The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ADMA BIOLOGICS INC | COM | 000899104 | 5,020 | 1,028,672 | SH | DFND | 1 | 1,028,672 | 0 | 0 | |
| AVADEL PHARMACEUTICALS PLC | SPONSORED ADR | 05337M104 | 42,538 | 4,394,464 | SH | DFND | 1 | 4,394,464 | 0 | 0 | |
| AVINGER INC | COM | 053734109 | 950 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |
| AVIRAGEN THERAPEUTICS INC | COM | 053761102 | 2,072 | 3,179,226 | SH | DFND | 1 | 3,179,226 | 0 | 0 | |
| BARD C R INC | COM | 067383109 | 6,785 | 27,300 | SH | DFND | 1 | 27,300 | 0 | 0 | |
| BIODELIVERY SCIENCES INTL IN | COM | 09060J106 | 10,258 | 5,398,794 | SH | DFND | 1 | 5,398,794 | 0 | 0 | |
| CATALYST PHARMACEUTICALS INC | COM | 14888U101 | 15,990 | 8,200,000 | SH | DFND | 1 | 8,200,000 | 0 | 0 | |
| CIDARA THERAPEUTICS INC | COM | 171757107 | 4,390 | 562,875 | SH | DFND | 1 | 562,875 | 0 | 0 | |
| COGENTIX MED INC | COM | 19243A104 | 1,357 | 753,773 | SH | DFND | 1 | 753,773 | 0 | 0 | |
| CONTRAFECT CORP | COM | 212326102 | 2,572 | 1,429,109 | SH | DFND | 1 | 1,429,109 | 0 | 0 | |
| CORIUM INTL INC | COM | 21887L107 | 11,650 | 2,787,121 | SH | DFND | 1 | 2,787,121 | 0 | 0 | |
| ADVAXIS INC | COM NEW | 007624208 | 12,412 | 1,519,259 | SH | DFND | 1 | 1,519,259 | 0 | 0 | |
| DEXCOM INC | COM | 252131107 | 4,177 | 49,300 | SH | DFND | 1 | 49,300 | 0 | 0 | |
| DEXTERA SURGICAL INC | COM | 252366109 | 635 | 599,440 | SH | DFND | 1 | 599,440 | 0 | 0 | |
| DURECT CORP | COM | 266605104 | 8,932 | 8,506,229 | SH | DFND | 1 | 8,506,229 | 0 | 0 | |
| EGALET CORP | NOTE 5.500% 4/0 | 28226BAB0 | 8,238 | 10,000,000 | SH | DFND | 1 | 10,000,000 | 0 | 0 | |
| ENDOLOGIX INC | COM | 29266S106 | 12,084 | 1,669,020 | SH | DFND | 1 | 1,669,020 | 0 | 0 | |
| HERON THERAPEUTICS INC | COM | 427746102 | 74,211 | 4,947,403 | SH | DFND | 1 | 4,947,403 | 0 | 0 | |
| IDERA PHARMACEUTICALS INC | COM NEW | 45168K306 | 9,517 | 3,852,945 | SH | DFND | 1 | 3,852,945 | 0 | 0 | |
| IGNYTA INC | COM | 451731103 | 22,681 | 2,637,346 | SH | DFND | 1 | 2,637,346 | 0 | 0 | |
| JUNO THERAPEUTICS INC | COM | 48205A109 | 3,899 | 175,700 | SH | DFND | 1 | 175,700 | 0 | 0 | |
| LA JOLLA PHARMACEUTICAL CO | COM PAR $.0001 2 | 503459604 | 23,369 | 782,887 | SH | DFND | 1 | 782,887 | 0 | 0 | |
| AEVI GENOMIC MEDICINE INC | COM | 00835P105 | 930 | 500,000 | SH | Call | DFND | 1 | 500,000 | 0 | 0 |
| LION BIOTECHNOLOGIES INC | COM | 53619R102 | 18,692 | 2,509,059 | SH | DFND | 1 | 2,509,059 | 0 | 0 | |
| MEDICINES CO | COM | 584688105 | 10,517 | 215,077 | SH | DFND | 1 | 215,077 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 10,872 | 2,090,801 | SH | DFND | 1 | 2,090,801 | 0 | 0 | |
| NOVELION THERAPEUTICS INC | COM NEW | 67001K202 | 20,927 | 1,948,554 | SH | DFND | 1 | 1,948,554 | 0 | 0 | |
| ONCOMED PHARMACEUTICALS INC | COM | 68234X102 | 2,763 | 300,000 | SH | Call | DFND | 1 | 300,000 | 0 | 0 |
