The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIOMED INC COM 003654100 240,570 1,921,484 SH   SOLE   1,921,484 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 54,679 1,590,430 SH   SOLE   1,590,430 0 0
ACELRX PHARMACEUTICALS INC COM 00444T100 3,253 1,032,715 SH   SOLE   1,032,715 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 25,500 1,173,498 SH   SOLE   1,173,498 0 0
ALCOBRA LTD SHS M2239P109 311 272,788 SH   SOLE   272,788 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 124,521 1,027,060 SH   SOLE   1,027,060 0 0
ALIGN TECHNOLOGY INC COM 016255101 25,593 223,107 SH   SOLE   223,107 0 0
ALIMERA SCIENCES INC COM 016259103 4,219 3,013,793 SH   SOLE   3,013,793 0 0
AMAG PHARMACEUTICALS INC COM 00163U106 75,421 3,344,620 SH   SOLE   3,344,620 0 0
AMICUS THERAPEUTICS INC COM 03152W109 56,206 7,882,988 SH   SOLE   7,882,988 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 209,146 2,382,619 SH   SOLE   2,382,619 0 0
CAPNIA INC COM 14066L105 301 423,738 SH   SOLE   423,738 0 0
CELGENE CORP COM 151020104 36,737 295,240 SH   SOLE   295,240 0 0
CEMPRA INC COM 15130J109 1,276 340,320 SH   SOLE   340,320 0 0
CLOVIS ONCOLOGY INC COM 189464100 247,992 3,894,963 SH   SOLE   3,894,963 0 0
CYTOKINETICS INC COM NEW 23282W605 1,589 123,686 SH   SOLE   123,686 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 1,637 481,519 SH   SOLE   481,519 0 0
EPIZYME INC COM 29428V104 82,167 4,791,051 SH   SOLE   4,791,051 0 0
EXACT SCIENCES CORP COM 30063P105 10,045 425,276 SH   SOLE   425,276 0 0
GILEAD SCIENCES INC COM 375558103 23,881 351,600 SH   SOLE   351,600 0 0
HISTOGENICS CORP COM 43358V109 524 302,922 SH   SOLE   302,922 0 0
IDERA PHARMACEUTICALS INC COM NEW 45168K306 1,522 616,355 SH   SOLE   616,355 0 0
INSMED INC COM PAR $.01 457669307 96,903 5,534,150 SH   SOLE   5,534,150 0 0
INTREXON CORP COM 46122T102 830 41,900 SH   SOLE   41,900 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 43,739 3,406,475 SH   SOLE   3,406,475 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 23,488 1,759,376 SH   SOLE   1,759,376 0 0
PROTHENA CORP PLC SHS G72800108 58,906 1,055,855 SH   SOLE   1,055,855 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 14,083 4,254,623 SH   SOLE   4,254,623 0 0
SAGE THERAPEUTICS INC COM 78667J108 78,316 1,101,951 SH   SOLE   1,101,951 0 0
SHIRE PLC SPONSORED ADR 82481R106 22,685 130,200 SH   SOLE   130,200 0 0
SOPHIRIS BIO INC COM NEW 83578Q209 699 247,000 SH   SOLE   247,000 0 0
STAAR SURGICAL CO COM PAR $0.01 852312305 34,037 3,473,170 SH   SOLE   3,473,170 0 0
SUNESIS PHARMACEUTICALS INC COM PAR 867328700 4,766 1,162,473 SH   SOLE   1,162,473 0 0
Trevena Inc COM 89532e109 1,253 341,300 SH   SOLE   341,300 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 254,963 1,883,315 SH   SOLE   1,883,315 0 0
VANDA PHARMACEUTICALS INC COM 921659108 58,846 4,203,270 SH   SOLE   4,203,270 0 0
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 81,789 2,628,193 SH   SOLE   2,628,193 0 0
ZELTIQ AESTHETICS INC COM 98933Q108 113,038 2,032,692 SH   SOLE   2,032,692 0 0
ZOGENIX INC COM NEW 98978L204 320 29,500 SH   SOLE   29,500 0 0