The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AAC HLDGS INC | COM | 000307108 | 16,850 | 1,975,347 | SH | DFND | 1,975,347 | 0 | 0 | ||
| ACLARIS THERAPEUTICS INC | COM | 00461U105 | 11,183 | 375,000 | SH | DFND | 375,000 | 0 | 0 | ||
| ACORDA THERAPEUTICS INC | NOTE 1.750% 6/1 | 00484MAA4 | 4,249 | 5,000,000 | PRN | DFND | 5,000,000 | 0 | 0 | ||
| ADEPTUS HEALTH INC | CL A | 006855100 | 2,882 | 1,600,861 | SH | DFND | 1,600,861 | 0 | 0 | ||
| ADVANCED ACCELERATOR APPLIC | SPONSORED ADS | 00790T100 | 20,848 | 523,023 | SH | DFND | 523,023 | 0 | 0 | ||
| AERIE PHARMACEUTICALS INC | COM | 00771V108 | 36,087 | 795,743 | SH | DFND | 795,743 | 0 | 0 | ||
| AETNA INC NEW | COM | 00817Y108 | 34,056 | 267,000 | SH | DFND | 267,000 | 0 | 0 | ||
| AGILE THERAPEUTICS INC | COM | 00847L100 | 3,114 | 971,739 | SH | DFND | 971,739 | 0 | 0 | ||
| AKARI THERAPEUTICS PLC | SPONSORED ADR | 00972G108 | 12,738 | 1,150,700 | SH | DFND | 1,150,700 | 0 | 0 | ||
| ALIMERA SCIENCES INC | COM | 016259103 | 8,229 | 5,878,015 | SH | DFND | 5,878,015 | 0 | 0 | ||
| ALLSCRIPTS HEALTHCARE SOLUTN | NOTE 1.250% 7/0 | 01988PAD0 | 9,718 | 9,671,000 | PRN | DFND | 9,671,000 | 0 | 0 | ||
| ANAPTYSBIO INC | COM | 032724106 | 23,469 | 845,746 | SH | DFND | 845,746 | 0 | 0 | ||
| ANTHEM INC | COM | 036752103 | 52,591 | 318,000 | SH | DFND | 318,000 | 0 | 0 | ||
| ARALEZ PHARMACEUTICALS INC | COM | 03852X100 | 3,519 | 1,644,583 | SH | DFND | 1,644,583 | 0 | 0 | ||
| ARDELYX INC | COM | 039697107 | 10,648 | 841,744 | SH | DFND | 841,744 | 0 | 0 | ||
| ARRAY BIOPHARMA INC | COM | 04269X105 | 10,216 | 1,142,744 | SH | DFND | 1,142,744 | 0 | 0 | ||
| ARRAY BIOPHARMA INC | NOTE 3.000% 6/0 | 04269XAA3 | 31,917 | 22,385,000 | PRN | DFND | 22,385,000 | 0 | 0 | ||
| ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 26,018 | 929,226 | SH | DFND | 929,226 | 0 | 0 | ||
| AUDENTES THERAPEUTICS INC | COM | 05070R104 | 23,918 | 1,403,653 | SH | DFND | 1,403,653 | 0 | 0 | ||
| AVADEL PHARMACEUTICALS PLC | SPONSORED ADR | 05337M104 | 39,425 | 4,072,809 | SH | DFND | 4,072,809 | 0 | 0 | ||
| AVEXIS INC | COM | 05366U100 | 170,056 | 2,236,701 | SH | DFND | 2,236,701 | 0 | 0 | ||
| AXOGEN INC | COM | 05463X106 | 19,209 | 1,838,225 | SH | DFND | 1,838,225 | 0 | 0 | ||
| AXOVANT SCIENCES LTD | COM | G0750W104 | 8,486 | 568,005 | SH | DFND | 568,005 | 0 | 0 | ||
| BIOCRYST PHARMACEUTICALS | COM | 09058V103 | 25,916 | 3,085,236 | SH | DFND | 3,085,236 | 0 | 0 | ||
| BIOSCRIP INC | COM | 09069N108 | 3,351 | 1,971,228 | SH | DFND | 1,971,228 | 0 | 0 | ||
| BLUEBIRD BIO INC | COM | 09609G100 | 9,732 | 107,064 | SH | DFND | 107,064 | 0 | 0 | ||
