The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AAC HLDGS INC | COM | 000307108 | 14,302 | 1,975,347 | SH | DFND | 1,975,347 | 0 | 0 | ||
| ACLARIS THERAPEUTICS INC | COM | 00461U105 | 10,178 | 375,000 | SH | DFND | 375,000 | 0 | 0 | ||
| ACURA PHARMACEUTICALS INC | COM PAR | 00509L802 | 786 | 1,025,641 | SH | DFND | 1,025,641 | 0 | 0 | ||
| ADEPTUS HEALTH INC | CL A | 006855100 | 12,231 | 1,600,861 | SH | DFND | 1,600,861 | 0 | 0 | ||
| ADVANCED ACCELERATOR APPLIC | SPONSORED ADS | 00790T100 | 5,620 | 210,000 | SH | DFND | 210,000 | 0 | 0 | ||
| AERIE PHARMACEUTICALS INC | COM | 00771V108 | 69,600 | 1,838,829 | SH | DFND | 1,838,829 | 0 | 0 | ||
| AETNA INC NEW | COM | 00817Y108 | 30,010 | 242,000 | SH | DFND | 242,000 | 0 | 0 | ||
| AGILE THERAPEUTICS INC | COM | 00847L100 | 2,269 | 398,000 | SH | DFND | 398,000 | 0 | 0 | ||
| AKARI THERAPEUTICS PLC | SPONSORED ADR | 00972G108 | 8,101 | 1,150,700 | SH | DFND | 1,150,700 | 0 | 0 | ||
| ALIMERA SCIENCES INC | COM | 016259103 | 6,348 | 5,878,015 | SH | DFND | 5,878,015 | 0 | 0 | ||
| ANTHEM INC | COM | 036752103 | 45,719 | 318,000 | SH | DFND | 318,000 | 0 | 0 | ||
| ARALEZ PHARMACEUTICALS INC | COM | 03852X100 | 7,253 | 1,644,583 | SH | DFND | 1,644,583 | 0 | 0 | ||
| ARDELYX INC | COM | 039697107 | 5,306 | 373,643 | SH | DFND | 373,643 | 0 | 0 | ||
| ARRAY BIOPHARMA INC | COM | 04269X105 | 14,504 | 1,650,000 | SH | DFND | 1,650,000 | 0 | 0 | ||
| ARRAY BIOPHARMA INC | NOTE 3.000% 6/0 | 04269XAA3 | 62,545 | 45,000,000 | PRN | DFND | 45,000,000 | 0 | 0 | ||
| ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 21,252 | 1,050,000 | SH | DFND | 1,050,000 | 0 | 0 | ||
| AUDENTES THERAPEUTICS INC | COM | 05070R104 | 25,645 | 1,403,653 | SH | DFND | 1,403,653 | 0 | 0 | ||
| AVEXIS INC | COM | 05366U100 | 106,758 | 2,236,701 | SH | DFND | 2,236,701 | 0 | 0 | ||
| AXOGEN INC | COM | 05463X106 | 16,544 | 1,838,225 | SH | DFND | 1,838,225 | 0 | 0 | ||
| AXOVANT SCIENCES LTD | COM | G0750W104 | 7,055 | 568,005 | SH | DFND | 568,005 | 0 | 0 | ||
| BIOCRYST PHARMACEUTICALS | COM | 09058V103 | 20,495 | 3,237,734 | SH | DFND | 3,237,734 | 0 | 0 | ||
| BIOSCRIP INC | COM | 09069N108 | 2,050 | 1,971,228 | SH | DFND | 1,971,228 | 0 | 0 | ||
| BLUEBIRD BIO INC | COM | 09609G100 | 18,635 | 302,027 | SH | DFND | 302,027 | 0 | 0 | ||
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 51,680 | 1,842,415 | SH | DFND | 1,842,415 | 0 | 0 | ||
| CAS MED SYS INC | COM PAR $0.004 | 124769209 | 5,152 | 3,200,000 | SH | DFND | 3,200,000 | 0 | 0 | ||
