The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 18,629 440,500 SH   DFND 1 185,300 0 255,200
ABBVIE INC COM 00287Y109 266,780 4,229,900 SH   DFND 1 1,406,100 0 2,823,800
ACHILLION PHARMACEUTICALS IN COM 00448Q201 106,168 13,107,200 SH   DFND 1 5,140,500 0 7,966,700
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 5,105 724,184 SH   SOLE   724,184 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 8,719 1,360,224 SH   SOLE   1,360,224 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 30,083 797,100 SH   DFND 1 320,300 0 476,800
AETNA INC NEW COM 00817Y108 13,461 116,600 SH   DFND 1 46,200 0 70,400
AFFIMED N V COM N01045108 9,383 3,375,000 SH   SOLE   3,375,000 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 174,930 3,714,800 SH   DFND 1 1,590,200 0 2,124,600
ALEXION PHARMACEUTICALS INC COM 015351109 323,262 2,638,011 SH   DFND 1 875,300 0 1,762,711
ALIMERA SCIENCES INC COM 016259103 373 250,000 SH   DFND 1 98,300 0 151,700
ALLERGAN PLC SHS G0177J108 179,340 778,690 SH   DFND 1 288,500 0 490,190
ALLERGAN PLC SHS G0177J108 11,516 50,000 SH Call DFND 1 22,000 0 28,000
ALLERGAN PLC PFD CONV SER A G0177J116 72,455 88,200 SH   DFND 1 30,300 0 57,900
AMARIN CORP PLC SPONS ADR NEW 023111206 1,117 350,000 SH   SOLE   350,000 0 0
AMEDISYS INC COM 023436108 3,392 71,500 SH   DFND 1 32,400 0 39,100
AMGEN INC COM 031162100 406,466 2,436,700 SH   DFND 1 725,000 0 1,711,700
ARALEZ PHARMACEUTICALS INC COM 03852X100 330 68,143 SH   DFND 1 27,339 0 40,804
ARRAY BIOPHARMA INC COM 04269X105 95,714 14,179,900 SH   DFND 1 5,395,600 0 8,784,300
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 15,876 2,159,973 SH   DFND 1 987,200 0 1,172,773
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 44,039 2,191,000 SH   SOLE   2,191,000 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 10,073 1,397,100 SH   DFND 1 647,100 0 750,000
AUDENTES THERAPEUTICS INC COM 05070R104 85,517 4,801,638 SH   SOLE   4,801,638 0 0
BARD C R INC COM 067383109 13,008 58,000 SH   DFND 1 26,300 0 31,700
BIOGEN INC COM 09062X103 417,551 1,333,900 SH   DFND 1 403,600 0 930,300
BIOLINERX LTD SPONSORED ADR 09071M106 1,194 1,038,600 SH   SOLE   1,038,600 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 106,574 1,151,900 SH   DFND 1 331,700 0 820,200
BIOMARIN PHARMACEUTICAL INC NOTE 0.750%10/1 09061GAE1 600 500,000 PRN   DFND 1 215,000 0 285,000
BIOMARIN PHARMACEUTICAL INC NOTE 1.500%10/1 09061GAF8 624 500,000 PRN   DFND 1 215,000 0 285,000
BLUEBIRD BIO INC COM 09609G100 80,374 1,185,800 SH   DFND 1 475,600 0 710,200
BOSTON SCIENTIFIC CORP COM 101137107 409,638 17,211,700 SH   DFND 1 6,316,400 0 10,895,300
BRISTOL MYERS SQUIBB CO COM 110122108 117,945 2,187,400 SH   DFND 1 730,200 0 1,457,200
BRISTOL MYERS SQUIBB CO COM 110122108 5,392 100,000 SH Call DFND 1 45,500 0 54,500
CELGENE CORP COM 151020104 308,215 2,948,577 SH   DFND 1 1,062,200 0 1,886,377
