The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACADIA PHARMACEUTICALS INC | COM | 004224108 | 6,392 | 200,938 | SH | DFND | 1 | 200,938 | 0 | 0 | |
| AKARI THERAPEUTICS PLC | SPONSORED ADR | 00972G108 | 1,191 | 139,899 | SH | DFND | 1 | 139,899 | 0 | 0 | |
| ALDEYRA THERAPEUTICS INC | COM | 01438T106 | 2,286 | 291,230 | SH | DFND | 1 | 291,230 | 0 | 0 | |
| AQUINOX PHARMACEUTICALS INC | COM | 03842B101 | 11,727 | 877,753 | SH | DFND | 1 | 877,753 | 0 | 0 | |
| ARADIGM CORP | COM NO PAR NEW | 038505400 | 6,402 | 930,513 | SH | DFND | 1 | 930,513 | 0 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 1,350 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| AVEXIS INC | COM | 05366U100 | 12,353 | 299,756 | SH | DFND | 1 | 299,756 | 0 | 0 | |
| BEIGENE LTD | SPONSORED ADR | 07725L102 | 15,209 | 493,630 | SH | DFND | 1 | 493,630 | 0 | 0 | |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 9,252 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 20,943 | 705,159 | SH | DFND | 1 | 705,159 | 0 | 0 | |
| CLOVIS ONCOLOGY INC | COM | 189464100 | 36,050 | 1,000,000 | SH | DFND | 1 | 1,000,000 | 0 | 0 | |
| EIGER BIOPHARMACEUTICALS INC | COM | 28249U105 | 1,852 | 138,331 | SH | DFND | 1 | 138,331 | 0 | 0 | |
| ELEVEN BIOTHERAPEUTICS INC | COM | 286221106 | 2,100 | 750,000 | SH | DFND | 1 | 750,000 | 0 | 0 | |
| ESSA PHARMA INC | COM | 29668H104 | 74 | 28,100 | SH | DFND | 1 | 28,100 | 0 | 0 | |
| HERON THERAPEUTICS INC | COM | 427746102 | 3,446 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| INCYTE CORP | COM | 45337C102 | 9,429 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| KURA ONCOLOGY INC | COM | 50127T109 | 3,333 | 533,251 | SH | DFND | 1 | 533,251 | 0 | 0 | |
| MEDICINES COMPANY | COM | 584688105 | 26,418 | 700,000 | SH | DFND | 1 | 700,000 | 0 | 0 | |
| MEDICINES COMPANY | CALL | 584688905 | 20,749 | 549,800 | SH | Call | DFND | 1 | 549,800 | 0 | 0 |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 5,010 | 757,935 | SH | DFND | 1 | 757,935 | 0 | 0 | |
| NABRIVA THERAPEUTICS AG | SPONSORED ADR | 62957M104 | 1,246 | 176,710 | SH | DFND | 1 | 176,710 | 0 | 0 | |
| NEXVET BIOPHARMA PUB LTD CO | ORD SHS | G6503X109 | 643 | 154,840 | SH | DFND | 1 | 154,840 | 0 | 0 | |
| ONCONOVA THERAPEUTICS INC | *W EXP 07/07/202 | 68232V116 | 242 | 241,644 | SH | DFND | 1 | 241,644 | 0 | 0 | |
| ONCONOVA THERAPEUTICS INC | COM NEW | 68232V306 | 838 | 316,386 | SH | DFND | 1 | 316,386 | 0 | 0 | |
| RIGEL PHARMACEUTICALS INC | COM NEW | 766559603 | 4,959 | 1,351,137 | SH | DFND | 1 | 1,351,137 | 0 | 0 | |
| SEATTLE GENETICS INC | COM | 812578102 | 12,563 | 232,600 | SH | DFND | 1 | 232,600 | 0 | 0 | |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 3,551 | 234,220 | SH | DFND | 1 | 234,220 | 0 | 0 | |
| TESARO INC | COM | 881569107 | 3,508 | 35,000 | SH | DFND | 1 | 35,000 | 0 | 0 | |