The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 5,267 80,825 SH   DFND 2 0 0 80,825
ACADIA PHARMACEUTICALS INC COM 004225108 258 7,505 SH   DFND 2 0 0 7,505
ACCELERON PHARMA INC COM 00434H108 130 4,897 SH   DFND 2 0 0 4,897
ACLARIS THERAPEUTICS INC COM 00461U105 2,430 81,500 SH   DFND 2 0 0 81,500
ACORDA THERAPEUTICS INC COM 00484M106 106 5,071 SH   DFND 2 0 0 5,071
AERIE PHARMACEUTICALS INC COM 00771V108 3,451 76,091 SH   DFND 2 0 0 76,091
AGIOS PHARMACEUTICALS INC COM 00847X104 105 1,800 SH   DFND 2 0 0 1,800
AIMMUNE THERAPEUTICS INC COM 00900T107 4,087 188,100 SH   DFND 2 0 0 188,100
AIR METHODS CORP COM PAR $.06 009128307 3,010 70,000 SH   DFND 2 0 0 70,000
ALEXION PHARMACEUTICALS INC COM 015351109 4,698 38,751 SH   DFND 2 0 0 38,751
ALGONQUIN PWR UTILS CORP COM 015857105 1,695 133,500 SH   DFND 1 133,500 0 0
ALGONQUIN PWR UTILS CORP COM 015857105 1,657 130,500 SH   DFND 2 0 0 130,500
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 80,840 749,696 SH   DFND 2 0 0 749,696
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 5,028 46,632 SH   DFND 1 46,632 0 0
ALLERGAN PLC SHS G0177J108 25,946 108,596 SH   DFND 2 0 0 108,596
ALPHABET INC CAP STK CL C 02079K107 380,225 458,345 SH   DFND 2 178,131 0 280,214
ALPHABET INC CAP STK CL C 02079K107 27,312 32,924 SH   DFND 1 32,924 0 0
ALPHABET INC CAP STK CL A 02079K305 11,067 13,054 SH   DFND 2 0 0 13,054
AMAZON INC COM 023135106 249,857 281,834 SH   DFND 2 96,377 0 185,457
AMAZON INC COM 023135106 18,132 20,452 SH   DFND 1 20,452 0 0
AMGEN INC COM 031162100 25,390 154,754 SH   DFND 2 0 0 154,754
ATHENAHEALTH INC COM 04685W103 2,236 19,843 SH   DFND 2 0 0 19,843
AUTOMATIC DATA PROCESSING IN COM 053015103 314 3,067 SH   DFND 2 0 0 3,067
AUTOMATIC DATA PROCESSING IN COM 053015103 281 2,748 SH   DFND 1 2,748 0 0
AUTOZONE INC COM 053332102 320 442 SH   DFND 2 0 0 442
AUTOZONE INC COM 053332102 286 395 SH   DFND 1 395 0 0
AXOVANT SCIENCES LTD COM G0750W104 1,637 109,600 SH   DFND 2 0 0 109,600
BAIDU INC SPON ADR REP A 056752108 39,098 226,627 SH   DFND 2 0 0 226,627
BAIDU INC SPON ADR REP A 056752108 2,330 13,506 SH   DFND 1 13,506 0 0
BIOGEN INC COM 09062X103 23,004 84,133 SH   DFND 2 0 0 84,133
BIOMARIN PHARMACEUTICAL INC COM 09061G101 14,438 164,485 SH   DFND 2 0 0 164,485
BLUEBIRD BIO INC COM 09609G100 223 2,458 SH   DFND 2 0 0 2,458
CARA THERAPEUTICS INC COM 140755109 3,946 214,584 SH   DFND 2 0 0 214,584
CARDINAL HEALTH INC COM 14149Y108 7,033 86,241 SH   DFND 2 0 0 86,241
CARDINAL HEALTH INC COM 14149Y108 740 9,072 SH   DFND 1 9,072 0 0
CELGENE CORP COM 151020104 32,832 263,859 SH   DFND 2 0 0 263,859
CEMPRA INC COM 15130J109 2,456 654,911 SH   DFND 2 0 0 654,911
CENTENE CORP DEL COM 15135B101 18,005 252,670 SH   DFND 2 0 0 252,670
CHEVRON CORP NEW COM 166764100 408 3,800 SH   DFND 2 0 0 3,800
CHEVRON CORP NEW COM 166764100 419 3,900 SH   DFND 1 3,900 0 0
CIGNA CORPORATION COM 125509109 17,832 121,728 SH   DFND 2 0 0 121,728
CITIGROUP INC COM NEW 172967424 329,912 5,515,072 SH   DFND 2 1,896,369 0 3,618,703
CITIGROUP INC COM NEW 172967424 24,154 403,775 SH   DFND 1 403,775 0 0