CELLECTIS S A SPONSORED ADS 15117K103 8,428 350,000 SH   DFND 1 162,100 0 187,900
CIGNA CORPORATION COM 125509109 42,445 325,700 SH   DFND 1 143,300 0 182,400
COGENTIX MED INC COM 19243A104 1,598 878,145 SH   DFND 1 386,807 0 491,338
COHERUS BIOSCIENCES INC COM 19249H103 17,985 671,600 SH   DFND 1 139,300 0 532,300
COOPER COS INC COM NEW 216648402 44,833 250,100 SH   DFND 1 83,500 0 166,600
CORVUS PHARMACEUTICALS INC COM 221015100 88,490 5,379,349 SH   SOLE   5,379,349 0 0
CYNAPSUS THERAPEUTICS INC COM PAR NO PAR 23257Y859 20,114 499,999 SH   SOLE   499,999 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 12,559 345,700 SH   SOLE   345,700 0 0
DERMIRA INC COM 24983L104 14,394 425,600 SH   SOLE   425,600 0 0
DIMENSION THERAPEUTICS INC COM 25433V105 43,128 5,397,698 SH   SOLE   5,397,698 0 0
EAGLE PHARMACEUTICALS INC COM 269796108 72,527 1,036,100 SH   DFND 1 457,200 0 578,900
EDWARDS LIFESCIENCES CORP COM 28176E108 165,553 1,373,200 SH   DFND 1 500,700 0 872,500
EHEALTH INC COM 28238P109 20,346 1,815,000 SH   DFND 1 833,900 0 981,100
EXACT SCIENCES CORP COM 30063P105 20,457 1,101,600 SH   SOLE   1,101,600 0 0
EXELIXIS INC COM 30161Q104 79,379 6,206,300 SH   DFND 1 2,430,400 0 3,775,900
EXPRESS SCRIPTS HLDG CO COM 30219G108 102,403 1,451,900 SH   DFND 1 551,800 0 900,100
FLUIDIGM CORP DEL COM 34385P108 13,986 1,746,100 SH   DFND 1 215,500 0 1,530,600
FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAA6 6,213 10,000,000 PRN   DFND 1 4,466,000 0 5,534,000
FORWARD PHARMA A/S SPONSORED ADR 34986J105 16,750 798,000 SH   DFND 1 226,500 0 571,500
GALAPAGOS NV SPON ADR 36315X101 29,608 457,900 SH   DFND 1 32,000 0 425,900
GILEAD SCIENCES INC COM 375558103 159,087 2,010,700 SH   DFND 1 618,400 0 1,392,300
GLAUKOS CORP COM 377322102 82,273 2,180,000 SH   SOLE   2,180,000 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 4,805 36,200 SH   SOLE   36,200 0 0
HCA HOLDINGS INC COM 40412C101 99,242 1,312,200 SH   DFND 1 344,800 0 967,400
HUMANA INC COM 444859102 74,913 423,500 SH   DFND 1 132,800 0 290,700
ILLUMINA INC COM 452327109 90,013 495,500 SH   DFND 1 108,100 0 387,400
IMMUNOGEN INC COM 45253H101 16,336 6,095,647 SH   DFND 1 1,919,480 0 4,176,167
IMMUNOMEDICS INC COM 452907108 12,357 3,802,000 SH   DFND 1 2,050,550 0 1,751,450
IMMUNOMEDICS INC NOTE 4.750% 2/1 452907AK4 25,479 30,000,000 PRN   DFND 1 16,014,000 0 13,986,000
IMPAX LABORATORIES INC COM 45256B101 89,764 3,787,500 SH   DFND 1 1,348,300 0 2,439,200
INCYTE CORP COM 45337C102 174,453 1,850,178 SH   DFND 1 475,200 0 1,374,978
INCYTE CORP NOTE 0.375%11/1 45337CAM4 8,090 4,250,000 PRN   DFND 1 1,816,000 0 2,434,000
INCYTE CORP NOTE 1.250%11/1 45337CAN2 8,267 4,250,000 PRN   DFND 1 1,816,000 0 2,434,000
INFINITY PHARMACEUTICALS INC COM 45665G303 5,070 3,250,300 SH   DFND 1 1,064,000 0 2,186,300
INOTEK PHARMACEUTICALS CORP COM 45780V102 17,531 1,849,300 SH   DFND 1 846,500 0 1,002,800
INOTEK PHARMACEUTICALS CORP NOTE 5.750% 8/0 45780VAB8 9,547 7,000,000 PRN   DFND 1 3,200,000 0 3,800,000