| PARATEK PHARMACEUTICALS INC | COM | 699374302 | 4,309 | 223,862 | SH | DFND | 1 | 223,862 | 0 | 0 | |
| PERNIX THERAPEUTICS HLDGS IN | DBCV 4.250% 4/0 | 71426VAK4 | 4,049 | 15,500,000 | SH | DFND | 1 | 15,500,000 | 0 | 0 | |
| PROGENICS PHARMACEUTICALS IN | COM | 743187106 | 18,866 | 1,998,531 | SH | DFND | 1 | 1,998,531 | 0 | 0 | |
| PROGENICS PHARMACEUTICALS IN | COM | 743187106 | 2,360 | 250,000 | SH | Call | DFND | 1 | 250,000 | 0 | 0 |
| RECRO PHARMA INC | COM | 75629F109 | 27,095 | 3,100,086 | SH | DFND | 1 | 3,100,086 | 0 | 0 | |
| ALPHATEC HOLDINGS INC | COM NEW | 02081G201 | 527 | 226,006 | SH | DFND | 1 | 226,006 | 0 | 0 | |
| RETROPHIN INC | COM | 761299106 | 53,390 | 2,892,178 | SH | DFND | 1 | 2,892,178 | 0 | 0 | |
| SPDR SERIES TRUST | S&P BIOTECH | 78464A870 | 69,340 | 1,000,000 | SH | Put | DFND | 1 | 1,000,000 | 0 | 0 |
| SCYNEXIS INC | COM | 811292101 | 4,077 | 1,477,273 | SH | DFND | 1 | 1,477,273 | 0 | 0 | |
| SEASPINE HLDGS CORP | COM | 81255T108 | 8,633 | 1,099,807 | SH | DFND | 1 | 1,099,807 | 0 | 0 | |
| STRATA SKIN SCIENCES INC | COM | 86272A107 | 582 | 961,422 | SH | DFND | 1 | 961,422 | 0 | 0 | |
| TELIGENT INC NEW | COM | 87960W104 | 15,087 | 1,931,711 | SH | DFND | 1 | 1,931,711 | 0 | 0 | |
| VERACYTE INC | COM | 92337F107 | 15,134 | 1,648,566 | SH | DFND | 1 | 1,648,566 | 0 | 0 | |
| WINDTREE THERAPEUTICS INC | COM | 97382D105 | 887 | 777,797 | SH | DFND | 1 | 777,797 | 0 | 0 | |
| ENDO INTL PLC | SHS | G30401106 | 21,023 | 1,883,738 | SH | DFND | 1 | 1,883,738 | 0 | 0 | |
| ENDO INTL PLC | SHS | G30401106 | 22,320 | 2,000,000 | SH | Call | DFND | 1 | 2,000,000 | 0 | 0 |
| AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 9,068 | 2,833,649 | SH | DFND | 1 | 2,833,649 | 0 | 0 | |
| HORIZON PHARMA PLC | SHS | G4617B105 | 83,717 | 5,664,219 | SH | DFND | 1 | 5,664,219 | 0 | 0 | |
| HORIZON PHARMA PLC | SHS | G4617B105 | 14,780 | 1,000,000 | SH | Call | DFND | 1 | 1,000,000 | 0 | 0 |
| NEXVET BIOPHARMA PUB LTD CO | ORD SHS | G6503X109 | 4,385 | 1,127,200 | SH | DFND | 1 | 1,127,200 | 0 | 0 | |
| STRONGBRIDGE BIOPHARMA PLC | SHS USD | G85347105 | 14,163 | 2,981,706 | SH | DFND | 1 | 2,981,706 | 0 | 0 | |
| ALCOBRA LTD | SHS | M2239P109 | 1,387 | 1,216,643 | SH | DFND | 1 | 1,216,643 | 0 | 0 | |
| MEDIWOUND LTD | ORD SHS | M68830104 | 4,178 | 633,102 | SH | DFND | 1 | 633,102 | 0 | 0 | |
| ANGIODYNAMICS INC | COM | 03475V101 | 25,426 | 1,465,452 | SH | DFND | 1 | 1,465,452 | 0 | 0 | |
| ANTARES PHARMA INC | COM | 036642106 | 21,704 | 7,642,206 | SH | DFND | 1 | 7,642,206 | 0 | 0 | |
| ARALEZ PHARMACEUTICALS INC | COM | 03852X100 | 11,110 | 5,191,590 | SH | DFND | 1 | 5,191,590 | 0 | 0 | |
| ARATANA THERAPEUTICS INC | COM | 03874P101 | 19,586 | 3,695,442 | SH | DFND | 1 | 3,695,442 | 0 | 0 | |