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 54,586 | 1,365,000 | SH | DFND | 1,365,000 | 0 | 0 | ||
| CAS MED SYS INC | COM PAR $0.004 | 124769209 | 2,608 | 1,798,434 | SH | DFND | 1,798,434 | 0 | 0 | ||
| CENTENE CORP DEL | COM | 15135B101 | 43,016 | 603,643 | SH | DFND | 603,643 | 0 | 0 | ||
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | 767 | 36,931 | SH | DFND | 36,931 | 0 | 0 | ||
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 16,293 | 943,433 | SH | DFND | 943,433 | 0 | 0 | ||
| DBV TECHNOLOGIES S A | SPONSORED ADR | 23306J101 | 61,397 | 1,743,229 | SH | DFND | 1,743,229 | 0 | 0 | ||
| DEXCOM INC | COM | 252131107 | 9,404 | 110,992 | SH | DFND | 110,992 | 0 | 0 | ||
| EDITAS MEDICINE INC | COM | 28106W103 | 38,154 | 1,709,400 | SH | DFND | 1,709,400 | 0 | 0 | ||
| EHEALTH INC | COM | 28238P109 | 31,793 | 2,640,609 | SH | DFND | 2,640,609 | 0 | 0 | ||
| ENDOLOGIX INC | NOTE 2.250%12/1 | 29266SAA4 | 49,220 | 51,117,000 | PRN | DFND | 51,117,000 | 0 | 0 | ||
| ENDOLOGIX INC | NOTE 3.250%11/0 | 29266SAB2 | 40,013 | 40,500,000 | PRN | DFND | 40,500,000 | 0 | 0 | ||
| EPIZYME INC | COM | 29428V104 | 24,243 | 1,413,596 | SH | DFND | 1,413,596 | 0 | 0 | ||
| ESSA PHARMA INC | COM | 29668H104 | 6,619 | 2,121,601 | SH | DFND | 2,121,601 | 0 | 0 | ||
| FIVE PRIME THERAPEUTICS INC | COM | 33830X104 | 4,989 | 138,000 | SH | DFND | 138,000 | 0 | 0 | ||
| FLUIDIGM CORP DEL | NOTE 2.750% 2/0 | 34385PAA6 | 18,639 | 27,715,000 | PRN | DFND | 27,715,000 | 0 | 0 | ||
| FOAMIX PHARMACEUTICALS LTD | SHS | M46135105 | 4,046 | 817,435 | SH | DFND | 817,435 | 0 | 0 | ||
| GALAPAGOS NV | SPON ADR | 36315X101 | 22,389 | 259,768 | SH | DFND | 259,768 | 0 | 0 | ||
| GENOCEA BIOSCIENCES INC | COM | 372427104 | 2,917 | 479,000 | SH | DFND | 479,000 | 0 | 0 | ||
| GILEAD SCIENCES INC | COM | 375558103 | 81,708 | 1,203,000 | SH | DFND | 1,203,000 | 0 | 0 | ||
| GLAUKOS CORP | COM | 377322102 | 9,234 | 180,000 | SH | DFND | 180,000 | 0 | 0 | ||
| GLOBUS MED INC | CL A | 379577208 | 9,123 | 308,000 | SH | DFND | 308,000 | 0 | 0 | ||
| GW PHARMACEUTICALS PLC | ADS | 36197T103 | 51,465 | 425,545 | SH | DFND | 425,545 | 0 | 0 | ||
| HEALTHWAYS INC | NOTE 1.500% 7/0 | 422245AB6 | 17,896 | 11,600,000 | PRN | DFND | 11,600,000 | 0 | 0 | ||
| HORIZON PHARMA INVT LTD | NOTE 2.500% 3/1 | 44052TAB7 | 83,284 | 90,100,000 | PRN | DFND | 90,100,000 | 0 | 0 | ||
| HORIZON PHARMA PLC | SHS | G4617B105 | 161,767 | 10,944,988 | SH | DFND | 10,944,988 | 0 | 0 | ||
| HUMANA INC | COM | 444859102 | 14,262 | 69,185 | SH | DFND | 69,185 | 0 | 0 | ||
| IMPAX LABORATORIES INC | NOTE 2.000% 6/1 | 45256BAE1 | 13,870 | 17,000,000 | PRN | DFND | 17,000,000 | 0 | 0 | ||