CLOVIS ONCOLOGY INC COM 189464100 19,685 309,169 SH   DFND 2 0 0 309,169
COCA COLA CO COM 191216100 12,137 285,988 SH   DFND 2 285,988 0 0
COHERUS BIOSCIENCES INC COM 19249H103 4,080 192,887 SH   DFND 2 0 0 192,887
COLGATE PALMOLIVE CO COM 194162103 15,198 207,653 SH   DFND 2 207,653 0 0
CREDICORP LTD COM G2519Y108 67 412 SH   DFND 1 412 0 0
CREDICORP LTD COM G2519Y108 122 749 SH   DFND 2 0 0 749
CROWN CASTLE INTL CORP NEW COM 22822V101 708 7,500 SH   DFND 1 7,500 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 642 6,800 SH   DFND 2 0 0 6,800
CVS HEALTH CORP COM 126650100 900 11,470 SH   DFND 1 11,470 0 0
CVS HEALTH CORP COM 126650100 864 11,000 SH   DFND 2 0 0 11,000
DERMIRA INC COM 24983L104 2,822 82,746 SH   DFND 2 0 0 82,746
DEX INC COM 252131107 4,342 51,244 SH   DFND 2 0 0 51,244
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 1,690 284,082 SH   DFND 2 0 0 284,082
EAGLE PHARMACEUTICALS INC COM 269796108 5,398 65,085 SH   DFND 2 0 0 65,085
ECOLAB INC COM 278865100 401,111 3,200,180 SH   DFND 2 1,211,740 0 1,988,440
ECOLAB INC COM 278865100 27,424 218,795 SH   DFND 1 218,795 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 9,946 105,728 SH   DFND 2 0 0 105,728
ENDOLOGIX INC COM 29266S106 3,798 524,556 SH   DFND 2 0 0 524,556
ESPERION THERAPEUTICS INC NE COM 29664W105 162 4,600 SH   DFND 2 0 0 4,600
EXACT SCIENCES CORP COM 30063P105 4,515 191,154 SH   DFND 2 0 0 191,154
EXELIXIS INC COM 30161Q104 12,037 555,458 SH   DFND 2 0 0 555,458
EXPRESS SCRIPTS HLDG CO COM 30219G108 4,580 69,495 SH   DFND 2 0 0 69,495
FACEBOOK INC CL A 30303M102 27,504 193,619 SH   DFND 1 193,619 0 0
FACEBOOK INC CL A 30303M102 382,738 2,694,387 SH   DFND 2 927,009 0 1,767,378
FIDELITY NATL INFORMATION SV COM 31620M106 324 4,071 SH   DFND 2 0 0 4,071
FIDELITY NATL INFORMATION SV COM 31620M106 315 3,959 SH   DFND 1 3,959 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 247,034 2,633,339 SH   DFND 2 1,037,872 0 1,595,467
FIRST REP BK SAN FRANCISCO C COM 33616C100 16,657 177,564 SH   DFND 1 177,564 0 0
FLEX PHARMA INC COM 33938A105 1,223 278,060 SH   DFND 2 0 0 278,060
GILEAD SCIENCES INC COM 375558103 256,055 3,769,952 SH   DFND 2 1,280,623 0 2,489,329
GILEAD SCIENCES INC COM 375558103 15,247 224,479 SH   DFND 1 224,479 0 0
GLAUKOS CORP COM 377322102 18,509 360,808 SH   DFND 2 0 0 360,808
GW PHARMACEUTICALS PLC ADS 36197T103 2,785 23,026 SH   DFND 2 0 0 23,026
HCA HOLDINGS INC COM 40412C101 13,249 148,885 SH   DFND 2 0 0 148,885
HDFC BANK LTD ADR REPS 3 SHS 40415F101 194,369 2,584,007 SH   DFND 2 2,266,485 0 317,522
HDFC BANK LTD ADR REPS 3 SHS 40415F101 7,579 100,753 SH   DFND 1 100,753 0 0
HOME DEPOT INC COM 437076102 431,302 2,937,427 SH   DFND 2 1,083,782 0 1,853,645
HOME DEPOT INC COM 437076102 29,874 203,461 SH   DFND 1 203,461 0 0
HORIZON PHARMA PLC SHS G4617B105 4,888 330,709 SH   DFND 2 0 0 330,709
HORMEL FOODS CORP COM 440452100 300 8,650 SH   DFND 1 8,650 0 0
HORMEL FOODS CORP COM 440452100 367 10,600 SH   DFND 2 0 0 10,600
ICICI BK LTD ADR 45104G104 33,591 3,905,895 SH   DFND 2 0 0 3,905,895
ICICI BK LTD ADR 45104G104 2,071 240,821 SH   DFND 1 240,821 0 0
