The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AGNICO EAGLE MINES LTD COM 008474108 32,153 757,600 SH   DFND 1 757,600 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 1,539 74,000 SH   DFND 1 74,000 0 0
ALLERGAN PLC SHS G0177J108 702,863 2,941,834 SH   DFND 1 2,941,834 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 40,518 334,200 SH   DFND 1 334,200 0 0
ALPHABET INC CAP STK CL C 02079K107 9,291 11,200 SH   DFND 1 11,200 0 0
ALEXION PHARMACEUTICALS INC CALL 015351109 24,248 200,000 SH Call DFND 1 200,000 0 0
AMAZON COM INC COM 023135106 4,876 5,500 SH   DFND 1 5,500 0 0
AMERICAN INTL GROUP INC COM NEW 026874784 283,969 4,548,593 SH   DFND 1 4,548,593 0 0
ANGLOGOLD ASHANTI LTD SPONSORED ADR 035128206 137,666 12,782,400 SH   DFND 1 12,782,400 0 0
AKORN INC COM 009728106 202,202 8,397,100 SH   DFND 1 8,397,100 0 0
ARADIGM CORP COM NO PAR NEW 038505400 299 192,727 SH   DFND 1 192,727 0 0
ARCONIC INC COM 03965L100 25,900 983,300 SH   DFND 1 983,300 0 0
ARES CAP CORP COM 04010L103 0 1 SH   DFND 1 1 0 0
ATLASSIAN CORP PLC CL A G06242104 4,715 157,415 SH   DFND 1 157,415 0 0
BANK OF AMERICA CORPORATION * W Exp 01/16/2019 060505146 70,778 6,263,526 SH   DFND 1 6,263,526 0 0
BANK OF AMERICA CORPORATION * W Exp 10/28/2018 060505153 8,194 8,928,344 SH   DFND 1 8,928,344 0 0
BIOCRYST PHARMACEUTICALS CALL 09058V103 2,940 350,000 SH Call DFND 1 350,000 0 0
BIOGEN INC COM 09062X103 4,730 17,300 SH   DFND 1 17,300 0 0
BROOKDALE SR LIVING INC COM 112463104 67,707 5,041,500 SH   DFND 1 5,041,500 0 0
CAESARS ACQUISITION CO CL A 12768T103 202,017 13,117,998 SH   DFND 1 13,117,998 0 0
CAESARS ENTMT CORP COM 127686103 137,691 14,417,900 SH   DFND 1 14,417,900 0 0
COBALT INTL ENERGY INC COM 19075F106 16,506 30,944,127 SH   DFND 1 30,944,127 0 0
COBALT INTL ENERGY INC NOTE 3.125% 5/15/2024 19075FAB2 54,807 219,229,000 SH   DFND 1 219,229,000 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 1,198 70,229 SH   DFND 1 70,229 0 0
CORESITE RLTY CORP COM 21870Q105 5,421 60,200 SH   DFND 1 60,200 0 0
COMMUNITY HEALTH SYS INC NEW PUT 203668108 3,016 340,000 SH Put DFND 1 340,000 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 1,099 50,500 SH   DFND 1 50,500 0 0
DEXCOM INC COM 252131107 20,395 240,700 SH   DFND 1 240,700 0 0
DISH NETWORK CORP CL A 25470M109 219,047 3,450,100 SH   DFND 1 3,450,100 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 2,755 463,000 SH   DFND 1 463,000 0 0
EBAY INC COM 278642103 15,818 471,200 SH   DFND 1 471,200 0 0
EDITAS MEDICINE INC COM 28106W103 1,116 50,000 SH   DFND 1 50,000 0 0
ENDO INTL PLC SHS G30401106 87,482 7,838,900 SH   DFND 1 7,838,900 0 0
ENZYMOTEC LTD SHS M4059L101 37,013 4,205,980 SH   DFND 1 4,205,980 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 8,185 231,800 SH   DFND 1 231,800 0 0
ETSY INC COM 29786A106 8,855 833,000 SH   DFND 1 833,000 0 0
EXTENDED STAY AMER INC UNIT 99/99/9999B 30224P200 318,573 20,086,590 SH   DFND 1 20,086,590 0 0
FACEBOOK INC CL A 30303M102 26,322 185,300 SH   DFND 1 185,300 0 0
FEDEX CORP COM 31428X106 9,660 49,500 SH   DFND 1 49,500 0 0
FIDELITY & GTY LIFE COM 315785105 11,120 400,000 SH   DFND 1 400,000 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 17,501 415,100 SH   DFND 1 415,100 0 0
HEADWATERS INC COM 42210P102 2,348 100,000 SH   DFND 1 100,000 0 0
IAMGOLD CORP COM 450913108 15,456 3,863,912 SH   DFND 1 3,863,912 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 1,107 78,600 SH   DFND 1 78,600 0 0
INTERSECT ENT INC COM 46071F103 10,978 640,100 SH   DFND 1 640,100 0 0
INSMED INC COM PAR $.01 457669307 1,576 90,000 SH   DFND 1 90,000 0 0
INTERNATIONAL SEAWAYS INC COM ADDED Y41053102 70,214 3,672,279 SH   DFND 1 3,672,279 0 0
INTERNATIONAL TOWER HILL MIN COM 46050R102 29,131 55,487,842 SH   DFND 1 55,487,842 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 5,672 7,400 SH   DFND 1 7,400 0 0
