The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abeona Therapeutics Inc. COM 00289Y107 8,422 1,684,364 SH   SOLE   1,684,364 0 0
ACADIA Pharmaceuticals Inc. COM 004225108 887,684 25,819,768 SH   SOLE   25,819,768 0 0
Acceleron Pharma Inc. COM 00434H108 761 28,765 SH   SOLE   28,765 0 0
Achaogen, Inc. COM 004449104 115,613 4,582,382 SH   SOLE   4,582,382 0 0
Achillion Pharmaceuticals, Inc. COM 00448Q201 7,816 1,856,637 SH   SOLE   1,856,637 0 0
Acorda Therapeutics, Inc. COM 00484M106 69,338 3,301,791 SH   SOLE   3,301,791 0 0
Adamas Pharmaceuticals, Inc. COM 00548A106 3,021 172,630 SH   SOLE   172,630 0 0
Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 551 100,000 SH   SOLE   600,000 0 0
Advanced Accelerator Applications S.A. SPONSORED ADS 00790T100 88,557 2,221,706 SH   SOLE   4,443,412 0 0
Aeglea BioTherapeutics, Inc. COM 00773J103 1,415 189,987 SH   SOLE   189,987 0 0
Aerie Pharmaceuticals, Inc. COM 00771V108 13,576 299,356 SH   SOLE   299,356 0 0
Aevi Genomic Medicine, Inc. COM 00835P105 3,010 1,618,089 SH   SOLE   1,618,089 0 0
Affimed N.V. COM N01045108 920 400,000 SH   SOLE   400,000 0 0
Agios Pharmaceuticals, Inc. COM 00847X104 7,514 128,666 SH   SOLE   128,666 0 0
Aimmune Therapeutics, Inc. COM 00900T107 14,644 673,908 SH   SOLE   673,908 0 0
Akari Therapeutics plc SPONSORED ADR 00972G108 5,501 496,901 SH   SOLE   49,690,100 0 0
Alder BioPharmaceuticals, Inc. COM 014339105 4,520 217,328 SH   SOLE   217,328 0 0
Alexion Pharmaceuticals, Inc. COM 015351109 793,410 6,544,130 SH   SOLE   6,544,130 0 0
Alkermes plc SHS G01767105 8,790 150,251 SH   SOLE   150,251 0 0
Amarin Corporation plc SPONSORED ADR NEW 023111206 72,501 22,656,469 SH   SOLE   22,656,469 0 0
AnaptysBio, Inc. COM ADDED 032724106 4,163 150,000 SH   SOLE   150,000 0 0
Aquinox Pharmaceuticals, Inc. COM 03842B101 182,491 10,934,154 SH   SOLE   10,934,154 0 0
Arbutus Biopharma Corporation COM 03879J100 587 180,582 SH   SOLE   180,582 0 0
Array BioPharma Inc. COM 04269X105 14,178 1,585,913 SH   SOLE   1,585,913 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101 37,841 1,351,463 SH   SOLE   1,351,463 0 0
Assembly Biosciences, Inc. COM 045396108 6,373 250,000 SH   SOLE   250,000 0 0
AveXis, Inc. COM 05366U100 38,015 500,000 SH   SOLE   500,000 0 0
BeiGene, Ltd. SPONSORED ADR 07725L102 134,475 3,673,175 SH   SOLE   47,751,275 0 0
Bellicum Pharmaceuticals, Inc. COM 079481107 62,099 5,032,313 SH   SOLE   5,032,313 0 0
BioCryst Pharmaceuticals, Inc. COM 09058V103 98,421 11,716,784 SH   SOLE   11,716,784 0 0
BioDelivery Sciences International, Inc. COM 09060J106 399 210,021 SH   SOLE   210,021 0 0
Biogen Inc. COM 09062X103 4,511 16,500 SH   SOLE   16,500 0 0
BioMarin Pharmaceutical Inc. COM 09061G101 421,913 4,806,483 SH   SOLE   4,806,483 0 0
BioPharmX Corporation COM 09072X101 191 377,295 SH   SOLE   377,295 0 0
BioTime, Inc. *W EXP 10/1/201 09066L162 12 20,084 SH   SOLE   20,084 0 0
Bioverativ Inc. COM ADDED 09075E100 449 8,249 SH   SOLE   8,249 0 0
bluebird bio, Inc. COM 09609G100 31,946 351,441 SH   SOLE   351,441 0 0
Catalyst Pharmaceuticals, Inc. COM 14888U101 9,949 5,102,153 SH   SOLE   5,102,153 0 0
Cellectis S.A. SPONSORED ADS 15117K103 1,200 50,000 SH   SOLE   50,000 0 0