| CATABASIS PHARMACEUTICALS IN | COM | 14875P107 | 2,465 | 682,940 | SH | DFND | 682,940 | 0 | 0 | ||
| CELLDEX THERAPEUTICS INC NEW | COM | 15117B103 | 2,241 | 632,944 | SH | DFND | 632,944 | 0 | 0 | ||
| CENTENE CORP DEL | COM | 15135B101 | 34,112 | 603,643 | SH | DFND | 603,643 | 0 | 0 | ||
| CLOVIS ONCOLOGY INC | NOTE 2.500% 9/1 | 189464AB6 | 16,979 | 16,500,000 | PRN | DFND | 16,500,000 | 0 | 0 | ||
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 10,368 | 943,433 | SH | DFND | 943,433 | 0 | 0 | ||
| DBV TECHNOLOGIES S A | SPONSORED ADR | 23306J101 | 61,240 | 1,743,229 | SH | DFND | 1,743,229 | 0 | 0 | ||
| EDITAS MEDICINE INC | COM | 28106W103 | 27,744 | 1,709,400 | SH | DFND | 1,709,400 | 0 | 0 | ||
| EHEALTH INC | COM | 28238P109 | 28,122 | 2,640,609 | SH | DFND | 2,640,609 | 0 | 0 | ||
| ENDOLOGIX INC | NOTE 2.250%12/1 | 29266SAA4 | 46,140 | 51,117,000 | PRN | DFND | 51,117,000 | 0 | 0 | ||
| ENDOLOGIX INC | NOTE 3.250%11/0 | 29266SAB2 | 35,425 | 40,500,000 | PRN | DFND | 40,500,000 | 0 | 0 | ||
| EPIZYME INC | COM | 29428V104 | 19,373 | 1,601,049 | SH | DFND | 1,601,049 | 0 | 0 | ||
| ESSA PHARMA INC | COM | 29668H104 | 4,646 | 2,121,601 | SH | DFND | 2,121,601 | 0 | 0 | ||
| EXACT SCIENCES CORP | COM | 30063P105 | 6,680 | 500,000 | SH | DFND | 500,000 | 0 | 0 | ||
| FIVE PRIME THERAPEUTICS INC | COM | 33830X104 | 6,915 | 138,000 | SH | DFND | 138,000 | 0 | 0 | ||
| FLAMEL TECHNOLOGIES SA | SPONSORED ADR | 338488109 | 42,316 | 4,072,809 | SH | DFND | 4,072,809 | 0 | 0 | ||
| FLUIDIGM CORP DEL | NOTE 2.750% 2/0 | 34385PAA6 | 19,228 | 27,715,000 | PRN | DFND | 27,715,000 | 0 | 0 | ||
| FOAMIX PHARMACEUTICALS LTD | SHS | M46135105 | 13,685 | 1,232,844 | SH | DFND | 1,232,844 | 0 | 0 | ||
| GALAPAGOS NV | SPON ADR | 36315X101 | 27,160 | 423,112 | SH | DFND | 423,112 | 0 | 0 | ||
| GENOCEA BIOSCIENCES INC | COM | 372427104 | 2,831 | 687,257 | SH | DFND | 687,257 | 0 | 0 | ||
| GLAUKOS CORP | COM | 377322102 | 13,488 | 393,228 | SH | DFND | 393,228 | 0 | 0 | ||
| GLOBAL BLOOD THERAPEUTICS IN | COM | 37890U108 | 2,477 | 171,428 | SH | DFND | 171,428 | 0 | 0 | ||
| GLOBUS MED INC | CL A | 379577208 | 25,703 | 1,036,000 | SH | DFND | 1,036,000 | 0 | 0 | ||
| GW PHARMACEUTICALS PLC | ADS | 36197T103 | 103,725 | 928,192 | SH | DFND | 928,192 | 0 | 0 | ||
| HEALTHWAYS INC | COM | 422245100 | 1,729 | 76,000 | SH | DFND | 76,000 | 0 | 0 | ||
| HEALTHWAYS INC | NOTE 1.500% 7/0 | 422245AB6 | 32,381 | 25,000,000 | PRN | DFND | 25,000,000 | 0 | 0 | ||
| HORIZON PHARMA INVT LTD | NOTE 2.500% 3/1 | 44052TAB7 | 78,342 | 82,600,000 | PRN | DFND | 82,600,000 | 0 | 0 | ||