INSMED INC COM PAR $.01 457669307 76,246 5,251,100 SH   DFND 1 2,329,260 0 2,921,840
INSYS THERAPEUTICS INC NEW COM NEW 45824V209 64,871 5,502,240 SH   DFND 1 2,228,100 0 3,274,140
INTELLIA THERAPEUTICS INC COM 45826J105 45,310 2,662,180 SH   SOLE   2,662,180 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 184,341 1,120,000 SH   SOLE   1,120,000 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 1,373 90,000 SH Call DFND 1 41,200 0 48,800
INTUITIVE SURGICAL INC COM NEW 46120E602 136,123 187,800 SH   DFND 1 40,600 0 147,200
INVITAE CORP COM 46185L103 4,000 456,666 SH   SOLE   456,666 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 157,990 9,949,000 SH   DFND 1 3,595,700 0 6,353,300
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 29,993 246,900 SH   DFND 1 83,500 0 163,400
JOHNSON & JOHNSON COM 478160104 101,356 858,000 SH   DFND 1 370,700 0 487,300
LILLY ELI & CO COM 532457108 163,771 2,040,500 SH   DFND 1 671,000 0 1,369,500
LILLY ELI & CO COM 532457108 20,065 250,000 SH Call DFND 1 112,500 0 137,500
LION BIOTECHNOLOGIES INC COM 53619R102 27,841 3,382,900 SH   DFND 1 1,446,500 0 1,936,400
LOXO ONCOLOGY INC COM 548862101 45,239 1,728,000 SH   SOLE   1,728,000 0 0
MAGELLAN HEALTH INC COM NEW 559079207 37,595 699,700 SH   DFND 1 310,900 0 388,800
MALLINCKRODT PUB LTD CO SHS G5785G107 81,657 1,170,200 SH   DFND 1 510,200 0 660,000
MARINUS PHARMACEUTICALS INC COM 56854Q101 1,033 567,600 SH   SOLE   567,600 0 0
MEDIGUS LTD SPONSORED ADR 58471G102 756 600,000 SH   SOLE   600,000 0 0
MEDTRONIC PLC SHS G5960L103 66,234 766,600 SH   DFND 1 322,100 0 444,500
MERCK & CO INC COM 58933Y105 218,859 3,506,800 SH   DFND 1 1,197,100 0 2,309,700
MERCK & CO INC COM 58933Y105 21,847 350,000 SH Call DFND 1 160,500 0 189,500
MINERVA NEUROSCIENCES INC COM 603380106 7,851 556,200 SH   SOLE   556,200 0 0
MOLINA HEALTHCARE INC COM 60855R100 153,656 2,634,700 SH   DFND 1 900,000 0 1,734,700
NABRIVA THERAPEUTICS AG SPONSORED ADR 62957M104 9,271 1,315,000 SH   SOLE   1,315,000 0 0
NATERA INC COM 632307104 14,178 1,276,190 SH   SOLE   1,276,190 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 91,936 1,815,474 SH   DFND 1 743,370 0 1,072,104
NEWLINK GENETICS CORP COM 651511107 29,113 1,938,300 SH   DFND 1 721,200 0 1,217,100
NIVALIS THERAPEUTICS INC COM 65481J109 480 59,000 SH   SOLE   59,000 0 0
NUVASIVE INC COM 670704105 8,233 123,500 SH   SOLE   123,500 0 0
OPHTHOTECH CORP COM 683745103 53,797 1,166,200 SH   DFND 1 419,460 0 746,740
OREXIGEN THERAPEUTICS INC NOTE 2.750%12/0 686164AB0 1,441 5,210,000 PRN   DFND 1 2,210,000 0 3,000,000
OTONOMY INC COM 68906L105 33,653 1,850,094 SH   SOLE   1,850,094 0 0
PERNIX THERAPEUTICS HLDGS IN COM 71426V108 668 1,073,000 SH   DFND 1 485,000 0 588,000
PERNIX THERAPEUTICS HLDGS IN DBCV 4.250% 4/0 71426VAK4 3,514 12,000,000 PRN   DFND 1 6,500,000 0 5,500,000
PFIZER INC COM 717081103 119,636 3,532,200 SH   DFND 1 1,486,000 0 2,046,200
