The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| Abeona Therapeutics Inc | COM | 00289Y107 | 116 | 19,391 | SH | SOLE | 1 | 19,391 | 0 | 0 | |
| Achillion Pharmaceuticals Inc | COM | 00448Q201 | 17,891 | 2,208,749 | SH | SOLE | 1 | 2,208,749 | 0 | 0 | |
| Agenus Inc | COM NEW | 00847G705 | 29,737 | 4,141,644 | SH | SOLE | 1 | 4,141,644 | 0 | 0 | |
| Alnylam Pharmaceuticals Inc | COM | 02043Q107 | 64,275 | 948,286 | SH | SOLE | 1 | 948,286 | 0 | 0 | |
| Arrowhead Pharmaceuticals Inc | COM | 04280A100 | 8,208 | 1,116,777 | SH | SOLE | 1 | 1,116,777 | 0 | 0 | |
| Atara Biotherapeutics Inc. | COM | 46513107 | 9,799 | 458,113 | SH | SOLE | 1 | 458,113 | 0 | 0 | |
| Audentes Therapeutics Inc | COM | 05070R104 | 356 | 20,000 | SH | SOLE | 1 | 20,000 | 0 | 0 | |
| Avexis Inc | COM | 05366U100 | 34,039 | 825,980 | SH | SOLE | 1 | 825,980 | 0 | 0 | |
| Barclays Bank Plc | ETN DJUBSCOFFE38 | 06739H297 | 4,018 | 180,500 | SH | SOLE | 1 | 180,500 | 0 | 0 | |
| BioCryst Pharmaceuticals Inc | COM | 09058V103 | 18,542 | 4,204,579 | SH | SOLE | 1 | 4,204,579 | 0 | 0 | |
| Biopharmx Corp | COM | 09072X101 | 389 | 700,636 | SH | SOLE | 1 | 700,636 | 0 | 0 | |
| bluebird bio Inc | COM | 09609G100 | 5,947 | 87,734 | SH | SOLE | 1 | 87,734 | 0 | 0 | |
| Celldex Therapeutics Inc | COM | 15117B103 | 5,022 | 1,243,164 | SH | SOLE | 1 | 1,243,164 | 0 | 0 | |
| Corium International Inc | COM | 21887L107 | 5,888 | 1,045,747 | SH | SOLE | 1 | 1,045,747 | 0 | 0 | |
| Dicerna Pharmaceuticals Inc | COM | 253031108 | 11,918 | 2,026,894 | SH | SOLE | 1 | 2,026,894 | 0 | 0 | |
| Five Prime Therapeutics Inc | COM | 33830X104 | 2,312 | 44,044 | SH | SOLE | 1 | 44,044 | 0 | 0 | |
| Global Blood Therapeutics Inc | COM | 37890U108 | 2,206 | 95,714 | SH | SOLE | 1 | 95,714 | 0 | 0 | |
| Heron Therapeutics Inc | COM | 427746102 | 6,664 | 386,787 | SH | SOLE | 1 | 386,787 | 0 | 0 | |
| Incyte Corp | COM | 45337C102 | 18,024 | 191,151 | SH | SOLE | 1 | 191,151 | 0 | 0 | |
| Invuity Inc | COM | 46187J205 | 5,390 | 392,838 | SH | SOLE | 1 | 392,838 | 0 | 0 | |
| La Jolla Pharmaceutical Co | COM PAR $.0001 2 | 503459604 | 27,838 | 1,170,151 | SH | SOLE | 1 | 1,170,151 | 0 | 0 | |
| Masimo Corp | COM | 574795100 | 1,541 | 25,900 | SH | SOLE | 1 | 25,900 | 0 | 0 | |
| Medicines Co | COM | 584688105 | 4,642 | 123,000 | SH | SOLE | 1 | 123,000 | 0 | 0 | |
| Mirati Therapeutics Inc | COM | 60468T105 | 854 | 129,129 | SH | SOLE | 1 | 129,129 | 0 | 0 | |
| MANNKIND CORP | COM | 56400P201 | 272 | 4,385 | SH | Put | SOLE | 1 | 4,385 | 0 | 0 |
| Natera Inc | COM | 632307104 | 352 | 31,693 | SH | SOLE | 1 | 31,693 | 0 | 0 | |
| Nivalis Therapeutics Inc | COM | 65481J109 | 244 | 30,000 | SH | SOLE | 1 | 30,000 | 0 | 0 | |
| Omeros Corp | COM | 682143102 | 4,274 | 383,012 | SH | SOLE | 1 | 383,012 | 0 | 0 | |
| Oxford Immunotec Global PLC | ORD SHS | G6855A103 | 2,963 | 235,900 | SH | SOLE | 1 | 235,900 | 0 | 0 | |
| Regenxbio Inc | COM | 75901B107 | 3,345 | 238,740 | SH | SOLE | 1 | 238,740 | 0 | 0 | |
| Sensus Healthcare Inc Cmn | COM | 81728J109 | 773 | 125,700 | SH | SOLE | 1 | 125,700 | 0 | 0 | |
| SPDR Gold Trust | GOLD SHS | 78463V107 | 10,428 | 83,000 | SH | SOLE | 1 | 83,000 | 0 | 0 | |
| Tactile Systems Technology Inc Cmn | COM | 87357P100 | 4,256 | 227,599 | SH | SOLE | 1 | 227,599 | 0 | 0 | |
| Viveve Medical Inc | COM NEW | 92852W204 | 6,060 | 839,274 | SH | SOLE | 1 | 839,274 | 0 | 0 | |
| Bristol-Myers Squibb Co | COM | 110122108 | 11,307 | 209,701 | SH | SOLE | 1 | 209,701 | 0 | 0 | |
| NOVAVAX INC | COM | 670002104 | 996 | 4,787 | SH | Call | SOLE | 1 | 4,787 | 0 | 0 |