| HORIZON PHARMA PLC | SHS | G4617B105 | 144,924 | 8,956,988 | SH | DFND | 8,956,988 | 0 | 0 | ||
| HUMANA INC | COM | 444859102 | 40,398 | 198,000 | SH | DFND | 198,000 | 0 | 0 | ||
| INVUITY INC | COM NEW | 46187J205 | 9,720 | 1,690,498 | SH | DFND | 1,690,498 | 0 | 0 | ||
| IONIS PHARMACEUTICALS INC | COM | 462222100 | 10,240 | 214,095 | SH | DFND | 214,095 | 0 | 0 | ||
| ISIS PHARMACEUTICALS INC DEL | NOTE 1.000%11/1 | 464337AJ3 | 33,802 | 33,186,000 | PRN | DFND | 33,186,000 | 0 | 0 | ||
| KEMPHARM INC | COM | 488445107 | 3,199 | 1,084,443 | SH | DFND | 1,084,443 | 0 | 0 | ||
| KERYX BIOPHARMACEUTICALS INC | COM | 492515101 | 7,568 | 1,291,531 | SH | DFND | 1,291,531 | 0 | 0 | ||
| KITE PHARMA INC | COM | 49803L109 | 13,358 | 297,902 | SH | DFND | 297,902 | 0 | 0 | ||
| LANNET INC | COM | 516012101 | 44,266 | 2,007,551 | SH | DFND | 2,007,551 | 0 | 0 | ||
| LOXO ONCOLOGY INC | COM | 548862101 | 8,061 | 251,000 | SH | DFND | 251,000 | 0 | 0 | ||
| MALLINCKRODT PUB LTD CO | SHS | G5785G107 | 20,277 | 407,000 | SH | DFND | 407,000 | 0 | 0 | ||
| MOLINA HEALTHCARE INC | DBCV 1.625% 8/1 | 60855RAD2 | 28,480 | 25,000,000 | PRN | DFND | 25,000,000 | 0 | 0 | ||
| MYLAN N V | SHS EURO | N59465109 | 67,387 | 1,766,378 | SH | DFND | 1,766,378 | 0 | 0 | ||
| MYLAN N V | SHS EURO | N59465109 | 17,168 | 450,000 | SH | Call | DFND | 450,000 | 0 | 0 | |
| MYOKARDIA INC | COM | 62857M105 | 5,501 | 424,800 | SH | DFND | 424,800 | 0 | 0 | ||
| MYOVANT SCIENCES LTD | COM | G637AM102 | 18,619 | 1,496,675 | SH | DFND | 1,496,675 | 0 | 0 | ||
| NANOSTRING TECHNOLOGIES INC | COM | 63009R109 | 3,100 | 139,000 | SH | DFND | 139,000 | 0 | 0 | ||
| NEOS THERAPEUTICS INC | COM | 64052L106 | 1,341 | 229,166 | SH | DFND | 229,166 | 0 | 0 | ||
| NEVRO CORP | COM | 64157F103 | 54,589 | 751,298 | SH | DFND | 751,298 | 0 | 0 | ||
| NEVRO CORP | NOTE 1.750% 6/0 | 64157FAA1 | 29,494 | 27,600,000 | PRN | DFND | 27,600,000 | 0 | 0 | ||
| NIVALIS THERAPEUTICS INC | COM | 65481J109 | 8,361 | 3,732,412 | SH | DFND | 3,732,412 | 0 | 0 | ||
| NOVELION THERAPEUTICS INC | COM NEW | 67001K202 | 1,435 | 170,454 | SH | DFND | 170,454 | 0 | 0 | ||
| NXSTAGE MEDICAL INC | COM | 67072V103 | 111,607 | 4,258,196 | SH | DFND | 4,258,196 | 0 | 0 | ||
| OCERA THERAPEUTICS INC | COM | 67552A108 | 1,203 | 572,893 | SH | DFND | 572,893 | 0 | 0 | ||
| OXFORD IMMUNOTEC GLOBAL PLC | ORD SHS | G6855A103 | 7,911 | 529,197 | SH | DFND | 529,197 | 0 | 0 | ||
| PARATEK PHARMACEUTICALS INC | COM | 699374302 | 1,540 | 100,000 | SH | DFND | 100,000 | 0 | 0 | ||