INCYTE CORP COM 45337C102 18,389 137,568 SH   DFND 2 0 0 137,568
INGREDION INC COM 457187102 843 7,000 SH   DFND 1 7,000 0 0
INGREDION INC COM 457187102 807 6,700 SH   DFND 2 0 0 6,700
INNOCOLL HLDGS PLC SHS G4783X105 331 295,184 SH   DFND 2 0 0 295,184
INSMED INC COM PAR $.01 457669307 2,144 122,450 SH   DFND 2 0 0 122,450
INSULET CORP COM 45784P101 3,853 89,421 SH   DFND 2 0 0 89,421
INTERCEPT PHARMACEUTICALS IN COM 45845P108 150 1,323 SH   DFND 2 0 0 1,323
INTERSECT ENT INC COM 46071F103 3,114 181,550 SH   DFND 2 0 0 181,550
INTRA CELLULAR THERAPIES INC COM 46116X101 3,052 187,823 SH   DFND 2 0 0 187,823
IONIS PHARMACEUTICALS INC COM 462222100 241 6,002 SH   DFND 2 0 0 6,002
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 14,290 98,465 SH   DFND 2 0 0 98,465
JOHNSON & JOHNSON COM 478160104 38,520 309,273 SH   DFND 2 0 0 309,273
JOHNSON & JOHNSON COM 478160104 1,059 8,500 SH   DFND 1 8,500 0 0
JPMORGAN CHASE & CO COM 46625H100 466 5,300 SH   DFND 1 5,300 0 0
JPMORGAN CHASE & CO COM 46625H100 439 5,000 SH   DFND 2 0 0 5,000
K2M GROUP HLDGS INC COM 48273J107 3,576 174,371 SH   DFND 2 0 0 174,371
KARYOPHARM THERAPEUTICS INC COM 48576U106 217 16,928 SH   DFND 2 0 0 16,928
KEMPHARM INC COM 488445107 890 181,699 SH   DFND 2 0 0 181,699
KITE PHARMA INC COM 49803L109 4,796 61,100 SH   DFND 2 0 0 61,100
LEXICON PHARMACEUTICALS INC COM NEW 528872302 167 11,677 SH   DFND 2 0 0 11,677
LILLY ELI & CO COM 532457108 12,111 143,995 SH   DFND 2 0 0 143,995
MASTERCARD INCORPORATED CL A 57636Q104 2,789 24,800 SH   DFND 2 0 0 24,800
MASTERCARD INCORPORATED CL A 57636Q104 394 3,500 SH   DFND 1 3,500 0 0
MEDTRONIC PLC SHS G5960L103 306 3,800 SH   DFND 2 0 0 3,800
MEDTRONIC PLC SHS G5960L103 322 4,000 SH   DFND 1 4,000 0 0
MERCK & CO INC COM 58933Y105 22,125 348,200 SH   DFND 2 0 0 348,200
MICROSOFT CORP COM 594918104 22,103 335,601 SH   DFND 2 335,601 0 0
MONDELEZ INTL INC CL A 609207105 15,734 365,238 SH   DFND 2 365,238 0 0
MYLAN N V SHS EURO N59465109 8,336 213,791 SH   DFND 2 0 0 213,791
NEWLINK GENETICS CORP COM 651511107 261 10,837 SH   DFND 2 0 0 10,837
NEXTERA ENERGY INC COM 65339F101 470 3,659 SH   DFND 2 0 0 3,659
NEXTERA ENERGY INC COM 65339F101 420 3,270 SH   DFND 1 3,270 0 0
NIKE INC CL B 654106103 1,816 32,580 SH   DFND 1 32,580 0 0
NIKE INC CL B 654106103 9,191 164,912 SH   DFND 2 0 0 164,912
NOVADAQ TECHNOLOGIES INC COM 66987G102 3,864 495,972 SH   DFND 2 0 0 495,972
OBALON THERAPEUTICS INC COM 67424L100 2,115 197,805 SH   DFND 2 0 0 197,805
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 2,728 176,118 SH   DFND 2 0 0 176,118
PARATEK PHARMACEUTICALS INC COM 699374302 1,540 80,000 SH   DFND 2 0 0 80,000
PFIZER INC COM 717081103 534 15,600 SH   DFND 1 15,600 0 0
PFIZER INC COM 717081103 25,422 743,111 SH   DFND 2 0 0 743,111
PHILIP MORRIS INTL INC COM 718172109 313,520 2,776,975 SH   DFND 2 786,202 0 1,990,773
PHILIP MORRIS INTL INC COM 718172109 28,250 250,218 SH   DFND 1 250,218 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 4,881 124,553 SH   DFND 2 0 0 124,553
PRICELINE GRP INC COM NEW 741503403 176,498 99,158 SH   DFND 2 34,000 0 65,158
