The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIOMED INC COM 003654100 242,294 1,884,384 SH   SOLE 0 1,884,384 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 47,140 1,481,930 SH   SOLE 0 1,481,930 0 0
ACELRX PHARMACEUTICALS INC COM 00444T100 6,359 1,634,608 SH   SOLE 0 1,634,608 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 5,696 379,727 SH   SOLE 0 379,727 0 0
ALCOBRA LTD SHS M2239P109 674 272,788 SH   SOLE 0 272,788 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 68,831 561,700 SH   SOLE 0 561,700 0 0
ALIGN TECHNOLOGY INC COM 016255101 3,512 37,457 SH   SOLE 0 37,457 0 0
ALIMERA SCIENCES INC COM 016259103 4,491 3,013,793 SH   SOLE 0 3,013,793 0 0
AMAG PHARMACEUTICALS INC COM 00163U106 81,538 3,326,720 SH   SOLE 0 3,326,720 0 0
AMICUS THERAPEUTICS INC COM 03152W109 42,072 5,685,388 SH   SOLE 0 5,685,388 0 0
ARIAD PHARMACEUTICALS INC COM 04033A100 35,424 2,587,617 SH   SOLE 0 2,587,617 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 165,694 1,790,899 SH   SOLE 0 1,790,899 0 0
CELGENE CORP COM 151020104 30,596 292,700 SH   SOLE 0 292,700 0 0
CEMPRA INC COM 15130J109 68,836 2,844,483 SH   SOLE 0 2,844,483 0 0
CLOVIS ONCOLOGY INC COM 189464100 137,137 3,804,088 SH   SOLE 0 3,804,088 0 0
CYTOKINETICS INC COM NEW 23282W605 1,135 123,686 SH   SOLE 0 123,686 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 1,575 267,890 SH   SOLE 0 267,890 0 0
ENDO INTL PLC SHS G30401106 19,048 945,330 SH   SOLE 0 945,330 0 0
EPIZYME INC COM 29428V104 27,695 2,814,540 SH   SOLE 0 2,814,540 0 0
EXACT SCIENCES CORP COM 30063P105 7,372 396,976 SH   SOLE 0 396,976 0 0
GILEAD SCIENCES INC COM 375558103 25,192 318,400 SH   SOLE 0 318,400 0 0
HISTOGENICS CORP COM 43358V109 1,459 454,545 SH   SOLE 0 454,545 0 0
IDERA PHARMACEUTICALS INC COM NEW 45168K306 3,220 1,257,748 SH   SOLE 0 1,257,748 0 0
INSMED INC COM PAR $.01 457669307 73,926 5,091,298 SH   SOLE 0 5,091,298 0 0
INTREXON CORP COM 46122T102 1,320 47,100 SH   SOLE 0 47,100 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 30,025 3,085,849 SH   SOLE 0 3,085,849 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 116 63,517 SH   SOLE 0 63,517 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 19,299 1,650,876 SH   SOLE 0 1,650,876 0 0
OREXIGEN THERAPEUTICS INC COM NEW 686164302 555 167,302 SH   SOLE 0 167,302 0 0
PROTHENA CORP PLC SHS G72800108 56,039 934,455 SH   SOLE 0 934,455 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 19,033 5,186,088 SH   SOLE 0 5,186,088 0 0
SAGE THERAPEUTICS INC COM 78667J108 41,539 902,051 SH   SOLE 0 902,051 0 0
SHIRE PLC SPONSORED ADR 82481R106 23,884 123,200 SH   SOLE 0 123,200 0 0
SOPHIRIS BIO INC COM NEW 83578Q209 768 247,000 SH   SOLE 0 247,000 0 0
STAAR SURGICAL CO COM PAR $0.01 852312305 30,499 3,244,610 SH   SOLE 0 3,244,610 0 0
SUNESIS PHARMACEUTICALS INC COM PAR 867328700 5,080 1,162,473 SH   SOLE 0 1,162,473 0 0
UNIQURE NV SHS N90064101 156 20,453 SH   SOLE 0 20,453 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 208,229 1,763,458 SH   SOLE 0 1,763,458 0 0
VANDA PHARMACEUTICALS INC COM 921659108 68,402 4,110,708 SH   SOLE 0 4,110,708 0 0
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 59,865 2,440,493 SH   SOLE 0 2,440,493 0 0
ZELTIQ AESTHETICS INC COM 98933Q108 55,479 1,414,563 SH   SOLE 0 1,414,563 0 0
ZOGENIX INC COM NEW 98978L204 337 29,500 SH   SOLE 0 29,500 0 0