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 6,361 | 1,969,225 | SH | DFND | 1,969,225 | 0 | 0 | ||
| INTERCEPT PHARMACEUTICALS IN | NOTE 3.250% 7/0 | 45845PAA6 | 39,540 | 42,500,000 | PRN | DFND | 42,500,000 | 0 | 0 | ||
| INVUITY INC | COM NEW | 46187J205 | 13,439 | 1,690,498 | SH | DFND | 1,690,498 | 0 | 0 | ||
| ISIS PHARMACEUTICALS INC DEL | NOTE 1.000%11/1 | 464337AJ3 | 60,243 | 62,500,000 | PRN | DFND | 62,500,000 | 0 | 0 | ||
| JOUNCE THERAPEUTICS INC | COM | 481116101 | 10,310 | 468,867 | SH | DFND | 468,867 | 0 | 0 | ||
| KEMPHARM INC | NOTE 5.500% 2/0 | 488445AB3 | 45,719 | 75,000,000 | PRN | DFND | 75,000,000 | 0 | 0 | ||
| KEMPHARM INC | COM | 488445107 | 5,314 | 1,084,443 | SH | DFND | 1,084,443 | 0 | 0 | ||
| KITE PHARMA INC | COM | 49803L109 | 6,358 | 81,000 | SH | DFND | 81,000 | 0 | 0 | ||
| LANNET INC | COM | 516012101 | 41,435 | 1,853,896 | SH | DFND | 1,853,896 | 0 | 0 | ||
| LOXO ONCOLOGY INC | COM | 548862101 | 31,699 | 753,300 | SH | DFND | 753,300 | 0 | 0 | ||
| MALLINCKRODT PUB LTD CO | SHS | G5785G107 | 32,489 | 728,949 | SH | DFND | 728,949 | 0 | 0 | ||
| MCKESSON CORP | COM | 58155Q103 | 33,952 | 229,000 | SH | DFND | 229,000 | 0 | 0 | ||
| MOLINA HEALTHCARE INC | DBCV 1.625% 8/1 | 60855RAD2 | 37,139 | 35,000,000 | PRN | DFND | 35,000,000 | 0 | 0 | ||
| MYLAN N V | SHS EURO | N59465109 | 79,626 | 2,042,224 | SH | DFND | 2,042,224 | 0 | 0 | ||
| MYLAN N V | SHS EURO | N59465109 | 17,546 | 450,000 | SH | Call | DFND | 450,000 | 0 | 0 | |
| MYOKARDIA INC | COM | 62857M105 | 5,586 | 424,800 | SH | DFND | 424,800 | 0 | 0 | ||
| MYOVANT SCIENCES LTD | COM | G637AM102 | 8,280 | 705,268 | SH | DFND | 705,268 | 0 | 0 | ||
| NANOSTRING TECHNOLOGIES INC | COM | 63009R109 | 7,002 | 352,375 | SH | DFND | 352,375 | 0 | 0 | ||
| NEOS THERAPEUTICS INC | COM | 64052L106 | 15,114 | 2,099,166 | SH | DFND | 2,099,166 | 0 | 0 | ||
| NEVRO CORP | COM | 64157F103 | 37,761 | 402,998 | SH | DFND | 402,998 | 0 | 0 | ||
| NEVRO CORP | NOTE 1.750% 6/0 | 64157FAA1 | 33,560 | 27,600,000 | PRN | DFND | 27,600,000 | 0 | 0 | ||
| NIVALIS THERAPEUTICS INC | COM | 65481J109 | 10,899 | 3,732,412 | SH | DFND | 3,732,412 | 0 | 0 | ||
| NXSTAGE MEDICAL INC | COM | 67072V103 | 100,456 | 3,744,151 | SH | DFND | 3,744,151 | 0 | 0 | ||
| OBALON THERAPEUTICS INC | COM | 67424L100 | 224 | 20,953 | SH | DFND | 20,953 | 0 | 0 | ||
| OXFORD IMMUNOTEC GLOBAL PLC | ORD SHS | G6855A103 | 9,550 | 616,508 | SH | DFND | 616,508 | 0 | 0 | ||
| PORTOLA PHARMACEUTICALS INC | COM | 737010108 | 56,876 | 1,451,301 | SH | DFND | 1,451,301 | 0 | 0 | ||