PRICELINE GRP INC COM NEW 741503403 12,826 7,206 SH   DFND 1 7,206 0 0
PTC THERAPEUTICS INC COM 69366J200 1,561 158,686 SH   DFND 2 0 0 158,686
PUMA BIOTECHNOLOGY INC COM 74587V107 1,241 33,369 SH   DFND 2 0 0 33,369
RADIUS HEALTH INC COM NEW 750469207 286 7,397 SH   DFND 2 0 0 7,397
REYNOLDS AMERICAN INC COM 761713106 1,386 22,000 SH   DFND 2 0 0 22,000
SAREPTA THERAPEUTICS INC COM 803607100 2,449 82,735 SH   DFND 2 0 0 82,735
SHIRE PLC SPONSORED ADR 82481R106 20,002 114,800 SH   DFND 2 0 0 114,800
SNAP ON INC COM 833034101 799 4,739 SH   DFND 2 0 0 4,739
SNAP ON INC COM 833034101 705 4,178 SH   DFND 1 4,178 0 0
SPARK THERAPEUTICS INC COM 84652J103 2,391 44,832 SH   DFND 2 0 0 44,832
SPECTRANETICS CORP COM 84760C107 1,928 66,206 SH   DFND 2 0 0 66,206
STARBUCKS CORP COM 855244109 17,770 304,335 SH   DFND 2 304,335 0 0
STORE CAP CORP COM 862121100 823 34,446 SH   DFND 2 0 0 34,446
STORE CAP CORP COM 862121100 730 30,550 SH   DFND 1 30,550 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 4,265 136,272 SH   DFND 2 0 0 136,272
SYNDAX PHARMACEUTICALS INC COM 87164F105 163 11,900 SH   DFND 2 0 0 11,900
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADR 874039100 46,616 1,419,501 SH   DFND 2 661,201 0 758,300
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADR 874039100 20,127 612,882 SH   DFND 1 612,882 0 0
TESARO INC COM 881569107 7,382 47,973 SH   DFND 2 0 0 47,973
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADR 881624209 8,762 273,050 SH   DFND 2 0 0 273,050
THERMO FISHER SCIENTIFIC INC COM 883556102 281,224 1,830,888 SH   DFND 2 687,536 0 1,143,352
THERMO FISHER SCIENTIFIC INC COM 883556102 18,303 119,161 SH   DFND 1 119,161 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 1,174 17,618 SH   DFND 1 17,618 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 1,313 19,714 SH   DFND 2 0 0 19,714
TOTAL SYS SVCS INC COM 891906109 642 12,000 SH   DFND 2 0 0 12,000
TOTAL SYS SVCS INC COM 891906109 620 11,600 SH   DFND 1 11,600 0 0
TRANSENTERIX INC COM NEW 89366M201 182 150,000 SH   DFND 2 0 0 150,000
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 3,977 58,670 SH   DFND 2 0 0 58,670
UNITEDHEALTH GROUP INC COM 91324P102 39,015 237,882 SH   DFND 2 0 0 237,882
UNITEDHEALTH GROUP INC COM 91324P102 902 5,500 SH   DFND 1 5,500 0 0
VALEANT PHARMACEUTICALS INTL COM 91911K102 2,361 214,021 SH   DFND 2 0 0 214,021
VERTEX PHARMACEUTICALS INC COM 92532F100 746 6,818 SH   DFND 2 0 0 6,818
VISA INC COM CL A 92826C839 695,549 7,826,593 SH   DFND 2 2,937,326 0 4,889,267
VISA INC COM CL A 92826C839 49,102 552,513 SH   DFND 1 552,513 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 897 10,800 SH   DFND 2 0 0 10,800
WALGREENS BOOTS ALLIANCE INC COM 931427108 419 5,044 SH   DFND 1 5,044 0 0
WELLS FARGO & CO NEW COM 949746101 276,432 4,966,448 SH   DFND 2 1,937,686 0 3,028,762
WELLS FARGO & CO NEW COM 949746101 19,382 348,222 SH   DFND 1 348,222 0 0
WEYERHAEUSER CO COM 962166104 14,877 437,818 SH   DFND 2 437,818 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 2,912 23,846 SH   DFND 2 0 0 23,846