Cerus Corporation COM 157085101 58,087 13,053,275 SH   SOLE   13,053,275 0 0
ChemoCentryx, Inc. COM 16383L106 357 49,064 SH   SOLE   49,064 0 0
Chimerix, Inc. COM 16934W106 735 115,216 SH   SOLE   115,216 0 0
ContraFect Corporation COM 212326102 7,283 4,045,876 SH   SOLE   4,045,876 0 0
Corbus Pharmaceuticals Holdings, Inc. COM 21833P103 1,074 130,129 SH   SOLE   130,129 0 0
Cyclacel Pharmaceuticals, Inc. PFD CONV EX 6% 23254L207 83 13,253 SH   SOLE   13,253 0 0
CymaBay Therapeutics, Inc. COM 23257D103 6,078 1,413,499 SH   SOLE   1,413,499 0 0
DBV Technologies S.A. SPONSORED ADR 23306J101 194,047 5,509,560 SH   SOLE   2,754,780 0 0
Dermira, Inc. COM 24983L104 14,171 415,448 SH   SOLE   415,448 0 0
Dimension Therapeutics, Inc. COM 25433V105 2,191 1,251,881 SH   SOLE   1,251,881 0 0
Dynavax Technologies Corporation COM NEW 268158201 446 75,000 SH   SOLE   75,000 0 0
Epizyme, Inc. COM 29428V104 3,987 232,481 SH   SOLE   232,481 0 0
Exelixis, Inc. COM 30161Q104 56,419 2,603,569 SH   SOLE   2,603,569 0 0
Five Prime Therapeutics, Inc. COM 33830X104 696 19,247 SH   SOLE   19,247 0 0
Foamix Pharmaceuticals Ltd. SHS M46135105 12,210 2,466,702 SH   SOLE   2,466,702 0 0
Fulgent Genetics, Inc. COM 359664109 1,365 125,000 SH   SOLE   125,000 0 0
Galapagos NV SPONSORED ADR 36315X101 22,400 259,894 SH   SOLE   259,894 0 0
Genomic Health, Inc. COM 37244C101 433,648 13,770,982 SH   SOLE   13,770,982 0 0
GlycoMimetics, Inc. COM 38000Q102 2,070 381,235 SH   SOLE   381,235 0 0
Halozyme Therapeutics, Inc. COM 40637H109 18,034 1,391,507 SH   SOLE   1,391,507 0 0
Heron Therapeutics, Inc. COM 427746102 41,754 2,783,569 SH   SOLE   2,783,569 0 0
Idera Pharmaceuticals, Inc. COM NEW 45168K306 25,408 10,286,483 SH   SOLE   10,286,483 0 0
Ignyta, Inc. COM 451731103 4,911 571,000 SH   SOLE   571,000 0 0
Immune Design Corp. COM 45252L103 1,013 148,937 SH   SOLE   148,937 0 0
ImmunoGen, Inc. COM 45253H101 11,669 3,015,353 SH   SOLE   3,015,353 0 0
Incyte Corporation COM 45337C102 4,559,485 34,110,011 SH   SOLE   34,110,011 0 0
Infinity Pharmaceuticals, Inc. COM 45665G303 1,875 580,400 SH   SOLE   580,400 0 0
Insmed Incorporated COM PAR $.01 457669307 7,004 400,000 SH   SOLE   400,000 0 0
Intellia Therapeutics, Inc. COM 45826J105 14,965 1,062,120 SH   SOLE   1,062,120 0 0
Intra-Cellular Therapies, Inc. COM 46116X101 9,899 609,166 SH   SOLE   609,166 0 0
Invitae Corporation COM 46185L103 80,609 7,288,300 SH   SOLE   7,288,300 0 0
InVivo Therapeutics Holdings Corp. COM NEW 46186M209 1,620 400,000 SH   SOLE   400,000 0 0
Jounce Therapeutics, Inc. COM ADDED 481116101 2,199 100,000 SH   SOLE   100,000 0 0
Juno Therapeutics, Inc. COM 48205A109 1,110 50,000 SH   SOLE   50,000 0 0
Karyopharm Therapeutics Inc. COM 48576U106 2,786 216,990 SH   SOLE   216,990 0 0
La Jolla Pharmaceutical Company COM PAR $.0001 2 503459604 11,317 379,134 SH   SOLE   379,134 0 0
Ligand Pharmaceuticals Incorporated COM NEW 53220K504 7,767 73,386 SH   SOLE   73,386 0 0
Loxo Oncology, Inc. COM 548862101 5,796 137,735 SH   SOLE   137,735 0 0
MacroGenics, Inc. COM 556099109 6,764 363,676 SH   SOLE   363,676 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105 890 57,762 SH   SOLE   57,762 0 0
MediWound Ltd. ORD SHS M68830104 1,492 226,000 SH   SOLE   226,000 0 0