K2M GROUP HLDGS INC COM 48273J107 1,979 96,500 SH   DFND 1 96,500 0 0
KAMADA LTD SHS M6240T109 4,969 730,800 SH   DFND 1 730,800 0 0
LOXO ONCOLOGY INC COM 548862101 34,190 812,500 SH   DFND 1 812,500 0 0
MALLINCKRODT PUB LTD CO SHS G5785G107 334,318 7,500,972 SH   DFND 1 7,500,972 0 0
MEAD JOHNSON NUTRITION CO COM 582839106 105,489 1,184,200 SH   DFND 1 1,184,200 0 0
MERCADOLIBRE INC COM 58733R102 5,794 27,400 SH   DFND 1 27,400 0 0
MOBILEYE N V AMSTELVEEN ORD SHS N51488117 4,666 76,000 SH   DFND 1 76,000 0 0
MONSANTO CO NEW COM 61166W101 4,019 35,500 SH   DFND 1 35,500 0 0
MULESOFT INC CL A ADDED 625207105 487 20,000 SH   DFND 1 20,000 0 0
MYLAN N V SHS EURO N59465109 673,528 17,274,387 SH   DFND 1 17,274,387 0 0
MYLAN N V CALL N59465109 7,798 200,000 SH Call DFND 1 200,000 0 0
NEUSTAR INC CL A 64126X201 6,630 200,000 SH   DFND 1 200,000 0 0
NOVAGOLD RES INC COM NEW 66987E206 107,776 22,130,696 SH   DFND 1 22,130,696 0 0
NOVADAQ TECHNOLOGIES INC PUT 66987G102 3,895 500,000 SH Put DFND 1 500,000 0 0
NXP SEMICONDUCTORS N V COM N6596X109 117,193 1,132,300 SH   DFND 1 1,132,300 0 0
OASIS PETE INC NEW COM 674215108 73,532 5,156,544 SH   DFND 1 5,156,544 0 0
OFFICE DEPOT INC COM 676220106 66,542 14,264,100 SH   DFND 1 14,264,100 0 0
OVERSEAS SHIPHOLDING GROUP I CL A NEW ADDED 69036R863 174 45,139 SH   DFND 1 45,139 0 0
PALO ALTO NETWORKS INC COM 697435105 17,556 155,800 SH   DFND 1 155,800 0 0
PFIZER INC COM 717081103 13,941 407,500 SH   DFND 1 407,500 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 584 15,690 SH   DFND 1 15,690 0 0
RANDGOLD RES LTD ADR 752344309 37,679 431,700 SH   DFND 1 431,700 0 0
REALOGY HLDGS CORP COM 75605Y106 142,545 4,785,000 SH   DFND 1 4,785,000 0 0
REYNOLDS AMERICAN INC COM 761713106 7,941 126,000 SH   DFND 1 126,000 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 1,821 550,000 SH   DFND 1 550,000 0 0
SANDRIDGE ENERGY INC COM NEW ADDED 80007P869 12,324 666,535 SH   DFND 1 666,535 0 0
SANOFI SPONSORED ADR 80105N105 6,788 150,000 SH   DFND 1 150,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 2,312 78,101 SH   DFND 1 78,101 0 0
SERVICEMASTER GLOBAL HLDGS I COM 81761R109 4,760 114,000 SH   DFND 1 114,000 0 0
SHIRE PLC SPONSORED ADR 82481R106 696,589 3,998,100 SH   DFND 1 3,998,100 0 0
SHIRE PLC CALL 82481R106 13,067 75,000 SH Call DFND 1 75,000 0 0
SHIRE PLC CALL 82481R106 4,356 25,000 SH Call DFND 1 25,000 0 0
SHIRE PLC CALL 82481R106 5,227 30,000 SH Call DFND 1 30,000 0 0
SNAP INC PUT 83304A106 13,067 580,000 SH Put DFND 1 580,000 0 0
SPDR GOLD TRUST GOLD SHS 78463V107 517,586 4,359,722 SH   DFND 1 4,359,722 0 0
STERIS PLC SHS USD G84720104 29,416 423,500 SH   DFND 1 423,500 0 0
SYNERGY PHARMACEUTICALS DEL COM NEW 871639308 112,253 24,088,655 SH   DFND 1 24,088,655 0 0
SYNTHESIS ENERGY SYS INC COM 871628103 8,520 10,000,000 SH   DFND 1 10,000,000 0 0
T MOBILE US INC COM 872590104 267,409 4,140,100 SH   DFND 1 4,140,100 0 0
TANDEM DIABETES CARE INC COM 875372104 600 500,000 SH   DFND 1 500,000 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADR 881624209 352,903 10,997,300 SH   DFND 1 10,997,300 0 0
TIM PARTICIPACOES S A SPONSORED ADR 88706P205 89,678 5,611,900 SH   DFND 1 5,611,900 0 0
TIME INC NEW COM 887228104 19,000 981,900 SH   DFND 1 981,900 0 0
TIME WARNER INC COM NEW 887317303 295,475 3,024,000 SH   DFND 1 3,024,000 0 0
TREVENA INC COM 89532E109 1,496 407,626 SH   DFND 1 407,626 0 0
TRILOGY METALS INC NEW COM 89621C105 6,370 11,584,373 SH   DFND 1 11,584,373 0 0
VALEANT PHARMACEUTICALS INTL COM 91911K102 213,811 19,384,500 SH   DFND 1 19,384,500 0 0
WEBMD HEALTH CORP COM 94770V102 7,665 145,500 SH   DFND 1 145,500 0 0
WHITEWAVE FOODS CO COM 966244105 37,621 670,000 SH   DFND 1 670,000 0 0
LYON WILLIAM HOMES CL A NEW 552074700 68,513 3,322,666 SH   DFND 1 3,322,666 0 0
ZILLOW GROUP INC CL C CAP STK 98954M200 5,606 166,500 SH   DFND 1 166,500 0 0