The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AAC HLDGS INC | COM | 000307108 | 38,081 | 2,189,849 | SH | DFND | 1 | 2,189,849 | 0 | 0 | |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 | 2,971 | 116,000 | SH | DFND | 1 | 116,000 | 0 | 0 | |
| ACORDA THERAPEUTICS INC | COM | 00484M106 | 3,373 | 161,552 | SH | DFND | 1 | 161,552 | 0 | 0 | |
| ACURA PHARMACEUTICALS INC | COM PAR | 00509L802 | 1,641 | 1,025,641 | SH | DFND | 1 | 1,025,641 | 0 | 0 | |
| ADEPTUS HEALTH INC | CL A | 006855100 | 68,917 | 1,600,861 | SH | DFND | 1 | 1,600,861 | 0 | 0 | |
| AERIE PHARMACEUTICALS INC | COM | 00771V108 | 50,527 | 1,338,829 | SH | DFND | 1 | 1,338,829 | 0 | 0 | |
| AETNA INC NEW | COM | 00817Y108 | 42,255 | 366,000 | SH | DFND | 1 | 366,000 | 0 | 0 | |
| AGILE THERAPEUTICS INC | COM | 00847L100 | 1,745 | 250,000 | SH | DFND | 1 | 250,000 | 0 | 0 | |
| AKARI THERAPEUTICS PLC | SPONSORED ADR | 00972G108 | 9,792 | 1,150,700 | SH | DFND | 1 | 1,150,700 | 0 | 0 | |
| ALIMERA SCIENCES INC | COM | 016259103 | 8,758 | 5,878,015 | SH | DFND | 1 | 5,878,015 | 0 | 0 | |
| ARALEZ PHARMACEUTICALS INC | COM | 03852X100 | 7,976 | 1,644,583 | SH | DFND | 1 | 1,644,583 | 0 | 0 | |
| ARDELYX INC | COM | 039697107 | 8,005 | 618,643 | SH | DFND | 1 | 618,643 | 0 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 11,138 | 1,650,000 | SH | DFND | 1 | 1,650,000 | 0 | 0 | |
| ARRAY BIOPHARMA INC | NOTE 3.000% 6/0 | 04269XAA3 | 53,278 | 45,000,000 | PRN | DFND | 1 | 45,000,000 | 0 | 0 | |
| AUDENTES THERAPEUTICS INC | COM | 05070R104 | 24,999 | 1,403,653 | SH | DFND | 1 | 1,403,653 | 0 | 0 | |
| AVEXIS INC | COM | 05366U100 | 92,174 | 2,236,701 | SH | DFND | 1 | 2,236,701 | 0 | 0 | |
| AXOGEN INC | COM | 05463X106 | 17,094 | 1,893,030 | SH | DFND | 1 | 1,893,030 | 0 | 0 | |
| AXOVANT SCIENCES LTD | COM | G0750W104 | 7,952 | 568,005 | SH | DFND | 1 | 568,005 | 0 | 0 | |
| BIOCRYST PHARMACEUTICALS | COM | 09058V103 | 19,412 | 4,401,846 | SH | DFND | 1 | 4,401,846 | 0 | 0 | |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 1,277 | 13,800 | SH | DFND | 1 | 13,800 | 0 | 0 | |
| BIOSCRIP INC | COM | 09069N108 | 5,697 | 1,971,228 | SH | DFND | 1 | 1,971,228 | 0 | 0 | |
| BLUEBIRD BIO INC | COM | 09609G100 | 15,183 | 224,000 | SH | DFND | 1 | 224,000 | 0 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 6,403 | 215,586 | SH | DFND | 1 | 215,586 | 0 | 0 | |
| CAS MED SYS INC | COM PAR $0.004 | 124769209 | 5,532 | 3,200,000 | SH | DFND | 1 | 3,200,000 | 0 | 0 | |
| CATABASIS PHARMACEUTICALS IN | COM | 14875P107 | 4,210 | 683,375 | SH | DFND | 1 | 683,375 | 0 | 0 | |
| CLOVIS ONCOLOGY INC | COM | 189464100 | 288 | 8,000 | SH | DFND | 1 | 8,000 | 0 | 0 | |
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 14,793 | 943,433 | SH | DFND | 1 | 943,433 | 0 | 0 | |
| DBV TECHNOLOGIES S A | SPONSORED ADR | 23306J101 | 63,332 | 1,743,229 | SH | DFND | 1 | 1,743,229 | 0 | 0 | |
| DAVITA INC | COM | 23918K108 | 23,125 | 350,000 | SH | DFND | 1 | 350,000 | 0 | 0 | |
| EDITAS MEDICINE INC | COM | 28106W103 | 23,043 | 1,709,400 | SH | DFND | 1 | 1,709,400 | 0 | 0 | |