| PROTEON THERAPEUTICS INC | COM | 74371L109 | 2,332 | 1,332,599 | SH | DFND | 1,332,599 | 0 | 0 | ||
| PSIVIDA CORP | COM | 74440J101 | 2,568 | 1,492,824 | SH | DFND | 1,492,824 | 0 | 0 | ||
| RA PHARMACEUTICALS INC | COM | 74933V108 | 3,786 | 177,830 | SH | DFND | 177,830 | 0 | 0 | ||
| RECRO PHARMA INC | COM | 75629F109 | 18,136 | 2,075,000 | SH | DFND | 2,075,000 | 0 | 0 | ||
| SAGE THERAPEUTICS INC | COM | 78667J108 | 8,671 | 122,000 | SH | DFND | 122,000 | 0 | 0 | ||
| SANGAMO THERAPEUTICS INC | COM | 800677106 | 4,357 | 837,963 | SH | DFND | 837,963 | 0 | 0 | ||
| SCYNEXIS INC | COM | 811292101 | 2,892 | 1,048,000 | SH | DFND | 1,048,000 | 0 | 0 | ||
| SELECTA BIOSCIENCES INC | COM | 816212104 | 15,179 | 1,060,000 | SH | DFND | 1,060,000 | 0 | 0 | ||
| SIERRA ONCOLOGY INC | COM | 82640U107 | 7,608 | 4,972,319 | SH | DFND | 4,972,319 | 0 | 0 | ||
| SPARK THERAPEUTICS INC | COM | 84652J103 | 15,095 | 283,000 | SH | DFND | 283,000 | 0 | 0 | ||
| STEADYMED LTD | SHS | M84920103 | 10,187 | 1,756,370 | SH | DFND | 1,756,370 | 0 | 0 | ||
| STREAMLINE HEALTH SOLUTIONS | COM | 86323X106 | 676 | 662,971 | SH | DFND | 662,971 | 0 | 0 | ||
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 523 | 38,130 | SH | DFND | 38,130 | 0 | 0 | ||
| SYROS PHARMACEUTICALS INC | COM | 87184Q107 | 25,729 | 1,615,136 | SH | DFND | 1,615,136 | 0 | 0 | ||
| TESARO INC | COM | 881569107 | 10,155 | 66,000 | SH | DFND | 66,000 | 0 | 0 | ||
| TG THERAPEUTICS INC | COM | 88322Q108 | 8,155 | 700,000 | SH | DFND | 700,000 | 0 | 0 | ||
| THRESHOLD PHARMACEUTICAL INC | COM NEW | 885807206 | 1,255 | 2,202,160 | SH | DFND | 2,202,160 | 0 | 0 | ||
| TIVITY HEALTH INC | COM | 88870R102 | 2,212 | 76,000 | SH | DFND | 76,000 | 0 | 0 | ||
| TRINITY BIOTECH INVT LTD | NOTE 4.000% 4/0 | 89643QAB4 | 38,917 | 48,000,000 | PRN | DFND | 48,000,000 | 0 | 0 | ||
| UNIVERSAL AMERN CORP NEW | COM | 91338E101 | 28,250 | 2,833,531 | SH | DFND | 2,833,531 | 0 | 0 | ||
| VALEANT PHARMACEUTICALS INTL | COM | 91911K102 | 16,545 | 1,500,000 | SH | DFND | 1,500,000 | 0 | 0 | ||
| VANDA PHARMACEUTICALS INC | COM | 921659108 | 32,187 | 2,299,046 | SH | DFND | 2,299,046 | 0 | 0 | ||
| VOYAGER THERAPEUTICS INC | COM | 92915B106 | 1,558 | 117,647 | SH | DFND | 117,647 | 0 | 0 | ||
| WALGREENS BOOTS ALLIANCE INC | COM | 931427108 | 29,562 | 355,957 | SH | DFND | 355,957 | 0 | 0 | ||
| WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 12,983 | 472,124 | SH | DFND | 472,124 | 0 | 0 | ||
| WRIGHT MED GROUP INC | NOTE 2.000% 2/1 | 98235TAE7 | 23,987 | 20,025,000 | PRN | DFND | 20,025,000 | 0 | 0 | ||
| XENCOR INC | COM | 98401F105 | 30,731 | 1,284,758 | SH | DFND | 1,284,758 | 0 | 0 | ||