | 0 | |
| SCYNEXIS INC | COM | 811292101 | 5,717 | 1,477,273 | SH | DFND | 1 | 1,477,273 | 0 | 0 | |
| SEASPINE HLDGS CORP | COM | 81255T108 | 11,121 | 1,100,007 | SH | DFND | 1 | 1,100,007 | 0 | 0 | |
| SPDR SERIES TRUST | S&P BIOTECH | 78464A870 | 33,145 | 500,000 | SH | Put | DFND | 1 | 500,000 | 0 | 0 |
| STRATA SKIN SCIENCES INC | COM | 86272A107 | 510 | 961,422 | SH | DFND | 1 | 961,422 | 0 | 0 | |
| STRONGBRIDGE BIOPHARMA PLC | SHS USD | G85347105 | 8,648 | 1,656,706 | SH | DFND | 1 | 1,656,706 | 0 | 0 | |
| TANDEM DIABETES CARE INC | COM | 875372104 | 2,561 | 334,300 | SH | DFND | 1 | 334,300 | 0 | 0 | |
| TELIGENT INC NEW | COM | 87960W104 | 16,734 | 2,201,901 | SH | DFND | 1 | 2,201,901 | 0 | 0 | |
| TENAX THERAPEUTICS INC | COM | 88032L100 | 4,557 | 1,968,631 | SH | DFND | 1 | 1,968,631 | 0 | 0 | |
| TEVA PHARMACEUTICAL INDS LTD | ADR | 881624209 | 13,803 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| TREVENA INC | COM | 89532E109 | 3,321 | 492,000 | SH | DFND | 1 | 492,000 | 0 | 0 | |
| TRUPANION INC | COM | 898202106 | 2,680 | 158,600 | SH | DFND | 1 | 158,600 | 0 | 0 | |
| WINDTREE THERAPEUTICS INC | COM | 97382D105 | 1,991 | 777,797 | SH | DFND | 1 | 777,797 | 0 | 0 | |
| ZOGENIX INC | COM NEW | 98978L204 | 10,085 | 882,312 | SH | DFND | 1 | 882,312 | 0 | 0 | |