| PORTOLA PHARMACEUTICALS INC | COM | 737010108 | 104,446 | 4,654,447 | SH | DFND | 4,654,447 | 0 | 0 | ||
| PRONAI THERAPEUTICS INC | COM | 74346L101 | 1,738 | 1,166,619 | SH | DFND | 1,166,619 | 0 | 0 | ||
| PROTEON THERAPEUTICS INC | COM | 74371L109 | 2,532 | 1,332,599 | SH | DFND | 1,332,599 | 0 | 0 | ||
| PROTEOSTASIS THERAPEUTICS IN | COM | 74373B109 | 2,280 | 186,000 | SH | DFND | 186,000 | 0 | 0 | ||
| PSIVIDA CORP | COM | 74440J101 | 2,553 | 1,492,824 | SH | DFND | 1,492,824 | 0 | 0 | ||
| RA PHARMACEUTICALS INC | COM | 74933V108 | 4,916 | 323,630 | SH | DFND | 323,630 | 0 | 0 | ||
| RECRO PHARMA INC | COM | 75629F109 | 16,725 | 2,075,000 | SH | DFND | 2,075,000 | 0 | 0 | ||
| SANGAMO BIOSCIENCES INC | COM | 800677106 | 2,556 | 837,963 | SH | DFND | 837,963 | 0 | 0 | ||
| SCYNEXIS INC | COM | 811292101 | 3,343 | 1,048,000 | SH | DFND | 1,048,000 | 0 | 0 | ||
| SELECTA BIOSCIENCES INC | COM | 816212104 | 14,632 | 853,205 | SH | DFND | 853,205 | 0 | 0 | ||
| SPARK THERAPEUTICS INC | COM | 84652J103 | 14,122 | 283,000 | SH | DFND | 283,000 | 0 | 0 | ||
| STEADYMED LTD | SHS | M84920103 | 4,567 | 1,756,370 | SH | DFND | 1,756,370 | 0 | 0 | ||
| STREAMLINE HEALTH SOLUTIONS | COM | 86323X106 | 829 | 662,971 | SH | DFND | 662,971 | 0 | 0 | ||
| SYROS PHARMACEUTICALS INC | COM | 87184Q107 | 22,043 | 1,812,778 | SH | DFND | 1,812,778 | 0 | 0 | ||
| TESARO INC | COM | 881569107 | 15,089 | 112,200 | SH | DFND | 112,200 | 0 | 0 | ||
| THRESHOLD PHARMACEUTICAL INC | COM NEW | 885807206 | 971 | 2,202,160 | SH | DFND | 2,202,160 | 0 | 0 | ||
| TRINITY BIOTECH INVT LTD | NOTE 4.000% 4/0 | 89643QAB4 | 40,401 | 48,000,000 | PRN | DFND | 48,000,000 | 0 | 0 | ||
| UNIVERSAL AMERN CORP NEW | COM | 91338E101 | 37,552 | 3,774,090 | SH | DFND | 3,774,090 | 0 | 0 | ||
| VANDA PHARMACEUTICALS INC | COM | 921659108 | 54,624 | 3,424,676 | SH | DFND | 3,424,676 | 0 | 0 | ||
| VOYAGER THERAPEUTICS INC | COM | 92915B106 | 2,998 | 235,294 | SH | DFND | 235,294 | 0 | 0 | ||
| WALGREENS BOOTS ALLIANCE INC | COM | 931427108 | 29,459 | 355,957 | SH | DFND | 355,957 | 0 | 0 | ||
| WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 12,346 | 472,124 | SH | DFND | 472,124 | 0 | 0 | ||
| WRIGHT MED GROUP INC | NOTE 2.000% 2/1 | 98235TAE7 | 41,818 | 40,050,000 | PRN | DFND | 40,050,000 | 0 | 0 | ||
| XENCOR INC | COM | 98401F105 | 53,166 | 2,020,000 | SH | DFND | 2,020,000 | 0 | 0 | ||
| ZIMMER BIOMET HLDGS INC | COM | 98956P102 | 15,480 | 150,000 | SH | DFND | 150,000 | 0 | 0 | ||