| EHEALTH INC | COM | 28238P109 | 29,601 | 2,640,609 | SH | DFND | 1 | 2,640,609 | 0 | 0 | |
| ENDOLOGIX INC | NOTE 2.250%12/1 | 29266SAA4 | 39,231 | 40,941,000 | PRN | DFND | 1 | 40,941,000 | 0 | 0 | |
| EPIZYME INC | COM | 29428V104 | 2,865 | 291,179 | SH | DFND | 1 | 291,179 | 0 | 0 | |
| ESSA PHARMA INC | COM | 29668H104 | 5,834 | 2,121,601 | SH | DFND | 1 | 2,121,601 | 0 | 0 | |
| EXACT SCIENCES CORP | COM | 30063P105 | 6,642 | 357,680 | SH | DFND | 1 | 357,680 | 0 | 0 | |
| EXELIXIS INC | COM | 30161Q104 | 3,158 | 246,907 | SH | DFND | 1 | 246,907 | 0 | 0 | |
| FIVE PRIME THERAPEUTICS INC | COM | 33830X104 | 16,324 | 311,000 | SH | DFND | 1 | 311,000 | 0 | 0 | |
| FLAMEL TECHNOLOGIES SA | SPONSORED ADR | 338488109 | 50,503 | 4,072,809 | SH | DFND | 1 | 4,072,809 | 0 | 0 | |
| FLUIDIGM CORP DEL | NOTE 2.750% 2/0 | 34385PAA6 | 17,021 | 27,715,000 | PRN | DFND | 1 | 27,715,000 | 0 | 0 | |
| FOAMIX PHARMACEUTICALS LTD | SHS | M46135105 | 12,103 | 1,307,058 | SH | DFND | 1 | 1,307,058 | 0 | 0 | |
| GALAPAGOS NV | SPON ADR | 36315X101 | 27,358 | 423,112 | SH | DFND | 1 | 423,112 | 0 | 0 | |
| GENOCEA BIOSCIENCES INC | COM | 372427104 | 3,519 | 687,257 | SH | DFND | 1 | 687,257 | 0 | 0 | |
| GLAUKOS CORP | COM | 377322102 | 18,994 | 503,277 | SH | DFND | 1 | 503,277 | 0 | 0 | |
| GLOBAL BLOOD THERAPEUTICS IN | COM | 37890U108 | 3,951 | 171,428 | SH | DFND | 1 | 171,428 | 0 | 0 | |
| GW PHARMACEUTICALS PLC | ADS | 36197T103 | 133,855 | 1,008,475 | SH | DFND | 1 | 1,008,475 | 0 | 0 | |
| HEALTHWAYS INC | COM | 422245100 | 2,011 | 76,000 | SH | DFND | 1 | 76,000 | 0 | 0 | |
| HEALTHWAYS INC | NOTE 1.500% 7/0 | 422245AB6 | 79,222 | 54,382,000 | PRN | DFND | 1 | 54,382,000 | 0 | 0 | |
| HORIZON PHARMA INVT LTD | NOTE 2.500% 3/1 | 44052TAB7 | 80,123 | 82,600,000 | PRN | DFND | 1 | 82,600,000 | 0 | 0 | |
| HORIZON PHARMA PLC | SHS | G4617B105 | 116,656 | 6,434,439 | SH | DFND | 1 | 6,434,439 | 0 | 0 | |
| HUMANA INC | COM | 444859102 | 28,214 | 159,500 | SH | DFND | 1 | 159,500 | 0 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 3,020 | 1,935,942 | SH | DFND | 1 | 1,935,942 | 0 | 0 | |
| INVUITY INC | COM NEW | 46187J205 | 17,597 | 1,282,598 | SH | DFND | 1 | 1,282,598 | 0 | 0 | |
| KEMPHARM INC | COM | 488445107 | 4,869 | 1,084,443 | SH | DFND | 1 | 1,084,443 | 0 | 0 | |
| LOXO ONCOLOGY INC | COM | 548862101 | 6,571 | 251,000 | SH | DFND | 1 | 251,000 | 0 | 0 | |
| MOLINA HEALTHCARE INC | DBCV 1.625% 8/1 | 60855RAD2 | 3,561 | 3,000,000 | PRN | DFND | 1 | 3,000,000 | 0 | 0 | |
| MYLAN N V | SHS EURO | N59465109 | 54,257 | 1,423,334 | SH | DFND | 1 | 1,423,334 | 0 | 0 | |
| MYOKARDIA INC | COM | 62857M105 | 8,167 | 499,800 | SH | DFND | 1 | 499,800 | 0 | 0 | |
| NANOSTRING TECHNOLOGIES INC | COM | 63009R109 | 4,529 | 226,691 | SH | DFND | 1 | 226,691 | 0 | 0 | |
| NEOS THERAPEUTICS INC | COM | 64052L106 | 1,508 | 229,166 | SH | DFND | 1 | 229,166 | 0 | 0 | |
| NEVRO CORP | COM | 64157F103 | 55,990 | 536,355 | SH | DFND | 1 | 536,355 | 0 | 0 | |
