The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIOMED INC COM 003654100 214,496 1,903,584 SH   SOLE   1,903,584 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 44,184 1,532,030 SH   SOLE   1,532,030 0 0
ACELRX PHARMACEUTICALS INC COM 00444T100 2,685 1,032,715 SH   SOLE   1,032,715 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 7,765 379,727 SH   SOLE   379,727 0 0
ALCOBRA LTD SHS M2239P109 573 272,788 SH   SOLE   272,788 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 87,326 713,742 SH   SOLE   713,742 0 0
ALIGN TECHNOLOGY INC COM 016255101 3,721 38,707 SH   SOLE   38,707 0 0
ALIMERA SCIENCES INC COM 016259103 3,255 3,013,793 SH   SOLE   3,013,793 0 0
AMAG PHARMACEUTICALS INC COM 00163U106 116,393 3,344,620 SH   SOLE   3,344,620 0 0
AMICUS THERAPEUTICS INC COM 03152W109 31,858 6,410,030 SH   SOLE   6,410,030 0 0
ARIAD PHARMACEUTICALS INC COM 04033A100 33,364 2,682,017 SH   SOLE   2,682,017 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 162,385 1,960,219 SH   SOLE   1,960,219 0 0
CELGENE CORP COM 151020104 34,174 295,240 SH   SOLE   295,240 0 0
CEMPRA INC COM 15130J109 953 340,320 SH   SOLE   340,320 0 0
CLOVIS ONCOLOGY INC COM 189464100 168,978 3,804,088 SH   SOLE   3,804,088 0 0
CYTOKINETICS INC COM NEW 23282W605 1,503 123,686 SH   SOLE   123,686 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 456 158,279 SH   SOLE   158,279 0 0
EPIZYME INC COM 29428V104 36,733 3,035,796 SH   SOLE   3,035,796 0 0
EXACT SCIENCES CORP COM 30063P105 5,304 396,976 SH   SOLE   396,976 0 0
GILEAD SCIENCES INC COM 375558103 22,801 318,400 SH   SOLE   318,400 0 0
HISTOGENICS CORP COM 43358V109 506 302,922 SH   SOLE   302,922 0 0
IDERA PHARMACEUTICALS INC COM NEW 45168K306 925 616,355 SH   SOLE   616,355 0 0
INSMED INC COM PAR $.01 457669307 72,057 5,446,516 SH   SOLE   5,446,516 0 0
INTREXON CORP COM 46122T102 1,018 41,900 SH   SOLE   41,900 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 30,084 3,200,396 SH   SOLE   3,200,396 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 25,997 1,727,380 SH   SOLE   1,727,380 0 0
PROTHENA CORP PLC SHS G72800108 48,888 993,855 SH   SOLE   993,855 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 9,940 4,176,623 SH   SOLE   4,176,623 0 0
SAGE THERAPEUTICS INC COM 78667J108 51,567 1,009,930 SH   SOLE   1,009,930 0 0
SHIRE PLC SPONSORED ADR 82481R106 21,144 124,100 SH   SOLE   124,100 0 0
SOPHIRIS BIO INC COM NEW 83578Q209 692 247,000 SH   SOLE   247,000 0 0
STAAR SURGICAL CO COM PAR $0.01 852312305 36,741 3,386,245 SH   SOLE   3,386,245 0 0
SUNESIS PHARMACEUTICALS INC COM PAR 867328700 4,208 1,162,473 SH   SOLE   1,162,473 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 268,044 1,868,815 SH   SOLE   1,868,815 0 0
VANDA PHARMACEUTICALS INC COM 921659108 67,042 4,203,270 SH   SOLE   4,203,270 0 0
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 59,854 2,604,593 SH   SOLE   2,604,593 0 0
ZELTIQ AESTHETICS INC COM 98933Q108 74,888 1,720,763 SH   SOLE   1,720,763 0 0
ZOGENIX INC COM NEW 98978L204 358 29,500 SH   SOLE   29,500 0 0