PIERIS PHARMACEUTICALS INC COM 720795103 13,267 7,259,620 SH   SOLE   7,259,620 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 8,423 370,900 SH   SOLE   370,900 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 15,377 2,305,446 SH   DFND 1 973,446 0 1,332,000
PUMA BIOTECHNOLOGY INC COM 74587V107 159,815 2,383,525 SH   DFND 1 949,000 0 1,434,525
QLT INC COM 746927102 1,030 500,000 SH   DFND 1 200,600 0 299,400
REDHILL BIOPHARMA LTD SPONSORED ADS 757468103 7,846 564,900 SH   SOLE   564,900 0 0
REGENERON PHARMACEUTICALS COM 75886F107 142,838 355,300 SH   DFND 1 101,200 0 254,100
ROKA BIOSCIENCE INC COM 775431109 2,238 3,220,429 SH   SOLE   3,220,429 0 0
SAGE THERAPEUTICS INC COM 78667J108 10,840 235,400 SH   DFND 1 107,500 0 127,900
SANGAMO BIOSCIENCES INC COM 800677106 3,850 831,500 SH   SOLE   831,500 0 0
SAREPTA THERAPEUTICS INC COM 803607100 16,077 261,800 SH   DFND 1 116,300 0 145,500
SELECTA BIOSCIENCES INC COM 816212104 26,260 1,842,797 SH   SOLE   1,842,797 0 0
SHIRE PLC SPONSORED ADR 82481R106 206,141 1,063,351 SH   DFND 1 368,100 0 695,251
SIENTRA INC COM 82621J105 8,248 917,500 SH   SOLE   917,500 0 0
SINOVAC BIOTECH LTD SHS P8696W104 15,738 2,667,500 SH   DFND 1 1,219,500 0 1,448,000
STEADYMED LTD SHS M84920103 11,029 3,072,196 SH   SOLE   3,072,196 0 0
STRYKER CORP COM 863667101 24,679 212,000 SH   DFND 1 77,000 0 135,000
SYNDAX PHARMACEUTICALS INC COM 87164F105 11,482 757,365 SH   SOLE   757,365 0 0
SYNERGY PHARMACEUTICALS DEL COM NEW 871639308 32,931 5,976,648 SH   DFND 1 3,262,300 0 2,714,348
TENET HEALTHCARE CORP COM NEW 88033G407 45,161 1,993,000 SH   DFND 1 888,900 0 1,104,100
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 84,263 1,831,400 SH   DFND 1 695,800 0 1,135,600
THERMO FISHER SCIENTIFIC INC COM 883556102 129,872 816,500 SH   DFND 1 308,200 0 508,300
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 12,010 169,300 SH   DFND 1 58,300 0 111,000
UNIQURE NV SHS N90064101 3,741 489,000 SH   SOLE   489,000 0 0
UNITEDHEALTH GROUP INC COM 91324P102 85,652 611,800 SH   DFND 1 197,000 0 414,800
VALEANT PHARMACEUTICALS INTL COM 91911K102 4,785 194,900 SH   DFND 1 76,800 0 118,100
VANDA PHARMACEUTICALS INC COM 921659108 12,480 750,000 SH Call DFND 1 343,000 0 407,000
VERTEX PHARMACEUTICALS INC COM 92532F100 140,583 1,612,000 SH   DFND 1 395,000 0 1,217,000
VIEWRAY INC COM 92672L107 41,259 9,127,990 SH   SOLE   9,127,990 0 0
WELLCARE HEALTH PLANS INC COM 94946T106 146,128 1,248,000 SH   DFND 1 437,600 0 810,400
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 180,448 7,356,233 SH   DFND 1 2,456,550 0 4,899,683
XENCOR INC COM 98401F105 18,233 744,522 SH   SOLE   744,522 0 0
XENON PHARMACEUTICALS INC COM 98420N105 8,100 1,000,000 SH   SOLE   1,000,000 0 0
XTANT MED HLDGS INC COM 98420P100 537 475,439 SH   SOLE   475,439 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 93,289 717,500 SH   DFND 1 315,700 0 401,800