| NIVALIS THERAPEUTICS INC | COM | 65481J109 | 30,345 | 3,732,412 | SH | DFND | 1 | 3,732,412 | 0 | 0 | |
| NXSTAGE MEDICAL INC | COM | 67072V103 | 102,438 | 4,099,175 | SH | DFND | 1 | 4,099,175 | 0 | 0 | |
| OCERA THERAPEUTICS INC | COM | 67552A108 | 1,512 | 572,893 | SH | DFND | 1 | 572,893 | 0 | 0 | |
| OXFORD IMMUNOTEC GLOBAL PLC | ORD SHS | G6855A103 | 5,835 | 464,541 | SH | DFND | 1 | 464,541 | 0 | 0 | |
| PARATEK PHARMACEUTICALS INC | COM | 699374302 | 1,301 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| PORTOLA PHARMACEUTICALS INC | COM | 737010108 | 128,078 | 5,639,727 | SH | DFND | 1 | 5,639,727 | 0 | 0 | |
| PRONAI THERAPEUTICS INC | COM | 74346L101 | 2,525 | 1,387,115 | SH | DFND | 1 | 1,387,115 | 0 | 0 | |
| PROTEON THERAPEUTICS INC | COM | 74371L109 | 14,652 | 1,570,467 | SH | DFND | 1 | 1,570,467 | 0 | 0 | |
| PROTEOSTASIS THERAPEUTICS IN | COM | 74373B109 | 2,900 | 186,000 | SH | DFND | 1 | 186,000 | 0 | 0 | |
| PSIVIDA CORP | COM | 74440J101 | 4,493 | 1,492,824 | SH | DFND | 1 | 1,492,824 | 0 | 0 | |
| REGENERON PHARMACEUTICALS | COM | 75886F107 | 1,327 | 3,300 | SH | DFND | 1 | 3,300 | 0 | 0 | |
| RITE AID CORP | COM | 767754104 | 2,115 | 275,000 | SH | DFND | 1 | 275,000 | 0 | 0 | |
| SCYNEXIS INC | COM | 811292101 | 4,056 | 1,048,000 | SH | DFND | 1 | 1,048,000 | 0 | 0 | |
| SELECT MED HLDGS CORP | COM | 81619Q105 | 18,288 | 1,354,662 | SH | DFND | 1 | 1,354,662 | 0 | 0 | |
| SPARK THERAPEUTICS INC | COM | 84652J103 | 22,102 | 368,000 | SH | DFND | 1 | 368,000 | 0 | 0 | |
| ST JUDE MED INC | COM | 790849103 | 7,976 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| STEADYMED LTD | SHS | M84920103 | 6,305 | 1,756,370 | SH | DFND | 1 | 1,756,370 | 0 | 0 | |
| STREAMLINE HEALTH SOLUTIONS | COM | 86323X106 | 1,220 | 662,971 | SH | DFND | 1 | 662,971 | 0 | 0 | |
| SYROS PHARMACEUTICALS INC | COM | 87184Q107 | 25,143 | 1,812,778 | SH | DFND | 1 | 1,812,778 | 0 | 0 | |
| TESARO INC | COM | 881569107 | 24,288 | 242,300 | SH | DFND | 1 | 242,300 | 0 | 0 | |
| TEVA PHARMACEUTICAL INDS LTD | ADR | 881624209 | 1,380 | 30,000 | SH | DFND | 1 | 30,000 | 0 | 0 | |
| THRESHOLD PHARMACEUTICAL INC | COM NEW | 885807206 | 1,492 | 2,202,160 | SH | DFND | 1 | 2,202,160 | 0 | 0 | |
| TRILLIUM THERAPEUTICS INC | COM NEW | 89620X506 | 2,547 | 172,307 | SH | DFND | 1 | 172,307 | 0 | 0 | |
| TRINITY BIOTECH INVT LTD | NOTE 4.000% 4/0 | 89643QAB4 | 46,775 | 48,000,000 | PRN | DFND | 1 | 48,000,000 | 0 | 0 | |
| UNIVERSAL AMERN CORP NEW | COM | 91338E101 | 35,129 | 4,592,060 | SH | DFND | 1 | 4,592,060 | 0 | 0 | |
| VANDA PHARMACEUTICALS INC | COM | 921659108 | 57,168 | 3,435,576 | SH | DFND | 1 | 3,435,576 | 0 | 0 | |
| VOYAGER THERAPEUTICS INC | COM | 92915B106 | 2,826 | 235,294 | SH | DFND | 1 | 235,294 | 0 | 0 | |
| WALGREENS BOOTS ALLIANCE INC | COM | 931427108 | 28,697 | 355,957 | SH | DFND | 1 | 355,957 | 0 | 0 | |
| WRIGHT MED GROUP INC | NOTE 2.000% 2/1 | 98235TAE7 | 42,847 | 40,050,000 | PRN | DFND | 1 | 40,050,000 | 0 | 0 | |
| XENCOR INC | COM | 98401F105 | 54,145 | 2,210,900 | SH | DFND | 1 | 2,210,900 | 0 | 0 | |