Merus N.V. COM N5749R100 28,293 1,160,014 SH   SOLE   1,160,014 0 0
Mirati Therapeutics, Inc. COM 60468T105 11,800 2,269,198 SH   SOLE   2,269,198 0 0
MyoKardia, Inc. COM 62857M105 1,315 100,000 SH   SOLE   100,000 0 0
Nabriva Therapeutics AG SPONSORED ADR 62957M104 4,200 350,000 SH   SOLE   35,000 0 0
Natera, Inc. COM 632307104 2,028 228,676 SH   SOLE   228,676 0 0
Neurocrine Biosciences, Inc. COM 64125C109 38,772 895,422 SH   SOLE   895,422 0 0
NeuroDerm Ltd. ORD SHS M74231107 15,178 571,667 SH   SOLE   571,667 0 0
Palatin Technologies, Inc. COM PAR $.01 696077403 671 2,050,000 SH   SOLE   2,050,000 0 0
Progenics Pharmaceuticals, Inc. COM 743187106 29,744 3,150,808 SH   SOLE   3,150,808 0 0
Proteon Therapeutics, Inc. COM 74371L109 523 298,591 SH   SOLE   298,591 0 0
Ra Pharmaceuticals, Inc. COM 74933V108 3,789 177,952 SH   SOLE   177,952 0 0
Rigel Pharmaceuticals, Inc. COM NEW 766559603 8,337 2,518,882 SH   SOLE   2,518,882 0 0
Ritter Pharmaceuticals, Inc. COM 767836109 568 400,000 SH   SOLE   400,000 0 0
Sage Therapeutics, Inc. COM 78667J108 14,806 208,328 SH   SOLE   208,328 0 0
Sangamo Therapeutics, Inc. COM 800677106 23,561 4,530,901 SH   SOLE   4,530,901 0 0
Seattle Genetics, Inc. COM 812578102 2,873,680 45,715,556 SH   SOLE   45,715,556 0 0
Selecta Biosciences, Inc. COM 816212104 2,516 175,712 SH   SOLE   175,712 0 0
Seres Therapeutics, Inc. COM 81750R102 1,409 125,000 SH   SOLE   125,000 0 0
Spark Therapeutics, Inc. COM 84652J103 70,320 1,318,341 SH   SOLE   1,318,341 0 0
Spring Bank Pharmaceuticals, Inc. COM 849431101 1,952 219,298 SH   SOLE   219,298 0 0
Stemline Therapeutics, Inc. COM 85858C107 5,416 633,497 SH   SOLE   633,497 0 0
Sunesis Pharmaceuticals, Inc. COM PAR 867328700 3,041 741,665 SH   SOLE   741,665 0 0
Syros Pharmaceuticals, Inc. COM 87184Q107 3,257 204,465 SH   SOLE   204,465 0 0
Tonix Pharmaceuticals Holdings Corp. COM ADDED 890260409 2,099 449,500 SH   SOLE   449,500 0 0
Trevena, Inc. COM 89532E109 3,146 857,206 SH   SOLE   857,206 0 0
Trillium Therapeutics Inc. COM NEW 89620X506 2,544 413,697 SH   SOLE   413,697 0 0
Ultragenyx Pharmaceutical Inc. COM 90400D108 3,389 50,000 SH   SOLE   50,000 0 0
Versartis, Inc. COM 92529L102 35,454 1,660,593 SH   SOLE   1,660,593 0 0
Windtree Therapeutics, Inc. COM 97382D105 291 254,973 SH   SOLE   254,973 0 0
Xencor, Inc. COM 98401F105 20,860 872,072 SH   SOLE   872,072 0 0
Zogenix, Inc. COM NEW 98978L204 4,144 381,939 SH   SOLE   381,939 0 0
Acorda Therapeutics, Inc. NOTE 1.75% 6/15/2021 00484MAA4 29,696 35,083,000 PRN   SOLE   35,083,000 0 0
Aegerion Pharmaceuticals, Inc. NOTE 2.0% 8/15/2019 00767EAB8 13,241 16,517,000 PRN   SOLE   16,517,000 0 0
Array BioPharma Inc. NOTE 3.0% 6/1/2020 04269XAA3 4,258 3,000,000 PRN   SOLE   3,000,000 0 0
BioMarin Pharmaceutical Inc. NOTE 1.875% 4/23/2017 09061GAD3 95,967 22,379,000 PRN   SOLE   22,379,000 0 0
BioMarin Pharmaceutical Inc. NOTE 0.75% 10/15/2018 09061GAE1 13,830 12,228,000 PRN   SOLE   12,228,000 0 0
Inotek Pharmaceuticals Corporation NOTE 5.75% 8/1/2021 45780VAB8 3,008 5,000,000 PRN   SOLE   5,000,000 0 0
Novavax, Inc. Note 3.75% 2/1/2023 ADDED 670002AB0 48,554 108,500,000 PRN   SOLE   108,500,000 0 0
Protalix BioTherapeutics, Inc. NOTE 4.5% 9/15/2018 74365AAB7 2,543 3,423,000 PRN   SOLE   3,423,000 0 0