The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC Common 004225108 17,130 614,200 SH   SOLE   614,200 0 0
AERIE PHARMACEUTICALS INC Common 00771V108 12,131 230,842 SH   SOLE   230,842 0 0
AGENUS INC Common 00847G705 12,449 3,183,828 SH   SOLE   3,183,828 0 0
ALIMERA SCIENCES INC Common 016259103 8,189 5,891,581 SH   SOLE   5,891,581 0 0
AMICUS THERAPEUTICS INC Common 03152W109 59,725 5,930,956 SH   SOLE   5,930,956 0 0
AMICUS THERAPEUTICS INC Common 03152W109 532 250,000 SH Call SOLE   250,000 0 0
ARGENX SE Sponsored ADR 04016X101 4,573 215,597 SH   SOLE   215,597 0 0
ARRAY BIOPHARMA INC Common 04269X105 34,948 4,175,376 SH   SOLE   4,175,376 0 0
ARRAY BIOPHARMA INC Common 04269X105 587 500,000 SH Call SOLE   500,000 0 0
ASCENDIS PHARMA Sponsored ADR 04351P101 27,508 990,924 SH   SOLE   990,924 0 0
ASSEMBLY BIOSCIENCES INC Common 045396108 12,538 607,162 SH   SOLE   607,162 0 0
AVEO PHARMACEUTICALS INC Common 053588109 14,724 6,632,452 SH   SOLE   6,632,452 0 0
AXOVANT SCIENCES LTD Common G0750W104 1,904 82,087 SH   SOLE   82,087 0 0
BIOCRYST PHARMACEUTICALS INC Common 09058V103 10,862 1,953,525 SH   SOLE   1,953,525 0 0
BIOMARIN PHARMACEUTICAL INC Common 09061G101 45,482 500,789 SH   SOLE   500,789 0 0
CASCADIAN THERAPEUTICS INC Common 14740B606 6,766 1,821,248 SH   SOLE   1,821,248 0 0
CATALYST PHARMACEUTICALS INC Common 14888U101 10,501 3,804,745 SH   SOLE   3,804,745 0 0
CELLECTIS - ADR Sponsored ADR 15117K103 2,212 85,689 SH   SOLE   85,689 0 0
CLOVIS ONCOLOGY INC Common 189464100 13,174 140,700 SH   SOLE   140,700 0 0
DERMIRA INC Common 24983L104 38,611 1,325,000 SH   SOLE   1,325,000 0 0
FORTRESS BIOTECH INC Common 34960Q109 2,867 603,657 SH   SOLE   603,657 0 0
GLOBAL BLOOD THERAPEUTICS INC Common 37890U108 23,521 860,000 SH   SOLE   860,000 0 0
IMMUNOMEDICS INC Common 452907108 92,610 10,488,076 SH   SOLE   10,488,076 0 0
IOVANCE BIOTHERAPEUTICS INC Common 462260100 30,512 4,151,343 SH   SOLE   4,151,343 0 0
KITE PHARMA INC Common 49803L109 83,636 806,750 SH   SOLE   806,750 0 0
MEDICINES CO Common 584688105 42,157 1,109,100 SH   SOLE   1,109,100 0 0
MEDICINES CO Common 584688105 20 100,000 SH Call SOLE   100,000 0 0
MEDICINES CO Common 584688105 30 100,000 SH Call SOLE   100,000 0 0
MIRATI THERAPEUTICS INC Common 60468T105 8,305 2,275,401 SH   SOLE   2,275,401 0 0
NEUROCRINE BIOSCIENCES INC Common 64125C109 10,097 219,500 SH   SOLE   219,500 0 0
NEURODERM LTD Common M74231107 1,331 44,516 SH   SOLE   44,516 0 0
NEVRO CORP Common 64157F103 3,722 50,000 SH   SOLE   50,000 0 0
ONCOBIOLOGICS INC Common 68235M105 684 683,531 SH   SOLE   683,531 0 0
ONCOBIOLOGICS INC - WARRANT A Warrant 68235M113 40 233,333 SH   SOLE   233,333 0 0
ONCOBIOLOGICS INC - WARRANT B Warrant 68235M121 22 233,333 SH   SOLE   233,333 0 0
OVASCIENCE INC Common 69014Q101 489 313,316 SH   SOLE   313,316 0 0
PACIRA PHARMACEUTICALS INC Common 695127100 22,220 465,818 SH   SOLE   465,818 0 0
PERNIX THERAPEUTICS HOLDINGS INC Convertible Debt 71426VAK4 1,859 6,000,000 PRN   SOLE   6,000,000 0 0
PTC THERAPEUTICS Common 69366J200 2,200 120,000 SH   SOLE   120,000 0 0
SPDR S&P 500 ETF Put 78462F953 1,456 250,000 SH Put SOLE   250,000 0 0
SANGAMO THERAPEUTICS INC Common 800677106 7,040 800,000 SH   SOLE   800,000 0 0
SORRENTO THERAPEUTICS INC Common 83587F202 832 416,230 SH   SOLE   416,230 0 0
TELIGENT INC Common 87960W104 37,797 4,130,800 SH   SOLE   4,130,800 0 0
TESARO INC Common 881569107 56,000 400,403 SH   SOLE   400,403 0 0
VANDA PHARMACEUTICALS INC Common 921659108 14,705 902,146 SH   SOLE   902,146 0 0
VERACYTE INC Common 92337F107 7,560 907,596 SH   SOLE   907,596 0 0
VIVEVE MEDICAL INC Common 92852W204 5,712 795,500 SH   SOLE   795,500 0 0