The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AKARI THERAPEUTICS PLC | SPONSORED ADR | 00972G108 | 985 | 139,899 | SH | DFND | 1 | 139,899 | 0 | 0 | |
| ALDEYRA THERAPEUTICS INC | COM | 01438T106 | 1,558 | 291,230 | SH | DFND | 1 | 291,230 | 0 | 0 | |
| ALEXION PHARMACEUTICALS INC | COM | 015351109 | 9,176 | 75,000 | SH | DFND | 1 | 75,000 | 0 | 0 | |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 9,360 | 250,000 | SH | DFND | 1 | 250,000 | 0 | 0 | |
| AQUINOX PHARMACEUTICALS INC | COM | 03842B101 | 14,492 | 877,753 | SH | DFND | 1 | 877,753 | 0 | 0 | |
| ARADIGM CORP | COM NO PAR NEW | 038505400 | 1,016 | 634,708 | SH | DFND | 1 | 634,708 | 0 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 1,758 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| AVEXIS INC | COM | 05366U100 | 49,103 | 1,028,763 | SH | DFND | 1 | 1,028,763 | 0 | 0 | |
| BEIGENE LTD | SPONSORED ADR | 07725L102 | 25,806 | 850,000 | SH | DFND | 1 | 850,000 | 0 | 0 | |
| BELLEROPHON THERAPEUTICS INC | COM | 078771102 | 966 | 1,857,143 | SH | DFND | 1 | 1,857,143 | 0 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 19,780 | 705,159 | SH | DFND | 1 | 705,159 | 0 | 0 | |
| CLOVIS ONCOLOGY INC | COM | 189464100 | 37,757 | 850,000 | SH | DFND | 1 | 850,000 | 0 | 0 | |
| EIGER BIOPHARMACEUTICALS INC | COM | 28249U105 | 1,612 | 138,331 | SH | DFND | 1 | 138,331 | 0 | 0 | |
| IGNYTA INC | COM | 451731103 | 663 | 125,000 | SH | DFND | 1 | 125,000 | 0 | 0 | |
| INCYTE CORP | COM | 45337C102 | 10,027 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| KURA ONCOLOGY INC | COM | 50127T109 | 3,146 | 533,251 | SH | DFND | 1 | 533,251 | 0 | 0 | |
| MEDICINES CO | COM | 584688105 | 28,109 | 828,198 | SH | DFND | 1 | 828,198 | 0 | 0 | |
| MEDICINES CO | CALL | 584688905 | 21,294 | 627,400 | SH | Call | DFND | 1 | 627,400 | 0 | 0 |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 3,600 | 757,935 | SH | DFND | 1 | 757,935 | 0 | 0 | |
| NABRIVA THERAPEUTICS AG | SPONSORED ADR | 62957M104 | 1,053 | 176,710 | SH | DFND | 1 | 176,710 | 0 | 0 | |
| NEXVET BIOPHARMA PUB LTD CO | ORD SHS | G6503X109 | 578 | 154,840 | SH | DFND | 1 | 154,840 | 0 | 0 | |
| ONCONOVA THERAPEUTICS INC | *W EXP 07/07/202 | 68232V116 | 150 | 241,644 | SH | DFND | 1 | 241,644 | 0 | 0 | |
| ONCONOVA THERAPEUTICS INC | COM NEW | 68232V306 | 718 | 316,380 | SH | DFND | 1 | 316,380 | 0 | 0 | |
| SEATTLE GENETICS INC | COM | 812578102 | 5,277 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| STRONGBRIDGE BIOPHARMA PLC | SHS USD | G85347105 | 2,256 | 940,000 | SH | DFND | 1 | 940,000 | 0 | 0 | |
| SUNESIS PHARMACEUTICALS INC | COM PAR | 867328700 | 1,901 | 525,000 | SH | DFND | 1 | 525,000 | 0 | 0 | |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 1,679 | 234,220 | SH | DFND | 1 | 234,220 | 0 | 0 | |
| TESARO INC | COM | 881569107 | 4,707 | 35,000 | SH | DFND | 1 | 35,000 | 0 | 0 | |